Epidemiology and clinical manifestations of enteroaggregative escherichia coli

Clinical Microbiology Reviews

Volumn 27, Issue 3, 2014, Pages 614-630

  Jensen, Betina Hebbelstrup ^a   Olsen, Katharina E P ^a   Struve, Carsten ^a   Krogfelt, Karen Angeliki ^a   Petersen, Andreas Munk ^a,b  

^a STATENS SERUM INSTITUT   (Denmark)

^b HVIDOVRE HOSPITAL   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; BACTERIAL TRANSMISSION; BACTERIUM ADHERENCE; BIOFILM; DIARRHEA; ENTEROAGGREGATIVE ESCHERICHIA COLI; ESCHERICHIA COLI INFECTION; HUMAN; INFLAMMATION; MOLECULAR PHYLOGENY; NONHUMAN; PATHOGENESIS; URINARY TRACT INFECTION; CHILD; DEVELOPED COUNTRY; DEVELOPING COUNTRY; DISEASE CARRIER; DRUG EFFECTS; EPIDEMIC; ESCHERICHIA COLI; ESCHERICHIA COLI INFECTIONS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MICROBIOLOGY; MIXED INFECTION; MULTIDRUG RESISTANCE; PATHOGENICITY; PHYSIOLOGY; TRANSMISSION; TRAVEL; URINARY TRACT INFECTIONS;

ANTIINFECTIVE AGENT;

ANTI-BACTERIAL AGENTS; CHILD; COINFECTION; DEVELOPED COUNTRIES; DEVELOPING COUNTRIES; DIARRHEA; DISEASE OUTBREAKS; DISEASE RESERVOIRS; DRUG RESISTANCE, MULTIPLE, BACTERIAL; ESCHERICHIA COLI; ESCHERICHIA COLI INFECTIONS; HIV INFECTIONS; HUMANS; TRAVEL; URINARY TRACT INFECTIONS;

EID: 84903556357     PISSN: 08938512     EISSN: 10986618     Source Type: Journal    
DOI: 10.1128/CMR.00112-13     Document Type: Article

References (160)

1. Farthing M, Salam MA, Lindberg G, Dite P, Khalif I, Salazar-Lindo E, Ramakrishna BS, Goh KL, Thomson A, Khan AG, Krabshuis J, Lemair A. 2013. Acute diarrhea in adults and children: a global perspective. J. Clin. Gastroenterol. 47:12-20. http://dx.doi.org/10.1097/MCG.0b013e3 1826df662.
2. Kotloff KL, Blackwelder WC, Nasrin D, Nataro JP, Farag TH, van Eijk A, Adegbola RA, Alonso PL, Breiman RF, Faruque AS, Saha D, Sow SO, Sur D, Zaidi AK, Biswas K, Panchalingam S, Clemens JD, Cohen D, Glass RI, Mintz ED, Sommerfelt H, Levine MM. 2012. The Global Enteric Multicenter Study (GEMS) of diarrheal disease in infants and young children in developing countries: epidemiologic and clinical methods of the case/control study. Clin. Infect. Dis. 55(Suppl 4):S232-S245. http://dx.doi.org/10.1093/cid/cis753.
3. Nataro JP, Kaper JB. 1998. Diarrheagenic Escherichia coli. Clin. Microbiol. Rev. 11:142-201.
4. Arenas-Hernández MM, Martínez-Laguna Y, Torres AG. 2012. Clinical implications of enteroadherent Escherichia coli. Curr. Gastroenterol. Rep. 14:386-394. http://dx.doi.org/10.1007/s11894-012-0277-1.
5. Croxen MA, Law RJ, Scholz R, Keeney KM, Wlodarska M, Finlay BB. 2013. Recent advances in understanding enteric pathogenic Escherichia coli. Clin. Microbiol. Rev. 26:822-880. http://dx.doi.org/10.1128/CMR.00022-13.
6. Nataro JP, Kaper JB, Robins-Browne R, Prado V, Vial P, Levine MM. 1987. Patterns of adherence of diarrheagenic Escherichia coli to HEp-2 cells. Pediatr. Infect. Dis. J. 6:829-831. http://dx.doi.org/10.1097 /00006454-198709000-00008.
7. Okeke IN, Macfarlane-Smith LR, Fletcher JN, Snelling AM. 2011. IS3 profiling identifies the enterohaemorrhagic Escherichia coli O-island 62 in a distinct enteroaggregative E. coli lineage. Gut Pathog. 3:4. http://dx.doi.org/10.1186/1757-4749-3-4.
8. Bangar R, Mamatha B. 2008. Identification of enteroaggregative Escherichia coli in infants with acute diarrhea based on biofilm production in Manipal, South India. Indian J. Med. Sci. 62:8-12. http://dx.doi.org/10.4103/0019-5359.38916.
9. Harrington SM, Dudley EG, Nataro JP. 2006. Pathogenesis of enteroaggregative Escherichia coli infection. FEMS Microbiol. Lett. 254:12-18. http://dx.doi.org/10.1111/j.1574-6968.2005.00005.x.
10. Hicks S, Candy DC, Phillips AD. 1996. Adhesion of enteroaggregative Escherichia coli to pediatric intestinal mucosa in vitro. Infect. Immun. 64:4751-4760.
11. Jiang ZD, Greenberg D, Nataro JP, Steffen R, DuPont HL. 2002. Rate of occurrence and pathogenic effect of enteroaggregative Escherichia coli virulence factors in international travelers. J. Clin. Microbiol. 40:4185-4190. http://dx.doi.org/10.1128/JCM.40.11.4185-4190.2002.
12. Da Re S, Valle J, Charbonnel N, Beloin C, Latour-Lambert P, Faure P, Turlin E, Le Bouguénec C, Renauld-Mongénie G, Forestier C, Ghigo JM. 2013. Identification of commensal Escherichia coli genes involved in biofilm resistance to pathogen colonization. PLoS One 8:e61628. http: //dx.doi.org/10.1371/journal.pone.0061628.
13. Roche JK, Cabel A, Sevilleja J, Nataro J, Guerrant RL. 2010. Enteroaggregative Escherichia coli (EAEC) impairs growth while malnutrition worsens EAEC infection: a novel murine model of the infection malnutrition cycle. J. Infect. Dis. 202:506-514. http://dx.doi.org/10.1086/654894.
14. Andrade JA, Freymüller E, Fagundes-Neto U. 2011. Adherence of enteroaggregative Escherichia coli to the ileal and colonic mucosa: an in vitro study utilizing the scanning electron microscopy. Arq. Gastroenterol. 48:199-204. http://dx.doi.org/10.1590/S0004-28032011000300009.
15. Sobieszczanska B, Duda AK, Turniak M, Duda-Madej A, Franiczek R, Kasprzykowska U. 2011. Characterization of genes associated with internalization of enteroaggregative Escherichia coli. Microb. Pathog. 50: 141-147. http://dx.doi.org/10.1016/j.micpath.2011.01.006.
16. Pereira AC, Britto-Filho JD, de Carvalho JJ, das Graças de Luna M, Rosa ACP. 2008. Enteroaggregative Escherichia coli (EAEC) strains enter and survive within cultured intestinal epithelial cells. Microb. Pathog. 45:310-314. http://dx.doi.org/10.1016/j.micpath.2008.07.001.
17. Thomazini CM, Samegima DA, Rodrigues MA, Victoria CR, Rodrigues J. 2011. High prevalence of aggregative adherent Escherichia coli strains in the mucosa-associated microbiota of patients with inflammatory bowel diseases. Int. J. Med. Microbiol. 301:475-479. http://dx.doi.org/10.1016/j.ijmm.2011.04.015.
18. Bhargava S, Johnson BB, Hwang J, Harris TA, George AS, Muir A, Dorff J, Okeke IN. 2009. Heat-resistant agglutinin 1 is an accessory enteroaggregative Escherichia coli colonization factor. J. Bacteriol. 191: 4934-4942. http://dx.doi.org/10.1128/JB.01831-08.
19. Czeczulin JR, Balepur S, Hicks S, Phillips A, Hall R, Kothary MH, Navarro-Garcia F, Nataro JP. 1997. Aggregative adherence fimbria II, a second fimbrial antigen mediating aggregative adherence in enteroaggregative Escherichia coli. Infect. Immun. 65:4135-4145.
20. Boisen N, Struve C, Scheutz F, Krogfelt KA, Nataro JP. 2008. New adhesin of enteroaggregative Escherichia coli related to the Afa/Dr/AAF family. Infect. Immun. 76:3281-3292. http://dx.doi.org/10.1128/IAI.01646-07.
21. Nataro JP, Deng Y, Maneval DR, German AL, Martin WC, Levine MM. 1992. Aggregative adherence fimbriae I of enteroaggregative Escherichia coli mediate adherence to HEp-2 cells and hemagglutination of human erythrocytes. Infect. Immun. 60:2297-2304.
22. Bernier C, Gounon P, Le Bouguénec C. 2002. Identification of an aggregative adhesion fimbria (AAF) type III-encoding operon in enteroaggregative Escherichia coli as a sensitive probe for detecting the AAFencoding operon family. Infect. Immun. 70:4302-4311. http://dx.doi.org/10.1128/IAI.70.8.4302-4311.2002.
23. Sheikh J, Czeczulin JR, Harrington S, Hicks S, Henderson IR, Le Bouguénec C, Gounon P, Phillips A, Nataro JP. 2002. A novel dispersin protein in enteroaggregative Escherichia coli. J. Clin. Invest. 110:1329-1337. http://dx.doi.org/10.1172/JCI16172.
24. Farfan MJ, Inman KG, Nataro JP. 2008. The major pilin subunit of the AAF/II fimbriae from enteroaggregative Escherichia coli mediates binding to extracellular matrix proteins. Infect. Immun. 76:4378-4384. http: //dx.doi.org/10.1128/IAI.00439-08.
25. Izquierdo M, Navarro-Garcia F, Nava-Acosta R, Nataro JP, Ruiz-Perez F, Farfan MJ. 2014. Identification of cell surface-exposed proteins involved in the fimbria-mediated adherence of enteroaggregative Escherichia coli to intestinal cells. Infect. Immun. 82:1719-1724. http://dx.doi.org/10.1128/IAI.01651-13.
26. Yamamoto T, Endo S, Yokota T, Echeverria P. 1991. Characteristics of adherence of enteroaggregative Escherichia coli to human and animal mucosa. Infect. Immun. 59:3722-3739.
27. Morin N, Santiago AE, Ernst R K, Guillot S J, Nataro JP. 2013. Characterization of the AggR regulon in enteroaggregative Escherichia coli. Infect. Immun. 81:122-132. http://dx.doi.org/10.1128/IAI.00676-12.
28. Dudley EG, Thomson NR, Parkhill J, Morin NP, Nataro JP. 2006. Proteomic and microarray characterization of the AggR regulon identifies a pheU pathogenicity island in enteroaggregative Escherichia coli. Mol. Microbiol. 61:1267-1282. http://dx.doi.org/10.1111/j.1365-2958.2006.05281.x.
29. Huang DB, Mohamed JA, Nataro JP, DuPont HL, Jiang ZD, Okhuysen PC. 2007. Virulence characteristics and the molecular epidemiology of enteroaggregative Escherichia coli isolates from travellers to developing countries. J. Med. Microbiol. 56:1386-1392. http://dx.doi.org/10.1099/jmm.0.47161-0.
30. Navarro-Garcia F, Gutierrez-Jimenez J, Garcia-Tovar C, Castro LA, Salazar-Gonzalez H, Cordova V. 2010. Pic, an autotransporter protein secreted by different pathogens in the Enterobacteriaceae family, is a potent mucus secretagogue. Infect. Immun. 78:4101-4109. http://dx.doi.org/10.1128/IAI.00523-10.
31. Tokuda K, Nishi J, Imuta N, Fujiyama R, Kamenosono A, Manago K, Kawano Y. 2010. Characterization of typical and atypical enteroaggregative Escherichia coli in Kagoshima, Japan: biofilm formation and acid resistance. Microbiol. Immunol. 54:320-329. http://dx.doi.org/10.1111 /j.1348-0421.2010.00210.x.
32. Pereira AL, Ferraz LR, Silva RS, Giugliano LG. 2007. Enteroaggregative Escherichia coli virulence markers: positive association with distinct clinical characteristics and segregation into 3 enteropathogenic E. coli serogroups. J. Infect. Dis. 195:366-374. http://dx.doi.org/10.1086/510538.
33. Sheikh J, Hicks S, Dall'Agnol M, Phillips AD, Nataro JP. 2001. Roles for Fis and YafK in biofilm formation by enteroaggregative Escherichia coli. Mol. Microbiol. 41:983-997. http://dx.doi.org/10.1046/j.1365-2958.2001.02512.x.
34. Boll EJ, Struve C, Boisen N, Olesen B, Stahlhut SG, Krogfelt KA. 2013. Role of enteroaggregative Escherichia coli virulence factors in uropathogenesis. Infect. Immun. 81:1164-1171. http://dx.doi.org/10.1128/IAI.01376-12.
35. Shamir ER, Warthan M, Brown SP, Nataro JP, Guerrant RL, Hoffman PS. 2010. Nitazoxanide inhibits biofilm production and hemagglutination by enteroaggregative Escherichia coli strains by blocking assembly of AafA fimbriae. Antimicrob. Agents Chemother. 54:1526-1533. http://dx.doi.org/10.1128/AAC.01279-09.
36. Fujiyama R, Nishi J, Imuta N, Tokuda K, Manago K, Kawano Y. 2008. The shf gene of a Shigella flexneri homologue on the virulent plasmid pAA2 of enteroaggregative Escherichia coli 042 is required for firm biofilm formation. Curr. Microbiol. 56:474-480. http://dx.doi.org/10.1007 /s00284-008-9115-y.
37. Mohamed JA, Huang DB, Jiang ZD, DuPont HL, Nataro JP, Belkind-Gerson J, Okhuysen PC. 2007. Association of putative enteroaggregative Escherichia coli virulence genes and biofilm production in isolates from travelers to developing countries. J. Clin. Microbiol. 45:121-126. http://dx.doi.org/10.1128/JCM.01128-06.
38. Wani SA, Hussain I, Rather MA, Kabli ZA, Nagamani K, Nishikawa Y, Qureshi SD, Khan I. 2012. Putative virulence genes and biofilm production among typical enteroaggregative Escherichia coli isolates from diarrhoeic children in Kashmir and Andhra Pradesh. Indian J. Microbiol. 52:587-592. http://dx.doi.org/10.1007/s12088-012-0284-9.
39. Mendez-Arancibia E, Vargas M, Soto S, Ruiz J, Kahigwa E, Schellenberg D, Urassa H, Gascón J, Vila J. 2008. Prevalence of different virulence factors and biofilm production in enteroaggregative Escherichia coli isolates causing diarrhea in children in Ifakara (Tanzania). Am. J. Trop. Med. Hyg. 78:985-989. http://www.ajtmh.org/content/78/6/98 5.long.
40. Nataro JP, Mai V, Johnson J, Blackwelder WC, Heimer R, Tirrell S, Edberg SC, Braden CR, Glenn Morris J, Jr, Hirshon JM. 2006. Diarrheagenic Escherichia coli infection in Baltimore, Maryland, and New Haven, Connecticut. Clin. Infect. Dis. 43:402-407. http://dx.doi.org/10.1086/505867.
41. Henderson IR, Navarro-Garcia F, Nataro JP. 1998. The great escape: structure and function of the autotransporter proteins. Trends Microbiol. 6:370-378. http://dx.doi.org/10.1016/S0966-842X(98)01318-3.
42. Boisen N, Scheutz F, Rasko DA, Redman JC, Persson S, Simon J, Kotloff KL, Levine MM, Sow S, Tamboura B, Toure A, Malle D, Panchalingam S, Krogfelt KA, Nataro JP. 2012. Genomic characterization of enteroaggregative Escherichia coli from children in Mali. J. Infect. Dis. 205:431-444. http://dx.doi.org/10.1093/infdis/jir757.
43. Benjelloun-Touimi Z, Sansonetti PJ, Parsot C. 1995. SepA, the major extracellular protein of Shigella flexneri: autonomous secretion and involvement in tissue invasion. Mol. Microbiol. 17:123-135. http://dx.doi.org/10.1111/j.1365-2958.1995.mmi_17010123.x.
44. Navarro-García F, Sears C, Eslava C, Cravioto A, Nataro JP. 1999. Cytoskeletal effects induced by pet, the serine protease enterotoxin of enteroaggregative Escherichia coli. Infect. Immun. 67:2184-2192.
45. Eslava C, Navarro-García F, Czeczulin JR, Henderson IR, Cravioto A, Nataro JP. 1998. Pet, an autotransporter enterotoxin from enteroaggregative Escherichia coli. Infect. Immun. 66:3155-3163.
46. Guyer DM, Radulovic S, Jones F, Mobley HLT. 2002. Sat, the secreted autotransporter toxin of uropathogenic Escherichia coli, is a vacuolating cytotoxin for bladder and kidney epithelial cells. Infect. Immun. 70: 4539-4546. http://dx.doi.org/10.1128/IAI.70.8.4539-4546.2002.
47. Henderson IR, Czeczulin J, Eslava C, Noriega F, Nataro JP. 1999. Characterization of pic, a secreted protease of Shigella flexneri and enteroaggregative Escherichia coli. Infect. Immun. 67:5587-5596.
48. Savarino SJ, McVeigh A, Watson J, Cravioto A, Molina J, Echeverria P, Bhan MK, Levine MM, Fasano A. 1996. Enteroaggregative Escherichia coli heat-stable enterotoxin is not restricted to enteroaggregative E. coli. J. Infect. Dis. 173:1019-1022. http://dx.doi.org/10.1093/infdis/173.4.1019.
49. Savarino S, Farsano A, Robertson D, Levine MM. 1991. Enteroaggregative Escherichia coli elaborate a heat-stable enterotoxin demonstrable in an in vitro rabbit intestinal model. J. Clin. Invest. 87:1450-1455.
50. Ménard L-P, Dubreuil JD. 2002. Enteroaggregative Escherichia coli heat-stable enterotoxin 1 (EAST1): a new toxin with an old twist. Crit. Rev. Microbiol. 28:43-60. http://dx.doi.org/10.1080/1040-84029104 6687.
51. Huang DB, Jiang Z-D, Dupont HL. 2003. Association of virulence factor-positive and-negative enteroaggregative Escherichia coli and occurrence of clinical illness in travelers from the United States to Mexico. Am. J. Trop. Med. Hyg. 69:506-508. http://www.ajtmh.org/content/69/ 5/506.long.
52. Aslani MM, Alikhani MY, Zavari A, Yousefi R, Zamani AR. 2011. Characterization of enteroaggregative Escherichia coli (EAEC) clinical isolates and their antibiotic resistance pattern. Int. J. Infect. Dis. 15: e136-e139. http://dx.doi.org/10.1016/j.ijid.2010.10.002.
53. Navarro-García F, Eslava C, Villaseca JM, López-Revilla R, Czeczulin JR, Srinivas S, Nataro JP, Cravioto A. 1998. In vitro effects of a highmolecular-weight heat-labile enterotoxin from enteroaggregative Escherichia coli. Infect. Immun. 66:3149-3154.
54. Fasano A, Noriega FR, Maneval DR, Jr, Chanasongcram S, Russell R, Guandalini S, Levine MM. 1995. Shigella enterotoxin 1: an enterotoxin of Shigella flexneri 2a active in rabbit small intestine in vivo and in vitro. J. Clin. Invest. 95:2853-2861. http://dx.doi.org/10.1172/JCI117991.
55. Nataro JP, Hicks S, Phillips AD, Vial PA, Sears CL. 1996. T84 cells in culture as a model for enteroaggregative Escherichia coli pathogenesis. Infect. Immun. 64:4761-4768.
56. Vial PA, Robins-Browne R, Lior H, Prado V, Kaper JB, Nataro JP, Maneval D, Elsayed A, Levine MM. 1988. Characterization of enteroadherent-aggregative Escherichia coli, a putative agent of diarrheal disease. J. Infect. Dis. 158:70-79.
57. Schubert S, Rakin A, Karch H, Carniel E, Heesemann J. 1998. Prevalence of the "high-pathogenicity island" of Yersinia species among Escherichia coli strains that are pathogenic to humans. Infect. Immun. 66: 480-485.
58. Herzer PJ, Inouye S, Inouye M, Whittam TS. 1990. Phylogenetic distribution of branched RNA-linked multicopy single-stranded DNA among natural isolates of Escherichia coli. J. Bacteriol. 172:6175-6181.
59. Czeczulin JR, Whittam TS, Henderson IR, Navarro-Garcia F, Nataro JP. 1999. Phylogenetic analysis of enteroaggregative and diffusely adherent Escherichia coli. Infect. Immun. 67:2692-2699.
60. Escobar-Páramo P, Clermont O, Blanc-Potard AB, Bui H, Le Bouguénec C, Denamur E. 2004. A specific genetic background is required for acquisition and expression of virulence factors in Escherichia coli. Mol. Biol. Evol. 21:1085-1094. http://dx.doi.org/10.1093/molbev/msh118.
61. Clermont O, Bonacorsi S, Bingen E. 2000. Rapid and simple determination of the Escherichia coli phylogenetic group. Appl. Environ. Microbiol. 66:4555-4558. http://dx.doi.org/10.1128/AEM.66.10.4555-4558.2000.
62. Okeke IN, Wallace-Gadsden F, Simons HR, Matthews N, Labar AS, Hwang J, Wain J. 2010. Multi-locus sequence typing of enteroaggregative Escherichia coli isolates from Nigerian children uncovers multiple lineages. PLoS One 5:e14093. http://dx.doi.org/10.1371/journal.pone.0014093.
63. Nataro JP, Deng Y, Cookson S, Cravioto A, Savarino SJ, Guers LD, Levine MM, Tacket CO. 1995. Heterogeneity of enteroaggregative Escherichia coli virulence demonstrated in volunteers. J. Infect. Dis. 171:465-468. http://dx.doi.org/10.1093/infdis/171.2.465.
64. Mathewson JJ, Johnson PC, DuPont HL, Satterwhite TK, Winsor DK. 1986. Pathogenicity of enteroadherent Escherichia coli in adult volunteers. J. Infect. Dis. 154:524-527. http://dx.doi.org/10.1093/infdis/154.3.524.
65. Jenkins C, Chart H, Willshaw GA, Cheasty T, Tompkins DS. 2007. Association of putative pathogenicity genes with adherence characteristics and fimbrial genotypes in typical enteroaggregative Escherichia coli from patients with and without diarrhoea in the United Kingdom. Eur. J. Clin. Microbiol. Infect. Dis. 26:901-906. http://dx.doi.org/10.1007 /s10096-007-0388-z.
66. Vial PA, Mathewson JJ, DuPont HL, Guers L, Levine MM. 1990. Comparison of two assay methods for patterns of adherence to HEp-2 cells of Escherichia coli from patients with diarrhea. J. Clin. Microbiol. 28:882-885.
67. Sarantuya J, Nishi J, Wakimoto N, Erdene S, Nataro JP, Sheikh J, Iwashita M, Manago K, Tokuda K, Yoshinaga M, Miyata K, Kawano Y. 2004. Typical enteroaggregative Escherichia coli is the most prevalent pathotype among E. coli strains causing diarrhea in Mongolian children. J. Clin. Microbiol. 42:133-139. http://dx.doi.org/10.1128/JCM.42.1.133-139.2004.
68. Elias WP, Uber AP, Tomita SK, Trabulsi LR, Gomes TA. 2002. Combinations of putative virulence markers in typical and variant enteroaggregative Escherichia coli strains from children with and without diarrhoea. Epidemiol. Infect. 129:49-55. http://www.ncbi.nlm.nih.gov /pmc/articles/PMC2869874/pdf/12211596.pdf.
69. Moon JY, Park JH, Kim YB. 2005. Molecular epidemiological characteristics of virulence factors on enteroaggregative E. coli. FEMS Microbiol. Lett. 253:215-220. http://dx.doi.org/10.1016/j.femsle.2005.09.038.
70. Cennimo DJ, Koo H, Mohamed JA, Huang DB, Chiang T. 2007. Enteroaggregative Escherichia coli: a review of trends, diagnosis, and treatment. Infect. Med. 2007:100-110. http://antimicrobe.org/h04c.files /history/E.%20Coli-Infect%20in%20Med%20-Cennimo%20et%20al% 20article.pdf.
71. Nishi J, Sheikh J, Mizuguchi K, Luisi B, Burland V, Boutin A, Rose DJ, Blattner FR, Nataro JP. 2003. The export of coat protein from enteroaggregative Escherichia coli by a specific ATP-binding cassette transporter system. J. Biol. Chem. 278:45680-45689. http://dx.doi.org/10.1074/jbc.M306413200.
72. Olesen B, Neimann J, Böttiger B, Ethelberg S, Schiellerup P, Jensen C, Helms M, Scheutz F, Olsen KE, Krogfelt K, Petersen E, Mølbak K, Gerner-Smidt P. 2005. Etiology of diarrhea in young children in Denmark: a case-control study. J. Clin. Microbiol. 43:3636-3641. http://dx.doi.org/10.1128/JCM.43.8.3636-3641.2005.
73. Jenkins C, Tembo M, Chart H, Cheasty T, Willshaw GA, Phillips AD, Tompkins D, Smith H. 2006. Detection of enteroaggregative Escherichia coli in faecal samples from patients in the community with diarrhoea. J. Med. Microbiol. 55:1493-1497. http://dx.doi.org/10.1099 /jmm.0.46683-0.
74. Regua-Mangia AH, Gomes TA, Vieira MA, Irino K, Teixeira LM. 2009. Molecular typing and virulence of enteroaggregative Escherichia coli strains isolated from children with and without diarrhoea in Rio de Janeiro city, Brazil. J. Med. Microbiol. 58:414-422. http://dx.doi.org/10.1099/jmm.0.006502-0.
75. Wilson A, Evans J, Chart H, Cheasty T, Wheeler JG, Tompkins D, Smith HR. 2001. Characterisation of strains of enteroaggregative Escherichia coli isolated during the infectious intestinal disease study in England. Eur. J. Epidemiol. 17:1125-1130. http://dx.doi.org/10.1023 /A:1021224915322.
76. Hien BT, Scheutz F, Cam PD, Serichantalergs O, Huong TT, Thu TM, Dalsgaard A. 2008. Diarrheagenic Escherichia coli and Shigella strains isolated from children in a hospital case-control study in Hanoi, Vietnam. J. Clin. Microbiol. 46:996-1004. http://dx.doi.org/10.1128/JCM.01219-07.
77. Bellini EM, Elias WP, Gomes TA, Tanaka TL, Taddei CR, Huerta R, Navarro-Garcia F, Martinez MB. 2005. Antibody response against plasmid-encoded toxin (Pet) and the protein involved in intestinal colonization (Pic) in children with diarrhea produced by enteroaggregative Escherichia coli. FEMS Immunol. Med. Microbiol. 43:259-264. http://dx.doi.org/10.1016/j.femsim.2004.08.008.
78. Scavia G, Staffolani M, Fisichella S, Striano G, Colletta S, Ferri G, Escher M, Minelli F, Caprioli A. 2008. Enteroaggregative Escherichia coli associated with a foodborne outbreak of gastroenteritis. J. Med. Microbiol. 57:1141-1146. http://dx.doi.org/10.1099/jmm.0.2008/001362-0.
79. Harada T, Hiroi M, Kawamori F, Furusawa A, Ohata K, Sugiyama K, Masuda T. 2007. A food poisoning diarrhea outbreak caused by enteroaggregative Escherichia coli serogroup O126:H27 in Shizuoka, Japan. Jpn. J. Infect. Dis. 60:154-155. http://www0.nih.go.jp/JJID/60/154.pdf.
80. Cobeljić M, Miljković-Selimović B, Paunović-Todosijević D, Velicković Z, Lepsanović Z, Zec N, Savić D, Ilić R, Konstantinović S, Jovanović B, Kostić V. 1996. Enteroaggregative Escherichia coli associated with an outbreak of diarrhoea in a neonatal nursery ward. Epidemiol. Infect. 117:11-16. http://dx.doi.org/10.1017/S0950268800001072.
81. Olesen B, Scheutz F, Andersen RL, Menard M, Boisen N, Johnston B, Hansen DS, Krogfelt KA, Nataro JP, Johnson JR. 2012. Enteroaggregative Escherichia coli O78:H10, the cause of an outbreak of urinary tract infection. J. Clin. Microbiol. 50:3703-3711. http://dx.doi.org/10.1128 /JCM.01909-12.
82. Spencer J, Smith HR, Chart H. 1999. Characterization of enteroaggregative Escherichia coli isolated from outbreaks of diarrhoeal disease in England. Epidemiol. Infect. 123:413-421. http://dx.doi.org/10.1017 /S0950268899002976.
83. Baudry B, Savarino SJ, Vial P, Kaper JB, Levine MM. 1990. A sensitive and specific DNA probe to identify enteroaggregative Escherichia coli, a recently discovered diarrheal pathogen. J. Infect. Dis. 161:1249-1251. http://dx.doi.org/10.1093/infdis/161.6.1249.
84. Kang G, Mathan M, Mathan V. 1995. Evaluation of a simplified HEp-2 cell adherence assay for Escherichia coli isolated from south Indian children with acute diarrhea and controls. J. Clin. Microbiol. 33:2204-2205.
85. Huang DB, Brown EL, DuPont HL, Cerf J, Carlin L, Flores J, Belkind-Gerson J, Nataro JP, Okhuysen PC. 2008. Seroprevalence of the enteroaggregative Escherichia coli virulence factor dispersin among USA travellers to Cuernavaca, Mexico: a pilot study. J. Med. Microbiol. 57:476-479. http://dx.doi.org/10.1099/jmm.0.47495-0.
86. Okhuysen PC, Jiang ZD, Carlin L, Forbes C, DuPont HL. 2004. Post-diarrhea chronic intestinal symptoms and irritable bowel syndrome in North American travelers to Mexico. Am. J. Gastroenterol. 99:1774-1778. http://dx.doi.org/10.1111/j.1572-0241.2004.30435.x.
87. Greenberg DE, Jiang ZD, Steffen R, Verenker MP, DuPont HL. 2002. Markers of inflammation in bacterial diarrhea among travelers, with a focus on enteroaggregative Escherichia coli pathogenicity. J. Infect. Dis. 185:944-949. http://dx.doi.org/10.1086/339617.
88. Shazberg G, Wolk M, Schmidt H, Sechter I, Gottesman G, Miron D. 2003. Enteroaggregative Escherichia coli serotype O126:H27, Israel. Emerg. Infect. Dis. 9:1170-1173. http://dx.doi.org/10.3201/eid0909.020695.
89. Abe CM, Knutton S, Pedroso MZ, Freymüller E, Gomes TA. 2001. An enteroaggregative Escherichia coli strain of serotype O111:H12 damages and invades cultured T84 cells and human colonic mucosa. FEMS Microbiol. Lett. 203:199-205. http://dx.doi.org/10.1111/j.1574-6968.2001.tb10841.x.
90. Itoh Y, Nagano I, Kunishima M, Ezaki T. 1997. Laboratory investigation of enteroaggregative Escherichia coli O untypeable:H10 associated with a massive outbreak of gastrointestinal illness. J. Clin. Microbiol. 35:2546-2550.
91. Huang DB, DuPont HL. 2004. Enteroaggregative Escherichia coli: an emerging pathogen in children. Semin. Pediatr. Infect. Dis. 15:266-271. http://dx.doi.org/10.1053/j.spid.2004.07.008.
92. Yatsuyanagi J, Saito S, Sato H, Miyajima Y, Amano K, Enomoto K. 2002. Characterization of enteropathogenic and enteroaggregative Escherichia coli isolated from diarrheal outbreaks. J. Clin. Microbiol. 40:294-297. http://dx.doi.org/10.1128/JCM.40.1.294-297.2002.
93. Steiner TS, Lima AA, Nataro JP, Guerrant RL. 1998. Enteroaggregative Escherichia coli produce intestinal inflammation and growth impairment and cause interleukin-8 release from intestinal epithelial cells. J. Infect. Dis. 177:88-96. http://dx.doi.org/10.1086/513809.
94. Samie A, Obi CL, Dillingham R, Pinkerton RC, Guerrant RL. 2007. Enteroaggregative Escherichia coli in Venda, South Africa: distribution of virulence-related genes by multiplex polymerase chain reaction in stool samples of human immunodeficiency virus (HIV)-positive and HIVnegative individuals and primary school children. Am. J. Trop. Med. Hyg. 77:142-150. http://www.ajtmh.org/content/77/1/142.long.
95. Denno DM, Shaikh N, Stapp JR, Qin X, Hutter CM, Hoffman V, Mooney JC, Wood KM, Stevens HJ, Jones R, Tarr PI, Klein EJ. 2012. Diarrhea etiology in a pediatric emergency department: a case control study. Clin. Infect. Dis. 55:897-904. http://dx.doi.org/10.1093/cid /cis553.
96. Scheutz F, Nielsen EM, Frimodt-Møller J, Boisen N, Morabito S, Tozzoli R, Nataro JP, Caprioli A. 2011. Characteristics of the enteroaggregative Shiga toxin/verotoxin-producing Escherichia coli O104:H4 strain causing the outbreak of haemolytic uraemic syndrome in Germany, May to June 2011. Euro Surveill. 16(24):pii_19889. http://www.eurosurveillance.org/ViewArticle.aspx?ArticleId_19889.
97. Beutin L, Martin A. 2012. Outbreak of Shiga toxin-producing Escherichia coli (STEC) O104:H4 infection in Germany causes a paradigm shift with regard to human pathogenicity of STEC strains. J. Food Prot. 75: 408-418. http://dx.doi.org/10.4315/0362-028X.JFP-11-452.
98. Rasko DA, Webster DR, Sahl JW, Bashir A, Boisen N, Scheutz F, Paxinos EE, Sebra R, Chin CS, Iliopoulos D, Klammer A, Peluso P, Lee L, Kislyuk AO, Bullard J, Kasarskis A, Wang S, Eid J, Rank D, Redman JC, Steyert SR, Frimodt-Møller J, Struve C, Petersen AM, Krogfelt KA, Nataro JP, Schadt EE, Waldor MK. 2011. Origins of the E. coli strain causing an outbreak of hemolytic-uremic syndrome in Germany. N. Engl. J. Med. 365:709-717. http://dx.doi.org/10.1056/NEJMoa1106920.
99. Bielaszewska M, Mellmann A, Zhang W, Köck R, Fruth A, Bauwens A, Peters G, Karch H. 2011. Characterisation of the Escherichia coli strain associated with an outbreak of haemolytic uraemic syndrome in Germany, 2011: a microbiological study. Lancet Infect. Dis. 11:671-676. http://dx.doi.org/10.1016/S1473-3099(11)70165-7.
100. Abe CM, Salvador FA, Falsetti IN, Vieira MA, Blanco J, Blanco JE, Blanco M, Machado AM, Elias WP, Hernandes RT, Gomes TA. 2008. Uropathogenic Escherichia coli (UPEC) strains may carry virulence properties of diarrhoeagenic E. coli. FEMS Immunol. Med. Microbiol. 52: 397-406. http://dx.doi.org/10.1111/j.1574-695X.2008.00388.x.
101. Guyer DM, Henderson IR, Nataro JP, Mobley HL. 2000. Identification of sat, an autotransporter toxin produced by uropathogenic Escherichia coli. Mol. Microbiol. 38:53-66. http://dx.doi.org/10.1046/j.1365-2958.2000.02110.x.
102. Herzog K, Engeler Dusel J, Hugentobler M, Beutin L, Sägesser G, Stephan R, Hächler H, Nüesch-Inderbinen M. 2014. Diarrheagenic enteroaggregative Escherichia coli causing urinary tract infection and bacteremia leading to sepsis. Infection 42:441-444. http://dx.doi.org/10.1007/s15010-013-0569-x.
103. Khan K, Konar M, Goyal A, Ghosh S. 2010. Enteroaggregative Escherichia coli infection induces IL-8 production via activation of mitogenactivated protein kinases and the transcription factors NF-kappaB and AP-1 in INT-407 cells. Mol. Cell. Biochem. 337:17-24. http://dx.doi.org /10.1007/s11010-009-0282-3.
104. Goyal A, Konar M, Setia A, Narang A, Ghosh S. 2010. Galactose specific adhesin of enteroaggregative E. coli induces IL-8 secretion via activation of MAPK and STAT-3 in INT-407 cells. Biochim. Biophys. Acta 1800:574-579. http://dx.doi.org/10.1016/j.bbagen.2010.03.009.
105. Opintan JA, Newman MJ, Ayeh-Kumi PF, Affrim R, Gepi-Attee R, Sevilleja JE, Roche JK, Nataro JP, Warren CA, Guerrant RL. 2010. Pediatric diarrhea in southern Ghana: etiology and association with intestinal inflammation and malnutrition. Am. J. Trop. Med. Hyg. 83:936-943. http://dx.doi.org/10.4269/ajtmh.2010.09-0792.
106. Steiner TS, Nataro JP, Poteet-Smith CE, Smith JA, Guerrant RL. 2000. Enteroaggregative Escherichia coli expresses a novel flagellin that causes IL-8 release from intestinal epithelial cells. J. Clin. Invest. 105:1769-1777. http://dx.doi.org/10.1172/JCI8892.
107. Garcia PG, Silva VL, Diniz CG. 2011. Occurrence and antimicrobial drug susceptibility patterns of commensal and diarrheagenic Escherichia coli in fecal microbiota from children with and without acute diarrhea. J. Microbiol. 49:46-52. http://dx.doi.org/10.1007/s12275-011-0172-8.
108. Amaya E, Reyes D, Vilchez S, Paniagua M, Mollby R, Nord CE, Weintraub A. 2011. Antibiotic resistance patterns of intestinal Escherichia coli isolates from Nicaraguan children. J. Med. Microbiol. 60:216-222. http://dx.doi.org/10.1099/jmm.0.020842-0.
109. Nüesch-Inderbinen MT, Hofer E, Hächler H, Beutin L, Stephan R. 2013. Characteristics of enteroaggregative Escherichia coli isolated from healthy carriers and from patients with diarrhoea. J. Med. Microbiol. 62(Part 12):1828-1834. http://dx.doi.org/10.1099/jmm.0.065177-0.
110. Chaudhuri RR, Sebaihia M, Hobman JL, Webber MA, Leyton DL, Goldberg MD, Cunningham AF, Scott-Tucker A, Ferguson PR, Thomas CM, Frankel G, Tang CM, Dudley EG, Roberts IS, Rasko DA, Pallen MJ, Parkhill J, Nataro JP, Thomson NR, Henderson IR. 2010. Complete genome sequence and comparative metabolic profiling of the prototypical enteroaggregative Escherichia coli strain 042. PLoS One 5:e8801. http://dx.doi.org/10.1371/journal.pone.0008801.
111. Mohamed JA, DuPont HL, Flores J, Palur H, Nair P, Jiang ZD, Guo D, Belkind-Gerson J, Okhuysen PC. 2011. Single nucleotide polymorphisms in the promoter of the gene encoding the lipopolysaccharide receptor CD14 are associated with bacterial diarrhea in US and Canadian travelers to Mexico. Clin. Infect. Dis. 52:1332-1341. http://dx.doi.org/10.1093/cid/cir228.
112. Monteiro BT, Campos LC, Sircili MP, Franzolin MR, Bevilacqua LF, Nataro JP, Elias WP. 2009. The dispersin-encoding gene (aap) is not restricted to enteroaggregative Escherichia coli. Diagn. Microbiol. Infect. Dis. 65:81-84. http://dx.doi.org/10.1016/j.diagmicrobio.2009.05.011.
113. Sutjita M, Bouckenooghe AR, Adachi JA, Jiang ZD, Mathewson JJ, Ericsson CD, DuPont HL. 2000. Intestinal secretory immunoglobulin A response to enteroaggregative Escherichia coli in travelers with diarrhea. Clin. Diagn. Lab. Immunol. 7:501-503. http://dx.doi.org/10.1128/CDLI.7.3.501-503.2000.
114. Gomez HF, Mathewson JJ, Johnson PC, DuPont HL. 1995. Intestinal immune response of volunteers ingesting a strain of enteroadherent (HEp-2 cell-adherent) Escherichia coli. Clin. Diagn. Lab. Immunol. 2: 10-13.
115. Oundo JO, Kariuki SM, Boga HI, Muli FW, Iijima Y. 2008. High incidence of enteroaggregative Escherichia coli among food handlers in three areas of Kenya: a possible transmission route of travelers' diarrhea. J. Travel Med. 15:31-38. http://dx.doi.org/10.1111/j.1708-8305.2007.00174.x.
116. Guiral E, Mendez-Arancibia E, Soto SM, Salvador P, Fabrega A, Gascon J, Vila J. 2011. CTX-M-15-producing enteroaggregative Escherichia coli as cause of travelers' diarrhea. Emerg. Infect. Dis. 17:1950-1953. http://dx.doi.org/10.3201/eid1710.110022.
117. Vila J, Vargas M, Ruiz J, Espasa M, Pujol M, Corachán M, Jiménez de Anta MT, Gascón J. 2001. Susceptibility patterns of enteroaggregative Escherichia coli associated with traveller's diarrhoea: emergence of quinolone resistance. J. Med. Microbiol. 50:996-1000. http://jmm.sgmjournals.org/content/50/11/996.long.
118. Raju B, Ballal M. 2009. Multidrug resistant enteroaggregative Escherichia coli diarrhoea in rural southern Indian population. Scand. J. Infect. Dis. 41:105-108. http://dx.doi.org/10.1080/00365540802641856.
119. Huppertz HI, Rutkowski S, Aleksic S, Karch H. 1997. Acute and chronic diarrhoea and abdominal colic associated with enteroaggregative Escherichia coli in young children living in western Europe. Lancet 349: 1660-1662. http://dx.doi.org/10.1016/S0140-6736(96)12485-5.
120. Vasudevan P, Annamalai T, Sartori L, Hoagland T, Venkitanarayanan K. 2003. Behavior of enteroaggregative Escherichia coli in bottled spring and mineral water. J. Food Prot. 66:497-500.
121. Sidhu JPS, Ahmed W, Hodgers L, Toze S. 2013. Occurrence of virulence genes associated with diarrheagenic pathotypes in Escherichia coli isolates from surface water. Appl. Environ. Microbiol. 79:328-335. http: //dx.doi.org/10.1128/AEM.02888-12.
122. Akter S, Islam M, Afreen KS, Azmuda N, Khan SI, Birkeland NK. 2013. Prevalence and distribution of different diarrhoeagenic Escherichia coli virulotypes in major water bodies in Bangladesh. Epidemiol. Infect. 141:2516-2525. http://dx.doi.org/10.1017/S0950268813000320.
123. Kagambèga A, Martikainen O, Lienemann T, Siitonen A, Traoré AS, Barro N, Haukka K. 2012. Diarrheagenic Escherichia coli detected by 16-plex PCR in raw meat and beef intestines sold at local markets in Ouagadougou, Burkina Faso. Int. J. Food Microbiol. 153:154-158. http: //dx.doi.org/10.1016/j.ijfoodmicro.2011.10.032.
124. Morais TB, Gomes TA, Sigulem DM. 1997. Enteroaggregative Esche-richia coli in infant feeding bottles. Lancet 349:1448-1449. http://dx.doi.org/10.1016/S0140-6736(05)63724-5.
125. Cassar CA, Ottaway M, Paiba GA, Futter R, Newbould S, Woodward MJ. 2004. Absence of enteroaggregative Escherichia coli in farmed animals in Great Britain. Vet. Rec. 154:237-239. http://dx.doi.org/10.1136 /vr.154.8.237.
126. Puño-Sarmiento J, Medeiros L, Chiconi C, Martins F, Pelayo J, Rocha S, Blanco J, Blanco M, Zanutto M, Kobayashi R, Nakazato G. 2013. Detection of diarrheagenic Escherichia coli strains isolated from dogs and cats in Brazil. Vet. Microbiol. 166:676-680. http://dx.doi.org/10.1016/j.vetmic.2013.07.007.
127. Bibbal D, Kérourédan M, Loukiadis E, Scheutz F, Oswald E, Brugère H. 2014. Slaughterhouse effluent discharges into rivers not responsible for environmental occurrence of enteroaggregative Escherichia coli. Vet. Microbiol. 168:451-454. http://dx.doi.org/10.1016/j.vetmic.2013.11.042.
128. Johnson JJR, Owens K, Gajewski A, Clabots C. 2008. Escherichia coli colonization patterns among human household members and pets, with attention to acute urinary tract infection. J. Infect. Dis. 197:218-224 http://dx.doi.org/10.1086/524844.
129. Lima AA, Moore SR, Barboza MS, Jr, Soares AM, Schleupner MA, Newman RD, Sears CL, Nataro JP, Fedorko DP, Wuhib T, Schorling JB, Guerrant RL. 2000. Persistent diarrhea signals a critical period of increased diarrhea burdens and nutritional shortfalls: a prospective cohort study among children in northeastern Brazil. J. Infect. Dis. 181: 1643-1645. http://dx.doi.org/10.1086/315423.
130. Dutta S, Pal S, Chakrabarti S, Dutta P, Manna B. 1999. Use of PCR to identify enteroaggregative Escherichia coli as an important cause of acute diarrhoea among children living in Calcutta, India. J. Med. Microbiol. 48:1011-1016. http://dx.doi.org/10.1099/00222615-48-11-1011.
131. Albert MJ, Faruque AS, Faruque SM, Sack RB, Mahalanabis D. 1999. Case-control study of enteropathogens associated with childhood diarrhea in Dhaka, Bangladesh. J. Clin. Microbiol. 37:3458-3464.
132. Albert MJ, Faruque SM, Faruque AS, Neogi PK, Ansaruzzaman M, Bhuiyan NA, Alam K, Akbar MS. 1995. Controlled study of Escherichia coli diarrheal infections in Bangladeshi children. J. Clin. Microbiol. 33: 973-977.
133. Rajendran P, Ajjampur SS, Chidambaram D, Chandrabose G, Thangaraj B, Sarkar R, Samuel P, Rajan DP, Kang G. 2010. Pathotypes of diarrheagenic Escherichia coli in children attending a tertiary care hospital in South India. Diagn. Microbiol. Infect. Dis. 68:117-122. http://dx.doi.org/10.1016/j.diagmicrobio.2010.06.003.
134. Durrer P, Zbinden R, Fleisch F, Altwegg M, Ledergerber B, Karch H, Weber R. 2000. Intestinal infection due to enteroaggregative Escherichia coli among human immunodeficiency virus-infected persons. J. Infect. Dis. 182:1540-1544. http://dx.doi.org/10.1086/315885.
135. Gassama-Sow A, Sow PS, Guèye M, Guèye-Ndiaye A, Perret JL, M'boup S, Aïdara-Kane A. 2004. Characterization of pathogenic Escherichia coli in human immunodeficiency virus-related diarrhea in Senegal. J. Infect. Dis. 189:75-78. http://dx.doi.org/10.1086/380489.
136. Schmidt H, Knop C, Franke S, Aleksic S, Heesemann J, Karch H. 1995. Development of PCR for screening of enteroaggregative Escherichia coli. J. Clin. Microbiol. 33:701-705.
137. Medina AM, Rivera FP, Romero LM, Kolevic LA, Castillo ME, Verne E, Hernandez R, Mayor YE, Barletta F, Mercado E, Ochoa TJ. 2010. Diarrheagenic Escherichia coli in human immunodeficiency virus (HIV) pediatric patients in Lima, Peru. Am. J. Trop. Med. Hyg. 83:158-163. http://dx.doi.org/10.4269/ajtmh.2010.09-0596.
138. Paschke C, Apelt N, Fleischmann E, Perona P, Walentiny C, Löscher T, Herbinger KH. 2011. Controlled study on enteropathogens in travellers returning from the tropics with and without diarrhoea. Clin. Microbiol. Infect. 17:1194-1200. http://dx.doi.org/10.1111/j.1469-0691.2010.03414.x.
139. Adachi JA, Jiang ZD, Mathewson JJ, Verenkar MP, Thompson S, Martinez-Sandoval F, Steffen R, Ericsson CD, DuPont HL. 2001. Enteroaggregative Escherichia coli as a major etiologic agent in traveler's diarrhea in 3 regions of the world. Clin. Infect. Dis. 32:1706-1709. http: //dx.doi.org/10.1086/320756.
140. Lääveri T, Pakkanen SH, Antikainen J, Riutta J, Mero S, Kirveskari J, Kantele A. 2014. High number of diarrhoeal coinfections in travellers to Benin, West Africa. BMC Infect. Dis. 14:81. http://dx.doi.org/10.1186 /1471-2334-14-81.
141. Ahn JY, Chung JW, Chang KJ, You MH, Chai JS, Kang YA, Kim SH, Jeoung H, Cheon D, Jeoung A, Choi ES. 2011. Clinical characteristics and etiology of travelers' diarrhea among Korean travelers visiting South-East Asia. J. Korean Med. Sci. 26:196-200. http://dx.doi.org/10.3346/jkms.2011.26.2.196.
142. Vernacchio L, Vezina RM, Mitchell AA, Lesko SM, Plaut AG, Acheson DW. 2006. Diarrhea in American infants and young children in the community setting. Pediatr. Infect. Dis. J. 25:2-7. http://dx.doi.org/10.1097/01.inf.0000195623.57945.87.
143. Cohen MB, Nataro JP, Bernstein DI, Hawkins J, Roberts N, Staat MA. 2005. Prevalence of diarrheagenic Escherichia coli in acute childhood enteritis: a prospective controlled study. J. Pediatr. 146:54-61. http://dx.doi.org/10.1016/j.jpeds.2004.08.059.
144. Chattaway MA, Harris R, Jenkins C, Tam C, Coia JE, Gray J, Iturriza-Gomara M, Wain J. 2013. Investigating the link between the presence of enteroaggregative Escherichia coli and infectious intestinal disease in the United Kingdom, 1993 to 1996 and 2008 to 2009. Euro Surveill. 18(37): pii_20582. http://www.eurosurveillance.org/ViewArticle.aspx?Article Id_20582.
145. Park HK, Jung YJ, Chae HC, Shin YJ, Woo SY, Park HS, Lee SJ. 2009. Comparison of Escherichia coli uropathogenic genes (kps, usp and ireA) and enteroaggregative genes (aggR and aap) via multiplex polymerase chain reaction from suprapubic urine specimens of young children with fever. Scand. J. Urol. Nephrol. 43:51-57. http://dx.doi.org/10.1080 /00365590802299338.
146. Buchholz U, Bernard H, Werber D, Böhmer MM, Remschmidt C, Wilking H, Deleré Y, an der Heiden M, Adlhoch C, Dreesman J, Ehlers J, Ethelberg S, Faber M, Frank C, Fricke G, Greiner M, Höhle M, Ivarsson S, Jark U, Kirchner M, Koch J, Krause G, Luber P, Rosner B, Stark K, Kühne M. 2011. German outbreak of Escherichia coli O104:H4 associated with sprouts. N. Engl. J. Med. 365:1763-1770. http://dx.doi.org/10.1056/NEJMoa1106482.
147. Morabito S, Karch H, Mariani-Kurkdjian P, Schmidt H, Minelli F, Bingen E, Caprioli A. 1998. Enteroaggregative, Shiga toxin-producing Escherichia coli O111:H2 associated with an outbreak of hemolyticuremic syndrome. J. Clin. Microbiol. 36:840-842.
148. Iyoda S, Tamura K, Itoh K, Izumiya H, Ueno N, Nagata K, Togo M, Terajima J, Watanabe H. 2000. Inducible stx2 phages are lysogenized in the enteroaggregative and other phenotypic Escherichia coli O86:HNM isolated from patients. FEMS Microbiol. Lett. 191:7-10. http://dx.doi.org/10.1111/j.1574-6968.2000.tb09311.x.
149. Dallman T, Smith GP, O'Brien B, Chattaway MA, Finlay D, Grant KA, Jenkins C. 2012. Characterization of a verocytotoxin-producing enteroaggregative Escherichia coli serogroup O111:H21 strain associated with a household outbreak in Northern Ireland. J. Clin. Microbiol. 50:4116-4119. http://dx.doi.org/10.1128/JCM.02047-12.
150. Boudailliez B, Berquin P, Mariani-Kurkdjian P, Ilef D, Cuvelier B, Capek I, Tribout B, Bingen E, Piussan C. 1997. Possible person-toperson transmission of Escherichia coli O111-associated hemolytic uremic syndrome. Pediatr. Nephrol. 11:36-39. http://dx.doi.org/10.1007 /s004670050229.
151. Pabst WL, Altwegg M, Kind C, Hardegger D, Nadal D, Mirjanic S. 2003. Prevalence of enteroaggregative Escherichia coli among children with and without diarrhea in Switzerland. J. Clin. Microbiol. 41:2289-2293. http://dx.doi.org/10.1128/JCM.41.6.2289-2293.2003.
152. Pass MA, Odedra R, Batt RM. 2000. Multiplex PCRs for identification of Escherichia coli virulence genes. J. Clin. Microbiol. 38:2001-2004. http: //jcm.asm.org/content/38/5/2001.long.
153. Zamboni A, Fabbricotti SH, Fagundes-Neto U, Scaletsky ICA. 2004. Enteroaggregative Escherichia coli virulence factors are found to be associated with infantile diarrhea in Brazil. J. Clin. Microbiol. 42:1058-1063. http://dx.doi.org/10.1128/JCM.42.3.1058-1063.2004.
154. Cennimo D, Abbas A, Huang DB, Chiang T. 2009. The prevalence and virulence characteristics of enteroaggregative Escherichia coli at an urgent-care clinic in the USA: a case-control study. J. Med. Microbiol. 58:403-407. http://dx.doi.org/10.1099/jmm.0.005793-0.
155. Jiang ZD, Okhuysen PC, Guo DC, He R, King TM, DuPont HL, Milewicz DM. 2003. Genetic susceptibility to enteroaggregative Escherichia coli diarrhea: polymorphism in the interleukin-8 promotor region. J. Infect. Dis. 188:506-511. http://dx.doi.org/10.1086/377102.
156. Taniuchi M, Walters CC, Gratz J, Maro A, Kumburu H, Serichantalergs O, Sethabutr O, Bodhidatta L, Kibiki G, Toney DM, Berkeley L, Nataro JP, Houpt ER. 2012. Development of a multiplex polymerase chain reaction assay for diarrheagenic Escherichia coli and Shigella spp. and its evaluation on colonies, culture broths, and stool. Diagn. Microbiol. Infect. Dis. 73:121-128. http://dx.doi.org/10.1016/j.diagmicrobio.2012.03.008.
157. Lima IFN, Boisen N, da Quetz Silva J, Havt A, de Carvalho EB, Soares AM, Lima NL, Mota RMS, Nataro JP, Guerrant RL, Lima AAM. 2013. Prevalence of enteroaggregative Escherichia coli and its virulence-related genes in a case-control study among children from north-eastern Brazil. J. Med. Microbiol. 62:683-693. http://dx.doi.org/10.1099/jmm.0.054262-0.
158. Meng CY, Smith BL, Bodhidatta L, Richard SA, Vansith K, Thy B, Srijan A, Serichantalergs O, Mason CJ. 2011. Etiology of diarrhea in young children and patterns of antibiotic resistance in Cambodia. Pediatr. Infect. Dis. J. 30:331-335. http://dx.doi.org/10.1097/INF.0b013e3181fb6f82.
159. Huppertz H, Busch D, Schmidt H, Aleksic S, Karch H. 1996. Diarrhea in young children associated with Escherichia coli non-O 157 organisms that produce Shiga-like toxin. J. Paediatr. 128:341-346. http://dx.doi.org /10.1016/S0022-3476(96)70278-0.
160. Tompkins DS, Hudson MJ, Smith HR, Eglin RP, Wheeler JG, Brett MM, Owen RJ, Brazier JS, Cumberland P, King V, Cook PE. 1999. A study of infectious intestinal disease in England: microbiological findings in cases and controls. Commun. Dis. Public Health 2:108-113.