Ramipril protects the endothelium from high glucose-induced dysfunction through CaMKKβ/AMPK and heme oxygenase-1 activation

Journal of Pharmacology and Experimental Therapeutics

Volumn 350, Issue 1, 2014, Pages 5-13

  Tian, Shiliu ^a,b   Ge, Xinfa ^a,c   Wu, Ke ^a,d   Yang, Huabing ^a,e   Liu, Yu ^a  

^a SHANGHAI UNIVERSITY OF SPORT   (China)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c Shandong Sport University   (China)

^d WUHAN UNIVERSITY   (China)

^e HUBEI UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ADVANCED GLYCATION END PRODUCT; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE KINASE; GLUCOSE; HEME OXYGENASE 1; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; INSULIN; RAMIPRIL; RAMIPRILAT; REACTIVE OXYGEN METABOLITE; STREPTOZOCIN; TRANSCRIPTION FACTOR NRF2;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; CELL NUCLEUS; CELLULAR DISTRIBUTION; CONTROLLED STUDY; ENDOTHELIAL DYSFUNCTION; ENDOTHELIUM CELL; GLYCEMIC CONTROL; HUMAN; HUMAN CELL; HYPERGLYCEMIA; INSULIN RESISTANCE; INSULIN SENSITIVITY; MALE; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; VASCULAR ENDOTHELIUM; VASODILATATION;

AMP-ACTIVATED PROTEIN KINASES; ANIMALS; AORTA; APOPTOSIS; BENZIMIDAZOLES; CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASE KINASE; CELLS, CULTURED; DIABETES MELLITUS, EXPERIMENTAL; ENDOTHELIAL CELLS; ENZYME ACTIVATION; GLUCOSE; GLYCOSYLATION END PRODUCTS, ADVANCED; HEME OXYGENASE (DECYCLIZING); HUMANS; INSULIN RESISTANCE; MALE; NAPHTHALIMIDES; NF-E2-RELATED FACTOR 2; OXIDATIVE STRESS; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; PROTOPORPHYRINS; PYRAZOLES; PYRIMIDINES; RAMIPRIL; RATS; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; VASODILATION;

EID: 84903547529     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.114.212928     Document Type: Article

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