Predicting and correcting ataxia using a model of cerebellar function

Brain

Volumn 137, Issue 7, 2014, Pages 1931-1944

  Bhanpuri, Nasir H ^a,b,c   Okamura, Allison M ^d,e   Bastian, Amy J ^a,b  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b KENNEDY KRIEGER INSTITUTE   (United States)

^c University of Southern California   (United States)

^d Stanford University   (United States)

^e Johns Hopkins University   (United States)

Author keywords

ataxia; cerebellum; computational model; dysmetria; internal model

Indexed keywords

ACCELERATION; ACCURACY; ADULT; AGED; ARTICLE; AUTOSOMAL DOMINANT CEREBELLAR ATAXIA; BODY MOVEMENT; BRAIN DYSFUNCTION; BRAIN FUNCTION; CEREBELLAR ATAXIA; CEREBELLUM; CLINICAL ARTICLE; COMPUTER MODEL; COMPUTER PREDICTION; CONTROLLED STUDY; DECELERATION; DYSMETRIA; FEMALE; HUMAN; KINEMATICS; MALE; MIDDLE AGED; MOTOR CONTROL; MUSCULOSKELETAL FUNCTION; PATIENT ATTITUDE; PRIORITY JOURNAL; ROBOTIC EXOSKELETON; SPINOCEREBELLAR DEGENERATION; SPORADIC ATAXIA; VELOCITY; ATAXIA; MOTOR COORDINATION; SIMULATION;

ATAXIA; CEREBELLUM; COMPUTATIONAL MODEL; DYSMETRIA; INTERNAL MODEL;

ADULT; AGED; BIOMECHANICAL PHENOMENA; CEREBELLAR ATAXIA; CEREBELLUM; COMPUTER SIMULATION; FEMALE; FUNCTIONAL LATERALITY; HUMANS; MALE; MIDDLE AGED; MODELS, BIOLOGICAL; MOVEMENT; PREDICTIVE VALUE OF TESTS; PSYCHOMOTOR PERFORMANCE;

EID: 84903537360     PISSN: 00068950     EISSN: 14602156     Source Type: Journal    
DOI: 10.1093/brain/awu115     Document Type: Article

References (52)

1. Angel RW. Barognosis in a patient with hemiataxia. Ann Neurol 1980; 7: 73-7. (Pubitemid 10129572)
2. Bastian AJ. Learning to predict the future: the cerebellum adapts feedforward movement control. Curr Opin Neurobiol 2006; 16: 645-9. (Pubitemid 44791921)
3. Bastian AJ, Martin TA, Keating JG, Thach WT. Cerebellar ataxia: abnormal control of interaction torques across multiple joints. J Neurophysiol 1996; 76: 492-509. (Pubitemid 26251183)
4. Bastian AJ, Zackowski KM, Thach WT. Cerebellar ataxia: torque deficiency or torque mismatch between joints? J Neurophysiol 2000; 83: 3019-30. (Pubitemid 30321490)
5. Bhanpuri NH, Okamura AM, Bastian AJ. Active force perception depends on cerebellar function. J Neurophysiol 2012; 107: 1612-20.
6. Bhanpuri NH, Okamura AM, Bastian AJ. Predictive Modeling by the Cerebellum Improves Proprioception. J Neurosci 2013; 33: 14301-6.
7. Blumenfeld H. Neuroanatomy through clinical cases. Second Edition with Sylvius 4.
8. Pap/Psc. Sunderland: Sinauer Associates, Inc.; 2010.
9. Chen-Harris H, Joiner WM, Ethier V, Zee DS, Shadmehr R. Adaptive control of saccades via internal feedback. J Neurosci 2008; 28: 2804-13. (Pubitemid 351398877)
10. Criscimagna-Hemminger SE, Bastian AJ, Shadmehr R. Size of error affects cerebellar contributions to motor learning. J Neurophysiol 2010; 103: 2275-84.
11. Diedrichsen J, Hashambhoy Y, Rane T, Shadmehr R. Neural correlates of reach errors. J Neurosci 2005; 25: 9919-31. (Pubitemid 41528030)
12. Donchin O, Rabe K, Diedrichsen J, Lally N, Schoch B, Gizewski ER, et al. Cerebellar regions involved in adaptation to force field and visuomotor perturbation. J Neurophysiol 2012; 107: 134-47.
13. Dow RS, Moruzzi G. The physiology and pathology of the cerebellum. Minnesota Archive Editions. Minnesota: University of Minnesota Press; 1958.
14. Flament D, Hore J. Movement and electromyographic disorders associated with cerebellar dysmetria. J Neurophysiol 1986; 55: 1221-33. (Pubitemid 16068462)
15. Galea JM, Vazquez A, Pasricha N, de Xivry J-JO, Celnik P. Dissociating the roles of the cerebellum and motor cortex during adaptive learning: the motor cortex retains what the cerebellum learns. Cereb Cortex 2011; 21: 1761-70.
16. Gibo TL, Bastian AJ, Okamura AM. Cerebellar ataxia impairs modulation of arm stiffness during postural maintenance. J Neurophysiol 2013; 110: 1611-20.
17. Hewer RL, Cooper R, Morgan MH. An investigation into the value of treating intention tremor by weighting the affected limb. Brain 1972; 95: 579-90.
18. Hewitt AL, Popa LS, Pasalar S, Hendrix CM, Ebner TJ. Representation of limb kinematics in Purkinje cell simple spike discharge is conserved across multiple tasks. J Neurophysiol 2011; 106: 2232-47.
19. Hogan N. An organizing principle for a class of voluntary movements. J Neurosci 1984; 4: 2745-54. (Pubitemid 15224418)
20. Hogan N. The mechanics of multi-joint posture and movement control. Biol Cybern 1985; 52: 315-31. (Pubitemid 15234729)
21. Hollerbach J, Khalil W, Gautier M. Model Identification. In: Siciliano B, Khatib O, editors. Springer handbook of robotics. Berlin: Springer; 2008.
22. Holmes G. The symptoms of acute cerebellar injuries due to gunshot injuries. Brain 1917; 40: 461-535.
23. Holmes G. The cerebellum of man. Brain 1939; 62: 1-30.
24. Hore J, Flament D. Changes in motor cortex neural discharge associated with the development of cerebellar limb ataxia. J Neurophysiol 1988; 60: 1285-302.
25. Ioannou PA, Sun J. Robust adaptive control. Har/Dis. Upper Saddle River: Prentice Hall PTR; 1995.
26. Kawato M. Internal models for motor control and trajectory planning. Curr Opin Neurobiol 1999; 9: 718-27.
27. Kurtzer I, Trautman P, Rasquinha RJ, Bhanpuri NH, Scott SH, Bastian AJ. Cerebellar damage diminishes long-latency responses to multijoint perturbations. J Neurophysiol 2013; 109: 2228-41.
28. Manto M. Mechanisms of human cerebellar dysmetria: experimental evidence and current conceptual bases. J Neuroeng Rehabil 2009; 6: 10.
29. Manto M, Godaux E, Jacquy J. Cerebellar hypermetria is larger when the inertial load is artificially increased. Ann Neurol 1994; 35: 45-52. (Pubitemid 24027605)
30. Manto M, Setta F, Jacquy J, Godaux E, Hildebrand J, Roland H, et al. Different types of cerebellar hypometria associated with a distinct topography of the lesion in cerebellum. J Neurol Sci 1998; 158: 88-95. (Pubitemid 28277541)
31. Martin JH, Cooper SE, Hacking A, Ghez C. Differential effects of deep cerebellar nuclei inactivation on reaching and adaptive control. J Neurophysiol 2000; 83: 1886-99. (Pubitemid 30198645)
32. Martin JH, Ghez C. Differential impairments in reaching and grasping produced by local inactivation within the forelimb representation of the motor cortex in the cat. Exp Brain Res 1993; 94: 429-43. (Pubitemid 23218100)
33. Maschke M, Gomez CM, Ebner TJ, Konczak J. Hereditary cerebellar ataxia progressively impairs force adaptation during goal-directed arm movements. J Neurophysiol 2004; 91: 230-8. (Pubitemid 38084368)
34. Miall RC, Christensen LOD, Cain O, Stanley J. Disruption of state estimation in the human lateral cerebellum. PLoS Biol 2007; 5: e316.
35. Miall RC, Weir DJ, Wolpert DM, Stein JF. Is the cerebellum a smith predictor? J Mot Behav 1993; 25: 203-16.
36. Morgan MH, Hewer RL, Cooper R. Application of an objective method of assessing intentiontremor - afurther studyonthe use of weights to reduce intention tremor. J Neurol Neurosurg Psychiatry 1975; 38: 259-64.
37. Moschner C, Perlman S, Baloh RW. Comparison of oculomotor findings in the progressive ataxia syndromes. Brain 1994; 117 (Pt 1): 15-25. (Pubitemid 24103381)
38. Pasalar S, Roitman AV, Durfee WK, Ebner TJ. Force field effects on cerebellar Purkinje cell discharge with implications for internal models. Nat Neurosci 2006; 9: 1404-11. (Pubitemid 44646213)
39. Richardson MJE, Flash T. Comparing smooth arm movements with the two-thirds power law and the related segmented-control hypothesis. J Neurosci 2002; 22: 8201-11. (Pubitemid 35379126)
40. Selen LPJ, van Dieën JH, Beek PJ. Impedance modulation and feedback corrections in tracking targets of variable size and frequency. J Neurophysiol 2006; 96: 2750-9. (Pubitemid 44785921)
41. Shadmehr R, Krakauer JW. A computational neuroanatomy for motor control. Exp Brain Res 2008; 185: 359-81.
42. Shadmehr R, Mussa-Ivaldi FA. Adaptive representation of dynamics during learning of a motor task. J Neurosci 1994; 14: 3208-24. (Pubitemid 24139004)
43. Shidara M, Kawano K, Gomi H, Kawato M. Inverse-dynamics model eye movement control by Purkinje cells in the cerebellum. Nature 1993; 365: 50-2. (Pubitemid 23305566)
44. Shmuelof L, Krakauer JW. Are we ready for a natural history of motor learning? Neuron 2011; 72: 469-76.
45. Smith MA, Shadmehr R. Intact ability to learn internal models of arm dynamics in Huntington's disease but not cerebellar degeneration. J Neurophysiol 2005; 93: 2809-21. (Pubitemid 40570859)
46. Synofzik M, Lindner A, Thier P. The cerebellum updates predictions about the visual consequences of one's behavior. Curr Biol 2008; 18: 814-18.
47. Topka H, Konczak J, Dichgans J. Coordination of multi-joint arm movements in cerebellar ataxia. Exp Brain Res 1998; 119: 483-92.
48. Trouillas P, Takayanagi T, Hallett M, Currier RD, Subramony SH, Wessel K, et al. International Cooperative Ataxia Rating Scale for pharmacological assessment of the cerebellar syndrome. The Ataxia Neuropharmacology Committee of the World Federation of Neurology. J Neurol Sci 1997; 145: 205-11. (Pubitemid 27121687)
49. Wolpert DM, Flanagan Jr. Motor prediction. Curr Biol 2001; 11: R729-32.
50. Wolpert DM, Miall RC, Kawato M. Internal models in the cerebellum. Trends Cognit Sci 1998; 2: 338-47. (Pubitemid 28396569)
51. Xu-Wilson M, Chen-Harris H, Zee DS, Shadmehr R. Cerebellar contributions to adaptive control of saccades in humans. J Neurosci 2009; 29: 12930-9.
52. Zee DS, Yee RD, Cogan DG, Robinson DA, Engel WK. Ocular motor abnormalities in hereditary cerebellar ataxia. Brain 1976; 99: 207-34.