Mutations in the control of virulence sensor gene from streptococcus pyogenes after infection in mice lead to clonal bacterial variants with altered gene regulatory activity and virulence

PLoS ONE

Volumn 9, Issue 6, 2014, Pages

  Mayfield, Jeffrey A ^a   Liang, Zhong ^a   Agrahari, Garima ^a   Lee, Shaun W ^a   Donahue, Deborah L ^a   Ploplis, Victoria A ^a   Castellino, Francis J ^a  

^a UNIVERSITY OF NOTRE DAME   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL PROTEIN; CLUSTER OF VIRULENCE SENSOR PROTEIN; CYSTEINE PROTEINASE; DEOXYRIBONUCLEASE; SPEB PROTEIN; SPHINGOSINE KINASE; UNCLASSIFIED DRUG; COVS PROTEIN, STREPTOCOCCUS PYOGENES; CSRR PROTEIN, STREPTOCOCCUS PYOGENES; REPRESSOR PROTEIN; SIGNAL PEPTIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIAL GENE; BACTERIAL GENETICS; BACTERIAL GENOME; BACTERIAL MUTATION; BACTERIAL STRAIN; BACTERIAL VIRULENCE; BACTERIUM CULTURE; CLONAL VARIATION; COLONY FORMING UNIT; CONTROLLED STUDY; COVR GENE; COVRS GENE; COVS GENE; DNA SEQUENCE; ENZYME ACTIVITY; FRAMESHIFT MUTATION; GENE CLUSTER; GENE CONTROL; GENE DELETION; GENE INSERTION; GROUP A STREPTOCOCCAL INFECTION; LETHALITY; MALE; MOUSE; NONHUMAN; OPERON; PATHOGENESIS; PHENOTYPE; PLASMINOGEN ACTIVATION; POLYMERASE CHAIN REACTION; PROMOTER REGION; PROTEIN DOMAIN; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA TRANSLATION; SEQUENCE ANALYSIS; SEROTYPE; SKIN; SPLEEN; STREPTOCOCCUS PYOGENES; SURVIVAL RATE; TRANSCRIPTION TERMINATION; ANIMAL; GENE EXPRESSION REGULATION; GENETIC ENGINEERING; GENETICS; HUMAN; IMMUNOLOGY; INNATE IMMUNITY; METABOLISM; MICROBIOLOGY; MOLECULAR CLONING; MUTATION; PATHOGENICITY; PHYSIOLOGY; STREPTOCOCCUS INFECTION; SURVIVAL;

ANIMALS; BACTERIAL PROTEINS; CLONING, MOLECULAR; DEOXYRIBONUCLEASES; GENE EXPRESSION REGULATION, BACTERIAL; GENETIC ENGINEERING; HUMANS; IMMUNITY, INNATE; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MICE; MUTATION; REPRESSOR PROTEINS; STREPTOCOCCAL INFECTIONS; STREPTOCOCCUS PYOGENES; SURVIVAL ANALYSIS;

EID: 84903532283     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0100698     Document Type: Article

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