-
1
-
-
34548857700
-
SIRT1 improves insulin sensitivity under insulin-resistant conditions by repressing PTP1B
-
Sun C., Zhang F., Ge X., Yan T., Chen X., Shi X., Zhai Q. SIRT1 improves insulin sensitivity under insulin-resistant conditions by repressing PTP1B. Cell Metab. 2007, 6:307-319.
-
(2007)
Cell Metab.
, vol.6
, pp. 307-319
-
-
Sun, C.1
Zhang, F.2
Ge, X.3
Yan, T.4
Chen, X.5
Shi, X.6
Zhai, Q.7
-
2
-
-
61749095297
-
SIRT1 exerts anti-inflammatory effects and improves insulin sensitivity in adipocytes
-
Yoshizaki T., Milne J.C., Imamura T., Schenk S., Sonoda N., Babendure J.L., Lu J.C., Smith J.J., Jirousek M.R., Olefsky J.M. SIRT1 exerts anti-inflammatory effects and improves insulin sensitivity in adipocytes. Mol. Cell. Biol. 2009, 29:1363-1374.
-
(2009)
Mol. Cell. Biol.
, vol.29
, pp. 1363-1374
-
-
Yoshizaki, T.1
Milne, J.C.2
Imamura, T.3
Schenk, S.4
Sonoda, N.5
Babendure, J.L.6
Lu, J.C.7
Smith, J.J.8
Jirousek, M.R.9
Olefsky, J.M.10
-
3
-
-
64549127790
-
PGC-1alpha, SIRT1 and AMPK, an energy sensing network that controls energy expenditure
-
Canto C., Auwerx J. PGC-1alpha, SIRT1 and AMPK, an energy sensing network that controls energy expenditure. Curr. Opin. Lipidol. 2009, 20:98-105.
-
(2009)
Curr. Opin. Lipidol.
, vol.20
, pp. 98-105
-
-
Canto, C.1
Auwerx, J.2
-
4
-
-
84878574279
-
Sirtuins as possible drug targets in type 2 diabetes
-
Kitada M., Kume S., Kanasaki K., Takeda-Watanabe A., Koya D. Sirtuins as possible drug targets in type 2 diabetes. Curr. Drug Targets 2013, 14:622-636.
-
(2013)
Curr. Drug Targets
, vol.14
, pp. 622-636
-
-
Kitada, M.1
Kume, S.2
Kanasaki, K.3
Takeda-Watanabe, A.4
Koya, D.5
-
5
-
-
80052291180
-
Sirtuin-3 (Sirt3) regulates skeletal muscle metabolism and insulin signaling via altered mitochondrial oxidation and reactive oxygen species production
-
Jing E., Emanuelli B., Hirschey M.D., Boucher J., Lee K.Y., Lombard D., Verdin E.M., Kahn C.R. Sirtuin-3 (Sirt3) regulates skeletal muscle metabolism and insulin signaling via altered mitochondrial oxidation and reactive oxygen species production. Proc. Natl. Acad. Sci. U. S. A. 2011, 108:14608-14613.
-
(2011)
Proc. Natl. Acad. Sci. U. S. A.
, vol.108
, pp. 14608-14613
-
-
Jing, E.1
Emanuelli, B.2
Hirschey, M.D.3
Boucher, J.4
Lee, K.Y.5
Lombard, D.6
Verdin, E.M.7
Kahn, C.R.8
-
6
-
-
78449248442
-
SIRT6 deficiency results in severe hypoglycemia by enhancing both basal and insulin-stimulated glucose uptake in mice
-
Xiao C., Kim H.S., Lahusen T., Wang R.H., Xu X., Gavrilova O., Jou W., Gius D., Deng C.X. SIRT6 deficiency results in severe hypoglycemia by enhancing both basal and insulin-stimulated glucose uptake in mice. J. Biol. Chem. 2010, 285:36776-36784.
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 36776-36784
-
-
Xiao, C.1
Kim, H.S.2
Lahusen, T.3
Wang, R.H.4
Xu, X.5
Gavrilova, O.6
Jou, W.7
Gius, D.8
Deng, C.X.9
-
7
-
-
34547397081
-
SIRT2 regulates adipocyte differentiation through FoxO1 acetylation/deacetylation
-
Jing E., Gesta S., Kahn C.R. SIRT2 regulates adipocyte differentiation through FoxO1 acetylation/deacetylation. Cell Metab. 2007, 6:105-114.
-
(2007)
Cell Metab.
, vol.6
, pp. 105-114
-
-
Jing, E.1
Gesta, S.2
Kahn, C.R.3
-
8
-
-
40849113090
-
The regulation of SIRT2 function by cyclin-dependent kinases affects cell motility
-
Pandithage R., Lilischkis R., Harting K., Wolf A., Jedamzik B., Luscher-Firzlaff J., Vervoorts J., Lasonder E., Kremmer E., Knoll B., Luscher B. The regulation of SIRT2 function by cyclin-dependent kinases affects cell motility. J. Cell Biol. 2008, 180:915-929.
-
(2008)
J. Cell Biol.
, vol.180
, pp. 915-929
-
-
Pandithage, R.1
Lilischkis, R.2
Harting, K.3
Wolf, A.4
Jedamzik, B.5
Luscher-Firzlaff, J.6
Vervoorts, J.7
Lasonder, E.8
Kremmer, E.9
Knoll, B.10
Luscher, B.11
-
9
-
-
34447626095
-
SIRT2 deacetylates FOXO3a in response to oxidative stress and caloric restriction
-
Wang F., Nguyen M., Qin F.X., Tong Q. SIRT2 deacetylates FOXO3a in response to oxidative stress and caloric restriction. Aging Cell 2007, 6:505-514.
-
(2007)
Aging Cell
, vol.6
, pp. 505-514
-
-
Wang, F.1
Nguyen, M.2
Qin, F.X.3
Tong, Q.4
-
10
-
-
79959906869
-
Acetylation regulates gluconeogenesis by promoting PEPCK1 degradation via recruiting the UBR5 ubiquitin ligase
-
Jiang W., Wang S., Xiao M., Lin Y., Zhou L., Lei Q., Xiong Y., Guan K.L., Zhao S. Acetylation regulates gluconeogenesis by promoting PEPCK1 degradation via recruiting the UBR5 ubiquitin ligase. Mol. Cell 2011, 43:33-44.
-
(2011)
Mol. Cell
, vol.43
, pp. 33-44
-
-
Jiang, W.1
Wang, S.2
Xiao, M.3
Lin, Y.4
Zhou, L.5
Lei, Q.6
Xiong, Y.7
Guan, K.L.8
Zhao, S.9
-
11
-
-
77952413052
-
SIRT2 inhibition achieves neuroprotection by decreasing sterol biosynthesis
-
Luthi-Carter R., Taylor D.M., Pallos J., Lambert E., Amore A., Parker A., Moffitt H., Smith D.L., Runne H., Gokce O., Kuhn A., Xiang Z., Maxwell M.M., Reeves S.A., Bates G.P., Neri C., Thompson L.M., Marsh J.L., Kazantsev A.G. SIRT2 inhibition achieves neuroprotection by decreasing sterol biosynthesis. Proc. Natl. Acad. Sci. U. S. A. 2010, 107:7927-7932.
-
(2010)
Proc. Natl. Acad. Sci. U. S. A.
, vol.107
, pp. 7927-7932
-
-
Luthi-Carter, R.1
Taylor, D.M.2
Pallos, J.3
Lambert, E.4
Amore, A.5
Parker, A.6
Moffitt, H.7
Smith, D.L.8
Runne, H.9
Gokce, O.10
Kuhn, A.11
Xiang, Z.12
Maxwell, M.M.13
Reeves, S.A.14
Bates, G.P.15
Neri, C.16
Thompson, L.M.17
Marsh, J.L.18
Kazantsev, A.G.19
-
12
-
-
0037437795
-
Development of insulin resistance and reversal by thiazolidinediones in C2C12 skeletal muscle cells
-
Kumar N., Dey C.S. Development of insulin resistance and reversal by thiazolidinediones in C2C12 skeletal muscle cells. Biochem. Pharmacol. 2003, 65:249-257.
-
(2003)
Biochem. Pharmacol.
, vol.65
, pp. 249-257
-
-
Kumar, N.1
Dey, C.S.2
-
13
-
-
0036791755
-
Metformin enhances insulin signaling in insulin-dependent and -independent pathways in insulin resistant muscle cells
-
Kumar N., Dey C.S. Metformin enhances insulin signaling in insulin-dependent and -independent pathways in insulin resistant muscle cells. Br. J. Pharmacol. 2002, 137:329-336.
-
(2002)
Br. J. Pharmacol.
, vol.137
, pp. 329-336
-
-
Kumar, N.1
Dey, C.S.2
-
14
-
-
0036914134
-
Gliclazide increases insulin receptor tyrosine phosphorylation but not p38 phosphorylation in insulin-resistant skeletal muscle cells
-
Kumar N., Dey C.S. Gliclazide increases insulin receptor tyrosine phosphorylation but not p38 phosphorylation in insulin-resistant skeletal muscle cells. J. Exp. Biol. 2002, 205:3739-3746.
-
(2002)
J. Exp. Biol.
, vol.205
, pp. 3739-3746
-
-
Kumar, N.1
Dey, C.S.2
-
15
-
-
11244348979
-
PPAR-γ expression modulates insulin sensitivity in C2C12 skeletal muscle cells
-
Verma N.K., Singh J., Dey C.S. PPAR-γ expression modulates insulin sensitivity in C2C12 skeletal muscle cells. Br. J. Pharmacol. 2004, 143:1006-1013.
-
(2004)
Br. J. Pharmacol.
, vol.143
, pp. 1006-1013
-
-
Verma, N.K.1
Singh, J.2
Dey, C.S.3
-
16
-
-
34147192140
-
Focal adhesion kinase regulates insulin resistance in skeletal muscle
-
Bisht B., Goel H.L., Dey C.S. Focal adhesion kinase regulates insulin resistance in skeletal muscle. Diabetologia 2007, 50:1058-1069.
-
(2007)
Diabetologia
, vol.50
, pp. 1058-1069
-
-
Bisht, B.1
Goel, H.L.2
Dey, C.S.3
-
17
-
-
67651160305
-
PTEN and SHIP2 regulates PI3K/Akt pathway through focal adhesion kinase
-
Gupta A., Dey C.S. PTEN and SHIP2 regulates PI3K/Akt pathway through focal adhesion kinase. Mol. Cell. Endocrinol. 2009, 309:55-62.
-
(2009)
Mol. Cell. Endocrinol.
, vol.309
, pp. 55-62
-
-
Gupta, A.1
Dey, C.S.2
-
18
-
-
79959643709
-
A fluorescence method for measurement of glucose transport in kidney cells
-
Blodgett A.B., Kothinti R.K., Kamyshko I., Petering D.H., Kumar S., Tabatabai N.M. A fluorescence method for measurement of glucose transport in kidney cells. Diabetes Technol. Ther. 2011, 13:743-751.
-
(2011)
Diabetes Technol. Ther.
, vol.13
, pp. 743-751
-
-
Blodgett, A.B.1
Kothinti, R.K.2
Kamyshko, I.3
Petering, D.H.4
Kumar, S.5
Tabatabai, N.M.6
-
19
-
-
51949111451
-
Chemical probes for histone-modifying enzymes
-
Cole P.A. Chemical probes for histone-modifying enzymes. Nat. Chem. Biol. 2008, 4:590-597.
-
(2008)
Nat. Chem. Biol.
, vol.4
, pp. 590-597
-
-
Cole, P.A.1
-
21
-
-
34547599329
-
Sirtuin 2 inhibitors rescue alpha-synuclein-mediated toxicity in models of Parkinson's disease
-
Outeiro T.F., Kontopoulos E., Altmann S.M., Kufareva I., Strathearn K.E., Amore A.M., Volk C.B., Maxwell M.M., Rochet J.C., McLean P.J., Young A.B., Abagyan R., Feany M.B., Hyman B.T., Kazantsev A.G. Sirtuin 2 inhibitors rescue alpha-synuclein-mediated toxicity in models of Parkinson's disease. Science 2007, 317:516-519.
-
(2007)
Science
, vol.317
, pp. 516-519
-
-
Outeiro, T.F.1
Kontopoulos, E.2
Altmann, S.M.3
Kufareva, I.4
Strathearn, K.E.5
Amore, A.M.6
Volk, C.B.7
Maxwell, M.M.8
Rochet, J.C.9
McLean, P.J.10
Young, A.B.11
Abagyan, R.12
Feany, M.B.13
Hyman, B.T.14
Kazantsev, A.G.15
-
22
-
-
84880746649
-
ERK1/2 regulates SIRT2 deacetylase activity
-
Choi Y.H., Kim H., Lee S.H., Jin Y.H., Lee K.Y. ERK1/2 regulates SIRT2 deacetylase activity. Biochem. Biophys. Res. Commun. 2013, 437:245-249.
-
(2013)
Biochem. Biophys. Res. Commun.
, vol.437
, pp. 245-249
-
-
Choi, Y.H.1
Kim, H.2
Lee, S.H.3
Jin, Y.H.4
Lee, K.Y.5
-
23
-
-
84876215872
-
Inhibitory cross-talk between the AMPK and ERK pathways mediates endoplasmic reticulum stress-induced insulin resistance in skeletal muscle
-
Hwang S.L., Jeong Y.T., Li X., Kim Y.D., Lu Y., Chang Y.C., Lee I.K., Chang H.W. Inhibitory cross-talk between the AMPK and ERK pathways mediates endoplasmic reticulum stress-induced insulin resistance in skeletal muscle. Br. J. Pharmacol. 2013, 169:69-81.
-
(2013)
Br. J. Pharmacol.
, vol.169
, pp. 69-81
-
-
Hwang, S.L.1
Jeong, Y.T.2
Li, X.3
Kim, Y.D.4
Lu, Y.5
Chang, Y.C.6
Lee, I.K.7
Chang, H.W.8
-
24
-
-
84879049413
-
Rac-1 superactivation triggers insulin-independent glucose transporter 4 (GLUT4) translocation that bypasses signaling defects exerted by c-Jun N-terminal kinase (JNK)- and ceramide-induced insulin resistance
-
Chiu T.T., Sun Y., Koshkina A., Klip A. Rac-1 superactivation triggers insulin-independent glucose transporter 4 (GLUT4) translocation that bypasses signaling defects exerted by c-Jun N-terminal kinase (JNK)- and ceramide-induced insulin resistance. J. Biol. Chem. 2013, 288:17520-17531.
-
(2013)
J. Biol. Chem.
, vol.288
, pp. 17520-17531
-
-
Chiu, T.T.1
Sun, Y.2
Koshkina, A.3
Klip, A.4
-
25
-
-
84879081348
-
SIRT2 overexpression in hepatocellular carcinoma mediates epithelial to mesenchymal transition by protein kinase B/glycogen synthase kinase-3β/β-catenin signaling
-
Chen J., Chan A.W., To K.F., Chen W., Zhang Z., Ren J., Song C., Cheung Y.S., Lai P.B., Cheng S.H., Ng M.H., Huang A., Ko B.C. SIRT2 overexpression in hepatocellular carcinoma mediates epithelial to mesenchymal transition by protein kinase B/glycogen synthase kinase-3β/β-catenin signaling. Hepatology 2013, 57:2287-2298.
-
(2013)
Hepatology
, vol.57
, pp. 2287-2298
-
-
Chen, J.1
Chan, A.W.2
To, K.F.3
Chen, W.4
Zhang, Z.5
Ren, J.6
Song, C.7
Cheung, Y.S.8
Lai, P.B.9
Cheng, S.H.10
Ng, M.H.11
Huang, A.12
Ko, B.C.13
-
26
-
-
79960620082
-
The deacetylase SIRT1 promotes membrane localization and activation of Akt and PDK1 during tumorigenesis and cardiac hypertrophy
-
Sundaresan N.R., Pillai V.B., Wolfgeher D., Samant S., Vasudevan P., Parekh V., Raghuraman H., Cunningham J.M., Gupta M., Gupta M.P. The deacetylase SIRT1 promotes membrane localization and activation of Akt and PDK1 during tumorigenesis and cardiac hypertrophy. Sci. Signal. 2011, 4:ra46.
-
(2011)
Sci. Signal.
, vol.4
-
-
Sundaresan, N.R.1
Pillai, V.B.2
Wolfgeher, D.3
Samant, S.4
Vasudevan, P.5
Parekh, V.6
Raghuraman, H.7
Cunningham, J.M.8
Gupta, M.9
Gupta, M.P.10
-
27
-
-
84896901019
-
Sirt2 deacetylase is a novel AKT binding partner critical for AKT activation by insulin
-
Ramakrishnan G., Davaakhuu G., Kaplun L., Chung W.C., Rana A., Atfi A., Miele L., Tzivion G. Sirt2 deacetylase is a novel AKT binding partner critical for AKT activation by insulin. J. Biol. Chem. January 20, 2014, 10.1074/jbc.M113.537266.
-
(2014)
J. Biol. Chem.
-
-
Ramakrishnan, G.1
Davaakhuu, G.2
Kaplun, L.3
Chung, W.C.4
Rana, A.5
Atfi, A.6
Miele, L.7
Tzivion, G.8
-
28
-
-
80555146753
-
Hepatic Sirt1 deficiency in mice impairs mTorc2/Akt signaling and results in hyperglycemia, oxidative damage, and insulin resistance
-
Wang R.H., Kim H.S., Xiao C., Xu X., Gavrilova O., Deng C.X. Hepatic Sirt1 deficiency in mice impairs mTorc2/Akt signaling and results in hyperglycemia, oxidative damage, and insulin resistance. J. Clin. Invest. 2011, 121:4477-4490.
-
(2011)
J. Clin. Invest.
, vol.121
, pp. 4477-4490
-
-
Wang, R.H.1
Kim, H.S.2
Xiao, C.3
Xu, X.4
Gavrilova, O.5
Deng, C.X.6
-
29
-
-
84876256827
-
Neuronal Sirt1 deficiency increases insulin sensitivity in both brain and peripheral tissues
-
Lu M., Sarruf D.A., Li P., Osborn O., Sanchez-Alavez M., Talukdar S., Chen A., Bandyopadhyay G., Xu J., Morinaga H., Dines K., Watkins S., Kaiyala K., Schwartz M.W., Olefsky J.M. Neuronal Sirt1 deficiency increases insulin sensitivity in both brain and peripheral tissues. J. Biol. Chem. 2013, 288:10722-10735.
-
(2013)
J. Biol. Chem.
, vol.288
, pp. 10722-10735
-
-
Lu, M.1
Sarruf, D.A.2
Li, P.3
Osborn, O.4
Sanchez-Alavez, M.5
Talukdar, S.6
Chen, A.7
Bandyopadhyay, G.8
Xu, J.9
Morinaga, H.10
Dines, K.11
Watkins, S.12
Kaiyala, K.13
Schwartz, M.W.14
Olefsky, J.M.15
-
30
-
-
84856628731
-
+ system
-
+ system. Genes Dev. 2012, 26:259-270.
-
(2012)
Genes Dev.
, vol.26
, pp. 259-270
-
-
Krishnan, J.1
Danzer, C.2
Simka, T.3
Ukropec, J.4
Walter, K.M.5
Kumpf, S.6
Mirtschink, P.7
Ukropcova, B.8
Gasperikova, D.9
Pedrazzini, T.10
Krek, W.11
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