Diallyl disulfide inhibits proliferation and transdifferentiation of lung fibroblasts through induction of cyclooxygenase and synthesis of prostaglandin E2

Molecular and Cellular Biochemistry

Volumn 393, Issue 1-2, 2014, Pages 77-87

  Wang, Yanhua ^a   Cao, Rong ^b   Wei, Bo ^a   Chai, Xiaoyu ^a   Sun, Dan ^a   Guan, Y ^b   Liu, Xin Min ^a  

^a PEKING UNIVERSITY FIRST HOSPITAL   (China)

^b PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

Author keywords

Cyclooxygenase; Diallyl disulfide; Fibrosis; Histone acetylation; PGE2

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; COLLAGEN TYPE 1; CYCLIC AMP; CYCLOOXYGENASE 2 INHIBITOR; DIALLYL DISULFIDE; FIBRONECTIN; HISTONE H3; INDOMETACIN; PLATELET DERIVED GROWTH FACTOR BB; PROSTAGLANDIN E2; TRANSFORMING GROWTH FACTOR BETA1; ALLYL COMPOUND; CYCLOOXYGENASE 2; DISULFIDE; PLATELET DERIVED GROWTH FACTOR B; PLATELET-DERIVED GROWTH FACTOR BB; PTGS2 PROTEIN, HUMAN; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL EXPERIMENT; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CELL CYCLE G2 PHASE; CELL PROLIFERATION; CELL TRANSDIFFERENTIATION; CONTROLLED STUDY; FLOW CYTOMETRY; HISTONE ACETYLATION; HUMAN; IMMUNOFLUORESCENCE; LUNG FIBROBLAST; LUNG FIBROSIS; MOUSE; MTT ASSAY; MYOFIBROBLAST; NONHUMAN; PROTEIN EXPRESSION; SYNTHESIS; UPREGULATION; WESTERN BLOTTING; ANIMAL; BIOSYNTHESIS; CHEMISTRY; CYTOLOGY; DRUG EFFECTS; FIBROBLAST; FIBROSIS; GARLIC; GENETICS; LUNG; METABOLISM; PATHOLOGY;

ALLYL COMPOUNDS; ANIMALS; CELL PROLIFERATION; CELL TRANSDIFFERENTIATION; CYCLOOXYGENASE 2; DINOPROSTONE; DISULFIDES; FIBROBLASTS; FIBROSIS; GARLIC; HUMANS; LUNG; MICE; PROTO-ONCOGENE PROTEINS C-SIS; TRANSFORMING GROWTH FACTOR BETA;

EID: 84903462065     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-014-2048-9     Document Type: Article

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