Glucocorticoid receptor function is decreased in neutrophils during endotoxic shock

Journal of Infection

Volumn 69, Issue 2, 2014, Pages 113-122

  Bergquist, Maria ^a,b   Jirholt, Pernilla ^b   Nurkkala, Merja ^b   Rylander, Christian ^c   Hedenstierna, Göran ^a   Lindholm, Catharina ^b  

^a UPPSALA UNIVERSITY   (Sweden)

^b UNIVERSITY OF GOTHENBURG   (Sweden)

^c SAHLGRENSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Dexamethasone; Endotoxin; Glucocorticoid receptor; Lipopolysaccharide; Sepsis

Indexed keywords

DEXAMETHASONE SODIUM PHOSPHATE; GAMMA INTERFERON; GLUCOCORTICOID RECEPTOR; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 10; INTERLEUKIN 17; INTERLEUKIN 1ALPHA; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 5; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MESSENGER RNA; TUMOR NECROSIS FACTOR; CYTOKINE; DEXAMETHASONE; GLUCOCORTICOID;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; B LYMPHOCYTE; BINDING AFFINITY; BLOOD; CD3+ T LYMPHOCYTE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; CYTOKINE RESPONSE; EOSINOPHIL COUNT; FLOW CYTOMETRY; GENE TRANSLOCATION; LEUKOCYTE COUNT; LYMPHOCYTE COUNT; MACROPHAGE; MALE; MONOCYTE; MOUSE; NEUTROPHIL; NEUTROPHIL COUNT; NONHUMAN; OVERALL SURVIVAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SEPTIC SHOCK; SPLEEN; ANIMAL; C57BL MOUSE; CYTOLOGY; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; PATHOLOGY; SHOCK, SEPTIC;

ANIMALS; CYTOKINES; DEXAMETHASONE; GENE EXPRESSION REGULATION; GLUCOCORTICOIDS; LIPOPOLYSACCHARIDES; MALE; MICE; MICE, INBRED C57BL; NEUTROPHILS; RECEPTORS, GLUCOCORTICOID; SHOCK, SEPTIC; SPLEEN;

EID: 84903442943     PISSN: 01634453     EISSN: 15322742     Source Type: Journal    
DOI: 10.1016/j.jinf.2014.03.011     Document Type: Article

References (47)

1. Dombrovskiy V.Y., Martin A.A., Sunderram J., Paz H.L. Rapid increase in hospitalization and mortality rates for severe sepsis in the United States: a trend analysis from 1993 to 2003. Crit Care Med 2007 May, 35(5):1244-1250.
2. Vincent J.-L., Zambon M. Why do patients who have acute lung injury/acute respiratory distress syndrome die from multiple organ dysfunction syndrome? Implications for management. Clin Chest Med 2006 Dec, 27(4):725.
3. Sakr Y., Vincent J.-L., Ruokonen E., Pizzamiglio M., Installe E., Reinhart K., et al. Sepsis and organ system failure are major determinants of post-intensive care unit mortality. J Crit Care 2008 Dec, 23(4):475-483.
4. Marik P. Steroids in patients with septic shock response. Chest 2009 Jul, 136(1):324.
5. Annane D., Sebille V., Charpentier C., Bollaert P.E., Francois B., Korach J.M., et al. Effect of treatment with low doses of hydrocortisone and fludrocortisone on mortality in patients with septic shock. J Am Med Assoc 2002 Aug 21, 288(7):862-871.
6. Sprung C.L., Annane D., Keh D., Moreno R., Singer M., Freivogel K., et al. Hydrocortisone therapy for patients with septic shock. N Engl J Med 2008 Jan 10, 358(2):111-124.
7. Webster J.I., Sternberg E.M. Role of the hypothalamic-pituitary-adrenal axis, glucocorticoids and glucocorticoid receptors in toxic sequelae of exposure to bacterial and viral products. J Endocrinol 2004 May, 181(2):207-221.
8. Oakley R.H., Sar M., Cidlowski J.A. The human glucocorticoid receptor beta isoform - expression, biochemical properties, and putative function. J Biol Chem 1996, 271(16):9550-9559.
9. Pujols L., Mullol J., Roca-Ferrer J., Torrego A., Xaubet A., Cidlowski J.A., et al. Expression of glucocorticoid receptor alpha- and beta-isoforms in human cells and tissues. Am J Physiol Cell Physiol 2002 Oct, 283(4):C1324-C1331.
10. Lewis-Tuffin L.J., Cidlowski J.A. The physiology of human glucocorticoid receptor beta (hGR beta) and glucocorticoid resistance. Basic Clin Aspects Neuroendocrine Immunol Rheumatic Dis 2006, 1069:1-9.
11. Ledderose C., Moehnle P., Limbeck E., Schuetz S., Weis F., Rink J., et al. Corticosteroid resistance in sepsis is influenced by microRNA-124-induced downregulation of glucocorticoid receptor-alpha. Crit Care Med 2012 Oct, 40(10):2745-2753.
12. van den Akker E.L.T., Koper J.W., Joosten K., de Jong F.H., Hazelzet J.A., Lamberts S.W.J., et al. Glucocorticoid receptor mRNA levels are selectively decreased in neutrophils of children with sepsis. Intens Care Med 2009 Jul, 35(7):1247-1254.
13. Hinds T.D., Ramakrishnan S., Cash H.A., Stechschulte L.A., Heinrich G., Najjar S.M., et al. Discovery of glucocorticoid receptor-beta in mice with a role in metabolism. Mol Endocrinol 2010 Sep, 24(9):1715-1727.
14. Beishuizen A., Thijs L.G. Endotoxin and the hypothalamo-pituitary-adrenal (HPA) axis. J Endotoxin Res 2003, 9(1):3-24.
15. Bergquist M., Nurkkala M., Rylander C., Kristiansson E., Hedenstierna G., Lindholm C. Expression of the glucocorticoid receptor is decreased in experimental Staphylococcus aureus sepsis. J Infect 2013 Dec, 67(6):574-583.
16. van den Berg J.W., van der Zee M., de Bruin R.W.F., van Holten-Neelen C., Bastiaans J., Nagtzaam N.M.A., et al. Mild versus strong anti-inflammatory therapy during early sepsis in mice: a matter of life and death. Crit Care Med 2011 Jun, 39(6):1275-1281.
17. Du J., Li M., Zhang D., Zhu X., Zhang W., Gu W., et al. Flow cytometry analysis of glucocorticoid receptor expression and binding in steroid-sensitive and steroid-resistant patients with systemic lupus erythematosus. Arthritis Res Ther 2009, 11(4).
18. Sun X.Y., Fischer D.R., Pritts T.A., Wray C.J., Hasselgren P.O. Expression and binding activity of the glucocorticoid receptor are upregulated in septic muscle. Am J Physiol Regul Integr Comp Physiol 2002 Feb, 282(2):R509-R518.
19. Verheggen M.M., van Hal P.T.W., Adriaansen-Soeting P.W.C., Goense B.J.A., Hoogsteden H.C., Brinkmann A.O., et al. Modulation of glucocorticoid receptor expression in human bronchial epithelial cell lines by IL-1 beta, TNF-alpha and LPS. Eur Respir J 1996 Oct, 9(10):2036-2043.
20. Da J.P., Chen L.N., Hedenstierna G. Nitric oxide up-regulates the glucocorticoid receptor and blunts the inflammatory reaction in porcine endotoxin sepsis. Crit Care Med 2007, 35(1):26-32.
21. Molijn G.J., Koper J.W., Vanuffelen C.J.C., Dejong F.H., Brinkmann A.O., Bruining H.A., et al. Temperature-induced down-regulation of the glucocorticoid receptor in peripheral blood mononuclear leucocytes in patients with sepsis or septic shock. Clin Endocrinol 1995 Aug, 43(2):197-203.
22. Gruver-Yates A.L., Quinn M.A., Cidlowski J.A. Analysis of glucocorticoid receptors and their apoptotic response to dexamethasone in male murine B cells during development. Endocrinology 2013, 155(2):463-474.
23. Kelly-Scumpia K.M., Scumpia P.O., Weinstein J.S., Delano M.J., Cuenca A.G., Nacionales D.C., et al. B cells enhance early innate immune responses during bacterial sepsis. J Exp Med 2011 Aug 1, 208(8):1673-1682.
24. Rauch P.J., Chudnovskiy A., Robbins C.S., Weber G.F., Etzrodt M., Hilgendorf I., et al. Innate response activator B cells protect against microbial sepsis. Science 2012 Feb 3, 335(6068):597-601.
25. Schleimer R.P. Effects of glucocorticosteroids on inflammatory cells relevant to their therapeutic applications in asthma. Am Rev Respir Dis 1990 Feb, 141(2):S59-S69.
26. Wen W., Liu W., Zhang L., Bai J., Fan Y., Xia W., et al. Increased neutrophilia in nasal polyps reduces the response to oral corticosteroid therapy. J Allergy Clin Immunol 2012 Jun, 129(6):1522.
27. Cox G., Austin R.C. Dexamethasone-induced suppression of apoptosis in human neutrophils requires continuous stimulation of new protein synthesis. J Leukoc Biol 1997 Feb, 61(2):224-230.
28. Di Baldassarre A., Secchiero P., Grilli A., Celeghini C., Falcieri E., Zauli G. Morphological features of apoptosis in hematopoietic cells belonging to the T-lymphoid and myeloid lineages. Cell Mol Biol 2000 Feb, 46(1):153-161.
29. Marshall J.C. Neutrophils in the pathogenesis of sepsis. Crit Care Med 2005 Dec, 33(12):S502-S505.
30. Thijs A., Thijs L.G. Pathogenesis of renal failure in sepsis. Kidney Int 1998 May, 53:S34-S37.
31. Brealey D., Singer M. Multi-organ dysfunction in the critically ill: effects on different organs. J R Coll Physicians Lond 2000 Sep-Oct, 34(5):428-431.
32. Goodwin J.E., Feng Y., Velazquez H., Sessa W.C. Endothelial glucocorticoid receptor is required for protection against sepsis. Proc Natl Acad Sci U S A 2013 Jan 2, 110(1):306-311.
33. Webster J.C., Oakley R.H., Jewell C.M., Cidlowski J.A. Proinflammatory cytokines regulate human glucocorticoid receptor gene expression and lead to the accumulation of the dominant negative beta isoform: a mechanism for the generation of glucocorticoid resistance. Proc Natl Acad Sci U S A 2001 Jun 5, 98(12):6865-6870.
34. Christodoulopoulos P., Leung D.Y.M., Elliott M.W., Hogg J.C., Muro S., Toda M., et al. Increased number of glucocorticoid receptor-beta-expressing cells in the airways in fatal asthma. J Allergy Clin Immunol 2000, 106(3):479-484.
35. Goleva E., Li L.B., Eves P.T., Strand M.J., Martin R.J., Leung D.Y.M. Increased glucocorticoid receptor beta alters steroid response in glucocorticoid-insensitive asthma. Am J Respir Crit Care Med 2006 Mar, 173(6):607-616.
36. Hamid Q.A., Wenzel S.E., Hauk P.J., Tsicopoulos A., Wallaert B., Lafitte J.J., et al. Increased glucocorticoid receptor beta in airway cells of glucocorticoid-insensitive asthma. Am J Respir Crit Care Med 1999, 159(5):1600-1604.
37. Li L.-B., Leung D.Y.M., Martin R.J., Goleva E. Inhibition of histone deacetylase 2 expression by elevated glucocorticoid receptor beta in steroid-resistant asthma. Am J Respir Crit Care Med 2010 Oct 1, 182(7):877-883.
38. Colli L.M., do Amaral F.C., Torres N., de Castro M. Interindividual glucocorticoid sensitivity in young healthy subjects: the role of glucocorticoid receptor alpha and beta isoforms ratio. Horm Metab Res 2007 Jun, 39(6):425-429.
39. Jakiela B., Bochenek G., Sanak M. Glucocorticoid receptor isoforms in steroid-dependent asthma. Pol Arch Med Wewn - Pol Archiv Intern Med 2010, 120(6):214-221.
40. Uchino S., Kellum J.A., Bellomo R., Doig G.S., Morimatsu H., Morgera S., et al. Acute renal failure in critically ill patients - a multinational, multicenter study. J Am Med Assoc 2005 Aug 17, 294(7):813-818.
41. Hoste E.A.J., Schurgers M. Epidemiology of acute kidney injury: how big is the problem?. Crit Care Med 2008 Apr, 36(4):S146-S151.
42. White L.E., Chaudhary R., Moore L.J., Moore F.A., Hassoun H.T. Surgical sepsis and organ crosstalk: the role of the kidney. J Surg Res 2011 May, 167(2):306-315.
43. Hotchkiss R.S., Tinsley K.W., Swanson P.E., Schmieg R.E., Hui J.J., Chang K.C., et al. Sepsis-induced apoptosis causes progressive profound depletion of B and CD4(+) T lymphocytes in humans. J Immunol 2001 Jun 1, 166(11):6952-6963.
44. Hotchkiss R.S., Swanson P.E., Cobb J.P., Jacobson A., Buchman T.G., Karl I.E. Apoptosis in lymphoid and parenchymal cells during sepsis: findings in normal and T- and B-cell-deficient mice. Crit Care Med 1997 Aug, 25(8):1298-1307.
45. Hotchkiss R.S., Monneret G., Payen D. Immunosuppression in sepsis: a novel understanding of the disorder and a new therapeutic approach. Lancet Infect Dis 2013 Mar, 13(3):260-268.
46. Annane D. Adjunct therapy for sepsis: how early?. Curr Infect Dis Rep 2010, 12(5):361-367.
47. Park H.Y., Suh G.Y., Song J.-U., Yoo H., Jo I.J., Shin T.G., et al. Early initiation of low-dose corticosteroid therapy in the management of septic shock: a retrospective observational study. Crit Care 2012, 16(1).