Expression of the glucocorticoid receptor is decreased in experimental Staphylococcus aureus sepsis

Journal of Infection

Volumn 67, Issue 6, 2013, Pages 574-583

  Bergquist, Maria ^a,b   Nurkkala, Merja ^b   Rylander, Christian ^c   Kristiansson, Erik ^d   Hedenstierna, Göran ^a   Lindholm, Catharina ^b  

^a UPPSALA UNIVERSITY   (Sweden)

^b UNIVERSITY OF GOTHENBURG   (Sweden)

^c SAHLGRENSKA UNIVERSITY HOSPITAL   (Sweden)

^d CHALMERS UNIVERSITY OF TECHNOLOGY   (Sweden)

Author keywords

Corticosteroids; Glucocorticoid receptor; Inflammation; Sepsis; Staphylococcus aureus

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; CLOXACILLIN; CORTICOSTERONE; DEXAMETHASONE; DEXAMETHASONE SODIUM PHOSPHATE; GAMMA INTERFERON; GLUCOCORTICOID RECEPTOR; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 10; INTERLEUKIN 17; INTERLEUKIN 1ALPHA; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 5; INTERLEUKIN 6; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIAL LOAD; BLOOD; BODY WEIGHT; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL NUCLEUS; CONTROLLED STUDY; CORTICOSTERONE BLOOD LEVEL; DEHYDRATION; DOSAGE SCHEDULE COMPARISON; EARLY INTERVENTION; FLOW CYTOMETRY; INOCULATION; LIGAND BINDING; LYMPH NODE; MALE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RECEPTOR BINDING; SPLEEN; STAPHYLOCOCCAL BACTEREMIA; STAPHYLOCOCCUS AUREUS; THERAPY DELAY; TREATMENT OUTCOME; WEIGHT GAIN;

CORTICOSTEROIDS; GLUCOCORTICOID RECEPTOR; INFLAMMATION; SEPSIS; STAPHYLOCOCCUS AUREUS;

ANALYSIS OF VARIANCE; ANIMALS; BACTEREMIA; BACTERIAL LOAD; CELL NUCLEUS; CORTICOSTERONE; CYTOKINES; DEXAMETHASONE; DISEASE MODELS, ANIMAL; GLUCOCORTICOIDS; HOST-PATHOGEN INTERACTIONS; MALE; MICE; MICE, INBRED C57BL; RECEPTORS, GLUCOCORTICOID; STAPHYLOCOCCAL INFECTIONS; STAPHYLOCOCCUS AUREUS; TIME FACTORS;

EID: 84887026103     PISSN: 01634453     EISSN: 15322742     Source Type: Journal    
DOI: 10.1016/j.jinf.2013.07.028     Document Type: Article

References (28)

1. Dombrovskiy V.Y., Martin A.A., Sunderram J., Paz H.L. Occurrence and outcomes of sepsis: influence of race. Critical Care Medicine 2007 Mar, 35(3):763-768.
2. Annane D., Sebille V., Charpentier C., Bollaert P.E., Francois B., Korach J.M., et al. Effect of treatment with low doses of hydrocortisone and fludrocortisone on mortality in patients with septic shock. JAMA - Journal of the American Medical Association 2002 Aug 21, 288(7):862-871.
3. Sprung C.L., Annane D., Keh D., Moreno R., Singer M., Freivogel K., et al. Hydrocortisone therapy for patients with septic shock. New England Journal of Medicine 2008 Jan 10, 358(2):111-124.
4. Evans R.M., Hollenberg S.M. Cooperative and positional independent trans-activation domains of the human glucocorticoid receptor. Cold Spring Harbor Symposia on Quantitative Biology 1988, 53:813-818.
5. De Bosscher K., Vanden Berghe W., Haegeman G. Mechanisms of anti-inflammatory action and of immunosuppression by glucocorticoids: negative interference of activated glucocorticoid receptor with transcription factors. Journal of Neuroimmunology 2000 Sep 1, 109(1):16-22.
6. Reichardt H.M., Tuckermann J.P., Gottlicher M., Vujic M., Weih F., Angel P., et al. Repression of inflammatory responses in the absence of DNA binding by the glucocorticoid receptor. Embo Journal 2001 Dec 17, 20(24):7168-7173.
7. Adcock I.M., Caramori G. Cross-talk between pro-inflammatory transcription factors and glucocorticoids. Immunology and Cell Biology 2001 Jul, 79(4):376-384.
8. Webster J.C., Oakley R.H., Jewell C.M., Cidlowski J.A. Proinflammatory cytokines regulate human glucocorticoid receptor gene expression and lead to the accumulation of the dominant negative beta isoform: a mechanism for the generation of glucocorticoid resistance. Proceedings of the National Academy of Sciences of the United States of America 2001 Jun 5, 98(12):6865-6870.
9. Molijn G.J., Koper J.W., Vanuffelen C.J.C., Dejong F.H., Brinkmann A.O., Bruining H.A., et al. Temperature-induced down-regulation of the glucocorticoid receptor in peripheral blood mononuclear leucocytes in patients with sepsis or septic shock. Clinical Endocrinology 1995 Aug, 43(2):197-203.
10. van den Akker E.L.T., Koper J.W., Joosten K., de Jong F.H., Hazelzet J.A., Lamberts S.W.J., et al. Glucocorticoid receptor mRNA levels are selectively decreased in neutrophils of children with sepsis. Intensive Care Medicine 2009 Jul, 35(7):1247-1254.
11. Sun X.Y., Fischer D.R., Pritts T.A., Wray C.J., Hasselgren P.O. Expression and binding activity of the glucocorticoid receptor are upregulated in septic muscle. American Journal of Physiology - Regulatory Integrative and Comparative Physiology 2002 Feb, 282(2):R509-R518.
12. Gjertsson I., Lagerquist M.K., Kristiansson E., Carlsten H., Lindholm C. Estradiol ameliorates arthritis and protects against systemic bone loss in Staphylococcus aureus infection in mice. Arthritis Research & Therapy 2012, 14(2).
13. van den Berg J.W., van der Zee M., de Bruin R.W.F., van Holten-Neelen C., Bastiaans J., Nagtzaam N.M.A., et al. Mild versus strong anti-inflammatory therapy during early sepsis in mice: a matter of life and death. Critical Care Medicine 2011 Jun, 39(6):1275-1281.
14. Du J., Li M., Zhang D., Zhu X., Zhang W., Gu W., et al. Flow cytometry analysis of glucocorticoid receptor expression and binding in steroid-sensitive and steroid-resistant patients with systemic lupus erythematosus. Arthritis Research & Therapy 2009, 11(4).
15. Galigniana M.D., Scruggs J.L., Herrington J., Welsh M.J., Carter-Su C., Housley P.R., et al. Heat shock protein 90-dependent (geldanamycin-inhibited) movement of the glucocorticoid receptor through the cytoplasm to the nucleus requires intact cytoskeleton. Molecular Endocrinology 1998 Dec, 12(12):1903-1913.
16. Hu J.M., Bodwell J.E., Munck A. Control by nasal phosphorylation of cell cycle-dependent, hormone-induced glucocorticoid receptor hyperphosphorylation. Molecular Endocrinology 1997 Mar, 11(3):305-311.
17. Irusen E., Matthews J.G., Takahashi A., Barnes P.J., Chung K.F., Adcock I.M. p38 mitogen-activated protein kinase-induced glucocorticoid receptor phosphorylation reduces its activity: role in steroid-insensitive asthma. Journal of Allergy and Clinical Immunology 2002 Apr, 109(4):649-657.
18. Munck A., Mendel D.B., Smith L.I., Orti E. Glucocorticoid receptors and actions. American Review of Respiratory Disease 1990 Feb, 141(2):S2-S10.
19. Pariante C.M., Pearce B.D., Pisell T.L., Sanchez C.I., Po C., Su C., et al. The proinflammatory cytokine, interleukin-1 alpha, reduces glucocorticoid receptor translocation and function. Endocrinology 1999 Sep, 140(9):4359-4366.
20. Galigniana M.D., Piwien-Pilipuk G., Assreuy J. Inhibition of glucocorticoid receptor binding by nitric oxide. Molecular Pharmacology 1999 Feb, 55(2):317-323.
21. Annane D. Adjunct therapy for sepsis: how early?. Current Infectious Disease Reports 2010, 12(5):361-367.
22. Park H.Y., Suh G.Y., Song J.-U., Yoo H., Jo I.J., Shin T.G., et al. Early initiation of low-dose corticosteroid therapy in the management of septic shock: a retrospective observational study. Critical Care 2012, 16(1).
23. Gwosdow A.R., Kumar M.S.A., Bode H.H. Interleukin-1 stimulation of the hypothalamic-pituary-adrenal axis. American Journal of Physiology 1990 Jan, 258(1):E65-E70.
24. Kern J.A., Lamb R.J., Reed J.C., Daniele R.P., Nowell P.C. Dexamethasone inhibition of interleukin-1 beta-production by human monocytes - posttranscriptional mechanisms. Journal of Clinical Investigation 1988 Jan, 81(1):237-244.
25. Kum W.W.S., Cameron S.B., Hung R.W.Y., Kalyan S., Chow A.W. Temporal sequence and kinetics of proinflammatory and anti-inflammatory cytokine secretion induced by toxic shock syndrome toxin 1 in human peripheral blood mononuclear cells. Infection and Immunity 2001 Dec, 69(12):7544-7549.
26. Zhao Y.X., Nilsson I.M., Tarkowski A. The dual role of interferon-gamma in experimental Staphylococcus aureus septicaemia versus arthritis. Immunology 1998 Jan, 93(1):80-85.
27. Rothwell P.M., Udwadia Z.F., Lawler P.G. Cortisol response to corticotropin and survival in septic shock. Lancet 1991 Mar 9, 337(8741):582-583.
28. Cooper M.S., Stewart P.M. Current concepts - corticosteroid insufficiency in acutely ill patients. New England Journal of Medicine 2003 Feb 20, 348(8):727-734.