Highly sensitive single domain antibody-quantum dot conjugates for detection of HER2 biomarker in lung and breast cancer cells

ACS Nano

Volumn 8, Issue 6, 2014, Pages 5682-5695

  Rakovich, Tatsiana Y ^a   Mahfoud, Omar K ^a   Mohamed, Bashir M ^a   Prina Mello, Adriele ^a   Crosbie Staunton, Kieran ^a   Van Den Broeck, Tina ^c   De Kimpe, Line ^c   Sukhanova, Alyona ^a,d,e   Baty, Daniel ^f   Rakovich, Aliaksandra ^b   Maier, Stefan A ^b   Alves, Frauke ^g   Nauwelaers, Frans ^c   Nabiev, Igor ^a,d,e   Chames, Patrick ^f   Volkov, Yuri ^a  

^a TRINITY COLLEGE DUBLIN   (Ireland)

^b IMPERIAL COLLEGE LONDON   (United Kingdom)

^c Physics Department Imperial College London ^*  (Belgium)

^d UNIVERSITÉ DE REIMS CHAMPAGNE ARDENNE   (France)

^e NATIONAL RESEARCH NUCLEAR UNIVERSITY MEPHI   (Russian Federation)

^f AIX MARSEILLE UNIVERSITY   (France)

^g MAX PLANCK INSTITUTE OF EXPERIMENTAL MEDICINE   (Germany)

Author keywords

breast cancer; cancer biomarker; cell line co culture; confocal microscopy imaging; ELISA; flow cytometry; fluorescence lifetime imaging microscopy; HER2 protein; immunohistochemistry; lung cancer; optical and fluorescence properties; primary macrophages; quantum dot; single domain antibodies; Western blot

Indexed keywords

BIOLOGICAL ORGANS; BIOMARKERS; CELL CULTURE; CELLS; DIAGNOSIS; DISEASES; FLOW CYTOMETRY; FLUORESCENCE; FLUORSPAR; MEDICAL IMAGING; MONOCLONAL ANTIBODIES; SEMICONDUCTOR QUANTUM DOTS;

BREAST CANCER; CANCER BIOMARKERS; COCULTURE; CONFOCAL MICROSCOPY IMAGING; ELISA; FLUORESCENCE LIFETIME IMAGING MICROSCOPY; FLUORESCENCE PROPERTIES; IMMUNOHISTOCHEMISTRY; LUNG CANCER; QUANTUM DOT; SINGLE-DOMAIN ANTIBODIES; WESTERN BLOTS;

CHEMICAL DETECTION;

ANTIBODY; EPIDERMAL GROWTH FACTOR RECEPTOR 2; ERBB2 PROTEIN, HUMAN; FLUORESCENT DYE; MONOCLONAL ANTIBODY; QUANTUM DOT; TUMOR MARKER;

BREAST TUMOR; CHEMISTRY; COCULTURE; CONFOCAL MICROSCOPY; FLOW CYTOMETRY; HUMAN; IMMUNOHISTOCHEMISTRY; LUNG TUMOR; MACROPHAGE; METABOLISM; TUMOR CELL LINE;

ANTIBODIES; ANTIBODIES, MONOCLONAL; BREAST NEOPLASMS; CELL LINE, TUMOR; COCULTURE TECHNIQUES; FLOW CYTOMETRY; FLUORESCENT DYES; HUMANS; IMMUNOHISTOCHEMISTRY; LUNG NEOPLASMS; MACROPHAGES; MICROSCOPY, CONFOCAL; QUANTUM DOTS; RECEPTOR, ERBB-2; TUMOR MARKERS, BIOLOGICAL;

EID: 84903442875     PISSN: 19360851     EISSN: 1936086X     Source Type: Journal    
DOI: 10.1021/nn500212h     Document Type: Article

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