Evaluating binding avidities of populations of heterogeneous multivalent ligand-functionalized nanoparticles

ACS Nano

Volumn 8, Issue 6, 2014, Pages 5600-5609

  Li, Ming Hsin ^a,b   Choi, Seok Ki ^b,c   Leroueil, Pascale R ^b,c   Baker, James R ^a,b,c  

^a UNIVERSITY OF MICHIGAN   (United States)

^b UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

^c UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

avidity; heterogeneity; multivalent binding; oligonucleotide; poly(amidoamine) dendrimer

Indexed keywords

DENDRIMERS; DISSOCIATION; DRUG DELIVERY; LIGANDS; MEDICAL APPLICATIONS; NANOPARTICLES; OLIGONUCLEOTIDES; SURFACE PLASMON RESONANCE;

AVIDITY; BIOMEDICAL APPLICATIONS; HETEROGENEITY; HETEROGENEOUS NANOPARTICLES; MULTIVALENT BINDING; MULTIVALENT INTERACTIONS; POLYAMIDOAMINE DENDRIMERS; SURFACE PLASMON RESONANCE BIOSENSOR;

SYNTHESIS (CHEMICAL);

DENDRIMER; LIGAND; MACROMOLECULE; NANOPARTICLE; OLIGONUCLEOTIDE; POLYAMIDOAMINE; POLYAMINE; PROTEIN BINDING; SINGLE STRANDED DNA;

ANTIBODY AFFINITY; CHEMISTRY; COMPUTER SIMULATION; GENETIC PROCEDURES; KINETICS; MACROMOLECULE; NANOTECHNOLOGY; PROCEDURES; STRUCTURE ACTIVITY RELATION; SURFACE PLASMON RESONANCE;

ANTIBODY AFFINITY; BIOSENSING TECHNIQUES; COMPUTER SIMULATION; DENDRIMERS; DNA, SINGLE-STRANDED; KINETICS; LIGANDS; MACROMOLECULAR SUBSTANCES; NANOPARTICLES; NANOTECHNOLOGY; OLIGONUCLEOTIDES; POLYAMINES; PROTEIN BINDING; STRUCTURE-ACTIVITY RELATIONSHIP; SURFACE PLASMON RESONANCE;

EID: 84903441971     PISSN: 19360851     EISSN: 1936086X     Source Type: Journal    
DOI: 10.1021/nn406455s     Document Type: Article

References (29)

1. Mammen, M.; Choi, S. K.; Whitesides, G. M. Polyvalent Interactions in Biological Systems: Implications for Design and Use of Multivalent Ligands and Inhibitors Angew. Chem., Int. Ed. 1998, 37, 2755-2794
2. Pieters, R. J. Maximising Multivalency Effects in Protein-Carbohydrate Interactions Org. Biomol. Chem. 2009, 7, 2013-2025
3. Levine, P. M.; Carberry, T. P.; Holub, J. M.; Kirshenbaum, K. Crafting Precise Multivalent Architectures MedChemComm 2013, 4, 493-509
4. Schrama, D.; Reisfeld, R. A.; Becker, J. C. Antibody Targeted Drugs as Cancer Therapeutics Nat. Rev. Drug Discovery 2006, 5, 147-159
5. Bergstrom, M.; Liu, S.; Kiick, K. L.; Ohlson, S. Cholera Toxin Inhibitors Studied with High-Performance Liquid Affinity Chromatography: A Robust Method to Evaluate Receptor-Ligand Interactions Chem. Biol. Drug Des. 2009, 73, 132-141
6. Toner, C. D.; Davis, C. D.; Milner, J. A. The Vitamin D and Cancer Conundrum: Aiming at a Moving Target J. Am. Diet. Assoc. 2010, 110, 1492-1500
7. Shen, Z.; Wei, W.; Tanaka, H.; Kohama, K.; Ma, G.; Dobashi, T.; Maki, Y.; Wang, H.; Bi, J.; Dai, S. A Galactosamine-Mediated Drug Delivery Carrier for Targeted Liver Cancer Therapy Pharmacol. Res. 2011, 64, 410-419
8. Sanchez-Navarro, M.; Rojo, J. Targeting Dc-Sign with Carbohydrate Multivalent Systems Drug News Perspect. 2010, 23, 557-572
9. Ono, M.; Kuwano, M. Molecular Mechanisms of Epidermal Growth Factor Receptor (EGFR) Activation and Response to Gefitinib and Other EGFR-Targeting Drugs Clin. Cancer Res. 2006, 12, 7242-7251 (Pubitemid 46095395)
10. Noolvi, M. N.; Patel, H. M. Small Molecule Tyrosine Kinase Inhibitors: The New Dawn for Cancer Therapy Lett. Drug Des. Discovery 2012, 9, 84-125
11. Kamaly, N.; Xiao, Z.; Valencia, P. M.; Radovic-Moreno, A. F.; Farokhzad, O. C. Targeted Polymeric Therapeutic Nanoparticles: Design, Development and Clinical Translation Chem. Soc. Rev. 2012, 41, 2971-3010
12. Yu, M. K.; Park, J.; Jon, S. Targeting Strategies for Multifunctional Nanoparticles in Cancer Imaging and Therapy Theranostics 2012, 2, 3-44
13. Rizzo, L. Y.; Theek, B.; Storm, G.; Kiessling, F.; Lammers, T. Recent Progress in Nanomedicine: Therapeutic, Diagnostic and Theranostic Applications Curr. Opin. Biotechnol. 2013, 24, 1159-1166
14. Li, M. H.; Choi, S. K.; Thomas, T. P.; Desai, A.; Lee, K. H.; Kotlyar, A.; Banaszak Holl, M. M.; Baker, J. R., Jr. Dendrimer-Based Multivalent Methotrexates as Dual Acting Nanoconjugates for Cancer Cell Targeting Eur. J. Med. Chem. 2012, 47, 560-572
15. Zhang, Y. H.; Thomas, T. P.; Lee, K. H.; Li, M. H.; Zong, H.; Desai, A. M.; Kotlyar, A.; Huang, B. H.; Holl, M. M. B.; Baker, J. R. Polyvalent Saccharide-Functionalized Generation 3 Poly(amidoamine) Dendrimer-Methotrexate Conjugate as a Potential Anticancer Agent Bioorg. Med. Chem. 2011, 19, 2557-2564
16. Zong, H.; Thomas, T. P.; Lee, K. H.; Desai, A. M.; Li, M. H.; Kotlyar, A.; Zhang, Y. H.; Leroueil, P. R.; Gam, J. J.; Holl, M. M. B.; Baker, J. R., Jr. Bifunctional PAMAM Dendrimer Conjugates of Folic Acid and Methotrexate with Defined Ratio Biomacromolecules 2012, 13, 982-991
17. Mullen, D. G.; Fang, M.; Desai, A.; Baker, J. R.; Orr, B. G.; Holl, M. M. B. A Quantitative Assessment of Nanoparticle-Ligand Distributions: Implications for Targeted Drug and Imaging Delivery in Dendrimer Conjugates ACS Nano 2010, 4, 657-670
18. Mullen, D. G.; Borgmeier, E. L.; Desai, A. M.; van Dongen, M. A.; Barash, M.; Cheng, X. M.; Baker, J. R.; Holl, M. M. B. Isolation and Characterization of Dendrimers with Precise Numbers of Functional Groups Chem.-Eur. J. 2010, 16, 10675-10678
19. Persson, B.; Stenhag, K.; Nilsson, P.; Larsson, A.; Uhlen, M.; Nygren, P. A. Analysis of Oligonucleotide Probe Affinities Using Surface Plasmon Resonance: A Means for Mutational Scanning Anal. Biochem. 1997, 246, 34-44 (Pubitemid 27100504)
20. Nishikawa, M.; Rattanakiat, S.; Takakura, Y. DNA-Based Nano-Sized Systems for Pharmaceutical and Biomedical Applications Adv. Drug Delivery Rev. 2010, 62, 626-632
21. Bandy, T. J.; Brewer, A.; Burns, J. R.; Marth, G.; Nguyen, T.; Stulz, E. DNA as Supramolecular Scaffold for Functional Molecules: Progress in DNA Nanotechnology Chem. Soc. Rev. 2011, 40, 138-148
22. Hong, S.; Leroueil, P. R.; Majoros, I. J.; Orr, B. G.; Baker, J. R., Jr.; Banaszak Holl, M. M. The Binding Avidity of a Nanoparticle-Based Multivalent Targeted Drug Delivery Platform Chem. Biol. 2007, 14, 107-115 (Pubitemid 46124068)
23. Tassa, C.; Duffner, J. L.; Lewis, T. A.; Weissleder, R.; Schreiber, S. L.; Koehler, A. N.; Shaw, S. Y. Binding Affinity and Kinetic Analysis of Targeted Small Molecule-Modified Nanoparticles Bioconjugate Chem. 2010, 21, 14-19
24. Svenson, S.; Tomalia, D. A. Dendrimers in Biomedical Applications- Reflections on the Field Adv. Drug Delivery Rev. 2005, 57, 2106-2129
25. Menjoge, A. R.; Kannan, R. M.; Tomalia, D. A. Dendrimer-Based Drug and Imaging Conjugates: Design Considerations for Nanomedical Applications Drug Discovery Today 2010, 15, 171-185
26. Edwards, P. R.; Leatherbarrow, R. J. Determination of Association Rate Constants by an Optical Biosensor Using Initial Rate Analysis Anal. Biochem. 1997, 246, 1-6 (Pubitemid 27100499)
27. Thomas, T. P.; Huang, B.; Choi, S. K.; Silpe, J. E.; Kotlyar, A.; Desai, A. M.; Zong, H.; Gam, J.; Joice, M.; Baker, J. R., Jr. Polyvalent Dendrimer-Methotrexate as a Folate Receptor-Targeted Cancer Therapeutic Mol. Pharmaceutics 2012, 9, 2669-2676
28. Choi, S. K.; Myc, A.; Silpe, J. E.; Sumit, M.; Wong, P. T.; McCarthy, K.; Desai, A. M.; Thomas, T. P.; Kotlyar, A.; Holl, M. M.; Orr, B. G.; Baker, J. R., Jr. Dendrimer-Based Multivalent Vancomycin Nanoplatform for Targeting the Drug-Resistant Bacterial Surface ACS Nano 2013, 7, 214-228
29. Silpe, J. E.; Sumit, M.; Thomas, T. P.; Huang, B.; Kotlyar, A.; van Dongen, M. A.; Banaszak Holl, M. M.; Orr, B. G.; Choi, S. K. Avidity Modulation of Folate-Targeted Multivalent Dendrimers for Evaluating Biophysical Models of Cancer Targeting Nanoparticles ACS Chem. Biol. 2013, 8, 2063-2071