Mitochondrial Pyruvate Carrier 2 Hypomorphism in Mice Leads to Defects in Glucose-Stimulated Insulin Secretion

Cell Reports

Volumn 7, Issue 6, 2014, Pages 2042-2053

  Vigueira, Patrick A ^a   McCommis, Kyle S ^a   Schweitzer, George G ^a   Remedi, Maria S ^a   Chambers, Kari T ^a   Fu, Xiaorong ^b   McDonald, William G ^c   Cole, Serena L ^c   Colca, Jerry R ^c   Kletzien, Rolf F ^c   Burgess, Shawn C ^b   Finck, Brian N ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^c Metabolic Solutions Development Company   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; LACTIC ACID; MITOCHONDRIAL PYRUVATE CARRIER 2; MONOCARBOXYLATE TRANSPORTER; PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP); UNCLASSIFIED DRUG; CARRIER PROTEIN; INSULIN; PYRUVATE TRANSPORT PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENDOCRINE PANCREAS FUNCTION TEST; ENDURANCE; FEMALE; GENE MUTATION; GLUCONEOGENESIS; GLUCOSE BLOOD LEVEL; GLUCOSE HOMEOSTASIS; GLUCOSE METABOLISM; GLUCOSE SENSING; GLUCOSE TOLERANCE TEST; HYPOMORPHISM; INSULIN RELEASE; INSULIN SENSITIVITY; KNOCKOUT MOUSE; LACTATE BLOOD LEVEL; LETHALITY; LOSS OF FUNCTION MUTATION; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRIAL RESPIRATION; MOUSE; NONHUMAN; OXYGEN CONSUMPTION; PANCREAS ISLET BETA CELL; PANCREAS ISLET CELL FUNCTION; PRIORITY JOURNAL; PROTEIN CONTENT; PROTEIN DEFICIENCY; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN TRANSPORT; PYRUVATE TOLERANCE TEST; WILD TYPE; ANIMAL; C57BL MOUSE; DEFICIENCY; DRUG EFFECTS; METABOLISM; SECRETION (PROCESS); SECRETION RATE; TRANSGENIC MOUSE;

ANIMALS; FEMALE; GLUCOSE; INSULIN; LACTIC ACID; MEMBRANE TRANSPORT PROTEINS; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; SECRETORY RATE;

EID: 84903390237     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2014.05.017     Document Type: Article

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