Safety and vasopressor effect of rosuvastatin in septic patients

Egyptian Journal of Anaesthesia

Volumn 30, Issue 3, 2014, Pages 311-317

  El Gendy, Hanaa A ^a   Elsharnouby, Noha M ^a  

^a AIN SHAMS UNIVERSITY   (Egypt)

Author keywords

ICU length of stay; Mortality; Rosuvastatin; Sepsis; Vasopressor

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CREATINE KINASE; LACTIC ACID; NORADRENALIN; PLACEBO; ROSUVASTATIN; ANALGESIC AGENT; ANTIINFECTIVE AGENT; ANTIPYRETIC AGENT; HYPERTENSIVE FACTOR; LOW MOLECULAR WEIGHT HEPARIN; PROTON PUMP INHIBITOR;

ADULT; ARTICLE; BLOOD PRESSURE; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG SAFETY; FEMALE; HOSPITALIZATION; HUMAN; INTENSIVE CARE UNIT; MAJOR CLINICAL STUDY; MALE; MORTALITY; MULTIPLE ORGAN FAILURE; OUTCOME ASSESSMENT; PERFUSION; RANDOMIZED CONTROLLED TRIAL; SEPSIS; SIDE EFFECT; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME; ALANINE AMINOTRANSFERASE BLOOD LEVEL; APACHE; ARTIFICIAL VENTILATION; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CREATINE KINASE BLOOD LEVEL; DRUG DOSE TITRATION; DRUG EFFICACY; ENTERIC FEEDING; FLUID RESUSCITATION; INFECTION; LENGTH OF STAY; MEAN ARTERIAL PRESSURE; ORGAN PERFUSION; PHYSICAL DISEASE BY BODY FUNCTION; PILOT STUDY; PROSPECTIVE STUDY; SEPTIC SHOCK; SEQUENTIAL ORGAN FAILURE ASSESSMENT SCORE; STRESS ULCER; TREATMENT DURATION;

EID: 84903381299     PISSN: 11101849     EISSN: 16871804     Source Type: Journal    
DOI: 10.1016/j.egja.2014.02.005     Document Type: Article

References (29)

1. C.C. McGown, and Z.L.S. Brookes Beneficial effects of statins on the microcirculation during sepsis: the role of nitric oxide Br J Anaesth 98 2007 163 175
2. B.B. Tan, R.L. Prewitt, and L.D. Britt Interleukin-10 prevents loss of rat skeletal muscle arterioles exposed to endotoxin J Surg Res 100 2001 110 115
3. J.L. Vincent Cardiovascular alterations in septic shock J Antimicrob Chemother 41 1998 9 15
4. R.J. Beale, S.M. Hollenberg, J.L. Vincent, and J.E. Parrillo Vasopressor and inotropic support in septic shock: an evidence based review Crit Care Med 32 11 suppl. 2004 S455 S465
5. D. Pruefer, J. Makowski, M. Schnell, U. Buerke, M. Dahm, and H. Oelert et al. Simvastatin inhibits inflammatory properties of Staphylococcus aureus alpha-toxin Circulation 106 2002 2104 2110
6. Y. Rikitake, S. Kawashima, S. Takeshita, T. Yamashita, H. Azumi, and M. Yasuhara et al. Anti-oxidative properties of fluvastatin, an HMG-CoA reductase inhibitor, contribute to prevention of atherosclerosis in cholesterol-fed rabbits Atherosclerosis 154 2001 87 96
7. R.C. Bone, R.A. Balk, and F.B. Cerra et al. ACCP/SCCM consensus conference. Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis Crit Care Med 20 1992 964 974
8. X. Viviand, M. Leone, and X. Thirion Effect of norepinephrine on the outcome of septic shock Crit Care Med 28 8 2000
9. T.M. Glembot, L.D. Britt, and M.A. Hill Lack of direct endotoxin induced vasoactive effects on isolated skeletal muscle arterioles Shock 3 1995 216 223
10. T.M. Glembot, L.D. Britt, and M.A. Hill Endotoxin interacts with tumour necrosis factor-alpha to induce vasodilation of isolated rat skeletal muscle arterioles Shock 5 1996 251 257
11. R. Scalia, and T.J. Stalker Microcirculation as a target for the anti-inflammatory properties of statins Microcirculation 9 2002 431 442
12. P.A. Vo, B. Lad, J.A. Tomlinson, S. Francis, and A. Ahluwalia Autoregulatory role of endothelium-derived nitric oxide (NO) on lipopolysaccharide-induced vascular inducible NO synthase expression and function J Biol Chem 280 2005 7236 7243
13. T. Yamashita, S. Kawashima, and Y. Ohashi et al. Resistance to endotoxin shock in transgenic mice over expressing endothelial nitric oxide synthase Circulation 101 2000 931 937
14. U. Laufs, V.L. Fata, and J.K. Liao Inhibition of 3-hydroxy-3- methylglutaryl (HMG)-CoA reductase blocks hypoxia mediated down-regulation of endothelial nitric oxide synthase J Biol Chem 272 1997 31725 31729
15. U. Laufs, V. La Fata, J. Plutzky, and J.K. Liao Upregulation of endothelial nitric oxide synthase by HMG CoA reductase inhibitors Circulation 97 1998 1129 1135
16. U. Laufs, K. Gertz, U. Dirnagl, M. Bohm, G. Nickenig, and M. Endres Rosuvastatin, a new HMG-CoA reductase inhibitor, upregulates endothelial nitric oxide synthase and protects from ischemic stroke in mice Brain Res 942 2002 23 30
17. Marsik, Polterauer Stefan, Kapiotis Stylianos, Pleiner Michael Wolzt Johannes, Schaller Georg, and Mittermayer Friedrich et al. Simvastatin prevents vascular hyporeactivity during inflammation Circulation 110 2004 3349 3354
18. A. Giusti-Paiva, M.R. Martinez, and J.V. Felix et al. Simvastatin decreases nitric oxide overproduction and reverts the impaired vascular responsiveness induced by endotoxic shock in rats Shock 21 2004 271 275
19. C.C. McGown, N.J. Brown, and P.G. Hellewell et al. Beneficial microvascular and anti-inflammatory effects of pravastatin during sepsis involve nitric oxide synthase III Br J Anaesth 104 2 2010 183 190
20. Almog Y, shefer A, Novack V, et al. Prior statin therapy protects against severe sepsis. Presented at: annual meeting of the Society of Critical Care Medicine; Orlando, Fla Circulation 2004; 110(7): 880-5.
21. Doson Chua, Karina Choice, Rochelle Gellatly, and Glen Brown Statin use and morbidity outcomes in septic shock patients: a retrospective cohort study Crit Care Shock 14 2011 15 18
22. P. Kruger, M. Bailey, R. Bellomo, D.J. Cooper, M. Harward, and A. Higgins et al. A multicenter randomized trial of atorvastatin therapy in intensive care patients with severe sepsis Am J Respir Crit Care Med 187 7 2013 743 750 10.1164/rccm.201209-1718OC
23. E. Rivers, B. Nguyen, and S. Havstad et al. Early goal- directed therapy collaborative group. Early goal-directed therapy in the treatment of severe sepsis and septic shock N Engl J Med 345 19 2001 1368 1377
24. B.M. Fuller, M. Gajera, and C. Schorr et al. The association of prior statin use in septic shock treated with early goal directed therapy Eur J Emerg Med 19 4 2012 226 230
25. R. Fernandez, V.J. De Pedro, and A. Artigas Statin therapy prior to ICU admission: protection against infection or a severity marker? Intens Care Med 32 2006 160 164
26. E.M. Mortensen, M.I. Restrepo, and L.A. Copeland et al. Impact on previous statin and angiotensin II receptor blocker use on mortality in patients hospitalized with sepsis Pharmacotherapy 27 12 2007 1619 1626
27. M.W. Donnino, M.N. Cocchi, and M. Howell et al. Statin therapy is associated with decreased mortality in patients with infection Acad Emerg Med 16 2009 230 234
28. M.J. Terblanche, R. Pinto, and C. Whiteley et al. Statins do not prevent acute organ failure in ventilated ICU patients: single-centre retrospective cohort study Crit Care 15 1 2011 74
29. L.J. Harris, R. Thapa, and M. Brown et al. Clinical and laboratory phenotype of patients experiencing statin intolerance attributable to myalgia J Clin Lipidol 5 4 2011 299 307