Evidence for the involvement of JAK/STAT/SOCS pathway in the mechanism of Tangshen formula-treated diabetic nephropathy

Planta Medica

Volumn 80, Issue 8-9, 2014, Pages 614-621

  Hu, Jingjing ^a   Fan, Xuemei ^c   Meng, Xiansheng ^a   Wang, Yiming ^c   Liang, Qionglin ^c   Luo, Guoan ^b,c  

^a LIAONING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

^b MACAU UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Macao)

^c TSINGHUA UNIVERSITY   (China)

Author keywords

diabetic nephropathy; JAK STAT SOCS; mechanism; microarray; Tangshen formula

Indexed keywords

ALBUMIN; ANTIDIABETIC AGENT; GLUCOSE; JANUS KINASE 1; JANUS KINASE 2; LOSARTAN; STAT3 PROTEIN; STAT4 PROTEIN; SUPPRESSOR OF CYTOKINE SIGNALING; SUPPRESSOR OF CYTOKINE SIGNALING 1; SUPPRESSOR OF CYTOKINE SIGNALING 3; SUPPRESSOR OF CYTOKINE SIGNALING 7; TANGSHEN FORMULA; UNCLASSIFIED DRUG; HERBACEOUS AGENT; JANUS KINASE; STAT PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DIABETIC NEPHROPATHY; DOWN REGULATION; GENE CONTROL; GENE EXPRESSION PROFILING; GLUCOSE BLOOD LEVEL; KIDNEY PARENCHYMA; MALE; MICROARRAY ANALYSIS; MOLECULAR MECHANICS; MOUSE; NEGATIVE FEEDBACK; NONHUMAN; PROTEIN FUNCTION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; UPREGULATION; URINE LEVEL; ANIMAL; CHEMISTRY; CHINESE MEDICINE; CLUSTER ANALYSIS; DIABETIC NEPHROPATHIES; DISEASE MODEL; DNA MICROARRAY; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; ISOLATION AND PURIFICATION; KIDNEY; MEDICINAL PLANT;

MUS;

ANIMALS; CLUSTER ANALYSIS; DIABETIC NEPHROPATHIES; DISEASE MODELS, ANIMAL; DRUGS, CHINESE HERBAL; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; JANUS KINASES; KIDNEY; MALE; MEDICINE, CHINESE TRADITIONAL; MICE; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PLANTS, MEDICINAL; REAL-TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; STAT TRANSCRIPTION FACTORS; SUPPRESSOR OF CYTOKINE SIGNALING PROTEINS;

EID: 84903379172     PISSN: 00320943     EISSN: 14390221     Source Type: Journal    
DOI: 10.1055/s-0034-1368454     Document Type: Article

References (29)

1. Molitch M. E., DeFronzo R. A., Franz M. J., Keane W. F., Mogensen C. E., Parving H. H., Steffes M. W. Nephropathy in diabetes. Diabetes Care: 2004; 27 S79 S83
2. Wang H., Mu W., Zhai J., Xing D., Miao S., Wang J., Shang H. The key role of Shenyan Kangfu tablets, a Chinese patent medicine for diabetic nephropathy: study protocol for a randomized, double-blind and placebo-controlled clinical trial. Trials: 2013; 14 165
3. Ma L., Hu J. Clinical observation of treatment of 36 cases of nephrosis diabetes by Western medicine and self-made Tangshen recipe. Beijing J Tradit Chin Med: 2005; 24 263 265
4. Huang M., Zhu C., Liang Q. L., Li P., Li J., Wang Y. M., Luo G. A. Effect of Tangshen formula on phospholipids metabolism in diabetic nephropathy patients. Acta Pharm Sin: 2011; 46 780 786
5. Xia J. F., Liang Q. L., Wang Y. M., Luo G. A. Effect of Tangshen formula on the purine and pyrimidine metabolism of patients with diabetic nephropathy. Chin Tradit Pat Med: 2011; 33 13 17
6. Zhang H., Li P., Zhao J. Effect of Tangshen formula on expressions of TGF- β 1 and MMP-9 of renal tissue in STZ-induced diabetic nephropathy rats. Chin J Integr Tradit Western Nephrol: 2009; 10 290 294
7. Marrero M. B., Banes-Berceli A. K., Stern D. M., Eaton D. C. Role of the JAK/STAT signaling pathway in diabetic nephropathy. Am J Physiol-Renal Physiol: 2006; 290 F762 F768
8. Berthier C. C., Zhang H., Schin M., Henger A., Nelson R. G., Yee B., Boucherot A., Neusser M. A., Cohen C. D., Carter-Su C., Argetsinger L. S., Rastaldi M. P., Brosius F. C., Kretzler M. Enhanced expression of Janus kinase-signal transducer and activator of transcription pathway members in human diabetic nephropathy. Diabetes: 2009; 58 469 477
9. Bromberg J., Darnell J. E. jr. The role of STATs in transcriptional control and their impact on cellular function. Oncogene: 2000; 19 2468 2473
10. Bromberg J. F., Wrzeszczynsk M. H., Devga G., Zhao Y., Pestell R. G., Albanese C., Darnell J. E. jr. Stat3 as an oncogene. Cell: 1999; 98 295 303
11. OSullivan L. A., Liongue C., Lewis R. S., Stephenson S. E., Ward A. C. Cytokine receptor signaling through the JAK-STAT-SOCS pathway in disease. Mol Immunol: 2007; 44 2497 2506
12. Yoshimura A., Naka T., Kubo M. SOCS proteins, cytokine signaling and immune regulation. Nat Rev Immunol: 2007; 7 454 465
13. Shuai K., Liu B. Regulation of JAK-STAT signaling in the immune system. Nat Rev Immunol: 2003; 3 900 911
14. Starr R., Willson T. A., Viney E. M., Murray L. J., Rayner J. R., Jenkins B. J., Gonda T. J., Alexander W. S., Metcalf D., Nicola N. A., Hilton D. J. A family of cytokine-inducible inhibitors of signaling. Nature: 1997; 387 917 921
15. Kubo M., Hanada T., Yoshimura A. Suppressors of cytokine signaling and immunity. Nat Immunol: 2003; 4 1169 1176
16. Cooper M. E. Pathogenesis, prevention, and treatment of diabetic nephropathy. Lancet: 1998; 352 213 219
17. Krolewski A. S. Genetics of diabetic nephropathy: evidence for major and minor gene effects. Kidney Int: 1999; 55 1582 1596
18. Nightingale J., Patel S., Suzuki N., Buxton R., Takagi K. I., Suzuki J., Sumi Y., Imaizumi A., Mason R. M., Zhang Z. Oncostatin M, a cytokine released by activated mononuclear cells, induces epithelial cell-myofibroblast transdifferentiation via Jak/Stat pathway activation. J Am Soc Nephrol: 2004; 15 21 32
19. Wang X., Shaw S., Amiri F., Eaton D. C. Marrero MB Inhibition of the Jak/STAT signaling pathway prevents the high glucose-induced increase in TGF- β and fibronectin synthesis in mesangial cells. Diabetes: 2002; 51 3505 3509
20. Liang Y., Jin Y., Li Y. Expression of JAKs/STATs pathway molecules in rat model of rapid focal segmental glomerulosclerosis. Pediatric Nephrol: 2009; 24 1661 1671
21. Shankland S. J. The podocytes response to injury: role in proteinuria and glomerulosclerosis. Kidney Int: 2006; 69 2131 2147
22. Yokota N., Burne-Taney M., Racusen L., Rabb H. Contrasting roles for STAT4 and STAT6 signal transduction pathways in murine renal ischemia-reperfusion injury. Am J Physiol-Renal Physiol: 2003; 285 F319 F325
23. Xu Z., Duan B., Croker B. P., Morel L. STAT4 deficiency reduces autoantibody production and glomerulonephritis in a mouse model of lupus. Clin Immunol: 2006; 120 189 198
24. Singh R. R., Saxena V., Zang S., Li L., Finkelman F. D., Witte D. P., Jacob C. O. Differential contribution of IL-4 and STAT6 vs. STAT4 to the development of lupus nephritis. J Immunol: 2003; 170 4818 4825
25. Lu T. C., Wang Z. H., Feng X., Chuang P. Y., Fang W., Shen Y., He J. C. Knockdown of Stat3 activity in vivo prevents diabetic glomerulopathy. Kidney Int: 2009; 76 63 71
26. Ortiz-Muñoz G., Lopez-Parra V., Lopez-Franco O., Fernandez-Vizarra P., Mallavia B., Flores C., Gomez-Guerrero C. Suppressors of cytokine signaling abrogate diabetic nephropathy. J Am Soc Nephrol: 2010; 21 763 772
27. Larsen L., Ropke C. Suppressors of cytokine signaling: SOCS. APMIS: 2002; 110 833 844
28. Kile B. T., Alexander W. S. The suppressors of cytokine signaling (SOCS). Cell Mol Life Sci: 2001; 58 1627 1635
29. Zhang H., Li P., Burczynski F. J., Gong Y., Choy P., Sha H., Li J. Attenuation of Diabetic Nephropathy in Otsuka Long-Evans Tokushima Fatty (OLETF) Rats with a Combination of Chinese Herbs (Tangshen Formula). Evid Based Complement Alternat Med: 2011; 2011 1 8