Calcium deficiency-induced and TRP channel-regulated IGF1R-PI3K-Akt signaling regulates abnormal epithelial cell proliferation

Cell Death and Differentiation

Volumn 21, Issue 4, 2014, Pages 568-581

  Dai, W ^a   Bai, Y ^a   Hebda, L ^a   Zhong, X ^a,b   Liu, J ^a   Kao, J ^a   Duan, C ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

^b CENTRAL CHINA NORMAL UNIVERSITY   (China)

Author keywords

colon cancer cell; epithelial growth; insulin like growth factor binding protein 5; membrane depolarization; transient receptor potential vanilloid; zebrafish

Indexed keywords

BROXURIDINE; CALCIUM; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; SOMATOMEDIN BINDING PROTEIN 5; SOMATOMEDIN BINDING PROTEIN 5A; SOMATOMEDIN C RECEPTOR; TRANSIENT RECEPTOR POTENTIAL CHANNEL; UNCLASSIFIED DRUG; VANILLOID RECEPTOR 5; VANILLOID RECEPTOR 6;

ACCLIMATIZATION; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CALCIUM DEFICIENCY; CALCIUM TRANSPORT; CELL COUNT; CELL CYCLE; CELL DENSITY; CELL LABELING; CELL MEMBRANE DEPOLARIZATION; CELL PROLIFERATION; CELL STIMULATION; COLON CANCER; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; EPITHELIUM CELL; EXTRACELLULAR CALCIUM; GENE AMPLIFICATION; GENE EXPRESSION; GENE SILENCING; HUMAN; HUMAN CELL; IONOCYTE; LARVA; MUTANT; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; SKIN; YOLK SAC; ZEBRA FISH;

ANIMALIA; DANIO RERIO;

ANIMALS; CACO-2 CELLS; CALCIUM; CELL PROLIFERATION; EPITHELIAL CELLS; HUMANS; INSULIN-LIKE GROWTH FACTOR I; INSULIN-LIKE GROWTH FACTOR II; LARVA; OLIGONUCLEOTIDES, ANTISENSE; PHOSPHATIDYLINOSITOL 3-KINASE; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTOR, IGF TYPE 1; SIGNAL TRANSDUCTION; SODIUM-POTASSIUM-EXCHANGING ATPASE; TRPV CATION CHANNELS; YOLK SAC; ZEBRAFISH; ZEBRAFISH PROTEINS;

EID: 84903364763     PISSN: 13509047     EISSN: 14765403     Source Type: Journal    
DOI: 10.1038/cdd.2013.177     Document Type: Article

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