Molecular hydrogen attenuates neuropathic pain in mice

PLoS ONE

Volumn 9, Issue 6, 2014, Pages

  Kawaguchi, Masanori ^a   Satoh, Yasushi ^a   Otsubo, Yukiko ^a   Kazama, Tomiei ^a  

^a NATIONAL DEFENSE MEDICAL COLLEGE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

4 HYDROXYNONENAL; 8 HYDROXYDEOXYGUANOSINE; DRINKING WATER; HYDROGEN; REACTIVE OXYGEN METABOLITE; 4-HYDROXY-2-NONENAL; 8-OXO-7-HYDRODEOXYGUANOSINE; ALDEHYDE; ANALGESIC AGENT; ANTIOXIDANT; DEOXYGUANOSINE;

ALLODYNIA; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; HYPERALGESIA; IMMUNOHISTOCHEMISTRY; LIGATION; MOUSE; NERVE INJURY; NEUROPATHIC PAIN; NONHUMAN; OXIDATIVE STRESS; PATHOGENESIS; SCIATIC NERVE; SPINAL GANGLION; VON FREY TEST; ANALOGS AND DERIVATIVES; ANIMAL; ANTAGONISTS AND INHIBITORS; C57BL MOUSE; DRUG EFFECTS; INJURIES; METABOLISM; NEURALGIA; PAIN MEASUREMENT; PATHOPHYSIOLOGY; PERIPHERAL NERVE INJURIES; SPINAL CORD;

ALDEHYDES; ANALGESICS; ANIMALS; ANTIOXIDANTS; DEOXYGUANOSINE; DRINKING WATER; GANGLIA, SPINAL; HYDROGEN; HYPERALGESIA; MICE; MICE, INBRED C57BL; NEURALGIA; OXIDATIVE STRESS; PAIN MEASUREMENT; PERIPHERAL NERVE INJURIES; SCIATIC NERVE; SPINAL CORD;

EID: 84903289489     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0100352     Document Type: Article

References (29)

1. Khalil Z, Liu T, Helme RD (1999) Free radicals contribute to the reduction in peripheral vascular responses and the maintenance of thermal hyperalgesia in rats with chronic constriction injury. Pain 79: 31-37. (Pubitemid 29012432)
2. Twining CM, Sloane EM, Milligan ED, Chacur M, Martin D, et al. (2004) Perisciatic proinflammatory cytokines, reactive oxygen species, and complement induce mirror-image neuropathic pain in rats. Pain 110: 299-309. (Pubitemid 38953295)
3. Janes K, Neumann WL, Salvemini D (2012) Anti-superoxide and antiperoxynitrite strategies in pain suppression. Biochim Biophys Acta 1822: 815-821.
4. Meeus M, Nijs J, Hermans L, Goubert D, Calders P (2013) The role of mitochondrial dysfunctions due to oxidative and nitrosative stress in the chronic pain or chronic fatigue syndromes and fibromyalgia patients: peripheral and central mechanisms as therapeutic targets? Expert Opin Ther Targets 17: 1081-1089.
5. Kim HK, Park SK, Zhou JL, Taglialatela G, Chung K, et al. (2004) Reactive oxygen species (ROS) play an important role in a rat model of neuropathic pain. Pain 111: 116-124. (Pubitemid 39141013)
6. Lee I, Kim HK, Kim JH, Chung K, Chung JM (2007) The role of reactive oxygen species in capsaicin-induced mechanical hyperalgesia and in the activities of dorsal horn neurons. Pain 133: 9-17. (Pubitemid 350138305)
7. Tal M (1996) A novel antioxidant alleviates heat hyperalgesia in rats with an experimental painful peripheral neuropathy. Neuroreport 7: 1382-1384.
8. Kim HK, Kim JH, Gao X, Zhou JL, Lee I, et al. (2006) Analgesic effect of vitamin E is mediated by reducing central sensitization in neuropathic pain. Pain 122: 53-62.
9. Ohsawa I, Ishikawa M, Takahashi K, Watanabe M, Nishimaki K, et al. (2007) Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals. Nat Med 13: 688-694. (Pubitemid 46889750)
10. Nagata K, Nakashima-Kamimura N, Mikami T, Ohsawa I, Ohta S (2009) Consumption of molecular hydrogen prevents the stress-induced impairments in hippocampus-dependent learning tasks during chronic physical restraint in mice. Neuropsychopharmacology 34: 501-508.
11. Fujita K, Seike T, Yutsudo N, Ohno M, Yamada H, et al. (2009) Hydrogen in drinking water reduces dopaminergic neuronal loss in the 1-methyl-4-phenyl-1,2, 3,6-tetrahydropyridine mouse model of Parkinson's disease. PLoS One 4: e7247.
12. Yanagihara T, Arai K, Miyamae K, Sato B, Shudo T, et al. (2005) Electrolyzed hydrogen-saturated water for drinking use elicits an antioxidative effect: a feeding test with rats. Biosci Biotechnol Biochem 69: 1985-1987. (Pubitemid 41558868)
13. Sauer H, Wartenberg M, Hescheler J (2001) Reactive oxygen species as intracellular messengers during cell growth and differentiation. Cell Physiol Biochem 11: 173-186. (Pubitemid 32786086)
14. Murad F (2004) Discovery of some of the biological effects of nitric oxide and its role in cell signaling. Biosci Rep 24: 452-474.
15. Liu H, Colavitti R, Rovira, II, Finkel T (2005) Redox-dependent transcriptional regulation. Circ Res 97: 967-974. (Pubitemid 41668909)
16. Zimmermann M (1983) Ethical guidelines for investigations of experimental pain in conscious animals. Pain 16: 109-110.
17. Otsubo Y, Satoh Y, Kodama M, Araki Y, Satomoto M, et al. (2012) Mechanical allodynia but not thermal hyperalgesia is impaired in mice deficient for ERK2 in the central nervous system. Pain 153: 2241-2252.
18. Narita M (2005) Protease-Activated Receptor-1 and Platelet-Derived Growth Factor in Spinal Cord Neurons Are Implicated in Neuropathic Pain after Nerve Injury. Journal of Neuroscience 25: 10000-10009.
19. Yonamine R, Satoh Y, Kodama M, Araki Y, Kazama T (2013) Coadministration of hydrogen gas as part of the carrier gas mixture suppresses neuronal apoptosis and subsequent behavioral deficits caused by neonatal exposure to sevoflurane in mice. Anesthesiology 118: 105-113.
20. Ishibashi T, Sato B, Rikitake M, Seo T, Kurokawa R, et al. (2012) Consumption of water containing a high concentration of molecular hydrogen reduces oxidative stress and disease activity in patients with rheumatoid arthritis: an open-label pilot study. Med Gas Res 2: 27.
21. Tao F, Li Q, Liu S, Wu H, Skinner J, et al. (2013) Role of neuregulin-1/ErbB signaling in stem cell therapy for spinal cord injury-induced chronic neuropathic pain. Stem Cells 31: 83-91.
22. Chen Q, Chen P, Zhou S, Yan X, Zhang J, et al. (2013) Hydrogen-rich saline attenuated neuropathic pain by reducing oxidative stress. Can J Neurol Sci 40: 857-863.
23. Hayashida K, Sano M, Ohsawa I, Shinmura K, Tamaki K, et al. (2008) Inhalation of hydrogen gas reduces infarct size in the rat model of myocardial ischemia-reperfusion injury. Biochem Biophys Res Commun 373: 30-35.
24. Ohsawa I, Nishimaki K, Yamagata K, Ishikawa M, Ohta S (2008) Consumption of hydrogen water prevents atherosclerosis in apolipoprotein E knockout mice. Biochem Biophys Res Commun 377: 1195-1198.
25. Nakashima-Kamimura N, Mori T, Ohsawa I, Asoh S, Ohta S (2009) Molecular hydrogen alleviates nephrotoxicity induced by an anti-cancer drug cisplatin without compromising anti-tumor activity in mice. Cancer Chemother Pharmacol 64: 753-761.
26. Fu Y, Ito M, Fujita Y, Ichihara M, Masuda A, et al. (2009) Molecular hydrogen is protective against 6-hydroxydopamine-induced nigrostriatal degeneration in a rat model of Parkinson's disease. Neurosci Lett 453: 81-85.
27. Kikkawa YS, Nakagawa T, Horie RT, Ito J (2009) Hydrogen protects auditory hair cells from free radicals. Neuroreport 20: 689-694.
28. Tedesco LS, Fuseler J, Grisham M, Wolf R, Roerig SC (2002) Therapeutic administration of nitric oxide synthase inhibitors reverses hyperalgesia but not inflammation in a rat model of polyarthritis. Pain 95: 215-223. (Pubitemid 34142645)
29. Ko YK, Youn AM, Hong BH, Kim YH, Shin YS, et al. (2012) Antinociceptive effect of phenyl N-tert-butylnitrone, a free radical scavenger, on the rat formalin test. Korean J Anesthesiol 62: 558-564.