The role of mitochondrial dysfunctions due to oxidative and nitrosative stress in the chronic pain or chronic fatigue syndromes and fibromyalgia patients: Peripheral and central mechanisms as therapeutic targets?

Expert Opinion on Therapeutic Targets

Volumn 17, Issue 9, 2013, Pages 1081-1089

  Meeus, Mira ^a,b   Nijs, Jo ^c   Hermans, Linda ^b   Goubert, Dorien ^b   Calders, Patrick ^b  

^a UNIVERSITY OF ANTWERP   (Belgium)

^b GHENT UNIVERSITY   (Belgium)

^c VRIJE UNIVERSITEIT BRUSSEL   (Belgium)

Author keywords

ATP; Central sensitization; Chronic pain; Mitochondria; Muscle; Nitric oxide; NMDA receptor; Peroxynitrite; Spinal cord; Superoxide

Indexed keywords

ADENOSINE TRIPHOSPHATE; ANTIOXIDANT; CAPSAICIN; CARNOSINE; CITRATE SYNTHASE; COENZYME 10; CYTOCHROME C OXIDASE; CYTOKINE; FATTY ACID; INDUCIBLE NITRIC OXIDE SYNTHASE; KETAMINE; LACTIC ACID; MALONALDEHYDE; MITOCHONDRIAL DNA; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NITRIC OXIDE; OXIDIZED LOW DENSITY LIPOPROTEIN; OXIDOREDUCTASE INHIBITOR; PEROXYNITRITE; PHOSPHATIDYLINOSITOL; REACTIVE OXYGEN METABOLITE; RESVERATROL; SUPEROXIDE; SUPEROXIDE DISMUTASE; SUPEROXIDE DISMUTASE INHIBITOR; UNCLASSIFIED DRUG;

AEROBIC METABOLISM; APOPTOSIS; ATTENUATION; AUTOPHAGY; BIOGENESIS; BRAIN MITOCHONDRION; CENTRAL NERVOUS SYSTEM; CHRONIC FATIGUE SYNDROME; CHRONIC PAIN; COENZYME; CYTOKINE PRODUCTION; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DNA FRAGMENTATION; DRUG TARGETING; ELECTRON MICROSCOPY; ENZYME ACTIVITY; ENZYME SYNTHESIS; FIBROMYALGIA; HISTOPATHOLOGY; HUMAN; HYPERALGESIA; HYPERSENSITIVITY; INFLAMMATION; KINESIOTHERAPY; LEUKOCYTE; LIPID PEROXIDATION; LOW DRUG DOSE; MITOPHAGY; MUSCLE; MUSCLE CELL; MYALGIA; NERVE CELL; NEUROPATHIC PAIN; NITROSATIVE STRESS; NOCICEPTION; NONHUMAN; OXIDATIVE PHOSPHORYLATION; OXIDATIVE STRESS; PAIN THRESHOLD; PATHOPHYSIOLOGY; PERIPHERAL NERVOUS SYSTEM; REVIEW; SENSITIZATION; SKELETAL MUSCLE; SPINAL CORD; TEMPORAL SUMMATION;

ANIMALS; CHRONIC PAIN; FATIGUE SYNDROME, CHRONIC; FIBROMYALGIA; HUMANS; MITOCHONDRIA; MITOCHONDRIAL DISEASES; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES;

EID: 84882657947     PISSN: 14728222     EISSN: 17447631     Source Type: Journal    
DOI: 10.1517/14728222.2013.818657     Document Type: Review

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