Hydrogen protects auditory hair cells from free radicals

NeuroReport

Volumn 20, Issue 7, 2009, Pages 689-694

  Kikkawa, Yayoi S ^a   Nakagawa, Takayuki ^a   Horie, Rie T ^a   Ito, Juichi ^a  

^a KYOTO UNIVERSITY   (Japan)

Author keywords

Antioxidant; Cochlea; Hearing loss; Hydroxyl radical; Molecular hydrogen; Reactive oxygen species

Indexed keywords

ANTIMYCIN A1; FREE RADICAL; HYDROGEN; REACTIVE OXYGEN METABOLITE; ANTIOXIDANT; NEUROPROTECTIVE AGENT; OXIDIZING AGENT;

ANIMAL TISSUE; ARTICLE; BIOSYNTHESIS; CELL DAMAGE; CELL DEGENERATION; CELL PROTECTION; CELL SURVIVAL; CILIATED EPITHELIUM; CONTROLLED STUDY; CULTURE MEDIUM; EXPLANT; HAIR CELL; HYDROGENATION; IMMUNOHISTOCHEMISTRY; LIPID PEROXIDATION; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; ANALYSIS OF VARIANCE; ANIMAL; CELL COUNT; CELL DEATH; DOSE RESPONSE; DRUG EFFECT; EPITHELIUM; IN VITRO STUDY; INSTITUTE FOR CANCER RESEARCH MOUSE; METABOLISM; MICROPHOTOGRAPHY;

ANALYSIS OF VARIANCE; ANIMALS; ANTIMYCIN A; ANTIOXIDANTS; CELL COUNT; CELL DEATH; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; EPITHELIUM; HAIR CELLS, AUDITORY; HYDROGEN; LIPID PEROXIDATION; MICE; MICE, INBRED ICR; NEUROPROTECTIVE AGENTS; OXIDANTS; PHOTOMICROGRAPHY; REACTIVE OXYGEN SPECIES;

EID: 67049164671     PISSN: 09594965     EISSN: None     Source Type: Journal    
DOI: 10.1097/WNR.0b013e32832a5c68     Document Type: Article

References (18)

1. Jiang H, Talaska AE, Schacht J, Sha SH. Oxidative imbalance in the aging inner ear. Neurobiol Aging 2007; 28:1605-1612.
2. Yamane H, Nakai Y, Takayama M, Iguchi H, Nakagawa T, Kojima A. Appearance of free radicals in the guinea pig inner ear after noise-induced acoustic trauma. Eur Arch Otorhinolaryngol 1995; 252:504-508.
3. Yamashita D, Jiang HY, Schacht J, Miller JM. Delayed production of free radicals following noise exposure. Brain Res 2004; 1019:201-209.
4. Lee JE, Nakagawa T, Kim TS, Endo T, Shiga A, Iguchi F, et al. Role of reactive radicals in degeneration of the auditory system of mice following cisplatin treatment. Acta Otolaryngol 2004; 124:1131-1135.
5. Clerici WJ, Hensley K, DiMartino DL, Butterfield DA. Direct detection of ototoxicant-induced reactive oxygen species generation in cochlear explants. Hear Res 1996; 98:116-124.
6. Linseman DA. Targeting oxidative stress for neuroprotection. Antioxid Redox Signal 2009; 11:421-424. Aug 20. [Epub ahead of print]
7. Klein M, Koedel U, Pfister HW. Oxidative stress in pneumococcal meningitis: a future target for adjunctive therapy? Prog Neurobiol 2006; 80:269-280.
8. Ohsawa I, Ishikawa M, Takahashi K, Watanabe M, Nishimaki K, Yamagata K, et al. Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals. Nat Med 2007; 13:688-694.
9. Fukuda K, Asoh S, Ishikawa M, Yamamoto Y, Ohsawa I, Ohta S. Inhalation of hydrogen gas suppresses hepatic injury caused by ischemia/reperfusion through reducing oxidative stress. Biochem Biophys Res Commun 2007; 361:670-674.
10. Hayashida K, Sano M, Ohsawa I, Shinmura K, Tamaki K, Kimura K, et al. Inhalation of hydrogen gas reduces infarct size in the rat model of myocardial ischemia-reperfusion injury. Biochem Biophys Res Commun 2008; 373:30-35.
11. Sato Y, Kajiyama S, Amano A, Kondo Y, Sasaki T, Handa S, et al. Hydrogen-rich pure water prevents superoxide formation in brain slices of vitamin C-depleted SMP30/GNL knockout mice. Biochem Biophys Res Commun 2008; 375:346-350.
12. Nagata K, Nakashima-Kamimura N, Mikami T, Ohsawa I, Ohta S. Consumption of molecular hydrogen prevents the stress-induced impairments in hippocampus-dependent learning tasks during chronic physical restraint in mice. Neuropsychopharmacology 2008; 34:501-508.
13. Kajiyama S, Hasegawa G, Asano M, Hosoda H, Fukui M, Nakamura N, et al. Supplementation of hydrogen-rich water improves lipid and glucose metabolism in patients with type 2 diabetes or impaired glucose tolerance. Nutr Res 2008; 28:137-143.
14. Sha SH, Taylor R, Forge A, Schacht J. Differential vulnerability of basal and apical hair cells is based on intrinsic susceptibility to free radicals. Hear Res 2001; 155:1-8.
15. Futai N, Gu W, Song JW, Takayama S. Handheld recirculation system and customized media for microfluidic cell culture. Lab Chip 2006; 6:149-154.
16. Setsukinai K, Urano Y, Kakinuma K, Majima HJ, Nagano T. Development of novel fluorescence probes that can reliably detect reactive oxygen species and distinguish specific species. J Biol Chem 2003; 278:3170-3175.
17. Coimbra RS, Loquet G, Leib SL. Limited efficacy of adjuvant therapy with dexamethasone in preventing hearing loss due to experimental pneumococcal meningitis in the infant rat. Pediatr Res 2007; 62:291-294.
18. Laurell GF,Teixeira M, Duan M, Sterkers O, Ferrary E. Intact blood-perilymph barrier in the rat after impulse noise trauma. Acta Otolaryngol 2008; 128:608-612.