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Volumn 6, Issue 8, 2014, Pages 871-883

Design of anticancer lysophosphatidic acid agonists and antagonists

Author keywords

[No Author keywords available]

Indexed keywords

ANTIMETASTATIC AGENT; ANTINEOPLASTIC AGENT; BMS 986020; LYSOPHOSPHATIDIC ACID; LYSOPHOSPHATIDIC ACID AGONIST; LYSOPHOSPHATIDIC ACID ANTAGONIST; LYSOPHOSPHATIDIC ACID RECEPTOR; SAR 100842; SCAFFOLD PROTEIN; SHORT HAIRPIN RNA; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; VANILLOID RECEPTOR 1; LYSOPHOSPHOLIPID;

EID: 84903280095     PISSN: 17568919     EISSN: 17568927     Source Type: Journal    
DOI: 10.4155/fmc.14.52     Document Type: Review
Times cited : (9)

References (74)
  • 1
    • 84856265412 scopus 로고    scopus 로고
    • Insights into the pharmacological relevance of lysophospholipid receptors
    • Mutoh T, Rivera R, Chun J. Insights into the pharmacological relevance of lysophospholipid receptors. Br. J. Pharmacol. 165(4), 829-844 (2012).
    • (2012) Br. J. Pharmacol. , vol.165 , Issue.4 , pp. 829-844
    • Mutoh, T.1    Rivera, R.2    Chun, J.3
  • 2
    • 84868556353 scopus 로고    scopus 로고
    • Integrating the puzzle pieces: The current atomistic picture of phospholipid-G protein coupled receptor interactions
    • Parrill AL, Tigyi G. Integrating the puzzle pieces: the current atomistic picture of phospholipid-G protein coupled receptor interactions. Biochim. Biophys. Acta 1831(1), 2-12 (2013).
    • (2013) Biochim. Biophys. Acta , vol.1 , pp. 2-12
    • Parrill, A.L.1    Tigyi, G.2
  • 3
    • 84868584067 scopus 로고    scopus 로고
    • Role of the autotaxinlysophosphatidate axis in cancer resistance to chemotherapy and radiotherapy
    • Brindley DN, Lin FT, Tigyi GJ. Role of the autotaxinlysophosphatidate axis in cancer resistance to chemotherapy and radiotherapy. Biochim. Biophys. Acta 1831(1), 74-85 (2013).
    • (2013) Biochim. Biophys. Acta , vol.1 , pp. 74-85
    • Brindley, D.N.1    Lin, F.T.2    Tigyi, G.J.3
  • 4
    • 80053131258 scopus 로고    scopus 로고
    • Insights into autotaxin: How to produce and present a lipid mediator
    • Moolenaar WH, Perrakis A. Insights into autotaxin: how to produce and present a lipid mediator. Nat. Rev. Mol. Cell Biol. 12(10), 674-679 (2011).
    • (2011) Nat. Rev. Mol. Cell Biol. , vol.12 , Issue.10 , pp. 674-679
    • Moolenaar, W.H.1    Perrakis, A.2
  • 5
    • 1542359873 scopus 로고    scopus 로고
    • Autotaxin has lysophospholipase D activity leading to tumor cell growth and motility by lysophosphatidic acid production
    • Umezu-Goto M, Kishi Y, Taira A et al. Autotaxin has lysophospholipase D activity leading to tumor cell growth and motility by lysophosphatidic acid production. J. Cell Biol. 158(2), 227-233 (2002).
    • (2002) J. Cell Biol. , vol.158 , Issue.2 , pp. 227-233
    • Umezu-Goto, M.1    Kishi, Y.2    Taira, A.3
  • 6
    • 0037131366 scopus 로고    scopus 로고
    • Identification of human plasma lysophospholipase D, a lysophosphatidic acid-producing enzyme, as autotaxin, a multifunctional phosphodiesterase
    • DOI 10.1074/jbc.M205623200
    • Tokumura A, Majima E, Kariya Y et al. Identification of human plasma lysophospholipase D, a lysophosphatidic acid-producing enzyme, as autotaxin, a multifunctional phosphodiesterase. J. Biol. Chem. 277(42), 39436-39442 (2002). (Pubitemid 35190918)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.42 , pp. 39436-39442
    • Tokumura, A.1    Majima, E.2    Kariya, Y.3    Tominaga, K.4    Kogure, K.5    Yasuda, K.6    Fukuzawa, K.7
  • 7
    • 1042268603 scopus 로고    scopus 로고
    • Biochemical and molecular characterization of two phosphatidic acidselective phospholipase A1s, mPA-PLA1alpha and mPAPLA1beta
    • Hiramatsu T, Sonoda H, Takanezawa Y et al. Biochemical and molecular characterization of two phosphatidic acidselective phospholipase A1s, mPA-PLA1alpha and mPAPLA1beta. J. Biol. Chem. 278(49), 49438-49447 (2003).
    • (2003) J. Biol. Chem. , vol.278 , Issue.49 , pp. 49438-49447
    • Hiramatsu, T.1    Sonoda, H.2    Takanezawa, Y.3
  • 8
    • 45549085738 scopus 로고    scopus 로고
    • Membrane-associated phospholipase A1 beta (LIPI) is an Ewing tumour-associated cancer/testis antigen
    • DOI 10.1002/pbc.21602
    • Foell JL, Hesse M, Volkmer I, Schmiedel BJ, Neumann I, Staege MS. Membrane-associated phospholipase A1 beta (LIPI) Is an Ewing tumour-associated cancer/testis antigen. Pediatr Blood Cancer 51(2), 228-234 (2008). (Pubitemid 351877042)
    • (2008) Pediatric Blood and Cancer , vol.51 , Issue.2 , pp. 228-234
    • Foell, J.L.1    Hesse, M.2    Volkmer, I.3    Schmiedel, B.J.4    Neumann, I.5    Staege, M.S.6
  • 9
    • 80052468890 scopus 로고    scopus 로고
    • Expression of multiple membrane-associated phospholipase A1 beta transcript variants and lysophosphatidic acid receptors in Ewing tumor cells
    • Schmiedel BJ, Hutter C, Hesse M, Staege MS. Expression of multiple membrane-associated phospholipase A1 beta transcript variants and lysophosphatidic acid receptors in Ewing tumor cells. Mol. Biol. Rep. 38(7), 4619-4628 (2011).
    • (2011) Mol. Biol. Rep. , vol.38 , Issue.7 , pp. 4619-4628
    • Schmiedel, B.J.1    Hutter, C.2    Hesse, M.3    Staege, M.S.4
  • 10
    • 84903283310 scopus 로고    scopus 로고
    • LPA receptor signaling: Pharmacology, physiology, and pathophysiology
    • doi:10.1194/jlr.R046458 Epub ahead of print
    • Yung YC, Stoddard NC, Chun J. LPA receptor signaling: pharmacology, physiology, and pathophysiology. J. Lipid Res. doi:10.1194/jlr.R046458 (2014) (Epub ahead of print).
    • (2014) J. Lipid Res
    • Yung, Y.C.1    Stoddard, N.C.2    Chun, J.3
  • 11
    • 80053598343 scopus 로고    scopus 로고
    • Lysophosphatidic acid (LPA) and endothelial differentiation gene (Edg) receptors in human pancreatic cancer
    • Lv GM, Li P, Wang WD, Wang Sh K, Chen JF, Gong YL. Lysophosphatidic acid (LPA) and endothelial differentiation gene (Edg) receptors in human pancreatic cancer. J. Surg. Oncol. 104(6), 685-691 (2011).
    • (2011) J. Surg. Oncol. , vol.104 , Issue.6 , pp. 685-691
    • Lv, G.M.1    Li, P.2    Wang, W.D.3    Wang Sh, K.4    Chen, J.F.5    Gong, Y.L.6
  • 12
    • 84863011845 scopus 로고    scopus 로고
    • Controlling cancer through the autotaxin-lysophosphatidic acid receptor axis
    • Gotoh M, Fujiwara Y, Yue J et al. Controlling cancer through the autotaxin-lysophosphatidic acid receptor axis. Biochem. Soc. Trans. 40(1), 31-36 (2012).
    • (2012) Biochem. Soc. Trans. , vol.40 , Issue.1 , pp. 31-36
    • Gotoh, M.1    Fujiwara, Y.2    Yue, J.3
  • 13
    • 84881230811 scopus 로고    scopus 로고
    • Lysophosphatidic acid (LPA) signalling in cell migration and cancer invasion: A focussed review and analysis of LPA receptor gene expression on the basis of more than 1700 cancer microarrays
    • Willier S, Butt E, Grunewald TG. Lysophosphatidic acid (LPA) signalling in cell migration and cancer invasion: a focussed review and analysis of LPA receptor gene expression on the basis of more than 1700 cancer microarrays. Biol. Cell 105(8), 317-333 (2013).
    • (2013) Biol. Cell , vol.105 , Issue.8 , pp. 317-333
    • Willier, S.1    Butt, E.2    Grunewald, T.G.3
  • 14
    • 79958719984 scopus 로고    scopus 로고
    • Autotaxin and LPA receptors represent potential molecular targets for the radiosensitization of murine glioma through effects on tumor vasculature
    • Schleicher SM, Thotala DK, Linkous AG et al. Autotaxin and LPA receptors represent potential molecular targets for the radiosensitization of murine glioma through effects on tumor vasculature. PLoS ONE 6(7), e22182 (2011).
    • (2011) PLoS ONE , vol.6 , Issue.7
    • Schleicher, S.M.1    Thotala, D.K.2    Linkous, A.G.3
  • 15
    • 78650510111 scopus 로고    scopus 로고
    • Regulation of lysophosphatidate signaling by autotaxin and lipid phosphate phosphatases with respect to tumor progression, angiogenesis, metastasis and chemo-resistance
    • Samadi N, Bekele R, Capatos D, Venkatraman G, Sariahmetoglu M, Brindley DN. Regulation of lysophosphatidate signaling by autotaxin and lipid phosphate phosphatases with respect to tumor progression, angiogenesis, metastasis and chemo-resistance. Biochimie 93(1), 61-70 (2011).
    • (2011) Biochimie , vol.93 , Issue.1 , pp. 61-70
    • Samadi, N.1    Bekele, R.2    Capatos, D.3    Venkatraman, G.4    Sariahmetoglu, M.5    Brindley, D.N.6
  • 16
    • 83855160838 scopus 로고    scopus 로고
    • Autotaxin and LPA receptor signaling in cancer
    • Houben AJ, Moolenaar WH. Autotaxin and LPA receptor signaling in cancer. Cancer Metastasis Rev. 30(3-4), 557-565 (2011).
    • (2011) Cancer Metastasis Rev. , vol.30 , Issue.3-4 , pp. 557-565
    • Houben, A.J.1    Moolenaar, W.H.2
  • 17
    • 77953288970 scopus 로고    scopus 로고
    • Biological roles of lysophosphatidic acid signaling through its production by autotaxin
    • Okudaira S, Yukiura H, Aoki J. Biological roles of lysophosphatidic acid signaling through its production by autotaxin. Biochimie 92(6), 698-706 (2010).
    • (2010) Biochimie , vol.92 , Issue.6 , pp. 698-706
    • Okudaira, S.1    Yukiura, H.2    Aoki, J.3
  • 18
    • 77950254571 scopus 로고    scopus 로고
    • Inhibition of tumor growth and angiogenesis by a lysophosphatidic acid antagonist in an engineered three-dimensional lung cancer xenograft model
    • Xu XY, Prestwich GD. Inhibition of tumor growth and angiogenesis by a lysophosphatidic acid antagonist in an engineered three-dimensional lung cancer xenograft model. Cancer Am. Cancer. Soc. 116(7), 1739-1750 (2010).
    • (2010) Cancer Am. Cancer. Soc. , vol.116 , Issue.7 , pp. 1739-1750
    • Xu, X.Y.1    Prestwich, G.D.2
  • 19
    • 67650458524 scopus 로고    scopus 로고
    • Dual activity lysophosphatidic acid receptor pan-antagonist/autotaxin inhibitor reduces breast cancer cell migration in vitro and causes tumor regression in vivo
    • Zhang H, Xu X, Gajewiak J et al. Dual activity lysophosphatidic acid receptor pan-antagonist/autotaxin inhibitor reduces breast cancer cell migration in vitro and causes tumor regression in vivo. Cancer Res. 69(13), 5441-5449 (2009).
    • (2009) Cancer Res , vol.69 , Issue.13 , pp. 5441-5449
    • Zhang, H.1    Xu, X.2    Gajewiak, J.3
  • 20
    • 69549117128 scopus 로고    scopus 로고
    • Evaluating dual activity LPA receptor pan-antagonist/autotaxin inhibitors as anti-cancer agents in vivo using engineered human tumors
    • Xu X, Yang G, Zhang H, Prestwich GD. Evaluating dual activity LPA receptor pan-antagonist/autotaxin inhibitors as anti-cancer agents in vivo using engineered human tumors. Prostaglandins Other Lipid Mediat. 89(3-4), 140-146 (2009).
    • (2009) Prostaglandins Other Lipid Mediat , vol.89 , Issue.3-4 , pp. 140-146
    • Xu, X.1    Yang, G.2    Zhang, H.3    Prestwich, G.D.4
  • 21
    • 62349115729 scopus 로고    scopus 로고
    • LPA1 receptors mediate stimulation, whereas LPA2 receptors mediate inhibition, of migration of pancreatic cancer cells in response to lysophosphatidic acid and malignant ascites
    • Komachi M, Tomura H, Malchinkhuu E et al. LPA1 receptors mediate stimulation, whereas LPA2 receptors mediate inhibition, of migration of pancreatic cancer cells in response to lysophosphatidic acid and malignant ascites. Carcinogenesis 30(3), 457-465 (2009).
    • (2009) Carcinogenesis , vol.30 , Issue.3 , pp. 457-465
    • Komachi, M.1    Tomura, H.2    Malchinkhuu, E.3
  • 22
    • 59449091267 scopus 로고    scopus 로고
    • Role of LPA4/p2y9/GPR23 in negative regulation of cell motility
    • Lee Z, Cheng CT, Zhang H et al. Role of LPA4/p2y9/GPR23 in negative regulation of cell motility. Mol. Biol. Cell 19(12), 5435-5445 (2008).
    • (2008) Mol. Biol. Cell , vol.19 , Issue.12 , pp. 5435-5445
    • Lee, Z.1    Cheng, C.T.2    Zhang, H.3
  • 23
    • 83355173005 scopus 로고    scopus 로고
    • LPA is a chemorepellent for B16 melanoma cells: Action through the cAMP-elevating LPA5 receptor
    • Jongsma M, Matas-Rico E, Rzadkowski A, Jalink K, Moolenaar WH. LPA is a chemorepellent for B16 melanoma cells: action through the cAMP-elevating LPA5 receptor. PLoS ONE 6(12), e29260 (2011).
    • (2011) PLoS ONE , vol.6 , Issue.12
    • Jongsma, M.1    Matas-Rico, E.2    Rzadkowski, A.3    Jalink, K.4    Moolenaar, W.H.5
  • 24
    • 78649500338 scopus 로고    scopus 로고
    • Involvement of lysophosphatidic acid in bone cancer pain by potentiation of TRPV1 via PKC epsilon pathway in dorsal root ganglion neurons
    • Pan HL, Zhang YQ, Zhao ZQ. Involvement of lysophosphatidic acid in bone cancer pain by potentiation of TRPV1 via PKC epsilon pathway in dorsal root ganglion neurons. Mol. Pain 6, 85 (2010).
    • Mol. Pain , vol.6 , Issue.85 , pp. 2010
    • Pan, H.L.1    Zhang, Y.Q.2    Zhao, Z.Q.3
  • 25
    • 84868576048 scopus 로고    scopus 로고
    • Lysophospholipid receptor activation of RhoA and lipid signaling pathways
    • Xiang SY, Dusaban SS, Brown JH. Lysophospholipid receptor activation of RhoA and lipid signaling pathways. Biochim. Biophys. Acta 1831(1), 213-222 (2013).
    • (2013) Biochim. Biophys. Acta , vol.1831 , Issue.1 , pp. 213-222
    • Xiang, S.Y.1    Dusaban, S.S.2    Brown, J.H.3
  • 29
    • 77950595309 scopus 로고    scopus 로고
    • The Nm23-H1 metastasis suppressor as a translational target
    • Marshall JC, Collins J, Marino N, Steeg P. The Nm23-H1 metastasis suppressor as a translational target. Eur. J. Cancer 46(7), 1278-1282 (2010).
    • (2010) Eur. J. Cancer , vol.46 , Issue.7 , pp. 1278-1282
    • Marshall, J.C.1    Collins, J.2    Marino, N.3    Steeg, P.4
  • 30
    • 84868574394 scopus 로고    scopus 로고
    • Pleiotropic activity of lysophosphatidic acid in bone metastasis
    • Peyruchaud O, Leblanc R, David M. Pleiotropic activity of lysophosphatidic acid in bone metastasis. Biochim. Biophys. Acta 1831(1), 99-104 (2013).
    • (2013) Biochim. Biophys. Acta , vol.1831 , Issue.1 , pp. 99-104
    • Peyruchaud, O.1    Leblanc, R.2    David, M.3
  • 31
    • 38049091636 scopus 로고    scopus 로고
    • The lysophosphatidic acid receptor LPA1 links pulmonary fibrosis to lung injury by mediating fibroblast recruitment and vascular leak
    • Tager AM, LaCamera P, Shea BS et al. The lysophosphatidic acid receptor LPA1 links pulmonary fibrosis to lung injury by mediating fibroblast recruitment and vascular leak. Nat. Med. 14(1), 45-54 (2008).
    • (2008) Nat. Med. , vol.14 , Issue.1 , pp. 45-54
    • Tager, A.M.1    Lacamera, P.2    Shea, B.S.3
  • 32
    • 84891325803 scopus 로고    scopus 로고
    • Development of lysophosphatidic acid pathway modulators as therapies for fibrosis
    • Budd DC, Qian Y. Development of lysophosphatidic acid pathway modulators as therapies for fibrosis. Future Med. Chem. 5(16), 1935-1952 (2013).
    • (2013) Future Med. Chem. , vol.5 , Issue.16 , pp. 1935-1952
    • Budd, D.C.1    Qian, Y.2
  • 33
    • 84879412193 scopus 로고    scopus 로고
    • CD97 amplifies LPA receptor signaling and promotes thyroid cancer progression in a mouse model
    • Ward Y, Lake R, Martin PL et al. CD97 amplifies LPA receptor signaling and promotes thyroid cancer progression in a mouse model. Oncogene 32(22), 2726-2738 (2013).
    • (2013) Oncogene , vol.32 , Issue.22 , pp. 2726-2738
    • Ward, Y.1    Lake, R.2    Martin, P.L.3
  • 34
    • 82655171586 scopus 로고    scopus 로고
    • LPA receptor heterodimerizes with CD97 to amplify LPA-initiated RHO-dependent signaling and invasion in prostate cancer cells
    • Ward Y, Lake R, Yin JJ et al. LPA receptor heterodimerizes with CD97 to amplify LPA-initiated RHO-dependent signaling and invasion in prostate cancer cells. Cancer Res. 71(23), 7301-7311 (2011).
    • (2011) Cancer Res. , vol.71 , Issue.23 , pp. 7301-7311
    • Ward, Y.1    Lake, R.2    Yin, J.J.3
  • 35
    • 1642279290 scopus 로고    scopus 로고
    • TRIP6 Enhances Lysophosphatidic Acid-induced Cell Migration by Interacting with the Lysophosphatidic Acid 2 Receptor
    • DOI 10.1074/jbc.M311891200
    • Xu J, Lai YJ, Lin WC, Lin FT. TRIP6 enhances lysophosphatidic acid-induced cell migration by interacting with the lysophosphatidic acid 2 receptor. J. Biol. Chem. 279(11), 10459-10468 (2004). (Pubitemid 38372655)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.11 , pp. 10459-10468
    • Xu, J.1    Lai, Y.-J.2    Lin, W.-C.3    Lin, F.-T.4
  • 37
    • 65249173527 scopus 로고    scopus 로고
    • The absence of LPA2 attenuates tumor formation in an experimental model of colitisassociated cancer
    • Lin S, Wang D, Iyer S et al. The absence of LPA2 attenuates tumor formation in an experimental model of colitisassociated cancer. Gastroenterology 136(5), 1711-1720 (2009).
    • (2009) Gastroenterology , vol.136 , Issue.5 , pp. 1711-1720
    • Lin, S.1    Wang, D.2    Iyer, S.3
  • 38
    • 78149285909 scopus 로고    scopus 로고
    • Colorectal cancer cells-proliferation, survival and invasion by lysophosphatidic acid
    • Lee SJ, Yun CC. Colorectal cancer cells-proliferation, survival and invasion by lysophosphatidic acid. Int. J. Biochem. Cell Biol. 42(12), 1907-1910 (2010).
    • (2010) Int. J. Biochem. Cell Biol. , vol.42 , Issue.12 , pp. 1907-1910
    • Lee, S.J.1    Yun, C.C.2
  • 39
    • 0036308503 scopus 로고    scopus 로고
    • Lysophosphatidic acid protects and rescues intestinal epithelial cells from radiation- and chemotherapy-induced apoptosis
    • DOI 10.1053/gast.2002.34209
    • Deng W, Balazs L, Wang DA, Van Middlesworth L, Tigyi G, Johnson LR. Lysophosphatidic acid protects and rescues intestinal epithelial cells from radiation-and chemotherapyinduced apoptosis. Gastroenterology 123(1), 206-216 (2002). (Pubitemid 34747541)
    • (2002) Gastroenterology , vol.123 , Issue.1 , pp. 206-216
    • Deng, W.1    Balazs, L.2    Wang, D.3    Van Middlesworth, L.4    Tigyi, G.5    Johnson, L.R.6
  • 40
    • 84868529772 scopus 로고    scopus 로고
    • Mitigation of radiation injury by selective stimulation of the LPA(2) receptor
    • Kiss GN, Lee SC, Fells JI et al. Mitigation of radiation injury by selective stimulation of the LPA(2) receptor. Biochim. Biophys. Acta 1831(1), 117-125 (2013).
    • (2013) Biochim. Biophys. Acta , vol.1831 , Issue.1 , pp. 117-125
    • Kiss, G.N.1    Lee, S.C.2    Fells, J.I.3
  • 41
    • 65449185457 scopus 로고    scopus 로고
    • Lysophosphatidic acid stimulates cell growth by different mechanisms in SKOV-3 and Caov-3 ovarian cancer cells: Distinct roles for Gi-and Rho-dependent pathways
    • Hurst JH, Hooks SB. Lysophosphatidic acid stimulates cell growth by different mechanisms in SKOV-3 and Caov-3 ovarian cancer cells: distinct roles for Gi-and Rho-dependent pathways. Pharmacology 83(6), 333-347 (2009).
    • (2009) Pharmacology , vol.83 , Issue.6 , pp. 333-347
    • Hurst, J.H.1    Hooks, S.B.2
  • 42
    • 56749151299 scopus 로고    scopus 로고
    • Lysophosphatidic acid receptors determine tumorigenicity and aggressiveness of ovarian cancer cells
    • Yu S, Murph MM, Lu Y et al. Lysophosphatidic acid receptors determine tumorigenicity and aggressiveness of ovarian cancer cells. J. Natl Cancer Inst. 100(22), 1630-1642 (2008).
    • (2008) J. Natl Cancer Inst. , vol.100 , Issue.22 , pp. 1630-1642
    • Yu, S.1    Murph, M.M.2    Lu, Y.3
  • 43
    • 80053027028 scopus 로고    scopus 로고
    • Lysophosphatidic acid stimulates the proliferation of ovarian cancer cells via the gep proto-oncogene Galpha(12)
    • Goldsmith ZG, Ha JH, Jayaraman M, Dhanasekaran DN. Lysophosphatidic acid stimulates the proliferation of ovarian cancer cells via the gep proto-oncogene Galpha(12). Genes Cancer 2(5), 563-575 (2011).
    • (2011) Genes Cancer , vol.2 , Issue.5 , pp. 563-575
    • Goldsmith, Z.G.1    Ha, J.H.2    Jayaraman, M.3    Dhanasekaran, D.N.4
  • 44
    • 78649953952 scopus 로고    scopus 로고
    • Epigenetic silencing of peroxisome proliferator-activated receptor gamma is a biomarker for colorectal cancer progression and adverse patients' outcome
    • Pancione M, Sabatino L, Fucci A et al. Epigenetic silencing of peroxisome proliferator-activated receptor gamma is a biomarker for colorectal cancer progression and adverse patients' outcome. PLoS ONE 5(12), e14229 (2010).
    • (2010) PLoS ONE , vol.5 , Issue.12
    • Pancione, M.1    Sabatino, L.2    Fucci, A.3
  • 45
    • 78149416565 scopus 로고    scopus 로고
    • Cyclic phosphatidic acid decreases proliferation and survival of colon cancer cells by inhibiting peroxisome proliferator-activated receptor gamma
    • Tsukahara T, Hanazawa S, Kobayashi T, Iwamoto Y, Murakami-Murofushi K. Cyclic phosphatidic acid decreases proliferation and survival of colon cancer cells by inhibiting peroxisome proliferator-activated receptor gamma. Prostaglandins Other Lipid Mediat. 93(3-4), 126-133 (2010).
    • (2010) Prostaglandins Other Lipid Mediat. , vol.93 , Issue.3-4 , pp. 126-133
    • Tsukahara, T.1    Hanazawa, S.2    Kobayashi, T.3    Iwamoto, Y.4    Murakami-Murofushi, K.5
  • 46
    • 68749121522 scopus 로고    scopus 로고
    • Lysophosphatidylmethanol is a pan lysophosphatidic acid receptor agonist and is produced by autotaxin in blood
    • Endo T, Kano K, Motoki R et al. Lysophosphatidylmethanol is a pan lysophosphatidic acid receptor agonist and is produced by autotaxin in blood. J. Biochem. 146(2), 283-293 (2009).
    • (2009) J. Biochem. , vol.146 , Issue.2 , pp. 283-293
    • Endo, T.1    Kano, K.2    Motoki, R.3
  • 47
    • 84874665319 scopus 로고    scopus 로고
    • Phosphorothioate analogs of sn-2 radyl lysophosphatidic acid (LPA): Metabolically stabilized LPA receptor agonists
    • Jiang G, Inoue A, Aoki J, Prestwich GD. Phosphorothioate analogs of sn-2 radyl lysophosphatidic acid (LPA): metabolically stabilized LPA receptor agonists. Bioorg. Med. Chem. Lett. 23(6), 1865-1869 (2013).
    • (2013) Bioorg. Med. Chem. Lett. , vol.23 , Issue.6 , pp. 1865-1869
    • Jiang, G.1    Inoue, A.2    Aoki, J.3    Prestwich, G.D.4
  • 48
    • 44149096032 scopus 로고    scopus 로고
    • Subtype-specific residues involved in ligand activation of the endothelial differentiation gene family lysophosphatidic acid receptors
    • Valentine WJ, Fells JI, Perygin DH et al. Subtype-specific residues involved in ligand activation of the endothelial differentiation gene family lysophosphatidic acid receptors. J. Biol. Chem. 283(18), 12175-12187 (2008).
    • (2008) J. Biol. Chem. , vol.283 , Issue.18 , pp. 12175-12187
    • Valentine, W.J.1    Fells, J.I.2    Perygin, D.H.3
  • 50
    • 79953905199 scopus 로고    scopus 로고
    • Development of a phosphatase-resistant, L-tyrosine derived LPA1/LPA3 dual antagonist
    • East JE, Carter KM, Kennedy PC et al. Development of a phosphatase-resistant, L-tyrosine derived LPA1/LPA3 dual antagonist. MedChemComm 2(4), 325-330 (2011).
    • (2011) MedChemComm , vol.2 , Issue.4 , pp. 325-330
    • East, J.E.1    Carter, K.M.2    Kennedy, P.C.3
  • 54
    • 77954321169 scopus 로고    scopus 로고
    • A novel, orally active LPA(1) receptor antagonist inhibits lung fibrosis in the mouse bleomycin model
    • Swaney JS, Chapman C, Correa LD et al. A novel, orally active LPA(1) receptor antagonist inhibits lung fibrosis in the mouse bleomycin model. Br. J. Pharmacol. 160(7), 1699-1713 (2010).
    • (2010) Br. J. Pharmacol. , vol.160 , Issue.7 , pp. 1699-1713
    • Swaney, J.S.1    Chapman, C.2    Correa, L.D.3
  • 55
    • 84866330250 scopus 로고    scopus 로고
    • Discovery of highly selective and orally active lysophosphatidic acid receptor-1 antagonists with potent activity on human lung fibroblasts
    • Qian Y, Hamilton M, Sidduri A et al. Discovery of highly selective and orally active lysophosphatidic acid receptor-1 antagonists with potent activity on human lung fibroblasts. J. Med. Chem. 55(17), 7920-7939 (2012).
    • (2012) J. Med. Chem. , vol.55 , Issue.17 , pp. 7920-7939
    • Qian, Y.1    Hamilton, M.2    Sidduri, A.3
  • 56
    • 84871716750 scopus 로고    scopus 로고
    • Comparing the differential effects of LPA on the barrier function of human pulmonary endothelial cells
    • Ren Y, Guo L, Tang X et al. Comparing the differential effects of LPA on the barrier function of human pulmonary endothelial cells. Microvasc. Res. 85, 59-67 (2013).
    • (2013) Microvasc. Res. , vol.85 , pp. 59-67
    • Ren, Y.1    Guo, L.2    Tang, X.3
  • 58
    • 84869786660 scopus 로고    scopus 로고
    • Virtual screening for LPA2-specific agonists identifies a nonlipid compound with antiapoptotic actions
    • Kiss GN, Fells JI, Gupte R et al. Virtual screening for LPA2-specific agonists identifies a nonlipid compound with antiapoptotic actions. Mol. Pharmacol. 82(6), 1162-1173 (2012).
    • (2012) Mol. Pharmacol. , vol.82 , Issue.6 , pp. 1162-1173
    • Kiss, G.N.1    Fells, J.I.2    Gupte, R.3
  • 59
    • 33747593309 scopus 로고    scopus 로고
    • Phosphonothioate and fluoromethylene phosphonate analogues of cyclic phosphatidic acid: Novel antagonists of lysophosphatidic acid receptors
    • DOI 10.1021/jm060351+
    • Xu Y, Jiang GW, Tsukahara R, Fujiwara Y, Tigyi G, Prestwich GD. Phosphonothioate and fluoromethylene phosphonate analogues of cyclic phosphatidic acid: Novel antagonists of lysophosphatidic acid receptors. J. Med. Chem. 49(17), 5309-5315 (2006). (Pubitemid 44262034)
    • (2006) Journal of Medicinal Chemistry , vol.49 , Issue.17 , pp. 5309-5315
    • Xu, Y.1    Jiang, G.2    Tsukahara, R.3    Fujiwara, Y.4    Tigyi, G.5    Prestwich, G.D.6
  • 60
    • 77954312353 scopus 로고    scopus 로고
    • Targeting melanoma growth and viability reveals dualistic functionality of the phosphonothionate analogue of carba cyclic phosphatidic acid
    • Altman MK, Gopal V, Jia W et al. Targeting melanoma growth and viability reveals dualistic functionality of the phosphonothionate analogue of carba cyclic phosphatidic acid. Mol. Cancer 9, 140 (2010).
    • Mol. Cancer , vol.9 , Issue.140 , pp. 2010
    • Altman, M.K.1    Gopal, V.2    Jia, W.3
  • 61
    • 78649422056 scopus 로고    scopus 로고
    • Effects of lysophosphatidic acid and its receptors LPA(1/3) on radiation pneumonitis
    • Xue J, Gan L, Li X et al. Effects of lysophosphatidic acid and its receptors LPA(1/3) on radiation pneumonitis. Oncol. Rep. 24(6), 1515-1520 (2010).
    • (2010) Oncol. Rep. , vol.24 , Issue.6 , pp. 1515-1520
    • Xue, J.1    Gan, L.2    Li, X.3
  • 62
    • 79956225304 scopus 로고    scopus 로고
    • Blockade of lysophosphatidic acid receptors LPAR1/3 ameliorates lung fibrosis induced by irradiation
    • Gan L, Xue JX, Li X et al. Blockade of lysophosphatidic acid receptors LPAR1/3 ameliorates lung fibrosis induced by irradiation. Biochem. Biophys. Res. Commun. 409(1), 7-13 (2011).
    • (2011) Biochem. Biophys. Res. Commun. , vol.409 , Issue.1 , pp. 7-13
    • Gan, L.1    Xue, J.X.2    Li, X.3
  • 63
    • 79951995418 scopus 로고    scopus 로고
    • Pharmacokinetic and pharmacodynamic characterization of an oral lysophosphatidic acid type 1 receptor-selective antagonist
    • Swaney JS, Chapman C, Correa LD et al. Pharmacokinetic and pharmacodynamic characterization of an oral lysophosphatidic acid type 1 receptor-selective antagonist. J. Pharmacol. Exp. Ther. 336(3), 693-700 (2011).
    • (2011) J. Pharmacol. Exp. Ther. , vol.336 , Issue.3 , pp. 693-700
    • Swaney, J.S.1    Chapman, C.2    Correa, L.D.3
  • 64
    • 84862815796 scopus 로고    scopus 로고
    • Orally active lysophosphatidic acid receptor antagonist attenuates pancreatic cancer invasion and metastasis in vivo
    • Komachi M, Sato K, Tobo M et al. Orally active lysophosphatidic acid receptor antagonist attenuates pancreatic cancer invasion and metastasis in vivo. Cancer Sci. 103(6), 1099-1104 (2012).
    • (2012) Cancer Sci. , vol.103 , Issue.6 , pp. 1099-1104
    • Komachi, M.1    Sato, K.2    Tobo, M.3
  • 65
    • 84858638522 scopus 로고    scopus 로고
    • Targeting lysophosphatidic acid receptor type 1 with Debio 0719 inhibits spontaneous metastasis dissemination of breast cancer cells independently of cell proliferation and angiogenesis
    • David M, Ribeiro J, Descotes F et al. Targeting lysophosphatidic acid receptor type 1 with Debio 0719 inhibits spontaneous metastasis dissemination of breast cancer cells independently of cell proliferation and angiogenesis. Int. J. Oncol. 40(4), 1133-1141 (2012).
    • (2012) Int. J. Oncol. , vol.40 , Issue.4 , pp. 1133-1141
    • David, M.1    Ribeiro, J.2    Descotes, F.3
  • 66
    • 84903283301 scopus 로고    scopus 로고
    • ClinicalTrials.gov.
    • ClinicalTrials.gov. www.clinicaltrials.gov
  • 67
    • 84884167456 scopus 로고    scopus 로고
    • At the frontiers of lung fibrosis therapy
    • Graber K. At the frontiers of lung fibrosis therapy. Nat. Biotech. 31(9), 781-783 (2013).
    • (2013) Nat. Biotech. , vol.31 , Issue.9 , pp. 781-783
    • Graber, K.1
  • 68
    • 84903283302 scopus 로고    scopus 로고
    • ClinicalTrials.gov: NCT01766817
    • ClinicalTrials.gov: NCT01766817. http://clinicaltrials.gov/show/ NCT01766817
  • 69
    • 84903283303 scopus 로고    scopus 로고
    • ClinicalTrials.gov: NCT02068053
    • ClinicalTrials.gov: NCT02068053. http://clinicaltrials.gov/ct2/show/ NCT02068053
  • 70
    • 84903283304 scopus 로고    scopus 로고
    • ClinicalTrials.gov: NCT02017730
    • ClinicalTrials.gov: NCT02017730. http://clinicaltrials.gov/ct2/show/ NCT02017730
  • 71
    • 84903283305 scopus 로고    scopus 로고
    • ClinicalTrials.gov: NCT01651143
    • ClinicalTrials.gov: NCT01651143. http://clinicaltrials.gov/show/ NCT01651143
  • 72
    • 77949915910 scopus 로고    scopus 로고
    • Autotaxin delays apoptosis induced by carboplatin in ovarian cancer cells
    • Vidot S, Witham J, Agarwal R et al. Autotaxin delays apoptosis induced by carboplatin in ovarian cancer cells. Cell Signal. 22(6), 926-935 (2010).
    • (2010) Cell Signal. , vol.22 , Issue.6 , pp. 926-935
    • Vidot, S.1    Witham, J.2    Agarwal, R.3
  • 73
    • 79957601666 scopus 로고    scopus 로고
    • Lysophosphatidate induces chemo-resistance by releasing breast cancer cells from taxol-induced mitotic arrest
    • Samadi N, Bekele RT, Goping IS, Schang LM, Brindley DN. Lysophosphatidate induces chemo-resistance by releasing breast cancer cells from taxol-induced mitotic arrest. PLoS ONE 6(5), e20608 (2011).
    • (2011) PLoS ONE , vol.6 , Issue.5
    • Samadi, N.1    Bekele, R.T.2    Goping, I.S.3    Schang, L.M.4    Brindley, D.N.5
  • 74
    • 84890258463 scopus 로고    scopus 로고
    • Autotaxin-lysophosphatidic acid signaling axis mediates tumorigenesis and development of acquired resistance to sunitinib in renal cell carcinoma
    • Su SC, Hu X, Kenney PA et al. Autotaxin-lysophosphatidic acid signaling axis mediates tumorigenesis and development of acquired resistance to sunitinib in renal cell carcinoma. Clin. Cancer Res. 19(23), 6461-6472 (2013).
    • (2013) Clin. Cancer Res. , vol.19 , Issue.23 , pp. 6461-6472
    • Su, S.C.1    Hu, X.2    Kenney, P.A.3


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