Aberrant promoter DNA methylation inhibits bone morphogenetic protein 2 expression and contributes to drug resistance in breast cancer

Molecular Medicine Reports

Volumn 10, Issue 2, 2014, Pages 1051-1055

  Du, Min ^a   Su, Xiao Mei ^a   Zhang, Tao ^a   Xing, Yong Jun ^a  

^a CHENGDU MILITARY GENERAL HOSPITAL   (China)

Author keywords

Bone morphogenetic protein 2; Breast cancer; DNA methylation; Drug resistance

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; BONE MORPHOGENETIC PROTEIN 2; MESSENGER RNA; SMALL INTERFERING RNA; AZACITIDINE;

ARTICLE; BREAST CANCER; CANCER GROWTH; CANCER TISSUE; DNA METHYLATION; DOWN REGULATION; EPIGENETICS; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; MCF 7 CELL LINE; MULTIDRUG RESISTANCE; PRIMARY TUMOR; PROMOTER REGION; PROTEIN EXPRESSION; ANALOGS AND DERIVATIVES; ANTAGONISTS AND INHIBITORS; BREAST TUMOR; CANCER STAGING; DRUG EFFECTS; DRUG RESISTANCE; FEMALE; GENE EXPRESSION; GENETICS; METABOLISM; PATHOLOGY; REAL TIME POLYMERASE CHAIN REACTION; RNA INTERFERENCE; TOXICITY;

AZACITIDINE; BONE MORPHOGENETIC PROTEIN 2; BREAST NEOPLASMS; DNA METHYLATION; DRUG RESISTANCE, NEOPLASM; FEMALE; GENE EXPRESSION; HUMANS; MCF-7 CELLS; NEOPLASM STAGING; PROMOTER REGIONS, GENETIC; REAL-TIME POLYMERASE CHAIN REACTION; RNA INTERFERENCE; RNA, MESSENGER; RNA, SMALL INTERFERING;

EID: 84903276137     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2014.2276     Document Type: Article

References (28)

1. Siegel R, Naishadham D and Jemal A: Cancer statistics, 2013. CA Cancer J Clin 63: 11-30, 2013.
2. Slattery ML, John EM, Torres-Mejia G, et al: Genetic variation in bone morphogenetic proteins and breast cancer risk in hispanic and non-hispanic white women: The breast cancer health disparities study. Int J Cancer 132: 2928-2939, 2013.
3. Thawani JP, Wang AC, Than KD, et al: Bone morphogenetic proteins and cancer: review of the literature. Neurosurgery 66: 233-246, 2010.
4. Buijs JT, Petersen M, van der Horst G, et al: Bone morphogenetic proteins and its receptors; therapeutic targets in cancer progression and bone metastasis? Curr Pharm 16: 1291-1300, 2010.
5. Ye S, Park BH, Song KJ, et al: In vivo inhibition of bone morphogenetic protein-2 on breast cancer cell growth. Spine (Phila Pa 1976) 38: E143-E150, 2013.
6. Guo D, Huang J and Gong J: Bone morphogenetic protein 4 (BMP4) is required for migration and invasion of breast cancer. Mol Cell Biochem 363: 179-190, 2012.
7. Lian WJ, Liu G, Liu YJ, et al: Downregulation of BMP6 enhances cell proliferation and chemoresistance via activation of the ERK signaling pathway in breast cancer. Oncol Rep 30: 193-200, 2013.
8. Rodriguez-Martinez A, Alarmo EL, Saarinen L, et al: Analysis of BMP4 and BMP7 signaling in breast cancer cells unveils time-dependent transcription patterns and highlights a common synexpression group of genes. BMC Med Genomics 4: 80, 2011.
9. Wang K, Feng H, Ren W, et al: BMP9 inhibits the proliferation and invasiveness of breast cancer cells MDA-MB-231. J Cancer Res Clin Oncol 137: 1687-1696, 2011.
10. Ye L, Bokobza S, Li J, et al: Bone morphogenetic protein-10 (BMP-10) inhibits aggressiveness of breast cancer cells and correlates with poor prognosis in breast cancer. Cancer Sci 101: 2137-2144, 2010.
11. You JS and Jones PA. Cancer genetics and epigenetics: two sides of the same coin? Cancer Cell 22: 9-20, 2012.
12. Kanwal R and Gupta S: Epigenetic modifications in cancer. Clin Genet 81: 303-311, 2012.
13. Wen XZ, Akiyama Y, Baylin SB, et al: Frequent epigenetic silencing of the bone morphogenetic protein 2 gene through methylation in gastric carcinomas. Oncogene 25: 2666-2673, 2006.
14. Fu B, Wang H, Wang J, et al: Epigenetic regulation of BMP2 by 1,25-dihydroxyvitamin D3 through DNA methylation and histone modification. PLoS One 8: e61423, 2013.
15. Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 25: 402-408, 2001. (Pubitemid 34164012)
16. Alarmo EL, Kuukasjärvi T, Karhu R, et al: A comprehensive expression survey of bone morphogenetic proteins in breast cancer highlights the importance of BMP4 and BMP7. Breast Cancer Res Treat 103: 239-246, 2007. (Pubitemid 46789146)
17. Davies SR, Watkins G, Douglas-Jones A, et al: Bone morphogenetic proteins 1 to 7 in human breast cancer, expression pattern and clinical/prognostic relevance. J Exp Ther Oncol 7: 327-338, 2008.
18. Ghosh-Choudhury N, Ghosh-Choudhury G, Celeste A, et al: Bone morphogenetic protein-2 induces cyclin kinase inhibitor p21 and hypophosphorylation of retinoblastoma protein in estradiol-treated MCF-7 human breast cancer cells. Biochim Biophys Acta 1497: 186-196, 2000. (Pubitemid 30618830)
19. Waite KA, Eng C: BMP2 exposure results in decreased PTEN protein degradation and increased PTEN levels. Hum Mol Genet 12: 679-684, 2003. (Pubitemid 36372494)
20. Clement JH, Raida M, Sänger J, et al: Bone morphogenetic protein 2 (BMP-2) induces in vitro invasion and in vivo hormone independent growth of breast carcinoma cells. Int J Oncol 27: 401-407, 2005.
21. Raida M, Clement JH, Leek RD, et al: Bone morphogenetic protein 2 (BMP-2) and induction of tumor angiogenesis. J Cancer Res Clin Oncol 131: 741-750, 2005. (Pubitemid 41577951)
22. Jones PA. Functions of DNA methylation: islands, start sites, gene bodies and beyond. Nat Rev Genet 13: 484-492, 2012.
23. De Carvalho DD, Sharma S, You JS, et al: DNA methylation screening identifies driver epigenetic events of cancer cell survival. Cancer Cell 21: 655-667, 2012.
24. Hervouet E, Cartron PF, Jouvenot M, et al: Epigenetic regulation of estrogen signaling in breast cancer. Epigenetics 8: 237-245, 2013.
25. Pang JM, Dobrovic A and Fox SB. DNA methylation in ductal carcinoma in situ of the breast. Breast Cancer Res 15: 206, 2013.
26. Connolly R and Stearns V: Epigenetics as a therapeutic target in breast cancer. J Mammary Gland Biol Neoplasia 17: 191-204, 2012.
27. Dagdemir A, Durif J, Ngollo M, et al: Breast cancer: mechanisms involved in action of phytoestrogens and epigenetic changes. In Vivo 27: 1-9, 2013.
28. Huang Y, Nayak S, Jankowitz R, et al: Epigenetics in breast cancer: what's new? Breast Cancer Res 13: 225, 2011.