3D Scaffolds

Principles of Tissue Engineering: Fourth Edition

Volumn , Issue , 2013, Pages 475-494

  Luo, Ying ^a   Engelmayr, George ^b   Auguste, Debra T ^c   da Silva Ferreira, Lino ^d,e   Karp, Jeffrey M ^f,g   Saigal, Rajiv ^h   Langer, Robert ^f,i  

^a PEKING UNIVERSITY   (China)

^b Duke University   (United States)

^c City College of New York   (United States)

^d UNIVERSITY OF COIMBRA   (Portugal)

^e Biocant Center of Innovation in Biotechnology   (Portugal)

^f MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^g HARVARD MEDICAL SCHOOL   (United States)

^h UNIVERSITY OF CALIFORNIA   (United States)

ⁱ Massachusetts Institute of Technology   (United States)

Author keywords

Extracellular matrix; Guidance; Mass transport; Mechanical property; Pore; Scaffold; Spatial; Temporal; Tissue formation

Indexed keywords

BIOMECHANICS; CELL ENGINEERING; CHEMICAL ANALYSIS; ELECTRONIC GUIDANCE SYSTEMS; MASS TRANSFER; MECHANICAL PROPERTIES; SCAFFOLDS; STRUCTURAL DESIGN; SURFACE CHEMISTRY; TISSUE;

EXTRACELLULAR MATRICES; PORE; SPATIAL; TEMPORAL; TISSUE FORMATION;

SCAFFOLDS (BIOLOGY);

EID: 84903265046     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-0-12-398358-9.00024-0     Document Type: Chapter

References (122)

1. Langer R., Vacanti J.P. Tissue engineering. Science 1993, 260(5110):920-926.
2. Griffith L.G. Emerging design principles in biomaterials and scaffolds for tissue engineering. Ann N Y Acad Sci 2002, 961:83-95.
3. Hollister S.J. Porous scaffold design for tissue engineering. Nat Mater 2005, 4(7):518-524.
4. Lutolf M.P., Hubbell J.A. Synthetic biomaterials as instructive extracellular microenvironments for morphogenesis in tissue engineering. Nat Biotechnol 2005, 23(1):47-55.
5. Stevens M.M., George J.H. Exploring and engineering the cell surface interface. Science 2005, 310(5751):1135-1138.
6. Malda J., Woodfield T.B., van der Vloodt F., Kooy F.K., Martens D.E., Tramper J. The effect of PEGT/PBT scaffold architecture on oxygen gradients in tissue engineered cartilaginous constructs. Biomaterials 2004, 25(26):5773-5780.
7. Botchwey E.A., Dupree M.A., Pollack S.R., Levine E.M., Laurencin C.T. Tissue engineered bone: measurement of nutrient transport in three-dimensional matrices. J Biomed Mater Res A 2003, 67(1):357-367.
8. Colton C.K. Implantable biohybrid artificial organs. Cell Transplant 1995, 4(4):415-436.
9. Ishaug S.L., Crane G.M., Miller M.J., Yasko A.W., Yaszemski M.J., Mikos A.G. Bone formation by three-dimensional stromal osteoblast culture in biodegradable polymer scaffolds. J Biomed Mater Res 1997, 36(1):17-28.
10. Freed L.E., Hollander A.P., Martin I., Barry J.R., Langer R., Vunjak-Novakovic G. Chondrogenesis in a cell-polymer-bioreactor system. Exp Cell Res 1998, 240(1):58-65.
11. Ma T., Li Y., Yang S.T., Kniss D.A. Tissue engineering human placenta trophoblast cells in 3D fibrous matrix: spatial effects on cell proliferation and function. Biotechnol Prog 1999, 15(4):715-724.
12. Ma T., Li Y., Yang S.T., Kniss D.A. Effects of pore size in 3D fibrous matrix on human trophoblast tissue development. Biotechnol Bioeng 2000, 70(6):606-618.
13. Wake M.C., Patrick C.W., Mikos A.G. Pore morphology effects on the fibrovascular tissue growth in porous polymer substrates. Cell Transplant 1994, 3(4):339-343.
14. Yannas I.V. Facts and theories of induced organ regeneration. Adv Biochem Eng Biotechnol 2005, 93:1-38.
15. Hulbert S.F., Young F.A., Mathews R.S., Klawitter J.J., Talbert C.D., Stelling F.H. Potential of ceramic materials as permanently implantable skeletal prostheses. J Biomed Mater Res 1970, 4(3):433-456.
16. Tsuruga E., Takita H., Itoh H., Wakisaka Y., Kuboki Y. Pore size of porous hydroxyapatite as the cell-substratum controls BMP-induced osteogenesis. J Biochem (Tokyo) 1997, 121(2):317-324.
17. Karageorgiou V., Kaplan D. Porosity of 3D biomaterial scaffolds and osteogenesis. Biomaterials 2005, 26(27):5474-5491.
18. Kuboki Y., Jin Q., Takita H. Geometry of carriers controlling phenotypic expression in BMP-induced osteogenesis and chondrogenesis. J Bone Joint Surg Am 2001, 83-A(Suppl. 1):S105-S115.
19. Malda J., Woodfield T.B., van der Vloodt F., Wilson C., Martens D.E., Tramper J., et al. The effect of PEGT/PBT scaffold architecture on the composition of tissue engineered cartilage. Biomaterials 2005, 26(1):63-72.
20. Weinberg C.B., Bell E. A blood vessel model constructed from collagen and cultured vascular cells. Science 1986, 231(4736):397-400.
21. Niklason L.E., Gao J., Abbott W.M., Hirschi K.K., Houser S., Marini R., et al. Functional arteries grown in vitro. Science 1999, 284(5413):489-493.
22. Sutherland F.W., Perry T.E., Yu Y., Sherwood M.C., Rabkin E., Masuda Y., et al. From stem cells to viable autologous semilunar heart valve. Circulation 2005, 111(21):2783-2791.
23. Papadaki M., Bursac N., Langer R., Merok J., Vunjak-Novakovic G., Freed L.E. Tissue engineering of functional cardiac muscle: molecular, structural, and electrophysiological studies. Am J Physiol Heart Circ Physiol 2001, 280(1):H168-H178.
24. Kim B.S., Mooney D.J. Engineering smooth muscle tissue with a predefined structure. J Biomed Mater Res 1998, 41(2):322-332.
25. Engelmayr G.C., Sacks M.S. A structural model for the flexural mechanics of nonwoven tissue engineering scaffolds. J Biomech Eng 2006, 128(4):610-622.
26. Engler A.J., Griffin M.A., Sen S., Bonnemann C.G., Sweeney H.L., Discher D.E. Myotubes differentiate optimally on substrates with tissue-like stiffness: pathological implications for soft or stiff microenvironments. J Cell Biol 2004, 166(6):877-887.
27. Wang Y., Kim Y.M., Langer R. In vivo degradation characteristics of poly(glycerol sebacate). J Biomed Mater Res A 2003, 66(1):192-197.
28. Zinn M., Witholt B., Egli T. Occurrence, synthesis and medical application of bacterial polyhydroxyalkanoate. Adv Drug Deliv Rev 2001, 53(1):5-21.
29. Engelmayr G.C., Sacks M.S. A structural model for the flexural mechanics of nonwoven tissue engineering scaffolds. J Biomech Eng 2006, 128(4):610-622.
30. Beatty M.W., Ojha A.K., Cook J.L., Alberts L.R., Mahanna G.K., Iwasaki L.R., et al. Small intestinal submucosa versus salt-extracted polyglycolic acid-poly-L-lactic acid: a comparison of neocartilage formed in two scaffold materials. Tissue Eng 2002, 8(6):955-968.
31. Stankus J.J., Guan J., Wagner W.R. Fabrication of biodegradable elastomeric scaffolds with sub-micron morphologies. J Biomed Mater Res A 2004, 70(4):603-614.
32. Guan J., Fujimoto K.L., Sacks M.S., Wagner W.R. Preparation and characterization of highly porous, biodegradable polyurethane scaffolds for soft tissue applications. Biomaterials 2005, 26(18):3961-3971.
33. Gao J., Crapo P.M., Wang Y. Macroporous elastomeric scaffolds with extensive micropores for soft tissue engineering. Tissue Eng 2006, 12(4):917-925.
34. Wang H., Wen Y., Mooney S., Behr B., Polan M.L. Phospholipase A(2) and cyclooxygenase gene expression in human preimplantation embryos. J Clin Endocrinol Metab 2002, 87(6):2629-2634.
35. Engelmayr G.C., Rabkin E., Sutherland F.W., Schoen F.J., Mayer J.E., Sacks M.S. The independent role of cyclic flexure in the early in vitro development of an engineered heart valve tissue. Biomaterials 2005, 26(2):175-187.
36. Engelmayr G.C., Hildebrand D.K., Sutherland F.W., Mayer J.E., Sacks M.S. A novel bioreactor for the dynamic flexural stimulation of tissue engineered heart valve biomaterials. Biomaterials 2003, 24(14):2523-2532.
37. Grashow J.S., Yoganathan A.P., Sacks M.S. Biaixal stress-stretch behavior of the mitral valve anterior leaflet at physiologic strain rates. Ann Biomed Eng 2006, 34(2):1-11.
38. Mirnajafi A., Raymer J., Scott M.J., Sacks M.S. The effects of collagen fiber orientation on the flexural properties of pericardial heterograft biomaterials. Biomaterials 2005, 26(7):795-804.
39. Hollister S.J., Maddox R.D., Taboas J.M. Optimal design and fabrication of scaffolds to mimic tissue properties and satisfy biological constraints. Biomaterials 2002, 23(20):4095-4103.
40. Gibson R.F. Principles of composite material mechanics 1994, McGraw-Hill, New York. (1st edition).
41. Zelikin A.N., Lynn D.M., Farhadi J., Martin I., Shastri V., Langer R. Erodible conducting polymers for potential biomedical applications. Angew Chem Int Ed Engl 2002, 41(1):141-144.
42. Rivers T.J., Hudson T.W., Schmidt C.E. Synthesis of a novel, biodegradable electrically conducting polymer for biomedical applications. Adv Funct Mater 2002, 12(1):33-37.
43. Shi G., Rouabhia M., Wang Z., Dao L.H., Zhang Z. A novel electrically conductive and biodegradable composite made of polypyrrole nanoparticles and polylactide. Biomaterials 2004, 25(13):2477-2488.
44. LaVan D.A., George P.M., Langer R. Simple, three-dimensional microfabrication of electrodeposited structures. Angew Chem Int Ed Engl 2003, 42(11):1262-1265.
45. Chen S.J., Wang D.Y., Yuan C.W., Wang X.D., Zhang P.Y., Gu X.S. Template synthesis of the polypyrrole tube and its bridging in vivo sciatic nerve regeneration. J Mater Sci Lett 2000, 19(23):2157-2159.
46. Saigal R., George P.M., Makhni M.C., Teng Y.D., Langer R. Conductive polymer scaffolds for delivery of human neural stem cells. Society for Neuroscience 2005, 35th Annual Meeting. Washington, DC, November, 2005.
47. Radisic M., Park H., Shing H., Consi T., Schoen F.J., Langer R., et al. Functional assembly of engineered myocardium by electrical stimulation of cardiac myocytes cultured on scaffolds. Proc Natl Acad Sci U S A 2004, 101(52):18129-18134.
48. Gerecht-Nir S., Radisic M., Park H., Cannizzaro C., Boublik J., Langer R., et al. Biophysical regulation during cardiac development and application to tissue engineering. Int J Dev Biol 2006, 50(2-3):233-243.
49. Wong J.Y., Langer R., Ingber D.E. Electrically conducting polymers can noninvasively control the shape and growth of mammalian cells. Proc Natl Acad Sci U S A 1994, 91(8):3201-3204.
50. Schmidt C.E., Shastri V.R., Vacanti J.P., Langer R. Stimulation of neurite outgrowth using an electrically conducting polymer. Proc Natl Acad Sci U S A 1997, 94(17):8948-8953.
51. Collier J.H., Camp J.P., Hudson T.W., Schmidt C.E. Synthesis and characterization of polypyrrole-hyaluronic acid composite biomaterials for tissue engineering applications. J Biomed Mater Res 2000, 50(4):574-584.
52. Kotwal A., Schmidt C.E. Electrical stimulation alters protein adsorption and nerve cell interactions with electrically conducting biomaterials. Biomaterials 2001, 22(10):1055-1064.
53. Patel N., Poo M.M. Orientation of neurite growth by extracellular electric fields. J Neurosci 1982, 2(4):483-496.
54. West A.E., Chen W.G., Dalva M.B., Dolmetsch R.E., Kornhauser J.M., Shaywitz A.J., et al. Calcium regulation of neuronal gene expression. Proc Natl Acad Sci U S A 2001, 98(20):11024-11031.
55. Mikos A.G., McIntire L.V., Anderson J.M., Babensee J.E. Host response to tissue engineered devices. Adv Drug Deliv Rev 1998, 33(1-2):111-139.
56. Hu W.J., Eaton J.W., Ugarova T.P., Tang L. Molecular basis of biomaterial-mediated foreign body reactions. Blood 2001, 98(4):1231-1238.
57. Nehrer S., Breinan H.A., Ramappa A., Shortkroff S., Young G., Minas T., et al. Canine chondrocytes seeded in type I and type II collagen implants investigated in vitro. J Biomed Mater Res 1997, 38(2):95-104.
58. Hubbell J.A. Materials as morphogenetic guides in tissue engineering. Curr Opin Biotechnol 2003, 14(5):551-558.
59. Hench L.L., Polak J.M., Xynos L.D., Buttery L.D.K. Bioactive materials to control cell cycle. Mat Res Innovat 2000, 3(6):313-323.
60. Mikos A.G., Lyman M.D., Freed L.E., Langer R. Wetting of poly(L-lactic acid) and poly(DL-lactic-co-glycolic acid) foams for tissue culture. Biomaterials 1994, 15(1):55-58.
61. Harrison J., Pattanawong S., Forsythe J.S., Gross K.A., Nisbet D.R., Beh H., et al. Colonization and maintenance of murine embryonic stem cells on poly(alpha-hydroxy esters). Biomaterials 2004, 25(20):4963-4970.
62. Gao J., Niklason L., Langer R. Surface hydrolysis of poly(glycolic acid) meshes increases the seeding density of vascular smooth muscle cells. J Biomed Mater Res 1998, 42(3):417-424.
63. Levenberg S., Huang N.F., Lavik E., Rogers A.B., Itskovitz-Eldor J., Langer R. Differentiation of human embryonic stem cells on three-dimensional polymer scaffolds. Proc Natl Acad Sci U S A 2003, 100(22):12741-12746.
64. Nuttelman C.R., Mortisen D.J., Henry S.M., Anseth K.S. Attachment of fibronectin to poly(vinyl alcohol) hydrogels promotes NIH3T3 cell adhesion, proliferation, and migration. J Biomed Mater Res 2001, 57(2):217-223.
65. Seliktar D. Extracellular stimulation in tissue engineering. Ann N Y Acad Sci 2005, 1047(1):386-394.
66. Plow E.F., Haas T.A., Zhang L., Loftus J., Smith J.W. Ligand binding to integrins. J Biol Chem 2000, 275(29):21785-21788.
67. Shin H., Jo S., Mikos A.G. Biomimetic materials for tissue engineering. Biomaterials 2003, 24(24):4353-4364.
68. Hersel U., Dahmen C., Kessler H. RGD modified polymers: biomaterials for stimulated cell adhesion and beyond. Biomaterials 2003, 24(24):4385-4415.
69. Barrera D.A., Zylstra E., Lansbury P.T., Langer R. Synthesis and RGD peptide modification of a new biodegradable copolymer-poly(lactic acid-co-lysine). J Amer Chem Soc 1993, 115(230):11010-11011.
70. Cook A.D., Hrkach J.S., Gao N.N., Johnson I.M., Pajvani U.B., Cannizzaro S.M., et al. Characterization and development of RGD-peptide-modified poly(lactic acid-co-lysine) as an interactive, resorbable biomaterial. J Biomed Mater Res 1997, 35(4):513-523.
71. Schense J.C., Hubbell J.A. Three-dimensional migration of neurites is mediated by adhesion site density and affinity. J Biol Chem 2000, 275(10):6813-6818.
72. Maheshwari G., Brown G., Lauffenburger D.A., Wells A., Griffith L.G. Cell adhesion and motility depend on nanoscale RGD clustering. J Cell Sci 2000, 113(Pt 10):1677-1686.
73. Flemming R.G., Murphy C.J., Abrams G.A., Goodman S.L., Nealey P.F. Effects of synthetic micro- and nano-structured surfaces on cell behavior. Biomaterials 1999, 20(6):573-588.
74. Zinger O., Zhao G., Schwartz Z., Simpson J., Wieland M., Landolt D., et al. Differential regulation of osteoblasts by substrate microstructural features. Biomaterials 2005, 26(14):1837-1847.
75. Takahashi Y., Tabata Y. Effect of the fiber diameter and porosity of non-woven PET fabrics on the osteogenic differentiation of mesenchymal stem cells. J Biomater Sci Polym Ed 2004, 15(1):41-57.
76. Pattison M.A., Wurster S., Webster T.J., Haberstroh K.M. Three-dimensional, nano-structured PLGA scaffolds for bladder tissue replacement applications. Biomaterials 2005, 26(15):2491-2500.
77. Yang F., Murugan R., Ramakrishna S., Wang X., Ma Y.X., Wang S. Fabrication of nano-structured porous PLLA scaffold intended for nerve tissue engineering. Biomaterials 2004, 25(10):1891-1900.
78. Woo K.M., Chen V.J., Ma P.X. Nano-fibrous scaffolding architecture selectively enhances protein adsorption contributing to cell attachment. J Biomed Mater Res A 2003, 67(2):531-537.
79. Ma Z., Kotaki M., Inai R., Ramakrishna S. Potential of nanofiber matrix as tissue-engineering scaffolds. Tissue Eng 2005, 11(1-2):101-109.
80. Zhang S. Emerging biological materials through molecular self-assembly. Biotechnol Adv 2002, 20(5-6):321-339.
81. Silva G.A., Czeisler C., Niece K.L., Beniash E., Harrington D.A., Kessler J.A., et al. Selective differentiation of neural progenitor cells by high-epitope density nanofibers. Science 2004, 303(5662):1352-1355.
82. Hartgerink J.D., Beniash E., Stupp S.I. Peptide-amphiphile nanofibers: a versatile scaffold for the preparation of self-assembling materials. Proc Natl Acad Sci U S A 2002, 99(8):5133-5138.
83. Shin M., Ishii O., Sueda T., Vacanti J.P. Contractile cardiac grafts using a novel nanofibrous mesh. Biomaterials 2004, 25(17):3717-3723.
84. Lee K.Y., Alsberg E., Mooney D.J. Degradable and injectable poly(aldehyde guluronate) hydrogels for bone tissue engineering. J Biomed Mater Res 2001, 56(2):228-233.
85. Cristofolini L. A critical analysis of stress shielding evaluation of hip prostheses. Crit Rev Biomed Eng 1997, 25(4-5):409-483.
86. Lee K.Y., Bouhadir K.H., Mooney D.J. Degradation behavior of covalently cross-linked poly(aldehyde guluronate) hydrogels. Macromolecules 2000, 33(1):97-101.
87. Ferreira L., Gil M.H., Cabrita A.M., Dordick J.S. Biocatalytic synthesis of highly ordered degradable dextran-based hydrogels. Biomaterials 2005, 26(23):4707-4716.
88. Tognana E., Padera R.F., Chen F., Vunjak-Novakovic G., Freed L.E. Development and remodeling of engineered cartilage-explant composites in vitro and in vivo. Osteoarthritis Cartilage 2005, 13(10):896-905.
89. Yuan H., Li Y., de Bruijn J.D., de Groot K., Zhang X. Tissue responses of calcium phosphate cement: a study in dogs. Biomaterials 2000, 21(12):1283-1290.
90. Hench L.L., Xynos I.D., Polak J.M. Bioactive glasses for in situ tissue regeneration. J Biomater Sci Polym 2004, 15(4):543-562.
91. Pietrzak W.S., Ronk R. Calcium sulfate bone void filler: a review and a look ahead. J Craniofac Surg 2000, 11(4):327-333.
92. Lutolf M.P., Lauer-Fields J.L., Schmoekel H.G., Metters A.T., Weber F.E., Fields G.B., et al. Synthetic matrix metalloproteinase-sensitive hydrogels for the conduction of tissue regeneration: Engineering cell-invasion characteristics. Proc Natl Acad Sci USA 2003, 100(9):5413-5418.
93. Gobin A.S., West J.L. Cell migration through defined, synthetic extracellular matrix analogues. Faseb J 2002, 16(7):751-753.
94. Lutolf M.P., Raeber G.P., Zisch A.H., Tirelli N., Hubbell J.A. Cell-responsive synthetic hydrogels. Advanced Materials 2003, 15(11):888-892.
95. Lutolf M.P., Weber F.E., Schmoekel H.G., Schense J.C., Kohler T., Muller R., et al. Repair of bone defects using synthetic mimetics of collagenous extracellular matrices. Nat Biotechnol 2003, 21(5):513-518.
96. Hedberg E.L., Tang A., Crowther R.S., Carney D.H., Mikos A.G. Controlled release of an osteogenic peptide from injectable biodegradable polymeric composites. Journal of Controlled Release 2002, 84(3):137-150.
97. Lee J.E., Kim K.E., Kwon I.C., Ahn H.J., Lee S.H., Cho H.C., et al. Effects of the controlled-released TGF-beta 1 from chitosan microspheres on chondrocytes cultured in a collagen/chitosan/glycosaminoglycan scaffold. Biomaterials 2004, 25(18):4163-4173.
98. Park Y.J., Ku Y., Chung C.P., Lee S.J. Controlled release of platelet-derived growth factor from porous poly(L-lactide) membranes for guided tissue regeneration. J Control Release 1998, 51(2-3):201-211.
99. Whang K., Goldstick T.K., Healy K.E. A biodegradable polymer scaffold for delivery of osteotropic factors. Biomaterials 2000, 21(24):2545-2551.
100. Jang J.H., Shea L.D. Controllable delivery of non-viral DNA from porous scaffolds. Journal of Controlled Release 2003, 86(1):157-168.
101. Murphy W.L., Peters M.C., Kohn D.H., Mooney D.J. Sustained release of vascular endothelial growth factor from mineralized poly(lactide-co-glycolide) scaffolds for tissue engineering. Biomaterials 2000, 21(24):2521-2527.
102. Luu Y.K., Kim K., Hsiao B.S., Chu B., Hadjiargyrou M. Development of a nanostructured DNA delivery scaffold via electrospinning of PLGA and PLA-PEG block copolymers. J Control Release 2003, 89(2):341-353.
103. Tabata Y. Tissue regeneration based on growth factor release. Tissue Eng 2003, 9(Suppl. 1):S5-15.
104. Sakiyama-Elbert S.E., Hubbell J.A. Controlled release of nerve growth factor from a heparin-containing fibrin-based cell ingrowth matrix. J Control Release 2000, 69(1):149-158.
105. Babensee J.E., McIntire L.V., Mikos A.G. Growth factor delivery for tissue engineering. Pharm Res 2000, 17(5):497-504.
106. Yamamoto M., Tabata Y., Hong L., Miyamoto S., Hashimoto N., Ikada Y. Bone regeneration by transforming growth factor beta1 released from a biodegradable hydrogel. J Control Release 2000, 64(1-3):133-142.
107. Borden M., Attawia M., Khan Y., El-Amin S.F., Laurencin C.T. Tissue-engineered bone formation in vivo using a novel sintered polymeric microsphere matrix. J Bone Joint Surg Br 2004, 86(8):1200-1208.
108. Richardson T.P., Peters M.C., Ennett A.B., Mooney D.J. Polymeric system for dual growth factor delivery. Nature Biotechnology 2001, 19(11):1029-1034.
109. Zisch A.H., Lutolf M.P., Ehrbar M., Raeber G.P., Rizzi S.C., Davies N., et al. Cell-demanded release of VEGF from synthetic, biointeractive cell-ingrowth matrices for vascularized tissue growth. Faseb Journal 2003, 17(15):2260-2262.
110. Sakiyama-Elbert S.E., Panitch A., Hubbell J.A. Development of growth factor fusion proteins for cell-triggered drug delivery. Faseb J 2001, 15(7):1300-1302.
111. Mikos A.G., Sarakinos G., Leite S.M., Vacanti J.P., Langer R. Laminated three-dimensional biodegradable foams for use in tissue engineering. Biomaterials 1993, 14(5):323-330.
112. Yang S., Leong K.F., Du Z., Chua C.K. The design of scaffolds for use in tissue engineering. Part II. Rapid prototyping techniques. Tissue Eng 2002, 8(1):1-11.
113. Hutmacher D.W. Scaffold design and fabrication technologies for engineering tissues-state of the art and future perspectives. J Biomater Sci Polym Ed 2001, 12(1):107-124.
114. Burdick J.A., Chung C., Jia X., Randolph M.A., Langer R. Controlled degradation and mechanical behavior of photopolymerized hyaluronic acid networks. Biomacromolecules 2005, 6(1):386-391.
115. Elisseeff J., Anseth K., Sims D., McIntosh W., Randolph M., Langer R. Transdermal photopolymerization for minimally invasive implantation. Proc Natl Acad Sci USA 1999, 96(6):3104-3107.
116. Hadlock T., Sundback C., Hunter D., Cheney M., Vacanti J.P. A polymer foam conduit seeded with Schwann cells promotes guided peripheral nerve regeneration. Tissue Eng 2000, 6(2):119-127.
117. Dubey N., Letourneau P.C., Tranquillo R.T. Neuronal contact guidance in magnetically aligned fibrin gels: effect of variation in gel mechano-structural properties. Biomaterials 2001, 22(10):1065-1075.
118. Dubey N., Letourneau P.C., Tranquillo R.T. Guided neurite elongation and schwann cell invasion into magnetically aligned collagen in simulated peripheral nerve regeneration. Exp Neurol 1999, 158(2):338-350.
119. Luo Y., Shoichet M.S. A photolabile hydrogel for guided three-dimensional cell growth and migration. Nat Mater 2004, 3(4):249-253.
120. Kapur T.A., Shoichet M.S. Immobilized concentration gradients of nerve growth factor guide neurite outgrowth. J Biomed Mater Res A 2004, 68(2):235-243.
121. Burdick J.A., Khademhosseini A., Langer R. Fabrication of gradient hydrogels using a microfluidics/photopolymerization process. Langmuir 2004, 20(13):5153-5156.
122. Tsang V.L., Bhatia S.N. Three-dimensional tissue fabrication. Adv Drug Deliv Rev 2004, 56(11):1635-1647.