Identification of inhibitors of inositol 5-phosphatases through multiple screening strategies

ACS Chemical Biology

Volumn 9, Issue 6, 2014, Pages 1359-1368

  Pirruccello, Michelle ^a,c   Nandez, Ramiro ^a   Idevall Hagren, Olof ^a,d   Alcazar Roman, Abel ^a   Abriola, Laura ^b   Berwick, Shana Alexandra ^a   Lucast, Louise ^a   Morel, Dayna ^a   De Camilli, Pietro ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b YALE UNIVERSITY   (United States)

^c Scholar Rock   (United States)

^d UPPSALA UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ESTERASE INHIBITOR; INOSITOL 5 PHOSPHATASE INHIBITOR; INOSITOL DERIVATIVE; SYNAPTOJANIN; SYNAPTOJANIN 1; UNCLASSIFIED DRUG; ENZYME INHIBITOR; FUCHSINE; INOSITOL-POLYPHOSPHATE 5-PHOSPHATASE; MALACHITE GREEN; MOLECULAR LIBRARY; OCRL PROTEIN, HUMAN; PHOSPHATASE; POLYPHOSPHOINOSITIDE; THIADIAZOLE DERIVATIVE; TRIAZOLE DERIVATIVE; YU142670;

ARTICLE; CAPILLARY ELECTROPHORESIS; CONTROLLED STUDY; DEPHOSPHORYLATION; DRUG EFFICACY; DRUG IDENTIFICATION; DRUG SCREENING; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; HIGH THROUGHPUT SCREENING; HUMAN; HYDROGEN BOND; IN VITRO STUDY; ISOTHERMAL TITRATION CALORIMETRY; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; ANTAGONISTS AND INHIBITORS; CELL CULTURE; CHEMICAL STRUCTURE; CHEMISTRY; CYTOLOGY; DERMIS; DRUG EFFECTS; ENZYMOLOGY; FIBROBLAST; FLUORESCENCE POLARIZATION; GEL MOBILITY SHIFT ASSAY; GENETICS; METABOLISM; MOLECULAR LIBRARY; PHARMACOLOGY; SIGNAL TRANSDUCTION;

CELLS, CULTURED; DERMIS; ELECTROPHORETIC MOBILITY SHIFT ASSAY; ENZYME INHIBITORS; FIBROBLASTS; FLUORESCENCE POLARIZATION; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; MOLECULAR STRUCTURE; PHOSPHATIDYLINOSITOL PHOSPHATES; PHOSPHORIC MONOESTER HYDROLASES; ROSANILINE DYES; SIGNAL TRANSDUCTION; SMALL MOLECULE LIBRARIES; THIADIAZOLES; TRIAZOLES;

EID: 84903214855     PISSN: 15548929     EISSN: 15548937     Source Type: Journal    
DOI: 10.1021/cb500161z     Document Type: Article

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