Screening assay for small-molecule inhibitors of synaptojanin 1, a synaptic phosphoinositide phosphatase

Journal of Biomolecular Screening

Volumn 19, Issue 4, 2014, Pages 585-594

  McIntire, Laura Beth J ^a   Lee, Kyu In ^a   Chang Ileto, Belle ^a   Di Paolo, Gilbert ^a   Kim, Tae Wan ^a  

^a NewYork Presbyterian Hospital   (United States)

Author keywords

Alzheimer disease; drug discovery; lipid phosphatase; phosphatidylinositol 4 5 bisphosphate; small molecule screening; src homology 2 domain containing inositol 5 phosphatase 2 (SHIP2); synaptojanin 1

Indexed keywords

PHOSPHATE; PHOSPHATIDYLINOSITIDE; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE; SYNAPTOJANIN; SYNAPTOJANIN 1; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL STRAIN HEK293; CONTROLLED STUDY; DRUG IDENTIFICATION; DRUG SCREENING; HETEROZYGOTE; HIGH THROUGHPUT SCREENING; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; SYNAPSE VESICLE; SYNAPTIC INHIBITION;

ALZHEIMER DISEASE; DRUG DISCOVERY; LIPID PHOSPHATASE; PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE; SMALL-MOLECULE SCREENING; SRC HOMOLOGY 2 DOMAIN-CONTAINING INOSITOL-5-PHOSPHATASE 2 (SHIP2); SYNAPTOJANIN 1;

CELL LINE; DRUG DISCOVERY; DRUG EVALUATION, PRECLINICAL; ENZYME ACTIVATION; ENZYME INHIBITORS; GENE EXPRESSION; GENES, REPORTER; GREEN FLUORESCENT PROTEINS; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; NERVE TISSUE PROTEINS; PHOSPHORIC MONOESTER HYDROLASES; RECOMBINANT FUSION PROTEINS; REPRODUCIBILITY OF RESULTS; SMALL MOLECULE LIBRARIES; SUBSTRATE SPECIFICITY;

EID: 84896792592     PISSN: 10870571     EISSN: 1552454X     Source Type: Journal    
DOI: 10.1177/1087057113510177     Document Type: Article

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