Seizures after single-agent overdose with pharmaceutical drugs: Analysis of cases reported to a poison center

Clinical Toxicology

Volumn 52, Issue 6, 2014, Pages 629-634

  Reichert, C ^a   Reichert, P ^b   Monnet Tschudi, F ^c   Kupferschmidt, H ^a   Ceschi, A ^a,d   Rauber Luthy C ^a  

^a UNIVERSITY OF ZURICH   (Switzerland)

^b SWISS FEDERAL INSTITUTE OF AQUATIC SCIENCE AND TECHNOLOGY   (Switzerland)

^c Swiss Centre for Applied Human Toxicology   (Switzerland)

^d UNIVERSITY HOSPITAL ZURICH   (Switzerland)

Author keywords

Adolescents; Age dependency; Convulsions; Poisoning; Seizure potential

Indexed keywords

AMFEBUTAMONE; AMITRIPTYLINE; ANTIDEPRESSANT AGENT; CARBAMAZEPINE; CHLORPROTHIXENE; CITALOPRAM; CLOMIPRAMINE; CLOTIAPINE; CLOZAPINE; CODEINE; DEXTROMETHORPHAN; DIBENZEPIN; DIPHENHYDRAMINE; DOXEPIN; FLUOXETINE; FLUVOXAMINE; IOXAGLIC ACID; ISONIAZID; LAMOTRIGINE; LIDOCAINE; MAPROTILINE; MEFENAMIC ACID; METHADONE; OLANZAPINE; QUETIAPINE; TOLPERISONE; TRAMADOL; TRIMIPRAMINE; UNINDEXED DRUG; VENLAFAXINE;

ADOLESCENT; ADULT; AGED; ARTICLE; DISEASE ASSOCIATION; DRUG ABUSE; DRUG EXPOSURE; DRUG OVERDOSE; FEMALE; HUMAN; INFANT; MAJOR CLINICAL STUDY; MALE; MEDICAL RECORD REVIEW; NEWBORN; PATIENT REFERRAL; POISON CENTER; SEIZURE; SINGLE DRUG DOSE; SUICIDE;

ADOLESCENTS; AGE-DEPENDENCY; CONVULSIONS; POISONING; SEIZURE POTENTIAL;

ADOLESCENT; ADULT; AGE FACTORS; AGED; AGED, 80 AND OVER; ANTIDEPRESSIVE AGENTS; CHILD; CHILD, PRESCHOOL; CITALOPRAM; CYCLOHEXANOLS; DRUG OVERDOSE; FEMALE; HUMANS; INFANT; MALE; MEFENAMIC ACID; MIDDLE AGED; POISON CONTROL CENTERS; RETROSPECTIVE STUDIES; SEIZURES; SWITZERLAND; TRIMIPRAMINE; YOUNG ADULT;

EID: 84903183365     PISSN: 15563650     EISSN: 15569519     Source Type: Journal    
DOI: 10.3109/15563650.2014.918627     Document Type: Article

References (41)

1. Beleza P. Acute symptomatic seizures: A clinically oriented review. Neurologist 2012; 18: 109-119.
2. Messing RO, Closson RG, Simon RP. Drug-induced seizures: A 10-year experience. Neurology 1984; 34: 1582-1586. (Pubitemid 15220506)
3. Pesola GR, Avasarala J. Bupropion seizure proportion among new-onset generalized seizures and drug related seizures presenting to an emergency department. J Emerg Med 2002; 22: 235-239. (Pubitemid 34257987)
4. Thundiyil JG, Rowley F, Papa L, Olson KR, Kearney TE. Risk factors for complications of drug-induced seizures. J Med Toxicol 2011; 7: 16-23.
5. Wills B, Erickson T. Chemically induced seizures. Clin Lab Med 2006; 26: 185-209.
6. Finkelstein Y, Hutson JR, Freedman SB, Wax P, Brent J. Drug-induced seizures in children and adolescents presenting for emergency care: Current and emerging trends. Clin Toxicol (Phila) 2013; 51: 761-766.
7. Citak A, Soysal DD, Ucsel R, Karabocuoglu M, Uzel N. Seizures associated with poisoning in children: Tricyclic antidepressant intoxication . Pediatr Int 2006; 48: 582-585. (Pubitemid 44813406)
8. Nitescu VG, Ulmeanu AI, Vivisenco IC, Babaca D, Ulmeanu CE. Seizures in acute poisoning in children-5 year study. Clin Toxicol 2010; 48: 248.
9. Kirschner RI, Cimikoski WJ, Squillante CM, Donovan JW. Drugs associated with seizure in patients admitted to a toxicology treatment center. Clin Toxicol 2008; 46: 600.
10. Thundiyil JG, Kearney TE, Olson KR. Evolving epidemiology of drug-induced seizures reported to a Poison Control Center System. J Med Toxicol 2007; 3: 15-19.
11. Olson KR, Kearney TE, Dyer JE, Benowitz NL, Blanc PD. Seizures associated with poisoning and drug overdose. Am J Emerg Med 1994; 12: 392-395.
12. Wilson EB. Probable inference, the law of succession, and statistical inference. J Am Stat Assoc 1927; 22: 209-12.
13. Agresti A, Coull BA. Approximate is better than " exact " for interval estimation of binomial proportions. Am Stat 1998; 52: 119-126.
14. Brown LD, Cai TT, DasGupta A, Agresti A, Coull B, Casella, et al. Interval estimation for a binomial proportion-comment-rejoinder. Stat Sci 2001; 16: 101-33. (Pubitemid 33636344)
15. R Development Core Team. R: A language and environment for statistical computing. R Foundation for Statistical Computing V, Austria; 2008. ISBN 3-900051-07-0, Available at: Http://www.R-project.org [Accessed on 8 January 2013].
16. Judge BS, Rentmeester LL. Antidepressant overdose-induced seizures. Neurol Clin 2011; 29: 565-580.
17. Balali-Mood M, Critchley JA, Proudfoot AT, Prescott LF. Mefenamic acid overdosage. Lancet 1981; 1: 1354-1356. (Pubitemid 11114491)
18. Belson MG, Kelley TR. Bupropion exposures: Clinical manifestations and medical outcome. J Emerg Med 2002; 23: 223-230. (Pubitemid 35300241)
19. Kumar VVP, Isbister GK, Duffull SB. The effect of decontamination procedures on the pharmacodynamics of venlafaxine in overdose. Br J Clin Pharmacol 2011; 72: 125-132.
20. White N, Litovitz T, Clancy C. Suicidal antidepressant overdoses: A comparative analysis by antidepressant type. J Med Toxicol 2008; 4: 238-250.
21. Y ilmaz Z, C eschi A, R auber-Luethy C, S auer O, S tedtler U, Prasa D, et al. Escitalopram causes fewer seizures in human overdose than citalopram. Clin Toxicol 2010; 48: 207-212.
22. Balit CR, Lynch CN, Isbister GK. Bupropion poisoning: A case series. Med J Aust 2003; 178: 61-63. (Pubitemid 36187621)
23. Serena-Zach S. Acute maprotiline intoxication: Symptomes, doseeffect relationship and decontamination [MD Thesis]. University of Z ü rich, Switzerland; 1993. Available at: Http://www.toxi.ch/upload/ pdf/Diss-Serena- 1993.pdf. Accessed on 30 January 2014.
24. Chan AN, Gunja N, Ryan CJ. A comparison of venlafaxine and SSRIs in deliberate self-poisoning. J Med Toxicol 2010; 6: 116-121.
25. Colbridge MG, Volans GN. Venlafaxine in overdose-experience of the national poisons information service (London Centre). J Toxicol Clin Toxicol 1999; 37: 383.
26. Kelly CA, Dhaun N, Laing WJ, Strachan FE, Good AM, Bateman DN. Comparative toxicity of citalopram and the newer antidepressants after overdose. J Toxicol Clin Toxicol 2004; 42: 67-71. (Pubitemid 38450941)
27. W hyte I M, D awson A H, B uckley N A. R elative toxicity of venlafaxine and selective serotonin reuptake inhibitors in overdose compared to tricyclic antidepressants. QJM 2003; 96: 369-374.
28. Hayes BD, Klein-Schwartz W, Clark RF, Muller AA, Miloradovich JE. Comparison of toxicity of acute overdoses with citalopram and escitalopram . J Emerg Med 2010; 39: 44-48.
29. Personne M, Persson H, Sjoberg E. Citalopram toxicity. Lancet 1997; 350: 518-519.
30. Waring WS, Gray JA, Graham A. Predictive factors for generalized seizures after deliberate citalopram overdose. Br J Clin Pharmacol 2008; 66: 861-865.
31. Court H, Volans GN. Poisoning after overdose with non-steroidal anti-infl ammatory drugs. Adverse Drug React Acute Poisoning Rev 1984; 3: 1-21. (Pubitemid 14132347)
32. Graf BC. Die akute Intoxikation mit Ponstan → [MD Thesis]. University of Z ü rich, Switzerland; 1994.
33. Laredo PB. Die akute Intoxikation mit Ponstan [MD Thesis]. University of Z ü rich, Switzerland; 2007. Available at: Http://www. toxi.ch/upload/pdf/ Laredo-Mefenaminsaeure-2007.pdf. Accessed on 30 January 2014.
34. Montgomery SA. Antidepressants and seizures: Emphasis on newer agents and clinical implications. Int J Clin Pract 2005; 59: 1435-1440. (Pubitemid 43922631)
35. Jain R, Balhara YP. Impact of alcohol and substance abuse on adolescent brain: A preclinical perspective. Indian J Physiol Pharmacol 2010; 54: 213-234.
36. Priel MR, dos Santos NF, Cavalheiro EA. Developmental aspects of the pilocarpine model of epilepsy. Epilepsy Res 1996; 26: 115-121.
37. Singleton MW, Holbert WH II, Ryan ML, Lee AT, Kurz JE, Churn SB. Age dependence of pilocarpine-induced status epilepticus and inhibition of CaM kinase II activity in the rat. Brain Res Dev Brain Res 2005; 156: 67-77. (Pubitemid 40603282)
38. Forsgren L, Beghi E, Oun A, Sillanpaa M. The epidemiology of epilepsy in Europe-A systematic review. Eur J Neurol 2005; 12: 245-253. (Pubitemid 40477131)
39. G utscher K, R auber-Luthy C, H aller M, B raun M, K upferschmidt H, Kullak-Ublick GA, Ceschi A. Patterns of toxicity and factors influencing severity in acute adult trimipramine poisoning. Br J Clin Pharmacol 2013; 75: 227-235.
40. Sharma AN, Hoffman RJ. Toxin-related seizures. Emerg Med Clin North Am 2011; 29: 125-139.
41. Hoffman RS. Understanding the limitations of retrospective analyses of poison center data. Clin Toxicol 2007; 45: 943-945.