Patterns of toxicity and factors influencing severity in acute adult trimipramine poisoning

British Journal of Clinical Pharmacology

Volumn 75, Issue 1, 2013, Pages 227-235

  Gutscher, Karen ^a   Rauber Lüthy, Christine ^a   Haller, Marina ^a   Braun, Michèle ^b   Kupferschmidt, Hugo ^a   Kullak Ublick, Gerd A ^c   Ceschi, Alessandro ^a,c  

^a UNIVERSITY OF ZURICH   (Switzerland)

^b UNIVERSITY OF BERN   (Switzerland)

^c UNIVERSITY HOSPITAL ZURICH   (Switzerland)

Author keywords

Decontamination; Overdose; Poisoning; Toxic dose; Tricyclic antidepressants

Indexed keywords

TRIMIPRAMINE;

ADULT; ARTICLE; CLINICAL FEATURE; DEPRESSION; DISEASE SEVERITY; DRUG INTOXICATION; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; QT PROLONGATION; SHOCK; SUICIDE; SUICIDE ATTEMPT; TACHYCARDIA;

ACUTE DISEASE; ADOLESCENT; ADULT; AGED; ANTIDEPRESSIVE AGENTS, TRICYCLIC; DRUG OVERDOSE; FEMALE; HUMANS; MALE; MIDDLE AGED; TRIMIPRAMINE;

EID: 84871156639     PISSN: 03065251     EISSN: 13652125     Source Type: Journal    
DOI: 10.1111/j.1365-2125.2012.04344.x     Document Type: Article

References (26)

1. Lapierre YD. A review of trimipramine - 30 years of clinical use. Drugs 1989; 38: 17-24.
2. Gastpar M. Clinical originality and new biology of trimipramine. Drugs 1989; 38: 43-8.
3. Pecknold JC, Luthe L. Trimipramine, anxiety, depression and sleep. Drugs 1989; 38: 25-31.
4. Settle EC, Ayd FJ. Trimipramine: twenty years' worldwide clinical experience. J Clin Psychiatry 1980; 41: 266-74.
5. Cohn JB, Wilcox CS, Goodman LI. Antidepressant efficacy and cardiac safety of trimipramine in patients with mild heart disease. Clin Ther 1993; 15: 114-26.
6. Gross G, Xin X, Gastpar M. Trimipramine: pharmacological reevaluation and comparison with clozapine. Neuropharmacology 1991; 30: 1159-66.
7. Michel K, Arestegui G, Spuhler T. Suicide with psychotropic drugs in Switzerland. Pharmacopsychiatry 1994; 27: 114-8.
8. Drasch G, Dahlmann F, von Meyer L, Roider G, Eisenmenger W. Frequency of different anti-depressants associated with suicides and drug deaths. Int J Legal Med 2008; 122: 115-21.
9. Woolf AD, Erdman AR, Nelson LS, Caravati EM, Cobaugh DJ, Booze LL, Wax PM, Manoguerra AS, Scharman EJ, Olson KR, Chyka PA, Christianson G, Troutman WG. Tricyclic antidepressant poisoning: an evidence-based consensus guideline for out-of-hospital management. Clin Toxicol (Phila) 2007; 45: 203-33.
10. Cassidy S, Henry J. Fatal toxicity of antidepressant drugs in overdose. BMJ 1987; 295: 1021-4.
11. Serafimovski N, Thorball N, Asmussen I, Lunding M. Tricyclic antidepressive poisoning with special reference to cardiac complications. Acta Anaesthesiol Scand 1975; 57: 55-63.
12. Malmvik J, Löwenhielm CGP, Melander A. Antidepressants in suicide: differences in fatality and drug utilisation. Eur J Clin Pharmacol 1994; 46: 291-4.
13. Druid H, Holmgren P. Fatal seizures associated with trimipramine poisoning. Forensic Sci Int 1991; 49: 75-9.
14. Musshoff F, Schmidt P, Madea B. Fatality caused by a combined trimipramine-citalopram intoxication. Forensic Sci Int 1999; 106: 125-31.
15. Liechti ME, Kupferschmidt H. Gamma-hydroxybutyrate (GHB) and gamma-butyrolactone (GBL): analysis of overdose cases reported to the Swiss Toxicological Information Centre. Swiss Med Wkly 2004; 134: 534-7.
16. Karch FE, Lasagna L. Toward the operational identification of adverse drug reactions. Clin Pharmacol Ther 1977; 21: 247-54.
17. Persson HE, Sjöberg GK, Haines JA, Pronczuk de Garbino J. Poisoning severity score. Grading of acute poisoning. J Toxicol Clin Toxicol 1998; 36: 205-13.
18. Friberg LE, Isbister GK, Hackett LP, Duffull SB. The population pharmacokinetics of citalopram after deliberate self-poisoning: a Bayesian approach. J Pharmacokinet Pharmacodyn 2005; 32: 571-605.
19. Isbister GK, Balit CR, Macleod D, Duffull SB. Amisulpride overdose is frequently associated with QT prolongation and torsades de pointes. J Clin Psychopharmacol 2010; 30: 391-5.
20. Isbister GK, Friberg LE, Hackett LP, Duffull SB. Pharmacokinetics of quetiapine in overdose and the effect of activated charcoal. Clin Pharmacol Ther 2007; 81: 821-7.
21. Baca-Garcia E, Perez-Rodriguez MM, Mann JJ, Oquendo MA. Suicidal behavior in young women. Psychiatr Clin North Am 2008; 31: 317-31.
22. Buckley NA, Dawson AH, Whyte IM, Hazell P, Meza A, Britt H. An analysis of age and gender influences on the relative risk for suicide and psychotropic drug self-poisoning. Acta Psychiatr Scand 1996; 93: 168-71.
23. Kerr GW, McGuffie AC, Wilkie S. Tricyclic antidepressant overdose: a review. Emerg Med J 2001; 18: 236-41.
24. Frommer DA, Kulig KW, Marx JA, Rumack B. Tricyclic antidepressant overdose - a review. JAMA 1987; 257: 521-6.
25. Chyka PA, Seger D, Krenzelok EP, Vale JA, American Academy of Clinical Toxicology, European Association of Poisons Centres and Clinical Toxicologists. Position paper: single-dose activated charcoal. Clin Toxicol (Phila) 2005; 43: 61-87.
26. Hoffman RS. Understanding the limitations of retrospective analyses of poison center data. Clin Toxicol (Phila) 2007; 45: 943-5.