A Comparison of Venlafaxine and SSRIs in Deliberate Self-poisoning

Journal of Medical Toxicology

Volumn 6, Issue 2, 2010, Pages 116-121

  Chan, Agnes N ^a,b   Gunja, Naren ^b,c,d   Ryan, Christopher J ^b,c  

^a ROYAL PRINCE ALFRED HOSPITAL   (Australia)

^b UNIVERSITY OF SYDNEY   (Australia)

^c WESTMEAD HOSPITAL   (Australia)

^d SYDNEY CHILDREN'S HOSPITAL   (Australia)

Author keywords

Overdose; Self poisoning; Serotonin reuptake inhibitors; Suicide; Venlafaxine

Indexed keywords

ALCOHOL; AMPHETAMINE; ANTICONVULSIVE AGENT; ANTIDEPRESSANT AGENT; BENZODIAZEPINE DERIVATIVE; CITALOPRAM; FLUOXETINE; FLUVOXAMINE; PAROXETINE; PROPRANOLOL; PSYCHOSTIMULANT AGENT; PSYCHOTROPIC AGENT; SEROTONIN UPTAKE INHIBITOR; SERTRALINE; VENLAFAXINE;

ADULT; ARTICLE; AUSTRALIA; CLINICAL ARTICLE; CLINICAL FEATURE; COHORT ANALYSIS; CONFUSION; CONTROLLED STUDY; DEPRESSION; DIAPHORESIS; DRUG OVERDOSE; FATALITY; FEMALE; GLASGOW COMA SCALE; HEART MUSCLE NECROSIS; HEART VENTRICLE TACHYCARDIA; HUMAN; HYPOTENSION; MALE; MYDRIASIS; PERICARDITIS; PROGNOSIS; QT INTERVAL; RETROSPECTIVE STUDY; SEIZURE; SELF POISONING; SUICIDE ATTEMPT;

ADULT; COHORT STUDIES; CYCLOHEXANOLS; ELECTROCARDIOGRAPHY; EMERGENCY MEDICAL SERVICES; FEMALE; HUMANS; INTENTION; LONG QT SYNDROME; MALE; OVERDOSE; POISON CONTROL CENTERS; RETROSPECTIVE STUDIES; SEROTONIN UPTAKE INHIBITORS; SUICIDE, ATTEMPTED; TREATMENT OUTCOME;

EID: 77956161122     PISSN: 15569039     EISSN: 19376995     Source Type: Journal    
DOI: 10.1007/s13181-010-0013-x     Document Type: Article

References (19)

1. Rudolph RL, Derivan AT (1996) The safety and tolerability of venlafaxine hydrochloride: analysis of the clinical trials database. J Clin Psychopharmacol 16(suppl 2): 54S-61S.
2. Baca-Garcia E, Diaz-Sastre C, Saiz-Ruiz J, de Leon J (2002) How safe are psychiatric medications after voluntary overdose? Eur Psychiatr 17: 466-470.
3. Buckley NA, McManus PR (2002) Fatal toxicity of serotinergic and other antidepressant drugs: analysis of UK mortality data. BMJ, Br Med J 325: 1332-1333.
4. Morgan O, Griffiths C, Baker A, Majeed A (2004) Fatal toxicity of antidepressants in England and Wales, 1993-2002. Health Stat Q 23: 18-24.
5. Cheeta S, Schifano F, Oyefeso A, Webb L, Ghodse AH (2004) Antidepressant-related deaths and antidepressant prescriptions in England and Wales, 1998-2000. Br J Psychiatry 184: 41-47.
6. Koski A, Vuori E, Ojanperä I (2005) Newer antidepressants: evaluation of fatal toxicity index and interaction with alcohol based on Finnish postmortem data. Int J Legal Med 119: 344-348.
7. Deshauer D (2007) Venlafaxine (Efexor): concerns about increased risk of fatal outcomes in overdose. Can Med Assoc J 176(1): 39-40.
8. Dunkley EJ, Isbister GK, Sibbritt D, Dawson AH, Whyte IM (2003) The Hunter Serotonin Toxicity Criteria: simple and accurate diagnostic decision rules for serotonin toxicity. Q J Med 96(9): 635-642.
9. World Health Organization Collaborating Centre for Drug Statistics Methodology (1999) ATC Index with DDDs. WHO, Oslo.
10. Chan A, Isbister GK, Kirkpatrick CMJ, Duffull SB (2007) Drug-induced QT prolongation and torsades de pointes: evaluation of a QT nomogram. Q J Med 100(10): 609-615.
11. Rubino A, Roskell N, Tennis P, Miles D, Weich S, Andrews E (2007) Risk of suicide during treatment with venlafaxine, citalopram, fluoxetine, and dothiepin: retrospective cohort study. BMJ, Br Med J 334: 242-247.
12. Whyte IM, Dawson AH, Buckley NA (2003) Relative toxicity of venlafaxine and selective serotonin reuptake inhibitors in overdose compared to tricyclic antidepressants. Q J Med 96: 369-374.
13. Kelly CA, Dhaun N, Laing WJ, Strachan FE, Good AM, Bateman DN (2004) Comparative toxicity of citalopram and the newer antidepressants after overdose. J Toxicol, Clin Toxicol 42(1): 67-71.
14. Howell C, Wilson AD, Waring WS (2007) Cardiovascular toxicity due to venlafaxine poisoning in adults: a review of 235 consecutive cases. BJCP, Br J Clin Pharmacol 64(2): 192-197.
15. Bosse GM, Spiller HA, Collins AM (2008) A fatal case of venlafaxine overdose. Journal of Medical Toxicology 4(1): 18-20.
16. Khalifa M, Daleau P, Turgeon J (1999) Mechanism of sodium channel block by venlafaxine in guinea pig ventricular myocytes. J Pharmacol Exp Ther 291(1): 280-284.
17. Isbister GK, Friberg LE, Duffull SB (2006) Application of pharmacokineticpharmacodynamic modelling in management of QT abnormalities after citalopram overdose. Intensive Care Med 32: 1060-1065.
18. Balit C, Isbister G, Hackett L (2003) Quetiapine poisoning: a case series. Emerg Med 42(6): 751-758.
19. Malik M, Camm A (2001) Evaluation of drug-induced QT interval prolongation: implications for drug approval and labelling. Drug Safety 24(323): 351.