Neuromodulation of chronic headaches: Position statement from the European Headache Federation

Journal of Headache and Pain

Volumn 14, Issue 1, 2013, Pages

  Martelletti, Paolo ^a   Jensen, Rigmor H ^b   Antal, Andrea ^c   Arcioni, Roberto ^a   Brighina, Filippo ^d   De Tommaso, Marina ^e   Franzini, Angelo ^f   Fontaine, Denys ^g   Heiland, Max ^h   Jürgens, Tim P ^h   Leone, Massimo ^f   Magis, Delphine ⁱ   Paemeleire, Koen ^j   Palmisani, Stefano ^k   Paulus, Walter ^c   May, Arne ^h  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

^c UNIVERSITY OF GÖTTINGEN   (Germany)

^d UNIVERSITY OF PALERMO   (Italy)

^e UNIVERSITY OF BARI MEDICAL SCHOOL   (Italy)

^f DEPARTMENT OF NEUROSURGERY   (Italy)

^g UNIVERSITY HOSPITAL OF NICE   (France)

^h UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

ⁱ UNIVERSITY OF LIÈGE   (Belgium)

^j GHENT UNIVERSITY HOSPITAL   (Belgium)

^k GUY'S AND ST THOMAS' NHS FOUNDATION TRUST   (United Kingdom)

more..

Author keywords

Chronic headache; Cluster headache; DBS; European headache federation; GON; Medically intractable headache; Migraine; Neurostimulation; ONS; SPG; TDCS; TENS; TMS; VNS

Indexed keywords

ARTICLE; BRAIN DEPTH STIMULATION; CERVICAL SPINAL CORD STIMULATION; CHRONIC DISEASE; EUROPE; HEALTH CARE QUALITY; HUMAN; NERVE STIMULATION; NEUROMODULATION; OCCIPITAL NERVE STIMULATION; PRIMARY HEADACHE; PRIORITY JOURNAL; REPETITIVE TRANSCRANIAL MAGNETIC STIMULATION; SPHENOPALATINE GANGLION STIMULATION; SPINAL CORD STIMULATION; TRANSCRANIAL DIRECT CURRENT STIMULATION; TRANSCUTANEOUS ELECTRICAL NERVE STIMULATION; VAGUS NERVE STIMULATION; CHRONIC PAIN; ELECTROSTIMULATION THERAPY; HEADACHE; HEADACHE DISORDERS; PRACTICE GUIDELINE; PROCEDURES; TRANSCRANIAL MAGNETIC STIMULATION;

CHRONIC PAIN; DEEP BRAIN STIMULATION; ELECTRIC STIMULATION THERAPY; HEADACHE; HEADACHE DISORDERS; HUMANS; TRANSCRANIAL MAGNETIC STIMULATION;

EID: 84903176262     PISSN: 11292369     EISSN: 11292377     Source Type: Journal    
DOI: 10.1186/1129-2377-14-86     Document Type: Article

References (160)

1. Vos T, Flaxman AD, Naghavi M, Lozano R, Michaud C, Ezzati M, Shibuya K, Salomon JA, Abdalla S, Aboyans V, Abraham J, Ackerman I, Aggarwal R, Ahn SY, Ali MK, Alvarado M, Anderson HR, Anderson LM, Andrews KG, Atkinson C, Baddour LM, Bahalim AN, Barker-Collo S, Barrero LH, Bartels DH, Basáñez MG, Baxter A, Bell ML, Benjamin EJ, Bennett D et al (2012) Years lived with disability (YLD) for 1160 sequelae of 289 diseases and injuries 1990–2010: a systematic analysis for the global burden of disease study 2010. Lancet 380:2163–2196
2. Steiner TJ, Stovner LJ, Birbeck GL (2013) Migraine: the seventh disabler. Headache Pain 14:1
3. May A, Leone M, Afra J, Linde M, Sándor PS, Evers S, Goadsby PJ, Task Force EFNS (2006) EFNS guidelines on the treatment of cluster headache and other trigeminal-autonomic cephalalgias. Eur J Neurol 13:1066–77
4. Evers S, Afra J, Frese A, Goadsby PJ, Linde M, May A, Sándor PS, European Federation of Neurological Societies (2009) EFNS guideline on the drug treatment of migraine-revised report of an EFNS task force. Eur J Neurol 16:968–981, doi: 10.1111/j.1468-1331.2009.02748.x
5. Steiner TJ, Antonaci F, Jensen R, Lainez MJ, Lanteri-Minet M, Valade D, European Headache Federation, Global Campaign against Headache (2011) Recommendations for headache service organisation and delivery in Europe. J Headache and Pain 12:419–426, doi: 10.1007/s10194-011-0320-x
6. Lionetto L, Negro A, Palmisani S, Gentile G, Del Fiore MR, Mercieri M, Simmaco M, Smith T, Al-Kaisy A, Arcioni R, Martelletti P (2012) Emerging treatment for chronic migraine and refractory chronic migraine. Expert Opin Emerg Drugs 17:393–406
7. Negro A, Martelletti P (2011) Chronic migraine plus medication overuse headache: two entities or not? J Headache Pain 12:593–601
8. Schulman EA, Peterlin BL, Lake AE 3rd, Lipton RB, Hanlon A, Siegel S, Levin M, Goadsby PJ, Markley HG (2009) Defining Refractory Migraine: results of the RHSIS Survey of American Headache Society Members. Headache 49:509–518
9. May A (2005) Cluster headache: pathogenesis, diagnosis, and management. Lancet 366:843–55
10. Goadsby PJ, Schoenen J, Ferrari MD, Silberstein SD, Dodick D (2006) Towards a definition of intractable headache for use in clinical practice and trials. Cephalalgia 26:1168–70
11. Matharu MS, Goadsby PJ (2002) Persistence of attacks of cluster headache after trigeminal nerve root section. Brain 125:976–984
12. Black D, Dodick DW (2002) Two cases of medically and surgically intractable SUNCT: a reason for caution and argument for a central mechanism. Cephalalgia 3:201–204
13. Jarrar RG, Black DF, Dodick DW, Davis DH (2003) Outcome of trigeminal nerve section in the treatment of chronic cluster headache. Neurology 60:1360–1362
14. Donnet A, Valade D, Regis J (2005) Gamma knife treatment for refractory cluster headache: a prospective open trial. J Neurol Neurosurg Psychiatry 76:218–221
15. Schoenen J, Jensen RH, Lantéri-Minet M, Láinez MJ, Gaul C, Goodman AM et al (2013) Stimulation of the sphenopalatine ganglion (SPG) for cluster headache treatment. Pathway CH-1: A randomized, sham-controlled study. Cephalalgia: doi: 10.1177/0333102412473667
16. Pedersen JL, Barloese M, Jensen RH (2013) Neurostimulation in cluster headache: A review of current progress. Cephalalgia: [Epub ahead of print] doi: 10.1177/0333102413489040
17. Leone M, May A, Franzini A, Broggi G, Dodick D, Rapoport A, Goadsby PJ, Schoenen J, Bonavita V, Bussone G (2004) Deep brain stimulation for intractable chronic cluster headache: proposals for patient selection. Cephalalgia 24:934–7
18. May A, Bahra A, Büchel C, Frackowiak RSJ, Goadsby PJ (1998) Hypothalamic activation in cluster headache attacks. Lancet 352:275–78
19. May A, Ashburner J, Buchel C et al (1999) Correlation between structural and functional changes in brain in an idiopathic headache syndrome. Nat Med 5:836–38
20. Leone M, Franzini A, Bussone G (2001) Stereotactic stimulation of posterior hypothalamic gray matter in a patient with intractable cluster headache. N Engl J Med 345:1428–29
21. Schoenen J, Di Clemente L, Vandenheede M et al (2005) Hypothalamic stimulation in chronic cluster headache: a pilot study of efficacy and mode of action. Brain 128:940–47
22. Leone M, Franzini A, Broggi G, Bussone G (2006) Hypothalamic stimulation for intractable cluster headache: long-term experience. Neurology 67:150–52
23. D’Andrea G, Nordera G, Piacentino M (2006) Effectiveness of hypothalamic stimulation in two patients affected by intractable chronic cluster headache. Neurology 66(suppl 2):A140, abstr
24. Benabid A, Seigneuret E, Torres N (2006) Intraventricular stimulation for targets close to the midline: periaqueductal gray, posterior hypothalamus, anterior hypothalamus, subcommissural structures. Acta Neurochir 148:1–64, abstr
25. Starr PA, Barbaro NM, Raskin NH, Ostrem JL (2007) Chronic stimulation of the posterior hypothalamic region for cluster headache: technique and 1-year results in four patients. J Neurosurg 106:999–1005
26. Owen SL, Green AL, Davies P et al (2007) Connectivity of an effective hypothalamic surgical target for cluster headache. J Clin Neurosci 14(10):955–60
27. Black D, Bartleson J, Torgrimson S, Davis D (2007) Two cases of chronic cluster headache treated successfully with hypothalamic deep brain stimulation. Neurology (abstract) 68(1):A307
28. Mateos V, Seijo F, Lozano B et al (2007) Deep brain stimulation in chronic refractory headaches: first national cases. Neurologia (abstract) 22:96
29. Bartsch T, Pinsker MO, Rasche D et al (2008) Hypothalamic deep brain stimulation for cluster headache: experience from a new multicase series. Cephalalgia 28:285–95
30. Fontaine D, Lazorthes Y, Mertens P et al (2010) Safety and efficacy of deep brain stimulation in refractory cluster headache: a randomized placebo-controlled double-blind trial followed by a 1-year open extension. J Headache Pain 11:23–31
31. Hidding U, May A (2011) Mere surgery will not cure cluster headache: implications for neurostimulation. Cephalalgia 31:112–15
32. Seijo F, Saiz A, Lozano B et al (2011) Neuromodulation of the posterolateral hypothalamus for the treatment of chronic refractory cluster headache: experience in five patients with a modified anatomical target. Cephalalgia 31:1634–41
33. Leone M, Franzini A, Proietti Cecchini A, Bussone G (2013) Success, failure, and putative mechanisms in hypothalamic stimulation for drug-resistant chronic cluster headache. Pain 154:89–94
34. Leone M, Franzini A, D’Andrea G, Broggi G, Casucci G, Bussone G (2005) Deep brain stimulation to relieve drug-resistant SUNCT. Ann Neurol 57:924–27
35. Lyons MK, Dodick DW, Evidente VG (2009) Responsiveness of short-lasting unilateral neuralgiform headache with conjunctival injection and tearing to hypothalamic deep brain stimulation. J Neurosurg 110:279–81
36. Bartsch T, Falk D, Knudsen K et al (2011) Deep brain stimulation of the posterior hypothalamic area in intractable short-lasting unilateral neuralgiform headache with conjunctival injection and tearing (SUNCT). Cephalalgia 31:1405–08
37. Walcott BP, Bamber NI, Anderson DE (2009) Successful treatment of chronic paroxysmal hemicrania with posterior hypothalamic stimulation: technical case report. Neurosurgery 65:E997
38. Headache classification subcommittee of the International Headache Society (2004) The International Classification of Headache Disorders, 2nd edn. Cephalalgia 24(suppl 1):9–160
39. Leone M, Franzini A, Broggi G, Mea E, Cecchini AP, Bussone G (2006) Acute hypothalamic stimulation and ongoing cluster headache attacks. Neurology 67:1844–45
40. The deep-brain stimulation for Parkinson’s disease group (2001) Deep-brain stimulation on the subthalamic nucleus or pars interna of the globus pallidus in Parkinson’s disease. N Engl J Med 345:956–96335
41. Fontaine D, Lanteri-Minet M, Ouchchane L et al (2010) Anatomical location of effective deep brain stimulation electrodes in chronic cluster headache. Brain 133:1214–23
42. Maniyar FH, Starr P, Goadsby PJ (2012) Paroxysmal sneezing after hypothalamic deep brain stimulation for cluster headache. Cephalalgia 32(8):641–644
43. Cortelli P, Guaraldi P, Leone M et al (2007) Effect of deep brain stimulation of the posterior hypothalamic area on the cardiovascular system in chronic cluster headache patients. Eur J Neurol 14:1008–1536
44. Vetrugno R, Pierangeli G, Leone M et al (2007) Effect on sleep of posterior hypothalamus stimulation in cluster headache. Headache 47:1085–90
45. Jürgens T, Leone M, Proietti-Cecchini A et al (2009) Hypothalamic deep-brain stimulation modulates thermal sensitivity and pain thresholds in cluster headache. Pain 146:84–90
46. May A, Leone M, Boecker H et al (2006) Hypothalamic deep brain stimulation in positron emission tomography. J Neurosci 26:3589–93
47. May A (2008) Chronic pain may change the structure of the brain. Pain 137:7–15
48. Zhuo M (2008) Cortical excitation and chronic pain. Trends Neurosci 31:199–207
49. Bartsch T, Goadsby PJ (2002) Stimulation of the greater occipital nerve induces increased central excitability of dural afferent input. Brain 125:1496–509
50. Bartsch T, Goadsby PJ (2003) Increased responses in trigeminocervical nociceptive neurons to cervical input after stimulation of the dura mater. Brain 126:1801–13
51. Anthony M (1992) Headache and the greater occipital nerve. Clinical neurology and neurosurgery 94:297–301
52. Ambrosini A, Vandenheede M, Rossi P, Aloj F, Sauli E, Pierelli F et al (2005) Suboccipital injection with a mixture of rapid- and long-acting steroids in cluster headache: a double-blind placebo-controlled study. Pain 118:92–6
53. Afridi SK, Shields KG, Bhola R, Goadsby PJ (2006) Greater occipital nerve injection in primary headache syndromes–prolonged effects from a single injection. Pain 122:126–9
54. Weiner RL, Reed KL (1999) Peripheral neurostimulation for control of intractable occipital neuralgia. Neuromodulation 2:217–22
55. Lipton R, Goadsby P, Cady R, Aurora SK, Grosberg B, Freitag F et al (2009) PRISM study: occipital nerve stimulation for treatment-refractory migraine. Cephalalgia 29:30
56. Saper JR, Dodick DW, Silberstein SD, McCarville S, Sun M, Goadsby PJ (2011) Occipital nerve stimulation for the treatment of intractable chronic migraine headache: ONSTIM feasibility study. Cephalalgia 31:271–85
57. Silberstein S, Dodick D, Saper J, Huh B, Slavin KV, Sharan A et al (2012) Safety and efficacy of peripheral nerve stimulation of the occipital nerves for the management of chronic migraine: Results from a randomized, multicenter, double-blinded, controlled study. Cephalalgia 32(16):1165–79
58. Magis D, Schoenen J (2012) Advances and challenges in neurostimulation for headaches. Lancet Neurol 11:708–19
59. Reed KL, Black SB, Banta CJ 2nd, Will KR (2010) Combined occipital and supraorbital neurostimulation for the treatment of chronic migraine headaches: initial experience. Cephalalgia 30:260–71
60. Burns B, Watkins L, Goadsby PJ (2009) Treatment of intractable chronic cluster headache by occipital nerve stimulation in 14 patients. Neurology 72:341–5
61. Magis D, Gerardy PY, Remacle JM, Schoenen J (2011) Sustained effectiveness of occipital nerve stimulation in drug-resistant chronic cluster headache. Headache 51:1191–201
62. Magis D, Allena M, Bolla M, De Pasqua V, Remacle JM, Schoenen J (2007) Occipital nerve stimulation for drug-resistant chronic cluster headache: a prospective pilot study. Lancet Neurol 6:314–21
63. Fontaine D, Christophe Sol J, Raoul S, Fabre N, Geraud G, Magne C et al (2011) Treatment of refractory chronic cluster headache by chronic occipital nerve stimulation. Cephalalgia 31:1101–5
64. Burns B, Watkins L, Goadsby PJ (2008) Treatment of hemicrania continua by occipital nerve stimulation with a bion device: long-term follow-up of a crossover study. Lancet Neurol 7:1001–12
65. Marin JC, Goadsby P (2010) Response of SUNCT (Short-Lasting Unilateral Neuralgiform Headaches with Conjunctival Injection and Tearing), SUNA (Short-LAsting Unilateral Neuralgifom Headaches with Autonomic Symptoms) and Primary Stabbing Headaches to Occipital Nerve Stimulation (ONS). Neurology 74:P04.006, abstract
66. Shanahan P, Watkins L, Matharu M (2009) Treatment of medically intractable short- lasting unilateral neuralgiform headache attacks with conjunctival injection and tearing (SUNCT) and short-lasting unilateral neuralgiform headache attacks with autonomic symptoms (SUNA) with occipital nerve stimulation (ONS) in 6 patients. Cephalalgia 29:150
67. Magis D, Bruno MA, Fumal A, Gerardy PY, Hustinx R, Laureys S et al (2011) Central modulation in cluster headache patients treated with occipital nerve stimulation: an FDG-PET study. BMC Neurol 11:25
68. Matharu MS, Bartsch T, Ward N, Frackowiak RS, Weiner R, Goadsby PJ (2004) Central neuromodulation in chronic migraine patients with suboccipital stimulators: a PET study. Brain 127:220–30
69. Natsis K, Baraliakos X, Appell HJ, Tsikaras P, Gigis I, Koebke J (2006) The course of the greater occipital nerve in the suboccipital region: a proposal for setting landmarks for local anesthesia in patients with occipital neuralgia. Clinical anatomy 19:332–6
70. Paemeleire K, Van Buyten JP, Van Buynder M, Alicino D, Van Maele G, Smet I et al (2010) Phenotype of patients responsive to occipital nerve stimulation for refractory head pain. Cephalalgia 30:662–73
71. May A (2003) Headaches with (ipsilateral) autonomic symptoms. J Neurol 250:1273–8
72. Devoghel JC (1981) Cluster headache and sphenopalatine block. Acta Anaesthesiol Belg 32:101–7
73. Felisati G, Arnone F, Lozza P, Leone M, Curone M, Bussone G (2006) Sphenopalatine endoscopic ganglion block: a revision of a traditional technique for cluster headache. Laryngoscope 116:1447–50
74. Narouze S, Kapural L, Casanova J, Mekhail N (2009) Sphenopalatine ganglion radiofrequency ablation for the management of chronic cluster headache. Headache 49:571–7
75. Ruskell GL (2003) Orbital passage of pterygopalatine ganglion efferents to paranasal sinuses and nasal mucosa in man. Cells Tissues Organs 175:223–28
76. Oomen KP, Van Wijck AJ, Hordijk GJ, De Ru JA (2012) Effects of radiofrequency thermocoagulation of the sphenopalatine ganglion on headache and facial pain: correlation with diagnosis. J Orofac Pain 26:59–64
77. Narouze SN (2010) Role of sphenopalatine ganglion neuroablation in the management of cluster headache. Curr Pain Headache Rep 14:160–3
78. Sanders M, Zuurmond WW (1997) Efficacy of sphenopalatine ganglion blockade in 66 patients suffering from cluster headache: a 12- to 70-month follow-up evaluation. J Neurosurg 87:876–80
79. Blumenfeld A, Ashkenazi A, Napchan U, Bender SD, Klein BC, Berliner R et al (2013) Expert Consensus Recommendations for the Performance of Peripheral Nerve Blocks for Headaches - A Narrative Review. Headache 53:437–46
80. Ansarinia M, Rezai A, Tepper SJ, Steiner CP, Stump J, Stanton-Hicks M et al (2010) Electrical stimulation of sphenopalatine ganglion for acute treatment of cluster headaches. Headache 50:1164–74
81. Tepper SJ, Rezai A, Narouze S, Steiner C, Mohajer P, Ansarinia M (2009) Acute treatment of intractable migraine with sphenopalatine ganglion electrical stimulation. Headache 49:983–9
82. Schytz HW, Barløse M, Guo S, Selb J, Caparso A, Jensen R et al (2013) Experimental activation of the sphenopalatine ganglion provokes cluster-like attacks in humans. Cephalalgia
83. Ammons WS, Blair RW, Foreman RD (1983) Vagal afferent inhibition of primate thoracic spinothalamic neurons. J Neurophysiol 50:926–940
84. Thies R, Foreman RD (1983) Inhibition and excitation of thoracic spinoreticular neurons by electrical stimulation of vagal afferent nerves. Exp Neurol 82:1–16
85. Maixner W, Randich A (1984) Role of the right vagal nerve trunk in antinociception. Brain Res 298:374–377
86. Ren K, Randich A, Gebhart GF (1989) Vagal afferent modulation of spinal nociceptive transmission in the rat. J Neurophysiol 62:401–415
87. Randich A, Ren K, Gebhart GF (1990) Electrical stimulation of cervical vagal afferents. II. Central relays for behavioral antinociception and arterial blood pressure decreases. J Neurophysiol 64:1115–1124
88. Chandler MJ, Hobbs SF, Bolser DC, Foreman RD (1991) Effects of vagal afferent stimulation on cervical spinothalamic tract neurons in monkeys. Pain 44:81–87
89. Aicher SA, Lewis SJ, Randich A (1991) Antinociception produced by electrical stimulation of vagal afferents: independence of cervical and subdiaphragmatic branches. Brain Res 542:63–70
90. Thurston CL, Randich A (1991) Quantitative characterization and spinal substrates of antinociception produced by electrical stimulation of the subdiaphragmatic vagus in rats. Pain 44:201–209
91. Thurston CL, Randich A (1992) Effects of vagal afferent stimulation on ON and OFF cells in the rostroventral medulla: Relationships to nociception and arterial blood pressure. J Neurophysiol 67:180–196
92. Rutecki P (1990) Anatomical, physiological, and theoretical basis for the antiepileptic effect of vagus nerve stimulation. Epilepsia 31(Suppl 2):S1–6
93. Bossut DF, Maixner W (1996) Effects of cardiac vagal afferent electrostimulation on the response of trigeminal and trigeminothalamic neurons to noxious orofacial stimulation. Pain 65:101–109
94. Evans AR, Jones SL, Blair RW (1994) Effects of vagal afferent nerve stimulation on noxious heat-evoked Fos-like immunoreactivity in the rat lumbar spinal cord. J Comp Neurol 22:490–498
95. Nishikawa Y, Koyama N, Yoshida Y, Yokota T (1999) Activation of ascending antinociceptive system by vagal afferent input as revealed in the nucleus ventralis posteromedialis. Brain Res 833:108–111
96. Hord ED, Evans MS, Mueed S, Adamolekun B, Naritoku DK (2003) The effect of vagus nerve stimulation on migraines. J Pain 4:530–534
97. Lenaerts ME, Oommen KJ, Couch JR, Skaggs V (2008) Can vagus nerve stimulation help migraine? Cephalalgia 28:392–395
98. Mauskop A (2005) Vagus nerve stimulation relieves chronic refractory migraine and cluster headaches. Cephalalgia 25:82–86
99. Ventureyra EC (2000) Transcutaneous vagus nerve stimulation for partial onset seizure therapy. A new concept. Childs Nerv Syst 16:101–102
100. Fallgatter AJ, Neuhauser B, Herrmann MJ, Ehlis AC, Wagener A, Scheuerpflug P, Reiners K, Riederer P (2003) Far field potentials from the brain stem after transcutaneous vagus nerve stimulation. J Neural Transm 110(12):1437–1443
101. Fallgatter AJ, Ehlis AC, Ringel TM, Herrmann MJ (2005) Age effect on far field potentials from the brain stem after transcutaneous vagus nerve stimulation. Int J Psychophysiol 56(1):37–43
102. Nesbitt AD, Marin JCA, Tomkins E, Ruttledge MH, Goadsby PJ (2013) Non-invasive vagus nerve stimulation for the treatment of cluster headache: a case series. J Headache Pain 1(Suppl 1):P231
103. Magis D, Gérard P, Schoenen J (2013) Transcutaneous Vagus Nerve Stimulation (tVNS) for headache prophylaxis: initial experience. J Headache Pain 1(Suppl 1):P198
104. Nitsche MA, Paulus W (2011) Transcranial direct current stimulation update 2011. Restor Neurol Neurosci 29:463–492
105. Antal A, Paulus W, Nitsche MA (2011) Electrical stimulation and visual network plasticity. Restor Neurol Neurosci 29:365–374
106. Bindman LJ, Lippold OC, Redfearn JW (1964) The Action of Brief Polarizing Currents on the Cerebral Cortex of the Rat (1) during Current Flow and (2) in the Production of Long-Lasting after-Effects. J Physiol 172:369–382
107. Bohotin V, Fumal A, Vandenheede M, Gerard P, Bohotin C, Maertens de Noordhout A, Schoenen J (2002) Effects of repetitive transcranial magnetic stimulation on visual evoked potentials in migraine. Brain 125:912–922
108. Brunoni AR, Amadera J, Berbel B, Volz MS, Rizzerio BG, Fregni F (2011) A systematic review on reporting and assessment of adverse effects associated with transcranial direct current stimulation. Int J Neuropsychopharmacol 14:1133–1145
109. Creutzfeldt OD, Fromm GH, Kapp H (1962) Influence of transcortical d-c currents on cortical neuronal activity. Exp Neurol 5:436–452
110. Nitsche MA, Paulus W (2000) Excitability changes induced in the human motor cortex by weak transcranial direct current stimulation. J Physiol 527(Pt 3):633–639
111. Nitsche MA, Paulus W (2001) Sustained excitability elevations induced by transcranial DC motor cortex stimulation in humans. Neurology 57:1899–1901
112. Liebetanz D, Nitsche MA, Tergau F, Paulus W (2002) Pharmacological approach to the mechanisms of transcranial DC-stimulation-induced after-effects of human motor cortex excitability. Brain 125:2238–2247
113. Antal A, Paulus W (2011) A case of refractory orofacial pain treated by transcranial direct current stimulation applied over hand motor area in combination with NMDA agonist drug intake. Brain Stimul 4:117–121
114. Antal A, Kriener N, Lang N, Boros K, Paulus W (2011) Cathodal transcranial direct current stimulation of the visual cortex in the prophylactic treatment of migraine. Cephalalgia 31:820–828
115. Auvichayapat P, Janyacharoen T, Rotenberg A, Tiamkao S, Krisanaprakornkit T, Sinawat S, Punjaruk W, Thinkhamrop B, Auvichayapat N (2012) Migraine prophylaxis by anodal transcranial direct current stimulation, a randomized, placebo-controlled trial. J Med Assoc Thai 95:1003–1012
116. Dasilva AF, Mendonca ME, Zaghi S, Lopes M, Dossantos MF, Spierings EL, Bajwa Z, Datta A, Bikson M, Fregni F (2012) tDCS-induced analgesia and electrical fields in pain-related neural networks in chronic migraine. Headache 52:1283–1295
117. Priori A, Hallett M, Rothwell JC (2009) Repetitive transcranial magnetic stimulation or transcranial direct current stimulation? Brain Stimul 2:241–245
118. Poreisz C, Boros K, Antal A, Paulus W (2007) Safety aspects of transcranial direct current stimulation concerning healthy subjects and patients. Brain Res Bull 72:208–214
119. Ambrus GG, Al-Moyed H, Chaieb L, Sarp L, Antal A, Paulus W (2012) The fade-in–short stimulation–fade out approach to sham tDCS–reliable at 1 mA for naive and experienced subjects, but not investigators. Brain Stimul 5:499–504
120. Nitsche MA, Fricke K, Henschke U, Schlitterlau A, Liebetanz D, Lang N, Henning S, Tergau F, Paulus W (2003) Pharmacological modulation of cortical excitability shifts induced by transcranial direct current stimulation in humans. J Physiol 553:293–301
121. Nitsche MA, Grundey J, Liebetanz D, Lang N, Tergau F, Paulus W (2004) Catecholaminergic consolidation of motor cortical neuroplasticity in humans. Cereb Cortex 14:1240–1245
122. Nitsche MA, Liebetanz D, Lang N, Antal A, Tergau F, Paulus W (2003) Safety criteria for transcranial direct current stimulation (tDCS) in humans. Clinical neurophysiology: official journal of the International Federation of Clinical Neurophysiology 114:2220–2222, author reply 2222–2223
123. Barker AT, Jalinous R, Freeston IL (1985) Non-invasive magnetic stimulation of human motor cortex. Lancet 1:1106–7
124. Thickbroom GW (2007) Transcranial magnetic stimulation and synaptic plasticity: experimental framework and human models. Exp Brain Res 180:583–93
125. Martens JW, Koehler PJ, Vijselaar J (2013) Magnetic flimmers: 'light in the electromagnetic darkness'. Brain 136:971–9
126. Coppola G, Pierelli F, Schoenen J (2007) Is the cerebral cortex hyperexcitable or hyperresponsive in migraine? Cephalalgia 27:1427–39
127. Siniatchkin M, Sendacki M, Moeller F et al (2012) Abnormal changes of synaptic excitability in migraine with aura. Cereb Cortex 22:2207–16
128. Brighina F, Palermo A, Fierro B (2009) Cortical inhibition and habituation to evoked potentials: relevance for pathophysiology of migraine. J Headache Pain 10:77–84
129. Bernstein C, Burstein R (2012) Sensitization of the trigeminovascular pathway: perspective and implications to migraine pathophysiology. J Clin Neurol 8:89–99
130. Moulton EA, Burstein R, Tully S, Hargreaves R, Becerra L, Borsook D (2008) Interictal dysfunction of a brainstem descending modulatory center in migraine patients. PLoS One 3:e3799
131. Lipton RB, Dodick DW, Silberstein SD, Saper JR, Aurora SK, Pearlman SH, Fischell RE, Ruppel PL, Goadsby PJ (2010) Single-pulse transcranial magnetic stimulation for acute treatment of migraine with aura: a randomised, double-blind, parallel-group, sham-controlled trial. Lancet Neurol 9:373–80
132. Brighina F, Piazza A, Vitello G et al (2004) rTMS of the prefrontal cortex in the treatment of chronic migraine: a pilot study. J Neurol Sci 227:67–71
133. Lorenz J, Minoshima S, Casey KL (2003) Keeping pain out of mind: the role of the dorsolateral prefrontal cortex in pain modulation. Brain 126:1079–91
134. Misra UK, Kalita J, Tripathi GM, Bhoi SK (2013) Is β endorphin related to migraine headache and its relief? Cephalalgia 33(5):316–22
135. Zaghi S, Thiele B, Pimentel D (2011) Assessment and treatment of pain with non-invasive cortical stimulation. Restor Neurol Neurosci 29:439–51
136. Dodick DW, Schembri CT, Helmuth M et al (2010) Transcranial magnetic stimulation for migraine: a safety review. Headache 50:1153–63
137. Richards EM, Payne JL (2013 Apr) The management of mood disorders in pregnancy: alternatives to antidepressants. CNS Spectr 10:1–11
138. Brighina F, Palermo A, Daniele O et al (2010) High-frequency transcranial magnetic stimulation on motor cortex of patients affected by migraine with aura: a way to restore normal cortical excitability? Cephalalgia 30:46–52
139. Brighina F, Cosentino G, Vigneri S, Talamanca S, Palermo A, Giglia G, Fierro B (2011) Abnormal facilitatory mechanisms in motor cortex of migraine with aura. Eur J Pain 15:928–35
140. de Tommaso M, Stramaglia S, Brighina F, Fierro B, Francesco VD, Todarello O, Serpino C, Pellicoro M (2011) Lack of effects of low frequency repetitive transcranial magnetic stimulation on alpha rhythm phase synchronization in migraine patients. Neurosci Lett 20:143–7
141. Fumal A, Coppola G, Bohotin V et al (2006) Induction of long-lasting changes of visual cortex excitability by five daily sessions of repetitive transcranial magnetic stimulation (rTMS) in healthy volunteers and migraine patients. Cephalalgia 26:143–149
142. de Tommaso M, Brighina F, Fierro B (2010) Effects of high-frequency repetitive transcranial magnetic stimulation of primary motor cortex on laser-evoked potentials in migraine. J Headache Pain 11:505–12
143. Nnoaham KE, Kumbang J (2008) Transcutaneous electrical nerve stimulation (TENS) for chronic pain. Cochrane Database Syst Rev 16(3):CD003222
144. Han JS, Chen XH, Sun SL, Xu XJ, Yuan Y, Yan SC, Hao JX, Terenius L (1991) Effect of low- and high-frequency TENS on Met-enkephalin-Arg-Phe and dynorphin A immunoreactivity in human lumbar CSF. Pain 47:295–8
145. Walsh DM, Howe TE, Johnson MI, Sluka KA (2009) Transcutaneous electrical nerve stimulation for acute pain. Cochrane Database Syst Rev 15(2): CD006142
146. Hurlow A, Bennett MI, Robb KA, Johnson MI, Simpson KH, Oxberry SG (2012) Transcutaneous electric nerve stimulation (TENS) for cancer pain in adults. Cochrane Database Syst Rev 3:CD006276
147. Khadilkar A, Odebiyi DO, Brosseau L, Wells GA (2008) Transcutaneous electrical nerve stimulation (TENS) versus placebo for chronic low-back pain. Cochrane Database Syst Rev 8(4):CD003008
148. Dubinsky RM, Miyasaki J (2010) Assessment: efficacy of transcutaneous electric nerve stimulation in the treatment of pain in neurologic disorders (an evidence-based review): report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology. Neurology 74:173–6
149. Appenzeller O, Atkinson R (1975) Transcutaneous nerve stimulation for the treatment of migraine and other head pain (author’s transl). MMW Munch Med Wochenschr 117:1953–4
150. Solomon S, Guglielmo KM (1985) Treatment of headache by transcutaneous electrical stimulation. Headache 25:12–5
151. Bronfort G, Nilsson N, Haas M, Evans R, Goldsmith CH, Assendelft WJ, Bouter LM (2004) Non-invasive physical treatments for chronic/recurrent headache. Cochrane Database Syst Rev 1(3):CD001878
152. Mousavi SA, Mirbod SM, Khorvash F (2011) Comparison between efficacy of imipramine and transcutaneous electrical nerve stimulation in the prophylaxis of chronic tension-type headache: a randomized controlled clinical trial. J Res Med Sci 16:923–27
153. Schoenen J, Vandersmissen B, Jeangette S, Herroelen L, Vandenheede M, Gerard P, Magis D (2013) Prevention of migraine by supraorbital transcutaneous neurostimulation using the Cefaly device (PREMICE): a multi-centre, randomized, sham-controlled trial. J Headache Pain 1(Suppl 1):P184
154. Ellens DJ, Levy RM (2011) Peripheral neuromodulation for migraine headache. Progress in neurological surgery 24:109–117, doi: 10.1159/000323890
155. Goadsby PJ, Charbit AR, Andreou AP, Akerman S, Holland PR (2009) Neurobiology of migraine. Neuroscience 161:327–341, doi: 10.1016/j. neuroscience.2009.03.019
156. Tomycz ND, Deibert CP, Moossy JJ (2011) Cervicomedullary Junction Spinal Cord Stimulation for Head and Facial Pain. Headache: The Journal of Head and Face Pain 51:418–425, doi: 10.1111/j.1526-4610.2010.01829.x
157. Wolter T, Kiemen A, Kaube H (2011) High cervical spinal cord stimulation for chronic cluster headache. Cephalalgia 31(11):1170–1180, doi: 10.1177 /0333102411412627
158. Gaul C, Jurgens T, May A (2011) Concerning high cervical spinal cord stimulation for chronic cluster headache. Cephalalgia 31(15):1588–1589, doi: 10.1177/0333102411422384
159. Palmisani S, Al-Kaisy A, Arcioni R, Smith T, Negro A, Lambru G, Bandikatla V, Carson E, Martelletti P (2013) A six year retrospective review of occipital nerve stimulation practice - controversies and challenges of an emerging technique for treating refractory headache syndromes. J Headache Pain 14(1):67, doi: 10.1186/1129-2377-14-67
160. Goadsby P (2012) Analysis of occipital nerve stimulation in studies of chronic migraine and broader implications of social media in clinical trials. Cephalalgia 33:214–215