Experimental activation of the sphenopalatine ganglion provokes cluster-like attacks in humans

Cephalalgia

Volumn 33, Issue 10, 2013, Pages 831-841

  Schytz, Henrik W ^a   Barløse, Mads ^a   Guo, Song ^a   Selb, Juliette ^b   Caparso, Anthony ^c   Jensen, Rigmor ^a   Ashina, Messoud ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c Autonomic Technologies Inc   (United States)

Author keywords

autonomic nervous system; Cluster headache; headache model; neurostimulation; sphenopalatine ganglion

Indexed keywords

AMITRIPTYLINE; CANDESARTAN; GABAPENTIN; LITHIUM; VERAPAMIL;

ADULT; ARTICLE; CLINICAL ARTICLE; CLUSTER HEADACHE; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; ELECTROSTIMULATION THERAPY; EXPERIMENTAL STUDY; FEMALE; HUMAN; IMPLANTABLE NEUROSTIMULATOR; MALE; NERVE STIMULATION; PARASYMPATHETIC FUNCTION; PROVOCATION; RANDOMIZED CONTROLLED TRIAL; SPHENOPALATINE GANGLION BLOCK; TREATMENT OUTCOME;

AUTONOMIC NERVOUS SYSTEM; CLUSTER HEADACHE; HEADACHE MODEL; NEUROSTIMULATION; SPHENOPALATINE GANGLION;

ADULT; CLUSTER HEADACHE; CROSS-OVER STUDIES; DOUBLE-BLIND METHOD; ELECTRIC STIMULATION THERAPY; ELECTRODES, IMPLANTED; FEMALE; GANGLIA, AUTONOMIC; HUMANS; MALE; MIDDLE AGED; PAIN MEASUREMENT; PTERYGOPALATINE FOSSA;

EID: 84879360817     PISSN: 03331024     EISSN: 14682982     Source Type: Journal    
DOI: 10.1177/0333102413476370     Document Type: Article

References (41)

1. Manzoni GC, Stovner LJ. Epidemiology of headache. Handb Clin Neurol. 2010 ; 97: 3-22
2. The International Classification of Headache Disorders, 2nd Edition. Cephalalgia. 2004 ; 24: 9-160
3. Uddman R, Tajti J, Moller S, et al. Neuronal messengers and peptide receptors in the human sphenopalatine and otic ganglia. Brain Res. 1999 ; 826: 193-199 (Pubitemid 29222933)
4. Goadsby PJ. Pathophysiology of cluster headache: A trigeminal autonomic cephalgia. Lancet Neurol. 2002 ; 1: 251-257 (Pubitemid 37159187)
5. Holland PR, Goadsby PJ. Cluster headache, hypothalamus, and orexin. Curr Pain Headache Rep. 2009 ; 13: 147-154
6. Ruskin AP. Sphenopalatine (nasal) ganglion: Remote effects including "psychosomatic" symptoms, rage reaction, pain, and spasm. Arch Phys Med Rehabil. 1979 ; 60: 353-359 (Pubitemid 9250287)
7. Sanders M, Zuurmond WW. Efficacy of sphenopalatine ganglion blockade in 66 patients suffering from cluster headache: A 12- to 70-month follow-up evaluation. J Neurosurg. 1997 ; 87: 876-880
8. Narouze S, Kapural L, Casanova J, et al. Sphenopalatine ganglion radiofrequency ablation for the management of chronic cluster headache. Headache. 2009 ; 49: 571-577
9. Lainez M, Jensen R, May A, et al. Pathway CH-1 Study: Sphenopalatine ganglion (SPG) stimulation for acute treatment of chronic cluster headache (CCH) - Initial experience. The 64th Annual Meeting of the American Academy of Neurology 2012; Abstract 2632.
10. Takahashi M, Zhang ZD, Macdonald RL. Sphenopalatine ganglion stimulation for vasospasm after experimental subarachnoid hemorrhage. J Neurosurg. 2011 ; 114: 1104-1109
11. Suzuki N, Gotoh F, Gotoh J, et al. Evidence for in vivo cerebrovascular neurogenic vasodilatation in the rat. Clin Auton Res. 1991 ; 1: 23-26
12. Suzuki N, Hardebo JE, Kahrstrom J, et al. Selective electrical stimulation of postganglionic cerebrovascular parasympathetic nerve fibers originating from the sphenopalatine ganglion enhances cortical blood flow in the rat. J Cereb Blood Flow Metab. 1990 ; 10: 383-391 (Pubitemid 20144618)
13. Thomsen LL, Iversen HK. Experimental and biological variation of three-dimensional transcranial Doppler measurements. J Appl Physiol. 1993 ; 75: 2805-2810 (Pubitemid 24008404)
14. Cope M, Delpy DT, Reynolds EO, et al. Methods of quantitating cerebral near infrared spectroscopy data. Adv Exp Med Biol. 1988 ; 222: 183-189
15. Gagnon L, Yucel MA, Dehaes M, et al. Quantification of the cortical contribution to the NIRS signal over the motor cortex using concurrent NIRS-fMRI measurements. Neuroimage. 2012 ; 9 (4). 3933-3940
16. Schytz HW, Schoonman GG, Ashina M. What have we learnt from triggering migraine?. Curr Opin Neurol. 2010 ; 23: 259-265
17. Narouze S, Kapural L, Casanova J, et al. Sphenopalatine ganglion radiofrequency ablation for the management of chronic cluster headache. Headache. 2009 ; 49: 571-577
18. Sanders M, Zuurmond WW. Efficacy of sphenopalatine ganglion blockade in 66 patients suffering from cluster headache: A 12- to 70-month follow-up evaluation. J Neurosurg. 1997 ; 87: 876-880
19. Bolay H, Reuter U, Dunn AK, et al. Intrinsic brain activity triggers trigeminal meningeal afferents in a migraine model. Nat Med. 2002 ; 8: 136-142 (Pubitemid 34155124)
20. Tanelian DL. Cholinergic activation of a population of corneal afferent nerves. Exp Brain Res. 1991 ; 86: 414-420
21. Levy D, Strassman AM. Modulation of dural nociceptor mechanosensitivity by the nitric oxide-cyclic GMP signaling cascade. J Neurophysiol. 2004 ; 92: 766-772 (Pubitemid 38931943)
22. Delepine L, Aubineau P. Plasma protein extravasation induced in the rat dura mater by stimulation of the parasympathetic sphenopalatine ganglion. Exp Neurol. 1997 ; 147: 389-400 (Pubitemid 27497300)
23. Khurana D, Kaul S, Bornstein NM. Implant for augmentation of cerebral blood flow trial 1: A pilot study evaluating the safety and effectiveness of the Ischaemic Stroke System for treatment of acute ischaemic stroke. Int J Stroke. 2009 ; 4: 480-485
24. Ekstrom J, Brodin E, Ekman R, et al. Depletion of neuropeptides in rat parotid glands and declining atropine-resistant salivary secretion upon continuous parasympathetic nerve stimulation. Regul Pept. 1985 ; 11: 353-359 (Pubitemid 15048913)
25. Akerman S, Holland PR, Lasalandra MP, et al. Oxygen inhibits neuronal activation in the trigeminocervical complex after stimulation of trigeminal autonomic reflex, but not during direct dural activation of trigeminal afferents. Headache. 2009 ; 49: 1131-1143
26. Cohen AS, Burns B, Goadsby PJ. High-flow oxygen for treatment of cluster headache: A randomized trial. JAMA. 2009 ; 302: 2451-2457
27. Kelm M, Schrader J. Control of coronary vascular tone by nitric oxide. Circ Res. 1990 ; 66: 1561-1575 (Pubitemid 20178705)
28. Burns B, Watkins L, Goadsby PJ. Treatment of intractable chronic cluster headache by occipital nerve stimulation in 14 patients. Neurology. 2009 ; 72: 341-345
29. Moore-Ede MC. The circadian timing system in mammals: Two pacemakers preside over many secondary oscillators. Fed Proc. 1983 ; 42: 2802-2808
30. May A, Bahra A, Buchel C, et al. Hypothalamic activation in cluster headache attacks. Lancet. 1998 ; 352: 275-278 (Pubitemid 28340145)
31. Malick A, Strassman RM, Burstein R. Trigeminohypothalamic and reticulohypothalamic tract neurons in the upper cervical spinal cord and caudal medulla of the rat. J Neurophysiol. 2000 ; 84: 2078-2112
32. May A, Leone M, Boecker H, et al. Hypothalamic deep brain stimulation in positron emission tomography. J Neurosci. 2006 ; 26: 3589-3593
33. Leone M, Proietti CA, Franzini A, et al. Lessons from 8 years' experience of hypothalamic stimulation in cluster headache. Cephalalgia. 2008 ; 28: 787-797
34. Magis D, Bruno MA, Fumal A, et al. Central modulation in cluster headache patients treated with occipital nerve stimulation: An FDG-PET study. BMC Neurol. 2011 ; 11: 25-25
35. Kilgore KL, Bhadra N. Nerve conduction block utilising high-frequency alternating current. Med Biol Eng Comput. 2004 ; 42: 394-406 (Pubitemid 38786703)
36. Hara H, Zhang QJ, Kuroyanagi T, et al. Parasympathetic cerebrovascular innervation: An anterograde tracing from the sphenopalatine ganglion in the rat. Neurosurgery. 1993 ; 32: 822-827 (Pubitemid 23134026)
37. Uddman R, Edvinsson L, Hara H. Axonal tracing of autonomic nerve fibers to the superficial temporal artery in the rat. Cell Tissue Res. 1989 ; 256: 559-565 (Pubitemid 19152881)
38. Uddman R, Hara H, Edvinsson L. Neuronal pathways to the rat middle meningeal artery revealed by retrograde tracing and immunocytochemistry. J Auton Nerv Syst. 1989 ; 26: 69-75 (Pubitemid 19075683)
39. Holzschuh M, Woertgen C, Metz C, et al. Comparison of changes in cerebral blood flow and cerebral oxygen saturation measured by near infrared spectroscopy (NIRS) after acetazolamide. Acta Neurochir (Wien). 1997 ; 139: 58-62
40. Goadsby PJ. Sphenopalatine ganglion stimulation increases regional cerebral blood flow independent of glucose utilization in the cat. Brain Res. 1990 ; 506: 145-148 (Pubitemid 20020087)
41. Seylaz J, Hara H, Pinard E, et al. Effect of stimulation of the sphenopalatine ganglion on cortical blood flow in the rat. J Cereb Blood Flow Metab. 1988 ; 8: 875-878 (Pubitemid 19008333)