Progressive engineering of a homing endonuclease genome editing reagent for the murine X-linked immunodeficiency locus

Nucleic Acids Research

Volumn 42, Issue 10, 2014, Pages 6463-6475

  Wang, Yupeng ^a   Khan, Iram F ^a   Boissel, Sandrine ^a,b   Jarjour, Jordan ^c   Pangallo, Joseph ^a   Thyme, Summer ^b   Baker, David ^b   Scharenberg, Andrew M ^a,d   Rawlings, David J ^a,d  

^a SEATTLE CHILDREN S RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^c Pregenen Inc   (United States)

^d UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BRUTON TYROSINE KINASE; ENDONUCLEASE; LEUCYLALANYLGLYCYLLEUCYLISOLEUCYLASPARTYLALANYLASPARTYLGLYCINE HOMING ENDONUCLEASE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRUTON TYROSINE KINASE GENE; CELL ASSAY; CONTROLLED STUDY; DNA BINDING; EMBRYO; ENZYME BINDING; ENZYME SPECIFICITY; GENE CLUSTER; GENE LOCUS; GENE MUTATION; GENE TARGETING; GENETIC ENGINEERING; GENETIC SELECTION; GENETIC VARIABILITY; HIGH THROUGHPUT SCREENING; HOMOLOGOUS RECOMBINATION; HUMAN; HUMAN CELL; IN VITRO STUDY; MOLECULAR EVOLUTION; MOLECULAR RECOGNITION; NONHUMAN; NUCLEOTIDE BINDING SITE; PRIORITY JOURNAL; PROTEIN CLEAVAGE; X LINKED AGAMMAGLOBULINEMIA;

ANIMALS; CELLS, CULTURED; DIRECTED MOLECULAR EVOLUTION; DNA CLEAVAGE; DNA-BINDING PROTEINS; ENDODEOXYRIBONUCLEASES; GENETIC LOCI; GENOMICS; HEK293 CELLS; HOMOLOGOUS RECOMBINATION; HUMANS; INDICATORS AND REAGENTS; MICE; MUTATION; PROTEIN STRUCTURE, TERTIARY; PROTEIN-TYROSINE KINASES;

EID: 84903168518     PISSN: 03051048     EISSN: 13624962     Source Type: Journal    
DOI: 10.1093/nar/gku224     Document Type: Article

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