Chemokine expression profile of freshly isolated human glioblastoma- associated macrophages/microglia

Oncology Reports

Volumn 32, Issue 1, 2014, Pages 270-276

  Hattermann, Kirsten ^a   Sebens, Susanne ^b   Helm, Ole ^b   Schmitt, Anne Dorothée ^b   Mentlein, Rolf ^a   Mehdorn, H Maximilian ^b   Held Feindt, Janka ^b  

^a UNIVERSITY OF KIEL   (Germany)

^b UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

Author keywords

Chemokine; Glioma; Macrophages; Microglia

Indexed keywords

CD163 ANTIGEN; CHEMOKINE; CHEMOKINE RECEPTOR; CHEMOKINE RECEPTOR CX3CR1; CHEMOKINE RECEPTOR CXCR4; CHEMOKINE RECEPTOR CXCR6; CHEMOKINE RECEPTOR CXCR7; CXCL16 CHEMOKINE; FRACTALKINE; INTERLEUKIN 1BETA; INTERLEUKIN 6; STROMAL CELL DERIVED FACTOR 1; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; CELL ISOLATION; CELL POLARITY; CONTROLLED STUDY; GLIOBLASTOMA; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; MICROGLIA; PRIORITY JOURNAL; PROTEIN EXPRESSION; TUMOR ASSOCIATED LEUKOCYTE; TUMOR ASSOCIATED MICROGLIAL; CYTOLOGY; GENE EXPRESSION REGULATION; GENETICS; IMMUNOLOGY; MACROPHAGE; METABOLISM; PATHOLOGY; STROMA CELL; TUMOR MICROENVIRONMENT;

CHEMOKINES; GENE EXPRESSION REGULATION, NEOPLASTIC; GLIOBLASTOMA; HUMANS; MACROPHAGES; MICROGLIA; RECEPTORS, CHEMOKINE; STROMAL CELLS; TUMOR MICROENVIRONMENT;

EID: 84903156472     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.2014.3214     Document Type: Article

References (46)

1. Elinav E, Nowarski R, Thaiss CA, Hu B, Jin C and Flavell RA: Inflammation-induced cancer: crosstalk between tumours, immune cells and microorganisms. Nat Rev Cancer 13: 759-771, 2013.
2. Ohgaki H and Kleihues P: Epidemiology and ethiology of gliomas. Acta Neuropathol 109: 93-108, 2005.
3. Badie B and Schartner JM: Flow cytometric characterization of tumor-associated macrophages in experimental gliomas. Neurosurgery 46: 957-961, 2000.
4. Li W and Graber MB: The molecular profile of microglia under the influence of glioma. Neuro Oncol 14: 958-978, 2012.
5. Markovic DS, Glass R, Synowitz M, Rooijen Nv and Kettenmann H: Microglia stimulate the invasiveness of glioma cells by increasing the activity of metalloprotease-2. J Neuropathol Exp Neurol 64: 754-762, 2005. (Pubitemid 41285807)
6. Zhai H, Heppner FL and Tsirka SE: Microglia/macrophages promote glioma progression. Glia 59: 472-485, 2011.
7. Mantovani A, Germano G, Marchesi F, Locatelli M and Biswas SK: Cancer-promoting tumor-associated macrophages: new vistas and open questions. Eur J Immunol 41: 2522-2525, 2011.
8. Kielian T, van Rooijen N and Hickey WF: MCP-1 expression in CNS-1 astrocytoma cells: implications for macrophage infiltration into tumors in vivo. J Neurooncol 56: 1-12, 2002. (Pubitemid 34256612)
9. Galasso JM, Stegman LD, Blaivas M, Harrison JK, Ross BD and Silverstein FS: Experimental gliosarcoma induces chemokine receptor expression in rat brain. Exp Neurol 161: 85-95, 2000. (Pubitemid 30136531)
10. Okada M, Saio M, Kito Y, Ohe N, Yano H, Yoshimura S, Iwama T and Takami T: Tumor-associated macrophage/microglia infiltration in human gliomas is correlated with MCP-3, but not MCP-1. Int J Oncol 34: 1621-1627, 2009.
11. Held-Feindt J, Hattermann K, Müerköster SS, Wedderkopp H, Knerlich-Lukoschus F, Ungefroren H, Mehdorn HM and Mentlein R: CX3CR1 promotes recruitment of human gliomainfiltrating microglia/macrophages (GIMs). Exp Cell Res 316: 1553-1566, 2010.
12. Hattermann K and Mentlein R: An infernal trio: the chemokine CXCL12 and its receptors CXCR4 and CXCR7 in tumor biology. Ann Anat 195: 103-110, 2013.
13. Hattermann K, Held-Feindt J, Ludwig A and Mentlein R: The CXCL16-CXCR6 axis in glial tumors. J Neuroimmunol 260: 47-54, 2013.
14. Hattermann K1, Held-Feindt J, Lucius R, Müerköster SS, Penfold ME, Schall TJ and Mentlein R: The chemokine receptor CXCR7 is highly expressed in human glioma cells and mediates antiapoptotic effects. Cancer Res 70: 3299-3308, 2010.
15. Hattermann K, Ludwig A, Gieselmann V, Held-Feindt J and Mentlein R: The chemokine CXCL16 induces migration and invasion of glial precursor cells via its receptor CXCR6. Mol Cell Neurosci 39: 133-141, 2008.
16. Domanska UM, Kruizinga RC, den Dunnen WF, Timmer-Bosscha H, de Vries EG and Walenkamp AM: The chemokine network, a newly discovered target in high grade gliomas. Crit Rev Oncol Hematol 79: 154-163, 2011.
17. Sciumè G, Santoni A and Bernardini G: Chemokines and glioma: invasion and more. J Neuroimmunol 224: 8-12, 2010.
18. + blood monocytes. Eur J Immunol 31: 48-56, 2001.
19. H17 responses. Nat Immunol 12: 231-238, 2011.
20. Verreck FA1, de Boer T, Langenberg DM, van der Zanden L and Ottenhoff TH: Phenotypic and functional profiling of human proinflammatory type-1 and anti-inflammatory type-2 macrophages in response to microbial antigens and IFN-γ- and CD40L-mediated costimulation. J Leukoc Biol 79: 285-292, 2006.
21. Schäfer H, Struck B, Feldmann EM, Bergmann F, Grage-Griebenow E, Geismann C, Ehlers S, Altevogt P and Sebens S: TGF-β1-dependent L1CAM expression has an essential role in macrophage-induced apoptosis resistance and cell migration of human intestinal epithelial cells. Oncogene 32: 180-189, 2013.
22. Kennedy BC, Showers CR, Anderson DE, Anderson L, Canoll P, Bruce JN and Anderson RCE: Tumor-associated macrophages in glioma: friend or foe? J Oncol 2013: 486912, 2013.
23. Ruffel B, Affara NI and Coussens LM: Differential macrophage programming in the tumor microenvironment. Trends Immunol 33: 119-126, 2012.
24. Miller RJ, Rostene W, Apartis E, Banisadr G, Biber K, Milligan ED, White FA and Zhang J: Chemokine action in the nervous system. J Neurosci 28: 11792-11795, 2008.
25. Vandercappellen J, Van Damme J and Struyf S: The role of CXC chemokines and their receptors in cancer. Cancer Lett 267: 226-244, 2008.
26. Kakinuma T and Hwang ST: Chemokines, chemokine receptors, and cancer metastasis. J Leukoc Biol 79: 639-651, 2006. (Pubitemid 44835596)
27. Zlotnik A: Chemokines and cancer. Int J Cancer 119: 2026-2029, 2006.
28. Lu H, Ouyang W and Huang C: Inflammation, a key event in cancer development. Mol Cancer Res 4: 221-233, 2006.
29. Ben-Baruch A: The multifaceted roles of chemokines in malignancy. Cancer Metastasis Rev 25: 357-371, 2006.
30. Platten M, Kretz A, Naumann U, Aulwurm S, Egashira K, Isenmann S and Weller M: Monocyte chemoattractant protein-1 increases microglial infiltration and aggressiveness of gliomas. Ann Neurol 54: 388-392, 2003. (Pubitemid 37072043)
31. Allavena P, Sica A, Solinas G, Porta C and Mantovani A: The inflammatory micro-environment in tumor progression: the role of tumor-associated macrophages. Crit Rev Oncol Hematol 66: 1-9, 2008. (Pubitemid 351324128)
32. Sica A, Schioppa T, Mantovani A and Allavena P: Tumour-associated macrophages are a distinct M2 polarised population promoting tumour progression: potential targets of anti-cancer therapy. Eur J Cancer 42: 717-727, 2006.
33. Helm O, Held-Feindt J, Grage-Griebenow E, Reiling N, Ungefroren H, Vogel I, Krüger U, Becker T, Ebsen M, Röcken C, Kabelitz D, Schäfer H and Sebens S: Tumor-associated macrophages exhibit pro- and anti-inflammatory properties by which they impact on pancreatic tumorigenesis. Int J Cancer: Jan 23, 2014 (Epub ahead of print). doi: 10.1002/ijc.28736.
34. Arenberg DA, Keane MP, DiGiovine B, Kunkel SL, Strom SR, Burdick MD, Iannettoni MD and Strieter RM: Macrophage infiltration in human non-small-cell lung cancer: the role of CC chemokines. Cancer Immunol Immunother 49: 63-70, 2000. (Pubitemid 30431641)
35. Balkwill F: Cancer and the chemokine network. Nat Rev Cancer 4: 540-550, 2004.
36. Mantovani A, Allavena P, Sozzani S, Vecchi A, Locati M and Sica A: Chemokines in the recruitment and shaping of the leukocyte infiltrate of tumors. Semin Cancer Biol 14: 155-160, 2004. (Pubitemid 38586740)
37. Ueno T, Toi M, Saji H, Muta M, Bando H, Kuroi K, Koike M, Inadera H and Matsushima K: Significance of macrophage chemoattractant protein-1 in macrophage recruitment, angiogenesis, and survival in human breast cancer. Clin Cancer Res 6: 3282-3289, 2000. (Pubitemid 30637758)
38. Monti P, Leone BE, Marchesi F, Balzano G, Zerbi A, Scaltrini F, Pasquali C, Calori G, Pessi F, Sperti C, Di Carlo V, Allavena P and Piemonti L: The CC chemokine MCP-1/CCL2 in pancreatic cancer progression: regulation of expression and potential mechanisms of antimalignant activity. Cancer Res 63: 7451-7461, 2003. (Pubitemid 37413488)
39. Bachleder RE, Wendt MA and Mercurio AM: Vascular endothelial growth factor promotes breast carcinoma invasion in an autocrine manner by regulating the chemokine receptor CXCR4. Cancer Res 62: 7203-7206, 2002. (Pubitemid 36025239)
40. Schioppa T, Uranchimeg B, Saccani A, Biswas SK, Doni A, Rapisarda A, Bernasconi S, Saccani S, Nebuloni M, Vago L, Mantovani A, Melillo G and Sica A: Regulation of the chemokine receptor CXCR4 by hypoxia. J Exp Med 198: 1391-1402, 2003. (Pubitemid 37392484)
41. Schutyser E, Struyf S, Proost P, Opdenakker G, Laureys G, Verhasselt B, Peperstraete L, Van de Putte I, Saccani A, Allavena P, Mantovani A and Van Damme J: Identification of biologically active chemokine isoforms from ascetic fluid and elevated levels of CCL18/pulmonary and activation-regulated chemokine in ovarian carcinoma. J Biol Chem 277: 24584-24593, 2002. (Pubitemid 34951986)
42. Sica A, Larghi P, Mancino A, Rubino L, Porta C, Totaro MG, Rimoldi M, Biswas SK, Allavena P and Mantovani A: Macrophage polarization in tumor progression. Semin Cancer Biol 18: 349-355, 2008.
43. Biswas SK, Gangi L, Paul S, Schioppa T, Saccani A, Sironi M, Bottazzi B, Doni A, Vincenzo B, Pasqualini F, Vago L, Nebuloni M, Mantovani A and Sica A: A distinct and unique transcriptional program expressed by tumor-associated macrophages (defective NF-κB and enhanced IRF-3/STAT1 activation). Blood 107: 2112-2122, 2006. (Pubitemid 43289397)
44. Pyonteck SM, Akkari L, Schuhmacher AJ, Bowman RL, Sevenich L, Quail DF, Olson OC, Quick ML, Huse JT, Teijeiro V, Setty M, Leslie CS, Oei Y, Pedraza A, Zhang J, Brennan CW, Sutton JC, Holland EC, Daniel D and Joyce JA: CSF-1R inhibition alters macrophage polarization and blocks glioma progression. Nat Med 19: 1264-1272, 2013.
45. Pong WW, Walker J, Wylie T, Magrini V, Luo J, Emnett RJ, Choi J, Cooper ML, Griffith M, Griffith OL, Rubin JB, Fuller GN, Piwnica-Worms D, Feng X, Hambardzumyan D, DiPersio JF, Mardis ER and Gutmann DH: F11R is a novel monocyte prognostic biomarker for malignant glioma. PLoS One: e77571, 2013.
46. Ye XZ, Xu SL, Xin YH, Yu SC, Ping YF, Chen L, Xiao HL, Wang B, Yi L, Wang QL, Jiang XF, Yang L, Zhang P, Qian C, Cui YH, Zhang X and Bian XW: Tumor-associated microglia/macrophages enhance the invasion of glioma stem-like cells via TGF-β1 signaling pathway. J Immunol 189: 444-453, 2012.