Methods for the development of tumor-targeting bacteria

Expert Opinion on Drug Discovery

Volumn 9, Issue 7, 2014, Pages 741-750

  Hoffman, Robert M ^a,b   Zhao, Ming ^a  

^a ANTICANCER INC   (United States)

^b UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

Cancer therapy; Green fluorescent protein; Imaging; Leucine arginine auxotrophs; Red fluorescent protein; Salmonella typhimurium

Indexed keywords

AMINO ACID; ANTINEOPLASTIC AGENT; BACTERIAL VACCINE; CANCER VACCINE; DNA VACCINE; GENTAMICIN; GREEN FLUORESCENT PROTEIN; SALMONELLA TYPHIMURIUM A1 R; SHORT HAIRPIN RNA; TUMOR ANTIGEN; UNCLASSIFIED DRUG;

AUXOTROPHY; BACTERIAL GROWTH; BACTERIUM; BIFIDOBACTERIUM; BIFIDOBACTERIUM LONGUM; BONE TUMOR; BRAIN CANCER; BREAST CANCER; CANCER CELL; CANCER CHEMOTHERAPY; CANCER THERAPY; CD8+ T LYMPHOCYTE; CELL KILLING; CHEMICAL LABELING; CHINESE MEDICINE; CLOSTRIDIUM; COLON CARCINOMA; COMPARATIVE STUDY; CRANIOTOMY; CYTOPLASM; DRUG EFFICACY; ELECTROPORATION; EWING SARCOMA; FLUORESCENCE IMAGING; GLIOMA; HUMAN; IMMUNOCOMPETENCE; IN VITRO STUDY; LUNG METASTASIS; LYMPH NODE METASTASIS; MELANOMA; METASTASIS; MUTAGENESIS; NONHUMAN; OSTEOSARCOMA; PANCREAS CANCER; PHASE 1 CLINICAL TRIAL (TOPIC); PRIORITY JOURNAL; PROSTATE CANCER; REVIEW; SALMONELLA TYPHIMURIUM; SERRATIA MARCESCENS; SKULL; STREPTOCOCCUS PYOGENES; TUMOR GROWTH; TUMOR REGRESSION; TUMOR TARGETING BACTERIA; TUMOR VASCULARIZATION; ANIMAL; MICROBIOLOGY; NEOPLASMS; SALMONELLA ENTERICA SUBSP. ENTERICA SEROVAR TYPHIMURIUM;

ANIMALS; HUMANS; NEOPLASMS; SALMONELLA TYPHIMURIUM;

EID: 84903153928     PISSN: 17460441     EISSN: 1746045X     Source Type: Journal    
DOI: 10.1517/17460441.2014.916270     Document Type: Review

References (47)

1. William Coley. Available from: http://en.wikipedia.org/wiki/William-Coley [Last accessed 12 December 2013]
2. Forbes NS. Engineering the perfect (bacterial) cancer therapy. Nat Rev Cancer 2010;10:785-94
3. McCarthy EF. The toxins of William B. Coley and the treatment of bone and soft-tissue sarcomas. Iowa Orthop J 2006;26:154-8
4. Karbach J, Neumann A, Brand K, et al. Phase I clinical trial of mixed bacterial vaccine (Coley's toxins) in patients with NY-ESO-1 expressing cancers: immunological effects and clinical activity. Clin Cancer Res 2012;18:5449-59
5. Starnes CO. Coley's toxins in perspective. Nature 1992;357:11-12
6. Deidier A. Dissertation. medicinal et Chirurgical sur les Tumeurs. Paris: 1725
7. Busch W. Aus der Sitzung der medicinischen Section vom 13 November 1867. Berl Klin Wochenschr 1868;5:137
8. Coley WB. Contribution to the knowledge of sarcoma. Ann Surg 1891;14:199-220
9. Coley WB. The treatment of malignant tumors by repeated inoculations of erysipelas: with a report of ten original cases. Am J Med Sci 1893;105:487-511
10. Coley WB. The treatment of malignant inoperable tumors with the mixed toxins of erysipelas and bacillus prodigiosus. M. Weissenbruch, Brussels; 1914
11. Bickels J, Kollender Y, et al. Coley's toxin: historical perspective. Isr Med Asscoc J 2002;4:1-472
12. Nauts HC, McLaren JR. Coley Toxins-the first century. Adv Exp Med Biol 1990;267:483
13. Hoption Cann SA, van Netten JP, van Netten C. Dr William Coley and tumour regression: a place in history or in the future. Postgrad Med J 2003;79:672-80
14. Richardson MA, Ramirez T, Russell NC, et al. Coley toxins immunotherapy: a retrospective review. Altern Ther Health Med 1999;5:42-7
15. Zhou H, Luo Y, Mizutani M, et al. A novel transgenic mousemodel for immunological evaluation of carcinoembryonic antigen-based DNA minigene vaccines. J Clin Invest 2004;113:1792-8
16. Yazawa K, Fujimori M, Nakamura T, et al. Bifidobacterium longum as a delivery system for gene therapy of chemically induced rat mammary tumors. Breast Cancer Res Treat 2001;66:165-70
17. Dang LH, Bettegowda C, Huso DL, et al. Combination bacteriolytic therapy for the treatment of experimental tumors. Proc Natl Acad Sci USA 2001;98:15155-60
18. Hoffman RM. Bugging tumors. Cancer Discov 2012;2:588-90
19. Pawelek JM, Low KB, Bermudes D. Bacteria as tumour-targeting vectors. Lancet Oncol 2003;4:548-56
20. Pawelek JM, Low KB, Bermudes D. Tumor-targeted Salmonella as a novel anticancer vector. Cancer Res 1997;57:4537-44
21. Toso JF, Gill VJ, Hwu P, et al. Phase I study of the intravenous administration of attenuated Salmonella typhimurium to patients with metastatic melanoma. J Clin Oncol 2002;20:142-52
22. Hoffman RM. Tumor growth control with IDO-silencing salmonella-letter. Cancer Res 2013;73:4591
23. Blache CA, Manuel ER, Kaltcheva TI, et al. Systemic delivery of Salmonella typhimurium transformed with IDO shRNA enhances intratumoral vector colonization and suppresses tumor growth. Cancer Res 2012;72:6447-56
24. Manuel ER, Blazer BR, Diamond DJ. Tumor-growth control with IDO-silencing salmonella-reply. Cancer Res 2013;73:4592-3
25. Binder DC, Engels B, Arina A, et al. Antigen-specific bacterial vaccine combined with anti-PD-L1 rescues dysfunctional endogenous T cells to reject long-established cancer. Cancer Immunol Res 2013;1:123-33
26. Zhao M, Yang M, Li X-M, et al. Tumor-targeting bacterial therapy with amino acid auxotrophs of GFP-expressing Salmonella typhimurium. Proc Natl Acad Sci USA 2005;102:755-60
27. Zhao M, Geller J, Ma H, et al. Monotherapy with a tumor-targeting mutant of Salmonella typhimurium cures orthotopic metastatic mouse models of human prostate cancer. Proc Natl Acad Sci USA 2007;104:10170-4
28. Zhao M, Yang M, Ma H, et al. Targeted therapy with a Salmonella typhimurium leucine-arginine auxotroph cures orthotopic human breast tumors in nude mice. Cancer Res 2006;66:7647-52
29. Uchugonova A, Zhao M, Zhang Y, et al. Cancer-cell killing by engineered Salmonella imaged by multiphoton tomography in live mice. Anticancer Res 2012;32:4331-8
30. Liu F, Zhang L, Hoffman RM, Zhao M. Vessel destruction by tumor-targeting Salmonella typhimurium A1-R is enhanced by high tumor vascularity. Cell Cycle 2010;9:4518-24
31. Nagakura C, Hayashi K, Zhao M, et al. Efficacy of a genetically-modified Salmonella typhimurium in an orthotopic human pancreatic cancer in nude mice. Anticancer Res 2009;29:1873-8
32. Yam C, Zhao M, Hayashi K, et al. Monotherapy with a tumor-targeting mutant of Salmonella typhimurium inhibits liver metastasis in a mouse model of pancreatic cancer. J Surg Res 2010;164:248-55
33. Hayashi K, Zhao M, Yamauchi K, et al. Cancer metastasis directly eradicated by targeted therapy with a modified Salmonella typhimurium. J Cell Biochem 2009;106:992-8
34. Hayashi K, Zhao M, Yamauchi K, et al. Systemic targeting of primary bone tumor and lung metastasis of high-grade osteosarcoma in nude mice with a tumor-selective strain of Salmonella typhimurium. Cell Cycle 2009;8:870-5
35. Kimura H, Zhang L, Zhao M, et al. Targeted therapy of spinal cord glioma with a genetically-modified Salmonella typhimurium. Cell Prolif 2010;43:41-8
36. Hoffman RM, Zhao M. Whole-body imaging of bacterial infection and antibiotic response. Nat Protoc 2006;1:2988-94
37. Taroncher-Oldenburg G. Research highlights: feed a bacterium, kill a tumor. Nat Biotechnol 2005;23:189
38. Hoffman RM, Yang M. Subcellular imaging in the live mouse. Nature Protoc 2006;1:775-82
39. Zhang Y, Tome Y, Suetsugu A, et al. Determination of the optimal route of administration of Salmonella typhimurium A1-R to target breast cancer in nude mice. Anticancer Res 2012;32:2501-8
40. Momiyama M, Suetsugu A, Chishima T, et al. Subcellular real-time imaging of the efficacy of temozolomide on cancer cells in the brain of live mice. Anticancer Res 2013;33:103-6
41. Momiyama M, Suetsugu A, Kimura H, et al. Dynamic subcellular imaging of cancer cell mitosis in the brain of live mice. Anticancer Res 2013;33:1367-71
42. Momiyama M, Zhao M, Kimura H, et al. Inhibition and eradication of human glioma with tumor-targeting Salmonella typhimurium in an orthotopic nude-mouse model. Cell Cycle 2012;11:628-32
43. Tome Y, Zhang Y, Momiyama M, et al. Primer dosing of Salmonella typhimurium A1-R potentiates tumor-targeting and efficacy in immunocompetent mice. Anticancer Res 2013;33:97-102
44. Zhang Y, Zhang N, Su S, et al. Salmonella typhimurium A1-R tumor targeting in immunocompetent mice is enhanced by a Traditional Chinese Medicine herbal mixture. Anticancer Res 2013;33:1837-43
45. Hiroshima Y, Zhao M, Zhang Y, et al. Comparison of efficacy of Salmonella typhimurium A1-R and chemotherapy on stem-like and non-stem human pancreatic cancer cells. Cell Cycle 2013;12:2774-80
46. Hassanein MK, Suetsugu A, Saji S, et al. Stem-like and non-stem human pancreatic cancer cells distinguished by morphology and metastatic behavior. J Cell Biochem 2011;112:3549-54
47. Sausville EA, Burger AM. Contributions of human tumor xenografts to anticancer drug development. Cancer Res 2006;66:3351-4