Determination of the optimal route of administration of Salmonella typhimurium A1-R to target breast cancer in nude mice

Anticancer Research

Volumn 32, Issue 7, 2012, Pages 2501-2508

  Zhang, Yong ^a   Tome, Yasunori ^a,b,c   Suetsugu, Atsushi ^a,d   Zhang, Lei ^a   Zhang, Nan ^a   Hoffman, Robert M ^a,b   Zhao, Ming ^a  

^a ANTICANCER INC   (United States)

^b UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^c UNIVERSITY OF THE RYUKYUS   (Japan)

^d GIFU UNIVERSITY   (Japan)

Author keywords

Cancer; Efficacy; GFP; i.t.; i.v.; MDA Mb 435 breast cancer cells; p.o.; RFP; S. typhimurium A1 R; Safety; Tumor targeting

Indexed keywords

ARGININE; GREEN FLUORESCENT PROTEIN; LEUCINE; RED FLUORESCENT PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; AUXOTROPHIC MUTANT; BACTERIAL STRAIN; BACTERIUM ADHERENCE; BREAST CANCER; COLONY FORMING UNIT; CONTROLLED STUDY; DNA MODIFICATION; DRUG ADMINISTRATION ROUTE; DRUG EFFICACY; DRUG SAFETY; FLUORESCENCE IMAGING; GENE TARGETING; HUMAN; HUMAN TISSUE; MOLECULARLY TARGETED THERAPY; MOUSE; NONHUMAN; NUDE MOUSE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SAFETY; SALMONELLA TYPHIMURIUM; SALMONELLA TYPHIMURIUM A1 R; TREATMENT OUTCOME; TUMOR GROWTH;

ADMINISTRATION, ORAL; ANIMALS; BREAST NEOPLASMS; FEMALE; GREEN FLUORESCENT PROTEINS; HUMANS; INJECTIONS, INTRALESIONAL; INJECTIONS, INTRAVENOUS; LUMINESCENT PROTEINS; MICE; MICE, NUDE; RECOMBINANT FUSION PROTEINS; SALMONELLA TYPHI; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84865695705     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (44)

1. Hoffman RM: The preclinical discovery of bacterial therapy for the treatment of metastatic cancer with unique advantages. Expert Opin Drug Discov 7: 73-83, 2012.
2. Parker RC, Plummer HC, Siebenmann CO and Chapman MG: Effect of histolyticus infection and toxin on transplantable mouse tumors. Proc Soc Exp Biol Med 66: 461-467, 1947.
3. Malmgren RA and Flanigan CC: Localization of the vegetative form of Clostridium tetani in mouse tumors following intravenous spore administration. Cancer Res 15: 473-478, 1955.
4. Moese JR and Moese G: Oncolysis by Clostridia. I. activity of Clostridium butyricum (M-55) and other nonpathogenic clostridia against the Ehrlich carcinoma. Cancer Res 24: 212-216, 1964.
5. Gericke D and Engelbart K: Oncolysis by Clostridia . II. Experiments on a tumor spectrum with a variety of clostridia in combination with heavy metal. Cancer Res 24: 217-221, 1963.
6. Thiele EH, Arison RN and Boxer GE: Oncolysis by Clostridia. III. Effects of Clostridia and chemotherapeutic agents on rodent tumors. Cancer Res 24: 222-233, 1964.
7. Carey RW, Holland JF, Whang HY, Neter E and Bryant B: Clostridia l oncolysis in man. Eur J Cancer 3: 37-42, 1967.
8. Kohwi Y, Imai K, Tamura Z and Hashimoto Y: Antitumor effect of Bifidobacterium infantis in mice. Gann 69: 613-618, 1978. (Pubitemid 9064809)
9. Brown JM and Giaccia AJ: The unique physiology of solid tumors: opportunities (and problems) for cancer therapy. Cancer Res 58: 1408-1416, 1998. (Pubitemid 28193601)
10. Fox ME, Lemmon MJ, Mauchline ML, Davis TO, Giaccia AJ, Minton NP and Brown JM: Anaerobic bacteria as a delivery system for cancer gene therapy: in vitro activation of 5-fluorocytosine by genetically engineered Clostridia . Gene Ther 3: 173-178, 1996. (Pubitemid 26117427)
11. Lemmon MJ, van Zijl P, Fox ME, Mauchline ML, Giaccia AJ, Minton NP and Brown JM: Anaerobic bacteria as a gene delivery system that is controlled by the tumor microenvironment. Gene Ther 4: 791-796, 1997. (Pubitemid 27380161)
12. Sznol M, Lin SL, Bermudes D, Zheng LM and King I: Use of preferentially replicating bacteria for the treatment of cancer. J Clin Invest 105: 1027-1030, 2000. (Pubitemid 30217683)
13. Low KB, Ittensohn M, Le T, Platt J, Sodi S, Amoss M, Ash O, Carmichael E, Chakraborty A, Fischer J, Lin SL, Luo X, Miller SI, Zheng L, King I, Pawelek JM and Bermudes D: Lipid A mutant Salmonella with suppressed virulence and TNF-alpha induction retain tumor-targeting in vivo. Nat Biotechnol 17: 37-41, 1999. (Pubitemid 29037207)
14. Clairmont C, Lee KC, Pike J, Ittensohn M, Low KB, Pawelek J, Bermudes D, Brecher SM, Margitich D, Turnier J, Li Z, Luo X, King I and Zheng LM: Biodistribution and genetic stability of the novel antitumor agent VNP20009, a genetically modified strain of Salmonella typhimurium. J Infect Dis 181: 1996-2002, 2000. (Pubitemid 30416163)
15. Yazawa K, Fujimori M, Amano J, Kano Y and Taniguchi S: Bifidobacterium longum as a delivery system for cancer gene therapy: selective localization and growth in hypoxic tumors. Cancer Gene Ther 7: 269-274, 2000. (Pubitemid 30194562)
16. Yazawa K, Fujimori M, Nakamura T, Sasaki T, Amano J, Kano Y and Taniguchi S: Bifidobacterium longum as a delivery system for gene therapy of chemically induced rat mammary tumors. Breast Cancer Res Treat 66: 165-170, 2001. (Pubitemid 32521423)
17. Kimura NT, Taniguchi S, Aoki K and Baba T: Selective localization and growth of Bifidobacterium bifidum in mouse tumors following intravenous administration. Cancer Res 40: 2061-2068, 1980. (Pubitemid 10116138)
18. Dang LH, Bettegowda C, Huso DL, Kinzler KW and Vogelstein B: Combination bacteriolytic therapy for the treatment of experimental tumors. Proc Natl Acad Sci USA 98: 15155-15160, 2001. (Pubitemid 34013985)
19. Yu YA, Shabahang S, Timiryasova TM, Zhang Q, Beltz R, Gentschev I, Goebel W and Szalay AA: Visualization of tumors and metastases in live animals with bacteria and vaccinia virus encoding light-emitting proteins. Nat Biotechnol 22: 313-320, 2004. (Pubitemid 38295764)
20. Zhao M, Yang M, Baranov E, Wang X, Penman S, Moossa AR and Hoffman RM: Spatial-temporal imaging of bacterial infection and antibiotic response in intact animals. Proc Natl Acad Sci USA 98: 9814-9818, 2001. (Pubitemid 32769386)
21. Toso JF, Gill VJ, Hwu P, Marincola FM, Restifo NP, Schwartzentruber DJ, Sherry RM, Topalian SL, Yang JC, Stock F, Freezer LJ, Morton KE, Seipp C, Haworth L, Mavroukakis S, White D, MacDonald S, Mao J, Sznol M and Rosenberg SA: Phase study of the intravenous administration of attenuated Salmonella typhimurium to patients with metastatic melanoma. J Clin Oncol 20: 142-152, 2002. (Pubitemid 34032605)
22. Zhao M, Yang M, Li XM, Jiang P, Baranov E, Li S, Xu M, Penman S and Hoffman RM: Tumor-targeting bacterial therapy with amino acid auxotrophs of GFP-expressing Salmonella typhimurium. Proc Natl Acad Sci USA 102: 755-760, 2005. (Pubitemid 40282738)
23. Zhao M, Yang M, Ma H, Li X, Tan X, Li S, Yang Z and Hoffman RM: Targeted therapy with a Salmonella typhimurium leucine-arginine auxotroph cures orthotopic human breast tumors in nude mice. Cancer Res 66: 7647-7652, 2006. (Pubitemid 44289222)
24. Zhao M, Geller J, Ma H, Yang M, Penman S and Hoffman RM: Monotherapy with a tumor-targeting mutant of Salmonella typhimurium cures orthotopic metastatic mouse models of human prostate cancer. Proc Natl Acad Sci USA 104: 10170-10174, 2007. (Pubitemid 47175281)
25. Hoffman RM and Zhao M: Whole-body imaging of bacterial infection and antibiotic response. Nature Protocols 1: 2988-2994, 2006.
26. Arrach N, Zhao M, Porwollik S, Hoffman RM and McClelland M: Salmonella promoters preferentially activated inside tumors. Cancer Res 68: 4827-4832, 2008.
27. Hayashi K, Zhao M, Yamauchi K, Yamamoto N, Tsuchiya H, Tomita K, Kishimoto H, Bouvet M and Hoffman RM: Systemic targeting of primary bone tumor and lung metastasis of high-grade osteosarcoma in nude mice with a tumor-selective strain of Salmonella typhimurium. Cell Cycle 8: 870-875, 2009 .
28. Hayashi K, Zhao M, Yamauchi K, Yamamoto N, Tsuchiya H, Tomita K and Hoffman RM: Cancer metastasis directly eradicated by targeted therapy with a modified Salmonella typhimurium. J Cell Biochem 106: 992-998, 2009.
29. Nagakura C, Hayashi K, Zhao M, Yamauchi K, Yamamoto N, Tsuchiya H, Tomita K, Bouvet M and Hoffman RM: Efficacy of a genetically modified Salmonella typhimurium in an orthotopic human pancreatic cancer in nude mice. Anticancer Res 29: 1873-1878, 2009.
30. Yam C, Zhao M, Hayashi K, Ma H, Kishimoto H, McElroy M, Bouvet M and Hoffman RM: Monotherapy with a tumor-targeting mutant of S. typhimurium inhibits liver metastasis in a mouse model of pancreatic cancer. J Surg Res 164: 248-255, 2010.
31. Kimura H, Zhang L, Zhao M, Hayashi K, Tsuchiya H, Tomita K, Bouvet M, Wessels J and Hoffman RM: Targeted therapy of spinal cord glioma with a genetically-modified Salmonella typhimurium. Cell Prolif 43: 41-48, 2010.
32. Arrach N, Cheng P, Zhao M, Santiviago CA, Hoffman RM and McClelland M: High-throughput screening for Salmonella avirulent mutants that retain targeting of solid tumors. Cancer Res 70: 2165-2170, 2010.
33. Liu F, Zhang L, Hoffman RM and Zhao M: Vessel destruction by tumor-targeting Salmonella typhimurium A1-R is enhanced by high tumor vascularity. Cell Cycle 9: 4518-4524, 2010.
34. Hoffman RM: Tumor-seeking Salmonella amino acid auxotrophs. Curr Opin Biotechnology 22: 917-923, 2011.
35. Zhao M, Suetsugu A, Ma H, Zhang L, Liu F, Zhang Y, Tran B and Hoffman RM: Efficacy against lung metastasis with a tumortargeting mutant of Salmonella typhimurium in immunocompetent mice. Cell Cycle 11: 187-193, 2012.
36. Momiyama M, Zhao M, Kimura H, Tran B, Chishima T, Bouvet M, Endo I and Hoffman RM: Inhibition and eradication of human glioma with tumor-targeting Salmonella typhimurium in an orthotopic nude-mouse model. Cell Cycle 11: 628-632, 2012.
37. Zhang Q, Fan H, Shen J, Hoffman RM and Xing HR: Human breast cancer cell lines co-express neuronal, epithelial, and melanocytic differentiation markers in vitro and in vivo. PLoS One 5: e9712, 2010.
38. Yamamoto N, Jiang P, Yang M, Xu M, Yamauchi K, Tsuchiya H, Tomita K, Wahl GM, Moossa AR and Hoffman RM: Cellular dynamics visualized in live cells in vitro and in vivo by differential dual-color nuclear-cytoplasmic fluorescent-protein expression. Cancer Res 64: 4251-4256, 2004. (Pubitemid 38802430)
39. Hoffman RM and Yang M: Subcellular imaging in the live mouse. Nature Protoc 1: 775-782, 2006.
40. Yamauchi K, Yang M, Jiang P, Xu M, Yamamoto N, Tsuchiya H, Tomita K, Moossa AR, Bouvet M and Hoffman RM: Development of real-time subcellular dynamic multicolor imaging of cancer-cell trafficking in live mice with a variable-magnification whole-mouse imaging system. Cancer Res 66: 4208-4214, 2006.
41. Tran Cao HS, Bouvet M, Kaushal S, Keleman A, Romney E, Kim G, Fruehauf J, Imagawa DK, Hoffman RM and Katz M: Metronomic gemcitabine in combination with sunitinib inhibits multisite metastasis and increases survival in an orthotopic model of pancreatic cancer. Mol Cancer Ther 9: 2068-2078, 2010.
42. Yang M, Jiang P and Hoffman RM. Whole-body subcellular multicolor imaging of tumor host interaction and drug response in real time. Cancer Res 67: 5195-5200, 2007. (Pubitemid 46997257)
43. Amoh Y, Hamada Y, Katsuoka K and Hoffman RM: In vivo imaging of nuclear-cytoplasmic deformation and partition during cancer cell death due to immune reaction. J Cell Biochem 113: 465-472, 2012.
44. Jia LJ, Wei DP, Sun QM, Huang Y, Wu Q and Hua ZC. Oral delivery of tumor-targeting Salmonella for cancer therapy in murine tumor models. Cancer Sci 98: 1107-1112, 2007. (Pubitemid 46865398)