Primer dosing of S. typhimurium a1-r potentiates tumor-targeting and efficacy in immunocompetent mice

Anticancer Research

Volumn 33, Issue 1, 2013, Pages 97-102

  Tome, Yasunori ^a,b,c   Zhang, Yong ^a   Momiyama, Masashi ^a   Maehara, Hiroki ^c   Kanaya, Fuminori ^c   Tomita, Katsuro ^d   Tsuchiya, Hiroyuki ^d   Bouvet, Michael ^b   Hoffman, Robert M ^a,b   Zhao, Ming ^a  

^a NtiCancer Inc   (United States)

^b UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^c UNIVERSITY OF THE RYUKYUS   (Japan)

^d KANAZAWA UNIVERSITY   (Japan)

Author keywords

Arginine; Auxotroph; GFP; High dose; Immunocompetent mice syngeneic mouse model; Leucine; Lewis lung carcinoma; Primer dosing; Salmonella typhimurium; Tumor targeting

Indexed keywords

ANTINEOPLASTIC AGENT; GREEN FLUORESCENT PROTEIN; NESTIN; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER INHIBITION; CANCER INVASION; CANCER SIZE; COLONY FORMING UNIT; CONTROLLED STUDY; DRUG EFFICACY; DRUG MEGADOSE; FEMALE; IMMUNOCOMPETENCE; LEWIS CARCINOMA; MOUSE; NONHUMAN; OUTCOME ASSESSMENT; PRIORITY JOURNAL; SALMONELLA TYPHIMURIUM; SALMONELLA TYPHIMURIUM A1 R;

ANIMALS; CARCINOMA, LEWIS LUNG; GREEN FLUORESCENT PROTEINS; HUMANS; IMMUNOCOMPETENCE; MICE; MICE, NUDE; NEOPLASMS; SALMONELLA TYPHIMURIUM; TUMOR NECROSIS FACTOR-ALPHA; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84873049481     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (36)

1. Zhao M, Yang M, Li X-M, Jiang P, Baranov E, Li S, Xu M, Penman S and Hoffman RM: Tumor-targeting bacterial therapy with amino acid auxotrophs of GFP-expressing Salmonella typhimurium. Proc Natl Acad Sci USA 102: 755-760, 2005.
2. Zhao M, Yang M, Ma H, Li X, Tan X, Li S, Yang Z and Hoffman RM: Targeted therapy with a Salmonella typhimurium leucine-arginine auxotroph cures orthotopic human breast tumors in nude mice. Cancer Res 66: 7647-7652, 2006.
3. Hoffman RM: Bugging tumors. Cancer Disc 2: 588-590, 2012.
4. Zhao M, Geller J, Ma H, Yang M, Penman S and Hoffman RM: Monotherapy with a tumor-targeting mutant of Salmonella typhimurium cures orthotopic metastatic mouse models of human prostate cancer. Proc Natl Acad Sci USA 104: 10170-10174, 2007.
5. Hayashi K, Zhao M, Yamauchi K, Yamamoto N, Tsuchiya H, Tomita K, Kishimoto H, Bouvet M and Hoffman RM: Systemic targeting of primary bone tumor and lung metastasis of highgrade osteosarcoma in nude mice with a tumor-selective strain of Salmonella typhimurium. Cell Cycle 8: 870-875, 2009.
6. Hayashi K, Zhao M, Yamauchi K, Yamamoto N, Tsuchiya H, Tomita K and Hoffman RM: Cancer metastasis directly eradicated by targeted therapy with a modified Salmonella typhimurium. J Cell Biochem 106: 992-998, 2009.
7. Nagakura C, Hayashi K, Zhao M, Yamauchi K, Yamamoto N, Tsuchiya H, Tomita K, Bouvet M and Hoffman RM: Efficacy of a genetically modified Salmonella typhimurium in an orthotopic human pancreatic cancer in nude mice. Anticancer Res 29: 1873-1878, 2009.
8. Yam C, Zhao M, Hayashi K, Ma H, Kishimoto H, McElroy M, Bouvet M and Hoffman RM: Monotherapy with a tumor-targeting mutant of S. typhimurium inhibits liver metastasis in a mouse model of pancreatic cancer. J Surg Res 164: 248-255, 2010.
9. Zhao M, Suetsugu A, Ma H, Zhang L, Liu F, Zhang Y, Tran B and Hoffman RM: Efficacy against lung metastasis with a tumortargeting mutant of Salmonella typhimurium in immunocompetent mice. Cell Cycle 11: 187-193, 2012.
10. Momiyama M, Zhao M, Kimura H, Tran B, Chishima T, Bouvet M, Endo I and Hoffman RM: Inhibition and eradication of human glioma with tumor-targeting Salmonella typhimurium in an orthotopic nude-mouse model. Cell Cycle 11: 628-632, 2012.
11. Kimura H, Zhang L, Zhao M, Hayashi K, Tsuchiya H, Tomita K, Bouvet M, Wessels J and Hoffman RM: Targeted therapy of spinal cord glioma with a genetically modified Salmonella typhimurium. Cell Prolif 43: 41-48, 2010.
12. Liu F, Zhang L, Hoffman RM and Zhao M: Vessel destruction by tumor-targeting Salmonella typhimurium A1-R is enhanced by high tumor vascularity. Cell Cycle 9: 4518-4524, 2010.
13. Leschner S, Westphal K, Dietrich N, Viegas N, Jablonska J, Lyszkiewicz M, Lienenklaus S, Falk W, Gekara N, Loessner H and Weiss S: Tumor invasion of Salmonella enterica serovar Typhimurium is accompanied by strong hemorrhage promoted by TNFα. PLoS ONE 4: e6692, 2009.
14. Yamauchi K, Yang M, Jiang P, Xu M, Yamamoto N, Tsuchiya H, Tomita K, Moossa AR, Bouvet M and Hoffman RM: Development of real-time subcellular dynamic multicolor imaging of cancer cell trafficking in live mice with a variablemagnification whole-mouse imaging system. Cancer Res 66: 4208-4214, 2006.
15. Hoffman RM: The preclinical discovery of bacterial therapy for the treatment of metastatic cancer with unique advantages. Expert Opin Drug Discov 7: 73-83, 2012.
16. Parker RC, Plummer HC, Siebenmann CO and Chapman MG. Effect of histolyticus infection and toxin on transplantable mouse tumors. Proc Soc Exp Biol Med 66, 461-467, 1947.
17. Malmgren RA and Flanigan CC: Localization of the vegetative form of Clostridium tetani in mouse tumors following intravenous spore administration. Cancer Res 15: 473-478, 1955.
18. Moese JR and Moese G: Oncolysis by Clostridia. I. activity of Clostridium butyricum (M-55) and other nonpathogenic clostridia against the Ehrlich carcinoma. Cancer Res 24: 212-216, 1964.
19. Gericke D and Engelbart K: Oncolysis by Clostridia. II. Experiments on a tumor spectrum with a variety of clostridia in combination with heavy metal. Cancer Res 24: 217-221, 1963.
20. Thiele EH, Arison RN and Boxer GE: Oncolysis by Clostridia.III. Effects of Clostridia and chemotherapeutic agents on rodent tumors. Cancer Res 24: 222-233, 1964.
21. Carey RW, Holland JF, Whang HY, Neter E and Bryant B: Clostridial oncolysis in Man. Eur J Cancer 3: 37-42, 1967.
22. Kohwi Y, Imai K, Tamura Z and Hashimoto Y: Antitumor effect of Bifidobacterium infantis in mice. Gann 69: 613-618, 1978.
23. Brown JM and Giaccia AJ: The unique physiology of solid tumors: opportunities (and problems) for cancer therapy. Cancer Res 58: 1408-1416, 1998.
24. Fox ME, Lemmon MJ, Mauchline ML, Davis TO, Giaccia AJ, Minton NP and Brown JM: Anaerobic bacteria as a delivery system for cancer gene therapy: In vitro activation of 5-fluorocytosine by genetically engineered Clostridia. Gene Ther 3: 173-178, 1996.
25. Lemmon MJ, van Zijl P, Fox ME, Mauchline ML, Giaccia AJ, Minton NP and Brown JM: Anaerobic bacteria as a gene delivery system that is controlled by the tumor microenvironment. Gene Ther 4: 791-796, 1997.
26. Sznol M, Lin SL, Bermudes D, Zheng LM and King I: Use of preferentially replicating bacteria for the treatment of cancer. J Clin Invest 105: 1027-1030, 2000.
27. Low KB, Ittensohn M, Le T, Platt J, Sodi S, Amoss M, Ash O, Carmichael E, Chakraborty A, Fischer J, Lin SL, Luo X, Miller SI, Zheng L, King I, Pawelek JM and Bermudes D: Lipid A mutant Salmonella with suppressed virulence and TNF-α induction retain tumor-targeting in vivo. Nat Biotechnol 17: 37-41, 1999.
28. Clairmont C, Lee KC, Pike J, Ittensohn M, Low KB, Pawelek J, Bermudes D, Brecher SM, Margitich D, Turnier J, Li Z, Luo X, King I and Zheng LM: Biodistribution and genetic stability of the novel antitumor agent VNP20009, a genetically modified strain of Salmonella typhimurium. J Infect Dis 181: 1996-2002, 2000.
29. Yazawa K, Fujimori M, Amano J, Kano Y and Taniguchi S: Bifidobacterium longum as a delivery system for cancer gene therapy: selective localization and growth in hypoxic tumors. Cancer Gene Ther 7: 269-274, 2000.
30. Yazawa K, Fujimori M, Nakamura T, Sasaki T, Amano J, Kano Y and Taniguchi S: Bifidobacterium longum as a delivery system for gene therapy of chemically induced rat mammary tumors. Breast Cancer Res Treat 66: 165-170, 2001.
31. Kimura NT, Taniguchi S, Aoki K and Baba T: Selective localization and growth of Bifidobacterium bifidum in mouse tumors following intravenous administration. Cancer Res 40: 2061-2068, 1980.
32. Dang LH, Bettegowda C, Huso DL, Kinzler KW and Vogelstein B: Combination bacteriolytic therapy for the treatment of experimental tumors. Proc Natl Acad Sci USA 98: 15155-15160, 2001.
33. Hoffman RM: Tumor-seeking Salmonella amino acid auxotrophs Curr Opin Biotechnol 22: 917-923, 2011
34. Yu YA, Shabahang S, Timiryasova TM, Zhang Q, Beltz R, Gentschev I, Goebel W and Szalay AA: Visualization of tumors and metastases in live animals with bacteria and vaccinia virus encoding light-emitting proteins. Nat Biotechnol 22: 313-320, 2004.
35. Zhao M, Yang M, Baranov E, Wang X, Penman S, Moossa AR and Hoffman RM: Spatial-temporal imaging of bacterial infection and antibiotic response in intact animals. Proc Natl Acad Sci USA 98: 9814-9818, 2001.
36. Toso JF, Gill VJ, Hwu P, Marincola FM, Restifo NP, Schwartzentruber DJ, Sherry RM, Topalian SL, Yang JC, Stock F, Freezer LJ, Morton KE, Seipp C, Haworth L, Mavroukakis S, White D, MacDonald S, Mao J, Sznol M and Rosenberg SA: Phase I study of the intravenous administration of attenuated Salmonella typhimurium to patients with metastatic melanoma. J Clin Oncol 20: 142-152, 2002.