A RG-II type polysaccharide purified from Aconitum coreanum alleviates lipopolysaccharide-induced inflammation by inhibiting the NF-κB signal pathway

PLoS ONE

Volumn 9, Issue 6, 2014, Pages

  Li, Xiaojun ^a   Jiang, Jiaye ^a   Shi, Songshan ^a,b   Bligh, S W Annie ^c   Li, Yuan ^a   Jiang, Yongbo ^a   Huang, Dan ^a   Ke, Yan ^a   Wang, Shunchun ^a,b  

^a SHANGHAI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

^b Shanghai R and D Center for Standardization of Chinese Medicines   (China)

^c UNIVERSITY OF WESTMINSTER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFLAMMATORY AGENT; CARRAGEENAN; DNA; I KAPPA B ALPHA; IBUPROFEN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; INTERLEUKIN 6; KOREAN MONSHOOD ROOT POLYSACCHARIDE 2E; LIPOPOLYSACCHARIDE; MONOSACCHARIDE; POLYSACCHARIDE; TOLL LIKE RECEPTOR 4; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; PLANT EXTRACT;

ACONITE; ACONITUM COREANUM; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG DNA INTERACTION; DRUG DOSE COMPARISON; DRUG HYDROLYSIS; DRUG ISOLATION; DRUG MEGADOSE; DRUG PURIFICATION; DRUG STRUCTURE; GEL MOBILITY SHIFT ASSAY; GENE EXPRESSION REGULATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IL 1BETA GENE; IL 6 GENE; IN VIVO STUDY; INFLAMMATION; INFRARED SPECTROSCOPY; INOS GENE; LOW DRUG DOSE; MACROPHAGE FUNCTION; MALE; MASS FRAGMENTOGRAPHY; METHYLATION; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PAW EDEMA; PROTEIN DEGRADATION; RAT; SINGLE DRUG DOSE; TNF ALPHA GENE; ANIMAL; CELL LINE; CHEMICALLY INDUCED; CHEMISTRY; DRUG EFFECTS; METABOLISM; MOUSE; SIGNAL TRANSDUCTION; WESTERN BLOTTING; WISTAR RAT;

ACONITUM; ANIMALS; BLOTTING, WESTERN; CELL LINE; ELECTROPHORETIC MOBILITY SHIFT ASSAY; INFLAMMATION; LIPOPOLYSACCHARIDES; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MICE; NF-KAPPA B; PLANT EXTRACTS; POLYSACCHARIDES; RATS; RATS, WISTAR; SIGNAL TRANSDUCTION;

EID: 84903138994     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0099697     Document Type: Article

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