-
1
-
-
84871657542
-
A method of moments estimator for random effect multivariate meta-analysis
-
Chen H, Manning AK, Dupuis J. 2012. A method of moments estimator for random effect multivariate meta-analysis. Biometrics 68:1278-1284.
-
(2012)
Biometrics
, vol.68
, pp. 1278-1284
-
-
Chen, H.1
Manning, A.K.2
Dupuis, J.3
-
3
-
-
84878020180
-
Meta-analysis methods for genome-wide association studies and beyond
-
Evangelou E, Ioannidis JP. 2013. Meta-analysis methods for genome-wide association studies and beyond. Nat Rev Genet 14:379-389.
-
(2013)
Nat Rev Genet
, vol.14
, pp. 379-389
-
-
Evangelou, E.1
Ioannidis, J.P.2
-
4
-
-
38749145596
-
Shifting paradigm of association studies: value of rare single-nucleotide polymorphisms
-
Gorlov IP, Gorlova OY, Sunyaev SR, Spitz MR, Amos CI. 2008. Shifting paradigm of association studies: value of rare single-nucleotide polymorphisms. Am J Hum Genet 82:100-112.
-
(2008)
Am J Hum Genet
, vol.82
, pp. 100-112
-
-
Gorlov, I.P.1
Gorlova, O.Y.2
Sunyaev, S.R.3
Spitz, M.R.4
Amos, C.I.5
-
5
-
-
79955860273
-
Random-effects model aimed at discovering associations in meta-analysis of genome-wide association studies
-
Han B, Eskin E. 2011. Random-effects model aimed at discovering associations in meta-analysis of genome-wide association studies. Am J Hum Genet 88:586-598.
-
(2011)
Am J Hum Genet
, vol.88
, pp. 586-598
-
-
Han, B.1
Eskin, E.2
-
6
-
-
84859246571
-
Interpreting meta-analyses of genome-wide association studies
-
Han B, Eskin E. 2012. Interpreting meta-analyses of genome-wide association studies. PLoS Genet 8:e1002555.
-
(2012)
PLoS Genet
, vol.8
-
-
Han, B.1
Eskin, E.2
-
7
-
-
73449085512
-
Meta-analysis of the INSIG2 association with obesity including 74,345 individuals: does heterogeneity of estimates relate to study design?
-
Heid IM, Huth C, Loos RJF, Kronenberg F, Adamkova V, Anand SS, Ardlie K, Biebermann H, Bjerregaard P, Boeing H and others. 2009. Meta-analysis of the INSIG2 association with obesity including 74, 345 individuals: does heterogeneity of estimates relate to study design? PLoS Genet 5:e1000694.
-
(2009)
PLoS Genet
, vol.5
-
-
Heid, I.M.1
Huth, C.2
Loos, R.J.F.3
Kronenberg, F.4
Adamkova, V.5
Anand, S.S.6
Ardlie, K.7
Biebermann, H.8
Bjerregaard, P.9
Boeing, H.10
-
8
-
-
78049349396
-
Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution
-
Heid IM, Jackson AU, Randall JC, Winkler TW, Qi L, Steinthorsdottir V, Thorleifsson G, Zillikens MC, Speliotes EK, Mägi R and others. 2010. Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. Nat Genet 42:949-960.
-
(2010)
Nat Genet
, vol.42
, pp. 949-960
-
-
Heid, I.M.1
Jackson, A.U.2
Randall, J.C.3
Winkler, T.W.4
Qi, L.5
Steinthorsdottir, V.6
Thorleifsson, G.7
Zillikens, M.C.8
Speliotes, E.K.9
Mägi, R.10
-
9
-
-
84881660693
-
Meta-analysis of gene-level associations for rare variants based on single-variant statistics
-
Hu YJ, Berndt SI, Gustafsson S, Ganna A, Hirschhorn J, North KE, Ingelsson E, Lin DY. 2013. Meta-analysis of gene-level associations for rare variants based on single-variant statistics. Am J Hum Genet 93:236-248.
-
(2013)
Am J Hum Genet
, vol.93
, pp. 236-248
-
-
Hu, Y.J.1
Berndt, S.I.2
Gustafsson, S.3
Ganna, A.4
Hirschhorn, J.5
North, K.E.6
Ingelsson, E.7
Lin, D.Y.8
-
10
-
-
0036184745
-
Generating samples under a Wright-Fisher neutral model of genetic variation
-
Hudson RR. 2002. Generating samples under a Wright-Fisher neutral model of genetic variation. Bioinformatics 18:337-338.
-
(2002)
Bioinformatics
, vol.18
, pp. 337-338
-
-
Hudson, R.R.1
-
11
-
-
41049087605
-
Heterogeneity in meta-analyses of genome-wide association investigations
-
Ioannidis JP, Patsopoulos NA, Evangelou E. 2007. Heterogeneity in meta-analyses of genome-wide association investigations. PLoS ONE 2:e841.
-
(2007)
PLoS ONE
, vol.2
-
-
Ioannidis, J.P.1
Patsopoulos, N.A.2
Evangelou, E.3
-
12
-
-
77952828976
-
Extending DerSimonian and Laird's methodology to perform multivariate random effects meta-analyses
-
Jackson D, White IR, Thompson SG. 2010. Extending DerSimonian and Laird's methodology to perform multivariate random effects meta-analyses. Stat Med 29:1282-1297.
-
(2010)
Stat Med
, vol.29
, pp. 1282-1297
-
-
Jackson, D.1
White, I.R.2
Thompson, S.G.3
-
13
-
-
62649084535
-
Power of deep, all-exon resequencing for discovery of human trait genes
-
Kryukov GV, Shpunt A, Stamatoyannopoulos JA, Sunyaev SR. 2009. Power of deep, all-exon resequencing for discovery of human trait genes. Proc Natl Acad Sci USA 106:3871-3876.
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, pp. 3871-3876
-
-
Kryukov, G.V.1
Shpunt, A.2
Stamatoyannopoulos, J.A.3
Sunyaev, S.R.4
-
14
-
-
84893720400
-
Whole-exome sequencing identifies rare and low-frequency coding variants associated with LDL cholesterol
-
Lange LA, Hu Y, Zhang H, Xue C, Schmidt EM, Tang ZZ, Bizon C, Lange EM, Smith JD, Turner EH and others. 2014. Whole-exome sequencing identifies rare and low-frequency coding variants associated with LDL cholesterol. Am J Hum Genet 94:233-245.
-
(2014)
Am J Hum Genet
, vol.94
, pp. 233-245
-
-
Lange, L.A.1
Hu, Y.2
Zhang, H.3
Xue, C.4
Schmidt, E.M.5
Tang, Z.Z.6
Bizon, C.7
Lange, E.M.8
Smith, J.D.9
Turner, E.H.10
-
15
-
-
84864942403
-
Optimal unified approach for rare-variant association testing with application to small-sample case-control whole-exome sequencing studies
-
Lee S, Emond MJ, Bamshad MJ, Barnes KC, Rieder MJ, Nickerson DA, Christiani DC, Wurfel MM, Lin X. 2012. Optimal unified approach for rare-variant association testing with application to small-sample case-control whole-exome sequencing studies. Am J Hum Genet 91:224-237.
-
(2012)
Am J Hum Genet
, vol.91
, pp. 224-237
-
-
Lee, S.1
Emond, M.J.2
Bamshad, M.J.3
Barnes, K.C.4
Rieder, M.J.5
Nickerson, D.A.6
Christiani, D.C.7
Wurfel, M.M.8
Lin, X.9
-
16
-
-
84880294630
-
General framework for meta-analysis of rare variants in sequencing association studies
-
Lee S, Teslovich T, Boehnke M, Lin X. 2013. General framework for meta-analysis of rare variants in sequencing association studies. Am J Hum Genet 93:42-53.
-
(2013)
Am J Hum Genet
, vol.93
, pp. 42-53
-
-
Lee, S.1
Teslovich, T.2
Boehnke, M.3
Lin, X.4
-
17
-
-
50949095168
-
Methods for detecting associations with rare variants for common diseases: application to analysis of sequence data
-
Li B, Leal SM. 2008. Methods for detecting associations with rare variants for common diseases: application to analysis of sequence data. Am J Hum Genet 83:311-321.
-
(2008)
Am J Hum Genet
, vol.83
, pp. 311-321
-
-
Li, B.1
Leal, S.M.2
-
18
-
-
80052731371
-
A general framework for detecting disease associations with rare variants in sequencing studies
-
Lin DY, Tang ZZ. 2011. A general framework for detecting disease associations with rare variants in sequencing studies. Am J Hum Genet 89:354-367.
-
(2011)
Am J Hum Genet
, vol.89
, pp. 354-367
-
-
Lin, D.Y.1
Tang, Z.Z.2
-
19
-
-
77952851091
-
On the relative efficiency of using summary statistics versus individual-level data in meta-analysis
-
Lin DY, Zeng D. 2010. On the relative efficiency of using summary statistics versus individual-level data in meta-analysis. Biometrika 97:321-332.
-
(2010)
Biometrika
, vol.97
, pp. 321-332
-
-
Lin, D.Y.1
Zeng, D.2
-
20
-
-
84880672305
-
Quantitative trait analysis in sequencing studies under trait-dependent sampling
-
Lin DY, Zeng D, Tang ZZ. 2013. Quantitative trait analysis in sequencing studies under trait-dependent sampling. Proc Natl Acad Sci USA 110:12247-12252.
-
(2013)
Proc Natl Acad Sci USA
, vol.110
, pp. 12247-12252
-
-
Lin, D.Y.1
Zeng, D.2
Tang, Z.Z.3
-
21
-
-
84895808047
-
Meta-analysis of gene-level tests for rare variant association
-
Liu DJ, Peloso GM, Zhan X, Holmen OL, Zawistowski M, Feng S, Nikpay M, Auer PL, Goel A, Zhang H and others. 2014. Meta-analysis of gene-level tests for rare variant association. Nat Genet 46:200-204.
-
(2014)
Nat Genet
, vol.46
, pp. 200-204
-
-
Liu, D.J.1
Peloso, G.M.2
Zhan, X.3
Holmen, O.L.4
Zawistowski, M.5
Feng, S.6
Nikpay, M.7
Auer, P.L.8
Goel, A.9
Zhang, H.10
-
22
-
-
61449168010
-
A groupwise association test for rare mutations using a weighted sum statistic
-
Madsen BE, Browning SR. 2009. A groupwise association test for rare mutations using a weighted sum statistic. PLoS Genet 5:e1000384.
-
(2009)
PLoS Genet
, vol.5
-
-
Madsen, B.E.1
Browning, S.R.2
-
23
-
-
42349112088
-
Genome-wide association studies for complex traits: consensus, uncertainty and challenges
-
McCarthy MI, Abecasis GR, Cardon LR, Goldstein DB, Little J, Ioannidis JP, Hirschhorn JN. 2008. Genome-wide association studies for complex traits: consensus, uncertainty and challenges. Nat Rev Genet 9:356-369.
-
(2008)
Nat Rev Genet
, vol.9
, pp. 356-369
-
-
McCarthy, M.I.1
Abecasis, G.R.2
Cardon, L.R.3
Goldstein, D.B.4
Little, J.5
Ioannidis, J.P.6
Hirschhorn, J.N.7
-
24
-
-
38649101531
-
Required sample size and nonreplicability thresholds for heterogeneous genetic associations
-
Moonesinghe R, Khoury MJ, Liu T, Ioannidis JP. 2008. Required sample size and nonreplicability thresholds for heterogeneous genetic associations. Proc Natl Acad Sci USA 105:617-622.
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 617-622
-
-
Moonesinghe, R.1
Khoury, M.J.2
Liu, T.3
Ioannidis, J.P.4
-
25
-
-
33846014328
-
A strategy to discover genes that carry multi-allelic or mono-allelic risk for common diseases: a cohort allelic sums test (CAST)
-
Morgenthaler S, Thilly WG. 2007. A strategy to discover genes that carry multi-allelic or mono-allelic risk for common diseases: a cohort allelic sums test (CAST). Mutat Res 615:28-56.
-
(2007)
Mutat Res
, vol.615
, pp. 28-56
-
-
Morgenthaler, S.1
Thilly, W.G.2
-
26
-
-
76649136928
-
An evaluation of statistical approaches to rare variant analysis in genetic association studies
-
Morris AP, Zeggini E. 2010. An evaluation of statistical approaches to rare variant analysis in genetic association studies. Genet Epidemiol 34:188-193.
-
(2010)
Genet Epidemiol
, vol.34
, pp. 188-193
-
-
Morris, A.P.1
Zeggini, E.2
-
27
-
-
79953752624
-
Testing for an unusual distribution of rare variants
-
Neale BM, Rivas MA, Voight BF, Altshuler D, Devlin B, Orho-Melander M, Kathiresan S, Purcell SM, Roeder K, Daly MJ. 2011. Testing for an unusual distribution of rare variants. PLoS Genet 7:e1001322.
-
(2011)
PLoS Genet
, vol.7
-
-
Neale, B.M.1
Rivas, M.A.2
Voight, B.F.3
Altshuler, D.4
Devlin, B.5
Orho-Melander, M.6
Kathiresan, S.7
Purcell, S.M.8
Roeder, K.9
Daly, M.J.10
-
28
-
-
84863541347
-
An abundance of rare functional variants in 202 drug target genes sequenced in 14,002 people
-
Nelson MR, Wegmann D, Ehm MG, Kessner D, St Jean P, Verzilli C, Shen J, Tang Z, Bacanu SA, Fraser D and others. 2012. An abundance of rare functional variants in 202 drug target genes sequenced in 14, 002 people. Science 337:100-104.
-
(2012)
Science
, vol.337
, pp. 100-104
-
-
Nelson, M.R.1
Wegmann, D.2
Ehm, M.G.3
Kessner, D.4
St Jean, P.5
Verzilli, C.6
Shen, J.7
Tang, Z.8
Bacanu, S.A.9
Fraser, D.10
-
29
-
-
77953121877
-
Pooled association tests for rare variants in exon-resequencing studies
-
Price AL, Kryukov GV, de Bakker PIW, Purcell SM, Staples J, Wei LJ, Sunyaev SR. 2010. Pooled association tests for rare variants in exon-resequencing studies. Am J Hum Genet 86:832-838.
-
(2010)
Am J Hum Genet
, vol.86
, pp. 832-838
-
-
Price, A.L.1
Kryukov, G.V.2
de Bakker, P.I.W.3
Purcell, S.M.4
Staples, J.5
Wei, L.J.6
Sunyaev, S.R.7
-
30
-
-
0034969437
-
Are rare variants responsible for susceptibility to complex diseases?
-
Pritchard JK. 2001. Are rare variants responsible for susceptibility to complex diseases? Am J Hum Genet 69:124-137.
-
(2001)
Am J Hum Genet
, vol.69
, pp. 124-137
-
-
Pritchard, J.K.1
-
31
-
-
84859436530
-
NCBI Reference Sequences (RefSeq): current status, new features and genome annotation policy
-
Pruitt KD, Tatusova T, Brown GR, Maglott DR. 2012. NCBI Reference Sequences (RefSeq): current status, new features and genome annotation policy. Nucleic Acids Res 40:130-135.
-
(2012)
Nucleic Acids Res
, vol.40
, pp. 130-135
-
-
Pruitt, K.D.1
Tatusova, T.2
Brown, G.R.3
Maglott, D.R.4
-
32
-
-
34047177395
-
Population-based resequencing of ANGPTL4 uncovers variations that reduce triglycerides and increase HDL
-
Romeo S, Pennacchio LA, Fu Y, Boerwinkle E, Tybjaerg-Hansen A, Hobbs HH, Cohen JC. 2007. Population-based resequencing of ANGPTL4 uncovers variations that reduce triglycerides and increase HDL. Nat Genet 39:513-516.
-
(2007)
Nat Genet
, vol.39
, pp. 513-516
-
-
Romeo, S.1
Pennacchio, L.A.2
Fu, Y.3
Boerwinkle, E.4
Tybjaerg-Hansen, A.5
Hobbs, H.H.6
Cohen, J.C.7
-
33
-
-
34249888775
-
Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels
-
Saxena R, Voight BF, Lyssenko V, Burtt NP, de Bakker PIW, Chen H, Roix JJ, Kathiresan S, Hirschhorn JN, Daly MJ and others. 2007. Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels. Science 316:1331-1336.
-
(2007)
Science
, vol.316
, pp. 1331-1336
-
-
Saxena, R.1
Voight, B.F.2
Lyssenko, V.3
Burtt, N.P.4
de Bakker, P.I.W.5
Chen, H.6
Roix, J.J.7
Kathiresan, S.8
Hirschhorn, J.N.9
Daly, M.J.10
-
34
-
-
34249885875
-
A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants
-
Scott LJ, Mohlke KL, Bonnycastle LL, Willer CJ, Li Y, Duren WL, Erdos MR, Stringham HM, Chines PS, Jackson AU and others. 2007. A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants. Science 316:1341-1345.
-
(2007)
Science
, vol.316
, pp. 1341-1345
-
-
Scott, L.J.1
Mohlke, K.L.2
Bonnycastle, L.L.3
Willer, C.J.4
Li, Y.5
Duren, W.L.6
Erdos, M.R.7
Stringham, H.M.8
Chines, P.S.9
Jackson, A.U.10
-
35
-
-
38349178429
-
Novel rare mutations and promoter haplotypes in ABCA1 contribute to low-HDL-C levels
-
Slatter TL, Jones GT, Williams MJA, Van Rij AM, McCormick SPA. 2008. Novel rare mutations and promoter haplotypes in ABCA1 contribute to low-HDL-C levels. Clin Genet 73:179-184.
-
(2008)
Clin Genet
, vol.73
, pp. 179-184
-
-
Slatter, T.L.1
Jones, G.T.2
Williams, M.J.A.3
Van Rij, A.M.4
McCormick, S.P.A.5
-
36
-
-
84880198559
-
MASS: meta-analysis of score statistics for sequencing studies
-
Tang ZZ, Lin DY. 2013. MASS: meta-analysis of score statistics for sequencing studies. Bioinformatics 29:1803-1805.
-
(2013)
Bioinformatics
, vol.29
, pp. 1803-1805
-
-
Tang, Z.Z.1
Lin, D.Y.2
-
37
-
-
84863556835
-
Evolution and functional impact of rare coding variation from deep sequencing of human exomes
-
Tennessen JA, Bigham AW, O'Connor TD, Fu W, Kenny EE, Gravel S, McGee S, Do R, Liu X, Jun G and others. 2012. Evolution and functional impact of rare coding variation from deep sequencing of human exomes. Science 337:64-69.
-
(2012)
Science
, vol.337
, pp. 64-69
-
-
Tennessen, J.A.1
Bigham, A.W.2
O'Connor, T.D.3
Fu, W.4
Kenny, E.E.5
Gravel, S.6
McGee, S.7
Do, R.8
Liu, X.9
Jun, G.10
-
38
-
-
35348887757
-
Haplotype-based association analysis via variance-components score test
-
Tzeng JY, Zhang D. 2007. Haplotype-based association analysis via variance-components score test. Am J Hum Genet 81:927-938.
-
(2007)
Am J Hum Genet
, vol.81
, pp. 927-938
-
-
Tzeng, J.Y.1
Zhang, D.2
-
39
-
-
77957370404
-
Consistent association of type 2 diabetes risk variants found in Europeans in diverse racial and ethnic groups
-
Waters KM, Stram DO, Hassanein MT, Le Marchand L, Wilkens LR, Maskarinec G, Monroe KR, Kolonel LN, Altshuler D, Henderson BE and others. 2010. Consistent association of type 2 diabetes risk variants found in Europeans in diverse racial and ethnic groups. PLoS Genet 6:e1001078.
-
(2010)
PLoS Genet
, vol.6
-
-
Waters, K.M.1
Stram, D.O.2
Hassanein, M.T.3
Le Marchand, L.4
Wilkens, L.R.5
Maskarinec, G.6
Monroe, K.R.7
Kolonel, L.N.8
Altshuler, D.9
Henderson, B.E.10
-
40
-
-
80051499915
-
Rare-variant association testing for sequencing data with the sequence kernel association test
-
Wu MC, Lee S, Cai T, Li Y, Boehnke M, Lin X. 2011. Rare-variant association testing for sequencing data with the sequence kernel association test. Am J Hum Genet 89:82-93.
-
(2011)
Am J Hum Genet
, vol.89
, pp. 82-93
-
-
Wu, M.C.1
Lee, S.2
Cai, T.3
Li, Y.4
Boehnke, M.5
Lin, X.6
-
41
-
-
34249895023
-
Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes
-
Zeggini E, Weedon MN, Lindgren CM, Frayling TM, Elliott KS, Lango H, Timpson NJ, Perry JRB, Rayner NW, Freathy RM and others. 2007. Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes. Science 316:1336-1341.
-
(2007)
Science
, vol.316
, pp. 1336-1341
-
-
Zeggini, E.1
Weedon, M.N.2
Lindgren, C.M.3
Frayling, T.M.4
Elliott, K.S.5
Lango, H.6
Timpson, N.J.7
Perry, J.R.B.8
Rayner, N.W.9
Freathy, R.M.10
-
42
-
-
84877793925
-
Association between PCSK9 and LDLR gene polymorphisms with coronary heart disease: case-control study and meta-analysis
-
Zhang L, Yuan F, Liu P, Fei L, Huang Y, Xu L, Hao L, Qiu X, Le Y, Yang X and others. 2013. Association between PCSK9 and LDLR gene polymorphisms with coronary heart disease: case-control study and meta-analysis. Clin Biochem 46:727-732.
-
(2013)
Clin Biochem
, vol.46
, pp. 727-732
-
-
Zhang, L.1
Yuan, F.2
Liu, P.3
Fei, L.4
Huang, Y.5
Xu, L.6
Hao, L.7
Qiu, X.8
Le, Y.9
Yang, X.10
|