P66Shc mediates increased platelet activation and aggregation in hypercholesterolemia

Biochemical and Biophysical Research Communications

Volumn 449, Issue 4, 2014, Pages 496-501

  Kumar, Santosh ^a   Vikram, Ajit ^a   Kim, Young Rae ^a   Jacobs, Julia S ^a   Irani, Kaikobad ^a  

^a UNIVERSITY OF IOWA   (United States)

Author keywords

Hypercholesterolemia; P66Shc; Platelets; Reactive oxygen species

Indexed keywords

ADAPTOR PROTEIN; CHOLESTEROL; PADGEM PROTEIN; PROTEIN P66SHC; REACTIVE OXYGEN METABOLITE; THROMBIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; HUMAN; HUMAN CELL; HYPERCHOLESTEROLEMIA; IMMUNOBLOTTING; LIPID DIET; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; REAL TIME POLYMERASE CHAIN REACTION; RNA INTERFERENCE; THROMBOCYTE ACTIVATION; THROMBOCYTE AGGREGATION; THROMBOCYTE MEMBRANE; TRANSGENIC MOUSE; UPREGULATION; WILD TYPE;

MUS; MUS MUSCULUS;

HYPERCHOLESTEROLEMIA; P66SHC; PLATELETS; REACTIVE OXYGEN SPECIES;

ANIMALS; DIET, HIGH-FAT; HUMANS; HYPERCHOLESTEROLEMIA; MICE; MICE, TRANSGENIC; PLATELET ACTIVATION; PLATELET AGGREGATION; RECEPTORS, PROTEINASE-ACTIVATED; SHC SIGNALING ADAPTOR PROTEINS;

EID: 84902867247     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2014.05.029     Document Type: Article

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