Knockdown of TWIST1 enhances arsenic trioxide- and ionizing radiation-induced cell death in lung cancer cells by promoting mitochondrial dysfunction

Biochemical and Biophysical Research Communications

Volumn 449, Issue 4, 2014, Pages 490-495

  Seo, Sung Keum ^a   Kim, Jae Hee ^a   Choi, Ha Na ^a   Choe, Tae Boo ^b   Hong, Seok Il ^c   Yi, Jae Youn ^a   Hwang, Sang Gu ^a   Lee, Hyun Gyu ^d   Lee, Yun Han ^d   Park, In Chul ^a  

^a Korea Institute of Radiation and Medical Science   (South Korea)

^b Konkuk University   (South Korea)

^c Korea Cancer Center Hospital   (South Korea)

^d Yonsei University College of Medicine   (South Korea)

Author keywords

Arsenic trioxide; Irradiation; Mitochondria dysfunction; Reactive oxygen species; TWIST1

Indexed keywords

ACETYLCYSTEINE; ARSENIC TRIOXIDE; BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; MITOCHONDRIAL PROTEIN; PROTEIN DRP1; PROTEIN FIS1; REACTIVE OXYGEN METABOLITE; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR TWIST1; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL DEATH; CELL VIABILITY; CONFOCAL MICROSCOPY; CONTROLLED STUDY; GENE SILENCING; HUMAN; HUMAN CELL; IONIZING RADIATION; LUNG NON SMALL CELL CANCER; MEMBRANE DEPOLARIZATION; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRIAL TOXICITY; MITOCHONDRION; OXIDATIVE STRESS; PRIORITY JOURNAL; UPREGULATION; WESTERN BLOTTING;

ARSENIC TRIOXIDE; IRRADIATION; MITOCHONDRIA DYSFUNCTION; REACTIVE OXYGEN SPECIES; TWIST1;

ACETYLCYSTEINE; ARSENICALS; CARCINOMA, NON-SMALL-CELL LUNG; CELL DEATH; GENE KNOCKDOWN TECHNIQUES; HUMANS; MEMBRANE POTENTIAL, MITOCHONDRIAL; NUCLEAR PROTEINS; OXIDES; RADIATION, IONIZING; REACTIVE OXYGEN SPECIES; RNA, SMALL INTERFERING; TWIST TRANSCRIPTION FACTOR;

EID: 84902852858     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2014.05.030     Document Type: Article

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