The BDNF/TrkB signaling pathway is involved in heat hyperalgesia mediated by Cdk5 in rats

PLoS ONE

Volumn 9, Issue 1, 2014, Pages

  Zhang, Hong Hai ^a,b   Zhang, Xiao Qin ^a   Xue, Qing Sheng ^a   Yan Luo, ^a   Huang, Jin Lu ^a   Zhang, Su ^a   Shao, Hai Jun ^a   Lu, Han ^a   Wang, Wen Yuan ^a   Yu, Bu Wei ^a  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b Department of Orthopaedics   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR RECEPTOR; CYCLIN DEPENDENT KINASE 5; FREUND ADJUVANT; K 252A; ROSCOVITINE;

ADULT; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME BLOOD LEVEL; HEAT HYPERALGESIA; HYPERALGESIA; IMMUNOPRECIPITATION; MALE; NONHUMAN; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN INTERACTION; RAT; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; SPINAL CORD DORSAL HORN;

ANIMALS; BRAIN-DERIVED NEUROTROPHIC FACTOR; CARBAZOLES; CYCLIN-DEPENDENT KINASE 5; FREUND'S ADJUVANT; GENE EXPRESSION REGULATION; HOT TEMPERATURE; HYPERALGESIA; INDOLE ALKALOIDS; MALE; PAIN; PAIN MEASUREMENT; PROTEIN KINASE INHIBITORS; PURINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, TRKB; SIGNAL TRANSDUCTION; SPINAL CORD;

EID: 84902774903     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0085536     Document Type: Article

References (38)

1. Pareek TK, Kulkarni AB (2006) A New Player in Pain Signaling. Cell cycle, 5:585-588.
2. Pareek TK, Keller J, Kesavapany S, Pant HC, Iadarola MJ, et al. (2006) Cyclin-dependent kinase 5 activity regulates pain signaling. Proc Natl Acad Sci 103: 791-796. (Pubitemid 43153104)
3. Pareek TK, Keller J, Kesavapany S, Agarwal N, Kuner R, et al. (2007) Cyclin-dependent kinase 5 modulates nociceptive signaling through direct phosphorylation of transient receptor potential vanilloid 1. Proc Natl Acad Sci 104: 660-665. (Pubitemid 46123081)
4. Xing B-M, Yang Y-R, Du J-X, Chen H-J, Qi C, et al. (2012) Cyclin-Dependent Kinase 5 Controls TRPV1 Membrane Trafficking and the Heat Sensitivity of Nociceptors through KIF13B. J Neurosci 32: 14709-14721.
5. Zhang R, Liu Y, Zhang J, Zheng Y, Gu X, et al. (2012) Intrathecal administration of roscovitine attenuates cancer pain and inhibits the expression of NMDA receptor 2B subunit mRNA. Pharmacol Biochem Behav 102: 139-145.
6. Utreras E, Terse A, Keller J, Iadarola MJ, Kulkarni AB (2011) Resveratrol inhibits Cdk5 activity through regulation of p35 expression. Mol Pain 7: 49.
7. Zhang H-H, Zhang X-Q, Wang W-Y, Xue Q-S, Lu H, et al. (2012) Increased synaptophysin is involved in inflammation-induced heat hyperalgesia mediated by cyclin-dependent kinase 5 in rats. PloS one 7: e46666.
8. Yang Y-R, He Y, Zhang Y, Li Y, Li Y, et al. (2007) Activation of cyclin-dependent kinase 5 (Cdk5) in primary sensory and dorsal horn neurons by peripheral inflammation contributes to heat hyperalgesia. Pain 127: 109-120. (Pubitemid 44959433)
9. Groth R, Aanonsen L (2002) Spinal brain-derived neurotrophic factor (BDNF) produces hyperalgesia in normal mice while antisense directed against either BDNF or trkB, prevent inflammation-induced hyperalgesia. Pain 100: 171-181. (Pubitemid 35305134)
10. Wang X, Ratnam J, Zou B, England PM, Basbaum AI (2009) TrkB signaling is required for both the induction and maintenance of tissue and nerve injury-induced persistent pain. J Neurosci 29: 5508-5515.
11. Lever IJ, Bradbury EJ, Cunningham JR, Adelson DW, Jones MG, et al. (2001) Brain-derived neurotrophic factor is released in the dorsal horn by distinctive patterns of afferent fiber stimulation. J Neurosci 21: 4469-4477. (Pubitemid 32538574)
12. Shu X-Q, Llinas A, Mendell L (1999) Effects of trkB and trkC neurotrophin receptor agonists on thermal nociception: a behavioral and electrophysiological study. Pain 80: 463-470. (Pubitemid 29182696)
13. Zhang W, Liu LY, Xu TL (2008) Reduced potassium-chloride co-transporter expression in spinal cord dorsal horn neurons contributes to inflammatory pain hypersensitivity in rats. Neuroscience1999,152:502-10.
14. Kerr B, Bradbury E, Bennett D, Trivedi P, Dassan P, et al. (1999) Brain-derived neurotrophic factor modulates nociceptive sensory inputs and NMDA-evoked responses in the rat spinal cord. J Neurosci 19: 5138-5148. (Pubitemid 29270149)
15. Mannion R, Costigan M, Decosterd I, Amaya F, Ma Q-P, et al. (1999) Neurotrophins: peripherally and centrally acting modulators of tactile stimulus-induced inflammatory pain hypersensitivity. Proc Natl Acad Sci 96: 9385-9390. (Pubitemid 29374764)
16. Cheung ZH, Chin WH, Chen Y, Ng YP, Ip NY (2007) Cdk5 is involved in BDNF-stimulated dendritic growth in hippocampal neurons. PLoS biology 5: e63.
17. Zhao L, Sheng A-L, Huang S-H, Yin Y-X, Chen B, et al. (2009) Mechanism underlying activity-dependent insertion of TrkB into the neuronal surface. J Cell Sci 122:3123.
18. Charlton E (1995) Ethical guidelines for pain research in humans. Committee on Ethical Issues of the International Association for the Study of Pain. Pain 63:277.
19. Yaksh TL, Rudy TA (1976) Chronic catheterization of the spinal subarachnoid space. Physiology & behavior 17: 1031-1036. (Pubitemid 8063691)
20. Hargreaves K, Dubner R, Brown F, Flores C, Joris J (1988) A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia. Pain 32: 77-88.
21. Zhang B, Tao F, Liaw W-J, Bredt DS, Johns RA, et al. (2003) Effect of knock down of spinal cord PSD-93/chapsin-110 on persistent pain induced by complete Freund's adjuvant and peripheral nerve injury. Pain 106: 187-196. (Pubitemid 37336543)
22. Meyer-Franke A, Wilkinson GA, Kruttgen A, Hu M, Munro E, et al. (1998) Depolarization and cAMP elevation rapidly recruit TrkB to the plasma membrane of CNS neurons. Neuron 21: 681-693. (Pubitemid 28498778)
23. Malcangio M, Garrett NE, Cruwys S, Tomlinson DR (1997) Nerve growth factor-and neurotrophin-3-induced changes in nociceptive threshold and the release of substance P from the rat isolated spinal cord. J Neurosci 17: 8459-8467. (Pubitemid 27461067)
24. Moore KA, Kohno T, Karchewski LA, Scholz J, Baba H, et al. (2002) Partial peripheral nerve injury promotes a selective loss of GABAergic inhibition in the superficial dorsal horn of the spinal cord. J Neurosci 22: 6724-6731. (Pubitemid 35386428)
25. Pezet S, McMahon SB (2006) Neurotrophins: mediators and modulators of pain. Annu Rev Neurosci 29: 507-538. (Pubitemid 44476854)
26. Guo W, Robbins MT, Wei F, Zou S, Dubner R, et al. (2006) Supraspinal brain-derived neurotrophic factor signaling: a novel mechanism for descending pain facilitation. J Neurosci 26: 126-137. (Pubitemid 43089525)
27. Garraway SM, Petruska JC, Mendell LM (2003) BDNF sensitizes the response of lamina II neurons to high threshold primary afferent inputs. Eur J Neurosci 18: 2467-2476. (Pubitemid 37452663)
28. Obata K, Noguchi K (2006) BDNF in sensory neurons and chronic pain. Neurosci Res 55: 1-10.
29. Kim SH, Ryan TA (2010) CDK5 serves as a major control point in neurotransmitter release. Neuron 67: 797-809.
30. Tomizawa K, Ohta J, Matsushita M, Moriwaki A, Li S-T, et al. (2002) Cdk5/p35 regulates neurotransmitter release through phosphorylation and downregulation of P/Q-type voltage-dependent calcium channel activity. J Neurosci 22: 2590-2597. (Pubitemid 37465808)
31. Jahn R, Schiebler W, Ouimet C, Greengard P (1985) A 38,000-dalton membrane protein (p38) present in synaptic vesicles. Proc Natl Acad Sci 82: 4137-4141. (Pubitemid 15053598)
32. Santi S, Cappello S, Riccio M, Bergami M, Aicardi G, et al. (2006) Hippocampal neurons recycle BDNF for activity-dependent secretion and LTP maintenance. EMBO J 25: 4372-4380. (Pubitemid 44435234)
33. Sandow S, Heydon K, Weible M, Reynolds A, Bartlett S, et al. (2000) Signalling organelle for retrograde axonal transport of internalized neurotrophins from the nerve terminal. Immunology and Cell Biology 78: 430-435. (Pubitemid 30655569)
34. Huang Y, Ko H, Cheung ZH, Yung KK, Yao T, et al. (2012) Dual actions of brain-derived neurotrophic factor on GABAergic transmission in cerebellar Purkinje neurons. Experimental neurology 233: 791-798.
35. Harada T, Morooka T, Ogawa S, Nishida E (2001) ERK induces p35, a neuron-specific activator of Cdk5, through induction of Egr1. Nat Cell Biol 3: 453-459. (Pubitemid 32422080)
36. Ren K, Dubner R (2007) Pain facilitation and activity-dependent plasticity in pain modulatory circuitry: role of BDNF-TrkB signaling and NMDA receptors. Mol Neuro biol 35: 224-235. Mol. Neuro. biol 2007, 35:224-35. (Pubitemid 350129684)
37. Lin Y-T, Ro L-S, Wang H-L, Chen J-C (2011) Up-regulation of dorsal root ganglia BDNF and trkB receptor in inflammatory pain: an in vivo and in vitro study. J Neuroinflammation 8: 126.
38. Meijer L, Borgne A, Mulner O, Chong JP, Blow JJ, et al. (1997) Biochemical and cellular effects of roscovitine, a potent and selective inhibitor of the cyclin-dependent kinases cdc2, cdk2 and cdk5. Eur J Biochem 243: 527-536. (Pubitemid 27060443)