Nerve growth factor- and neurotrophin-3-induced changes in nociceptive threshold and the release of substance P from the rat isolated spinal cord

Journal of Neuroscience

Volumn 17, Issue 21, 1997, Pages 8459-8467

  Malcangio, Marzia ^a,b   Garrett, Neil E ^a   Cruwys, Simon ^a   Tomlinson, David R ^a  

^a ST BARTHOLOMEW S HOSPITAL   (United Kingdom)

^b QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

Adult rat; Hyperalgesia; Hypoalgesia; NGF; NT 3; Release; Spinal cord; Substance P

Indexed keywords

3 AMINOPROPYLBUTYLPHOSPHINIC ACID; CAPSAICIN; NALOXONE; NERVE GROWTH FACTOR; NEUROTROPHIN 3; SUBSTANCE P;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINOCICEPTION; ARTICLE; CONTROLLED STUDY; ETIOLOGY; EVOKED RESPONSE; HYPERALGESIA; HYPOALGESIA; MALE; NONHUMAN; PAIN THRESHOLD; PRIORITY JOURNAL; PROTEIN SECRETION; RAT; SPINAL CORD; SPINAL CORD DORSAL HORN; THERMAL STIMULATION;

EID: 0030782407     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.17-21-08459.1997     Document Type: Article

References (17)

1. Airaksinen MS, Koltzenburg M, Lewin GR, Masu Y, Helbig C, Wolf E, Brem G, Toyka KV, Thoenen H, Meyer M (1996) Specific subtypes of cutaneous mechanoreceptors require neurotrophin-3 following peripheral target innervation. Neuron 16:287-295.
2. Andreev NY, Dimitrieva N, Koltzenburg M, McMahon SB (1995) Peripheral administration of nerve growth factor in the adult rat produces a thermal hyperalgesia that requires the presence of sympathetic postganglionic neurones. Pain 63:109-115.
3. AndreevaL, Rang HP (1993) Effect of bradykinin and prostaglandins on the release of CGRP-like immunoreactivity from the rat spinal cord in vitro. Br J Pharmacol 108:185-190.
4. Apfel SC, Newel M, Dormia C, Kessler JA (1995) Kappa opioid receptors participate in nerve growth factor-induced hyperalgesia. Neuroscience 68:1199-1206.
5. Ardvisson U, Risling M, Frisen J, Piehl F, Fried K, Hokfelt T, Cullheim S (1994) TrkC-like immunoreactivity in the primate descending serotoninergic system. Eur J Neurosci 6:230-236.
6. Belliveau DJ, Krivko I, Kohn J, Lachance C, Pozniak C, Rusakov D, Kaplan D, Miller FD (1997) NGF and neurotrophin-3 both activate trk A on sympathetic neurons but differentially regulate survival and neuritogenesis. J Cell Biol 136:375-388.
7. Dirig DM, Hua X-Y, Yaksh TL (1997) Temperature dependency of basal and evoked release of amino acids and calcitonin gene-related peptide from rat dorsal spinal cord. J Neurosci 17:4406-4414.
8. DiStefano PS, Friedman B, Radziejewski C, Alexander C, Boland P, Schick CM, Lindsay RM, Wiegand SJ (1992) The neurotrophins BDNF, NT-3, and NGF display distinct patterns of retrograde axonal transport in peripheral and central neurons. Neuron 8:983-993.
9. Ebendal T (1992) Function and evolution in the NGF family and its receptors. J Neurosci Res 32:461-470.
10. Ernfors P, Persson H (1991) Developmentally regulated expression of HDNF/NT-3 mRNA in rat spinal cord motor neurones and expression of BDNF mRNA in embryonic dorsal root ganglion. Eur J Neurosci 3:953-961.
11. Go VLW, Yaksh TL (1987) Release of substance P from the cat spinal cord. J Physiol (Lond) 391:141-167.
12. Goedert M, Stoeckel K, Otten U (1981) Biological importance of the retrograde axonal transport of nerve growth factor in sensory neurons. Proc Natl Acad Sci USA 78:5895-5898.
13. Hargreaves K, Dubner R, Brown F, Flores C, Joris J (1988) A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia. Pain 32:77-88.
14. Helgren ME, Cliffer KD, Torrento K, Cavnor C, Curtis R, DiStefano PS, Wiegand SJ, Lindsay RM (1997) Neurotrophin-3 administration attenuates deficits of pyridoxine-induced large-fiber sensory neuropathy. J Neurosci 17:372-382.
15. Kangrga I, Randic M (1990) Tachykiniris and calcitonin gene-related peptide enhance release of endogenous glutamate and aspartate from the rat spinal dorsal horn slice. J Neurosci 10:2026-2038.
16. Kangrga I, Randic M (1991) Outflow of endogenous aspartate and glutamate from the rat spinal dorsal horn in vitro by activation of low- and high-threshold primary afferent fibers. Modulation by μ-opioids. Brain Res 553:347-352.
17. Kashiba H, Ueda Y, Senba E (1996) Coexpression of preprotachykinin-A, α-calcitonin gene-related peptide, somatostatin, and neurotrophin receptor family messenger RNAs in rat dorsal root ganglion neurons. Neuroscience 70:179-189.