Knockdown of miR-214 promotes apoptosis and inhibits cell proliferation in nasopharyngeal carcinoma

PLoS ONE

Volumn 9, Issue 1, 2014, Pages

  Zhang, Zi Chen ^a   Li, Yang Yang ^a   Wang, Hai Yun ^a   Fu, Sha ^a   Wang, Xiao Pai ^a   Zeng, Mu Sheng ^a   Zeng, Yi Xin ^a   Shao, Jian Yong ^a  

^a SUN YAT SEN UNIVERSITY CANCER CENTER   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BIM PROTEIN; MICRORNA 214;

ADOLESCENT; AGED; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CANCER SURVIVAL; CARCINOGENESIS; CONTROLLED STUDY; DOWN REGULATION; FEMALE; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; GENE SILENCING; GENE TARGETING; HUMAN; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; LUCIFERASE ASSAY; MITOSIS INHIBITION; MOUSE; NASOPHARYNX CARCINOMA; NONHUMAN; OVERALL SURVIVAL; PROTEIN DETERMINATION; UPREGULATION;

ADOLESCENT; ADULT; AGED; ANIMALS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; BASE SEQUENCE; CARCINOGENESIS; CELL LINE, TUMOR; CELL PROLIFERATION; FEMALE; FOLLOW-UP STUDIES; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE KNOCKDOWN TECHNIQUES; GENE SILENCING; HUMANS; MALE; MEMBRANE PROTEINS; MICE; MICRORNAS; MIDDLE AGED; MOLECULAR SEQUENCE DATA; NASOPHARYNGEAL NEOPLASMS; PROTO-ONCOGENE PROTEINS; SURVIVAL ANALYSIS; TREATMENT OUTCOME; YOUNG ADULT;

EID: 84902686206     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0086149     Document Type: Article

References (44)

1. Bartel DP (2004) MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 116: 281-297.
2. Lagos-Quintana M, Rauhut R, Lendeckel W, Tuschl T (2001) Identification of novel genes coding for small expressed RNAs. Science 294: 853-858. (Pubitemid 33032103)
3. Esquela-Kerscher A, Slack FJ (2006) Oncomirs - microRNAs with a role in cancer. Nat Rev Cancer 6: 259-269.
4. Lu J, Getz G, Miska EA, Alvarez-Saavedra E, Lamb J, et al. (2005) MicroRNA expression profiles classify human cancers. Nature 435: 834-838. (Pubitemid 40839735)
5. Zhang Y, Yan LX, Wu QN, Du ZM, Chen J, et al. (2011) miR-125b is methylated and functions as a tumor suppressor by regulating the ETS1 proto-oncogene in human invasive breast cancer. Cancer Res 71: 3552-3562.
6. Yan LX, Wu QN, Zhang Y, Li YY, Liao DZ, et al. (2011) Knockdown of miR-21 in human breast cancer cell lines inhibits proliferation, in vitro migration and in vivo tumor growth. Breast Cancer Res 13: R2.
7. Visone R, Croce CM (2009) MiRNAs and cancer. Am J Pathol 174: 1131-1138.
8. Di Leva G, Croce CM (2010) Roles of small RNAs in tumor formation. Trends Mol Med 16: 257-267.
9. Baranwal S, Alahari SK (2010) miRNA control of tumor cell invasion and metastasis. Int J Cancer 126: 1283-1290.
10. Yin G, Chen R, Alvero AB, Fu HH, Holmberg J, et al. (2010) TWISTing stemness, inflammation and proliferation of epithelial ovarian cancer cells through MIR199A2/214. Oncogene 29: 3545-3553.
11. Ueda T, Volinia S, Okumura H, Shimizu M, Taccioli C, et al. (2010) Relation between microRNA expression and progression and prognosis of gastric cancer: a microRNA expression analysis. Lancet Oncol 11: 136-146.
12. Narducci MG, Arcelli D, Picchio MC, Lazzeri C, Pagani E, et al. (2011) MicroRNA profiling reveals that miR-21, miR486 and miR-214 are upregulated and involved in cell survival in Sezary syndrome. Cell Death Dis 2: e151.
13. Penna E, Orso F, Cimino D, Tenaglia E, Lembo A, et al. (2011) microRNA-214 contributes to melanoma tumour progression through suppression of TFAP2C. EMBO J 30: 1990-2007.
14. Yang Z, Chen S, Luan X, Li Y, Liu M, et al. (2009) MicroRNA-214 is aberrantly expressed in cervical cancers and inhibits the growth of HeLa cells. IUBMB Life 61: 1075-1082.
15. Peng RQ, Wan HY, Li HF, Liu M, Li X, et al. (2012) MicroRNA-214 suppresses growth and invasiveness of cervical cancer cells by targeting UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 7. J Biol Chem 287: 14301-14309.
16. Qiang R, Wang F, Shi LY, Liu M, Chen S, et al. (2011) Plexin-B1 is a target of miR-214 in cervical cancer and promotes the growth and invasion of HeLa cells. Int J Biochem Cell Biol 43: 632-641.
17. Zhang XJ, Ye H, Zeng CW, He B, Zhang H, et al. (2010) Dysregulation of miR-15a and miR-214 in human pancreatic cancer. J Hematol Oncol 3: 46.
18. Duan Q, Wang X, Gong W, Ni L, Chen C, et al. (2012) ER stress negatively modulates the expression of the miR-199a/214 cluster to regulates tumor survival and progression in human hepatocellular cancer. PLoS One 7: e31518.
19. Shih TC, Tien YJ, Wen CJ, Yeh TS, Yu MC, et al. (2012) MicroRNA-214 downregulation contributes to tumor angiogenesis via inducing secretion of hepatoma-derived growth factor in human hepatoma. J Hepatol.
20. Derfoul A, Juan AH, Difilippantonio MJ, Palanisamy N, Ried T, et al. (2011) Decreased microRNA-214 levels in breast cancer cells coincides with increased cell proliferation, invasion and accumulation of the Polycomb Ezh2 methyltransferase. Carcinogenesis 32: 1607-1614.
21. Yang H, Kong W, He L, Zhao JJ, O'Donnell JD, et al. (2008) MicroRNA expression profiling in human ovarian cancer: miR-214 induces cell survival and cisplatin resistance by targeting PTEN. Cancer Res 68: 425-433. (Pubitemid 351380068)
22. Volinia S, Calin GA, Liu CG, Ambs S, Cimmino A, et al. (2006) A microRNA expression signature of human solid tumors defines cancer gene targets. Proc Natl Acad Sci U S A 103: 2257-2261. (Pubitemid 43271657)
23. Deng M, Ye Q, Qin Z, Zheng Y, He W, et al. (2013) miR-214 promotes tumorigenesis by targeting lactotransferrin in nasopharyngeal carcinoma. Tumour Biol 34: 1793-1800.
24. Liao Y, Du X, Lonnerdal B (2010) miR-214 regulates lactoferrin expression and pro-apoptotic function in mammary epithelial cells. J Nutr 140: 1552-1556.
25. Gillings AS, Balmanno K, Wiggins CM, Johnson M, Cook SJ (2009) Apoptosis and autophagy: BIM as a mediator of tumour cell death in response to oncogene-targeted therapeutics. FEBS J 276: 6050-6062.
26. Akiyama T, Dass CR, Choong PF (2009) Bim-targeted cancer therapy: a link between drug action and underlying molecular changes. Mol Cancer Ther 8: 3173-3180.
27. Gilley J, Coffer PJ, Ham J (2003) FOXO transcription factors directly activate bim gene expression and promote apoptosis in sympathetic neurons. Journal of Cell Biology 162: 613-622. (Pubitemid 37022939)
28. Sunters A, Fernandez de Mattos S, Stahl M, Brosens JJ, Zoumpoulidou G, et al. (2003) FoxO3a transcriptional regulation of Bim controls apoptosis in paclitaxel-treated breast cancer cell lines. J Biol Chem 278: 49795-49805. (Pubitemid 37548813)
29. Yano T, Ito K, Fukamachi H, Chi XZ, Wee HJ, et al. (2006) The RUNX3 tumor suppressor upregulates Bim in gastric epithelial cells undergoing transforming growth factor beta-induced apoptosis. Mol Cell Biol 26: 4474-4488. (Pubitemid 43877568)
30. Hubner A, Barrett T, Flavell RA, Davis RJ (2008) Multisite phosphorylation regulates Bim stability and apoptotic activity. Mol Cell 30: 415-425. (Pubitemid 351672377)
31. Clybouw C, Merino D, Nebl T, Masson F, Robati M, et al. (2012) Alternative splicing of Bim and Erk-mediated Bim(EL) phosphorylation are dispensable for hematopoietic homeostasis in vivo. Cell Death Differ 19: 1060-1068.
32. Cai B, Chang SH, Becker EB, Bonni A, Xia Z (2006) p38 MAP kinase mediates apoptosis through phosphorylation of BimEL at Ser-65. J Biol Chem 281: 25215-25222. (Pubitemid 44401908)
33. Lei K, Davis RJ (2003) JNK phosphorylation of Bim-related members of the Bcl2 family induces Bax-dependent apoptosis. Proc Natl Acad Sci U S A 100: 2432-2437. (Pubitemid 36297516)
34. Putcha GV, Le S, Frank S, Besirli CG, Clark K, et al. (2003) JNK-mediated BIM phosphorylation potentiates BAX-dependent apoptosis. Neuron 38: 899-914. (Pubitemid 36782382)
35. Ramesh S, Qi XJ, Wildey GM, Robinson J, Molkentin J, et al. (2008) TGF beta-mediated BIM expression and apoptosis are regulated through SMAD3-dependent expression of the MAPK phosphatase MKP2. EMBO Rep 9: 990-997.
36. Wakeyama H, Akiyama T, Kadono Y, Nakamura M, Oshima Y, et al. (2007) Posttranslational regulation of Bim by caspase-3. Ann N Y Acad Sci 1116: 271-280. (Pubitemid 350274312)
37. Vo TT, Letai A (2010) BH3-only proteins and their effects on cancer. Adv Exp Med Biol 687: 49-63.
38. Ni Chonghaile T, Letai A (2008) Mimicking the BH3 domain to kill cancer cells. Oncogene 27 Suppl 1: S149-157.
39. Letai A (2003) BH3 domains as BCL-2 inhibitors: prototype cancer therapeutics. Expert Opin Biol Ther 3: 293-304.
40. Tsubaki M, Komai M, Itoh T, Imano M, Sakamoto K, et al. (2013) Inhibition of the tumour necrosis factor-alpha autocrine loop enhances the sensitivity of multiple myeloma cells to anticancer drugs. Eur J Cancer.
41. Chen C, Hu SY, Luo DQ, Zhu SY, Zhou CQ (2013) Potential antitumor agent from the endophytic fungus Pestalotiopsis photiniae induces apoptosis via the mitochondrial pathway in HeLa cells. Oncol Rep 30: 1773-1781.
42. Min H, Hong M, Ma J, Zhang E, Zheng Q, et al. (1994) A new staging system for nasopharyngeal carcinoma in China. Int J Radiat Oncol Biol Phys 30: 1037-1042.
43. Yan LX, Huang XF, Shao Q, Huang MY, Deng L, et al. (2008) MicroRNA miR-21 overexpression in human breast cancer is associated with advanced clinical stage, lymph node metastasis and patient poor prognosis. RNA 14: 2348-2360.
44. Wang HY, Sun BY, Zhu ZH, Chang ET, To KF, et al. (2011) Eight-signature classifier for prediction of nasopharyngeal carcinoma survival. J Clin Oncol 29: 4516-4525.