Synthesis, antimicrobial and cytotoxic activities, and structure-activity relationships of gypsogenin derivatives against human cancer cells

European Journal of Medicinal Chemistry

Volumn 82, Issue , 2014, Pages 565-573

  Emirdaǧ Öztürk, Safiye ^a   Karayildirim, Tamer ^a   Çapci Karagöz, Aysun ^b   Alankuş Çalişkan, Özgen ^a   Özmen, Ali ^c   Poyrazoǧlu Çoban, Esin ^c  

^a EGE UNIVERSITY   (Turkey)

^b UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^c ADNAN MENDERES UNIVERSITY   (Turkey)

Author keywords

Apoptosis; Cytotoxic; Gypsogenin; Gypsophila; Saponin

Indexed keywords

3 (ACETYLOXY) 23 (HYDROXYIMINO)OLEAN 12 EN 28 OIC; 3 (ACETYLOXY) 23 OXOOLEAN 12 EN 28 OIC ACID; 3 (ACETYLOXY) 23 [(AMINOCARBONOTHIOYL) HYDRAZONO]OLEAN 12 EN 28 OIC ACID; 3 HYDROXY 23 (HYDROXYIMINO)OLEAN 12 EN 28 OIC ACID; 4 [5 (4 METHYL 1 PIPERAZINYL)[2,5' BI 1H BENZIMIDAZOL] 2' YL]PHENOL; BENZYL 23 [(AMINOCARBONOTHIOYL) HYDRAZONO] 3 HYDROXYOLEAN 12 EN 28 OATE; BENZYL 3 (ACETYLOXY) 23 (HYDROXYIMINO)OLEAN 12 EN 28 OATE; BENZYL 3 (ACETYLOXY) 23 OXOOLEAN 12 EN 28 OATE; BENZYL 3 HYDROXY 23 (HYDROXYIMINO)OLEAN 12 EN 28 OATE; BENZYL 3 HYDROXY 23 OXOOLEAN 12 EN 28 OATE; DOXORUBICIN; GYPSOGENIN; NATURAL PRODUCT; PACLITAXEL; PROPIDIUM IODIDE; UNCLASSIFIED DRUG; ANTIFUNGAL AGENT; ANTIINFECTIVE AGENT; ANTINEOPLASTIC AGENT; SAPONIN;

ANTIBACTERIAL ACTIVITY; ANTIFUNGAL ACTIVITY; ANTIMICROBIAL ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; BACILLUS CEREUS; BACILLUS SUBTILIS; BACILLUS THURINGIENSIS; CANCER CELL LINE; CARBON NUCLEAR MAGNETIC RESONANCE; CELL DEATH; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYTOTOXICITY; DRUG STRUCTURE; DRUG SYNTHESIS; FEMALE; HL 60 CELL LINE; HUMAN; HUMAN CELL; IC 50; INFRARED SPECTROSCOPY; LIQUID CHROMATOGRAPHY; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION; ULTRAVIOLET SPECTROSCOPY; BACILLUS; CACO 2 CELL LINE; CANDIDA; CELL PROLIFERATION; CHEMISTRY; CONFORMATION; DOSE RESPONSE; DRUG EFFECTS; DRUG SCREENING; HELA CELL LINE; HT 29 CELL LINE; MCF 7 CELL LINE; MICROBIAL SENSITIVITY TEST; SYNTHESIS; TUMOR CELL CULTURE;

ANTI-BACTERIAL AGENTS; ANTIFUNGAL AGENTS; ANTINEOPLASTIC AGENTS; BACILLUS; CACO-2 CELLS; CANDIDA; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; HELA CELLS; HL-60 CELLS; HT29 CELLS; HUMANS; MCF-7 CELLS; MICROBIAL SENSITIVITY TESTS; MOLECULAR CONFORMATION; SAPONINS; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 84902679064     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2014.05.084     Document Type: Article

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