Antitumor activity of Pulsatilla koreana saponins and their structure-activity relationship

Chemical and Pharmaceutical Bulletin

Volumn 53, Issue 11, 2005, Pages 1451-1454

  Bang, Seong Cheol ^a,b   Lee, Ji Hyun ^a   Song, Gyu Yong ^b   Kim, Dong Hee ^c   Yoon, Mi Young ^c   Ahn, Byung Zun ^a  

^a SB Pharmaceutical Co Ltd   (South Korea)

^b Chungnam National University   (South Korea)

^c Daejeon University   (South Korea)

Author keywords

Antitumor activity; Cytotoxicity; Pulsatilla koreana saponin

Indexed keywords

23 HYDROXY 3BETA [(O ALPHA LEVO RHAMNOPYRANOSYL (1-2) ALPHA LEVO ARABINOPYRANOSYL)OXY]LUP 20(29) EN OIC ACID; 23 HYDROXY 3BETA [(O ALPHA LEVO RHAMNOPYRANOSYL (1-2) ALPHA LEVO ARABINOPYRANOSYL)OXY]LUP 20(29) EN OIC ACID 28 O ALPHA LEVO RHAMNOPYRANOSYL (1-4) O BETA DEXTRO GLUCOPYRANOSYL (1-6) BETA DEXTRO GLUCOPYRANOSYL ESTER; 23 HYDROXY 3BETA [(O BETA DEXTRO GLUCOPYRANOSYL (1-3) ALPHA LEVO RHAMNOPYRANOSYL)OXY]LUP 20(29) EN 28 OIC ACID; 23 HYDROXY 3BETA [(O BETA DEXTRO GLUCOPYRANOSYL (1-4) ALPHA LEVO ARABINOPYRANOSYL)OXY]LUP 20(29) EN 28 OIC ACID; 23 HYDROXY 3BETA [[O ALPHA LEVO RHAMNOPYRANOSYL (1-2) (BETA DEXTRO GLUCOPYRANOSYL (1-4)) ALPHA LEVO ARABINOPYRANOSYL]OXY]LUP 20(29) EN 28 OIC ACID; 23 HYDROXY 3BETA [O ALPHA LEVO RHAMNOPYRANOSYL (1-2) (BETA DEXTRO GLUCOPYRANOSYL (1-4) ALPHA LEVO ARABINOPYRANOSYL)OXY]LUP 20(29) EN OIC ACID 28 O ALPHA RHAMNOPYRANOSYL (1-4) BETA DEXTRO GLUCOPYRANOSYL (1-6) BETA DEXTRO GLUCOPYRANOSYL ESTER; 3 O ALPHA LEVO RHAMNOPYRANOSYL (1-2) ALPHA LEVO ARABINOPYRANOSYLHEDERAGENIN 28 O ALPHA LEVO RHAMNOPYRANOSYL (1-4) BETA DEXTRO GLUCOPYRANOSYL (1-6) BETA DEXTRO GLUCOPYRANOSYL ESTER; 3 O ALPHA LEVO RHAMNOPYRANOSYL (1-2) BETA DEXTRO GLUCOPYRANOSYL (1-4) ALPHA LEVO ARABINOPYRANOSYLHEDERAGENIN 28 O ALPHA LEVO RHAMNOPYRANOSYL (1-4) BETA DEXTRO GLUCOPYRANOSYL (1-6) BETA DEXTRO GLUCOPYRANOSYL ESTER; 3 O BETA DEXTRO GLUCOPYRANOSYL (1-4) O BETA DEXTRO GLUCOPYRANOSYL (1-3) O ALPHA LEVO RHAMNOPYRANOSYL (1-2) ALPHA LEVO ARABINOPYRANOSIDE; 3BETA [(O BETA DEXTRO GLUCOPYRANOSYL (1-3) ALPHA LEVO RHAMNOPYRANOSYL (1-2) ALPHA LEVO ARABINOPYRANOSYL)OXY]LUP 20(29) EN 28 OIC ACID; 3BETA [[O ALPHA LEVO RHAMNOPYRANOSYL (1-2) (BETA DEXTRO GLUCOPYRANOSYL (1-4)) ALPHA LEVO ARABINOPYRANOSYL]OXY]LUP 20(29) EN 28 OIC ACID; DOXORUBICIN; HEDERAGENIN 3 O ALPHA LEVO RHAMNOPYRANOSYL (1-2) [BETA DEXTRO GLUCOPYRANOSYL (1-4)] ALPHA LEVO ARABINOPYRANOSIDE; HEDERAGENIN 3 O ALPHA LEVO RHAMNOPYRANOSYL (1-2) ALPHA LEVO ARABINOPYRANOSIDE; HEDERAGENIN 3 O BETA DEXTRO GLUCOPYRANOSYL (1-3) ALPHA LEVO RHAMNOPYRANOSYL (1-2) ALPHA LEVO ARABINOPYRANOSIDE; HEDERAGENIN 3 O BETA DEXTRO GLUCOPYRANOSYL (1-4) ALPHA LEVO ARABINOPYRANOSIDE; HEDERAGENIN 3 O BETA DEXTRO GLUCOPYRANOSYL (1-4) BETA DEXTRO GLUCOPYRANOSYL (1-3) ALPHA LEVO RHAMNOPYRANOSYL (1-2) ALPHA LEVO ARABINOPYRANOSIDE; O ALPHA LEVO RHAMNOPYRANOSYL (1-2) ALPHA LEVO ARABINOPYRANOSIDE; OLEANIC ACID 3 O ALPHA LEVO RHAMNOPYRANOSYL (1-2) [BETA DEXTRO GLUCOPYRANOSYL (1-4)] ALPHA LEVO ARABINOPYRANOSIDE; OLEANOLIC ACID 3 O BETA DEXTRO GLUCOPYRANOSYL (1-3) ALPHA LEVO RHAMNOPYRANOSYL (1-2) ALPHA LEVO ARABINOPYRANOSIDE; PACLITAXEL; SAPONIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANTINEOPLASTIC ACTIVITY; ARTICLE; BIOASSAY; CANCER CELL CULTURE; COMPARATIVE STUDY; CONTROLLED STUDY; CYTOTOXICITY; DRUG DETERMINATION; DRUG ISOLATION; DRUG POTENCY; DRUG SCREENING; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LUNG CARCINOMA; MOUSE; NONHUMAN; PLANT ROOT; PULSATILLA; PULSATILLA KOREANA; SOLID TUMOR; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; CARCINOMA, LEWIS LUNG; CELL LINE, TUMOR; CELL SURVIVAL; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; MALE; MICE; PLANT ROOTS; PULSATILLA; SAPONINS; SPECTROMETRY, MASS, FAST ATOM BOMBARDMENT; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 27744592640     PISSN: 00092363     EISSN: 13475223     Source Type: Journal    
DOI: 10.1248/cpb.53.1451     Document Type: Article

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