Update in asthma 2013

American Journal of Respiratory and Critical Care Medicine

Volumn 189, Issue 12, 2014, Pages 1487-1493

  Cohn, Lauren ^a   Woodruff, Prescott G ^b  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ABATACEPT; BRODALUMAB; CIGARETTE SMOKE; CORTICOSTEROID; DUPILUMAB; OMALIZUMAB;

AIRWAY OBSTRUCTION; AIRWAY REMODELING; ASTHMA; DISEASE COURSE; DISEASE EXACERBATION; HUMAN; OBESITY; POLLUTION; PRIORITY JOURNAL; PSYCHOLOGICAL ASPECT; REVIEW; SOCIAL ASPECT; TH2 CELL;

AIR POLLUTANTS; ANTI-ASTHMATIC AGENTS; ASTHMA; DISEASE PROGRESSION; GENETIC PREDISPOSITION TO DISEASE; HUMANS; OBESITY; RISK FACTORS; SOCIOECONOMIC FACTORS;

EID: 84902665591     PISSN: 1073449X     EISSN: 15354970     Source Type: Journal    
DOI: 10.1164/rccm.201403-0498UP     Document Type: Review

References (68)

1. Boudier A, Curjuric I, Basagaña X, Hazgui H, Anto JM, Bousquet J, Bridevaux PO, Dupuis-Lozeron E, Garcia-Aymerich J, Heinrich J, et al. Ten-year follow-up of cluster-based asthma phenotypes in adults: a pooled analysis of three cohorts. Am J Respir Crit Care Med 2013;188:550-560.
2. Prosperi MC, Sahiner UM, Belgrave D, Sackesen C, Buchan IE, Simpson A, Yavuz TS, Kalayci O, Custovic A. Challenges in identifying asthma subgroups using unsupervised statistical learning techniques. Am J Respir Crit Care Med 2013;188:1303-1312.
3. Denlinger LC, Shi L, Guadarrama A, Schell K, Green D, Morrin A, Hogan K, Sorkness RL, Busse WW, Gern JE. Attenuated P2X7 pore function as a risk factor for virus-induced loss of asthma control. Am J Respir Crit Care Med 2009;179:265-270.
4. Hoskins A, Reiss S, Wu P, Chen N, Han W, Do RH, Abdolrasulnia R, Dworski R. Asthmatic airway neutrophilia after allergen challenge is associated with the glutathione S-transferase M1 genotype. Am J Respir Crit Care Med 2013;187:34-41.
5. Bonini M, Permaul P, Kulkarni T, Kazani S, Segal A, Sorkness CA, Wechsler ME, Israel E. Loss of salmeterol bronchoprotection against exercise in relation to ADRB2 Arg16Gly polymorphism and exhaled nitric oxide. Am J Respir Crit Care Med 2013;188:1407-1412.
6. Çalişkan M, Bochkov YA, Kreiner-Møller E, Bønnelykke K, Stein MM, Du G, Bisgaard H, Jackson DJ, Gern JE, Lemanske RF Jr, et al. Rhinovirus wheezing illness and genetic risk of childhood-onset asthma. N Engl J Med 2013;368:1398-1407.
7. Ogden CL, Carroll MD, Kit BK, Flegal KM. Prevalence of childhood and adult obesity in the United States, 2011-2012. JAMA 2014;311:806-814.
8. Shore SA. Obesity and asthma: possible mechanisms. J Allergy Clin Immunol 2008;121:1087-1093; quiz 1094-1085.
9. Borrell LN, Nguyen EA, Roth LA, Oh SS, Tcheurekdjian H, Sen S, Davis A, Farber HJ, Avila PC, Brigino-Buenaventura E, et al. Childhood obesity and asthma control in the GALA II and SAGE II studies. Am J Respir Crit Care Med 2013;187:697-702.
10. Assad N, Qualls C, Smith LJ, Arynchyn A, Thyagarajan B, Schuyler M, Jacobs DR Jr, Sood A. Body mass index is a stronger predictor than the metabolic syndrome for future asthma in women: the longitudinal CARDIA study. Am J Respir Crit Care Med 2013;188:319-326.
11. Brumpton B, Langhammer A, Romundstad P, Chen Y, Mai XM. General and abdominal obesity and incident asthma in adults: the HUNT study. Eur Respir J 2013;41:323-329.
12. Shore SA. Obesity and asthma: location, location, location. Eur Respir J 2013;41:253-254.
13. Brumpton BM, Camargo CA Jr, Romundstad PR, Langhammer A, Chen Y, Mai XM. Metabolic syndrome and incidence of asthma in adults: the HUNT study. Eur Respir J 2013;42:1495-1502.
14. Wright RJ, Fisher K, Chiu YH, Wright RO, Fein R, Cohen S, Coull BA. Disrupted prenatal maternal cortisol, maternal obesity, and childhood wheeze: insights into prenatal programming. Am J Respir Crit Care Med 2013;187:1186-1193.
15. Halonen M, Lohman IC, Stern DA, Ellis WL, Rothers J, Wright AL. Perinatal tumor necrosis factor-α production, influenced by maternal pregnancy weight gain, predicts childhood asthma. Am J Respir Crit Care Med 2013;188:35-41.
16. Berg CM, Thelle DS, Rosengren A, Lissner L, Torén K, Olin AC. Decreased fraction of exhaled nitric oxide in obese subjects with asthma symptoms: data from the population study INTERGENE/ADONIX. Chest 2011;139:1109-1116.
17. Komakula S, Khatri S, Mermis J, Savill S, Haque S, Rojas M, Brown L, Teague GW, Holguin F. Body mass index is associated with reduced exhaled nitric oxide and higher exhaled 8-isoprostanes in asthmatics. Respir Res 2007;8:32.
18. Holguin F, Comhair SA, Hazen SL, Powers RW, Khatri SS, Bleecker ER, Busse WW, Calhoun WJ, Castro M, Fitzpatrick AM, et al. An association between L-arginine/asymmetric dimethyl arginine balance, obesity, and the age of asthma onset phenotype. Am J Respir Crit Care Med 2013;187:153-159.
19. McLaughlin T, Stühlinger M, Lamendola C, Abbasi F, Bialek J, Reaven GM, Tsao PS. Plasma asymmetric dimethylarginine concentrations are elevated in obese insulin-resistant women and fall with weight loss. J Clin Endocrinol Metab 2006;91:1896-1900.
20. Sterk PJ, Ricciardolo FL. Clinical-biological phenotyping beyond inflammation in asthma delivers. Am J Respir Crit Care Med 2013;187:117-118.
21. Desai D, Newby C, Symon FA, Haldar P, Shah S, Gupta S, Bafadhel M, Singapuri A, Siddiqui S, Woods J, et al. Elevated sputum interleukin-5 and submucosal eosinophilia in obese individuals with severe asthma. Am J Respir Crit Care Med 2013;188:657-663.
22. Peters MC, Fahy JV. Type 2 immune responses in obese individuals with asthma. Am J Respir Crit Care Med 2013;188:633-634.
23. Nishimura KK, Galanter JM, Roth LA, Oh SS, Thakur N, Nguyen EA, Thyne S, Farber HJ, Serebrisky D, Kumar R, et al. Early-life air pollution and asthma risk in minority children: the GALA II and SAGE II studies. Am J Respir Crit Care Med 2013;188:309-318.
24. Lajunen TK, Jaakkola JJ, Jaakkola MS. The synergistic effect of heredity and exposure to second-hand smoke on adult-onset asthma. Am J Respir Crit Care Med 2013;188:776-782.
25. Matsui EC, Hansel NN, Aloe C, Schiltz AM, Peng RD, Rabinovitch N, Ong MJ, Williams DL, Breysse PN, Diette GB, et al. Indoor pollutant exposures modify the effect of airborne endotoxin on asthma in urban children. Am J Respir Crit Care Med 2013;188:1210-1215.
26. Bisgaard H, Hermansen MN, Buchvald F, Loland L, Halkjaer LB, Bønnelykke K, Brasholt M, Heltberg A, Vissing NH, Thorsen SV, et al. Childhood asthma after bacterial colonization of the airway in neonates. N Engl J Med 2007;357:1487-1495. (Pubitemid 47572634)
27. Følsgaard NV, Schjørring S, Chawes BL, Rasmussen MA, Krogfelt KA, Brix S, Bisgaard H. Pathogenic bacteria colonizing the airways in asymptomatic neonates stimulates topical inflammatory mediator release. Am J Respir Crit Care Med 2013;187:589-595.
28. Charlson ES, Bittinger K, Haas AR, Fitzgerald AS, Frank I, Yadav A, Bushman FD, Collman RG. Topographical continuity of bacterial populations in the healthy human respiratory tract. Am J Respir Crit Care Med 2011;184:957-963.
29. Goleva E, Jackson LP, Harris JK, Robertson CE, Sutherland ER, Hall CF, Good JT Jr, Gelfand EW, Martin RJ, Leung DY. The effects of airway microbiome on corticosteroid responsiveness in asthma. Am J Respir Crit Care Med 2013;188:1193-1201.
30. Thakur N, Oh SS, Nguyen EA, Martin M, Roth LA, Galanter J, Gignoux CR, Eng C, Davis A, Meade K, et al. Socioeconomic status and childhood asthma in urban minority youths: the GALA II and SAGE II studies. Am J Respir Crit Care Med 2013;188:1202-1209.
31. Ressler KJ, Mercer KB, Bradley B, Jovanovic T, Mahan A, Kerley K, Norrholm SD, Kilaru V, Smith AK, Myers AJ, et al. Post-traumatic stress disorder is associated with PACAP and the PAC1 receptor. Nature 2011;470:492-497.
32. Chen W, Boutaoui N, Brehm JM, Han YY, Schmitz C, Cressley A, Acosta-Pérez E, Alvarez M, Colón-Semidey A, Baccarelli AA, et al. ADCYAP1R1 and asthma in Puerto Rican children. Am J Respir Crit Care Med 2013;187:584-588.
33. Bahreinian S, Ball GD, Vander Leek TK, Colman I, McNeil BJ, Becker AB, Kozyrskyj AL. Allostatic load biomarkers and asthma in adolescents. Am J Respir Crit Care Med 2013;187:144-152.
34. Lavoie KL, Joseph M, Favreau H, Lemiere C, Labrecque M, Cartier A, Malo JL, Gautrin D, Bacon SL. Prevalence of psychiatric disorders among patients investigated for occupational asthma: an overlooked differential diagnosis? Am J Respir Crit Care Med 2013;187:926-932.
35. Cohn L, Elias JA, Chupp GL. Asthma: mechanisms of disease persistence and progression. Annu Rev Immunol 2004;22:789-815. (Pubitemid 38680442)
36. Hansbro PM, Scott GV, Essilfie AT, Kim RY, Starkey MR, Nguyen DH, Allen PD, Kaiko GE, Yang M, Horvat JC, et al. Th2 cytokine antagonists: potential treatments for severe asthma. Expert Opin Investig Drugs 2013;22:49-69.
37. Scanlon ST, McKenzie AN. Type 2 innate lymphoid cells: new players in asthma and allergy. Curr Opin Immunol 2012;24:707-712.
38. Mjösberg JM, Trifari S, Crellin NK, Peters CP, van Drunen CM, Piet B, Fokkens WJ, Cupedo T, Spits H. Human IL-25- and IL-33-responsive type 2 innate lymphoid cells are defined by expression of CRTH2 and CD161. Nat Immunol 2011;12:1055-1062.
39. Shaw JL, Fakhri S, Citardi MJ, Porter PC, Corry DB, Kheradmand F, Liu YJ, Luong A. IL-33-responsive innate lymphoid cells are an important source of IL-13 in chronic rhinosinusitis with nasal polyps. Am J Respir Crit Care Med 2013;188:432-439.
40. 4 regulates natural killer cell and type 2 innate lymphoid cell activation in asthma. Sci Transl Med 2013;5:174ra26.
41. Levy BD, Bonnans C, Silverman ES, Palmer LJ, Marigowda G, Israel E; Severe Asthma Research Program, National Heart, Lung, and Blood Institute. Diminished lipoxin biosynthesis in severe asthma. Am J Respir Crit Care Med 2005;172:824-830. (Pubitemid 41369064)
42. Ahern GP. 5-HT and the immune system. Curr Opin Pharmacol 2011;11:29-33.
43. Dürk T, Duerschmied D, Müller T, Grimm M, Reuter S, Vieira RP, Ayata K, Cicko S, Sorichter S, Walther DJ, et al. Production of serotonin by tryptophan hydroxylase 1 and release via platelets contribute to allergic airway inflammation. Am J Respir Crit Care Med 2013;187:476-485.
44. Takyar S, Vasavada H, Zhang JG, Ahangari F, Niu N, Liu Q, Lee CG, Cohn L, Elias JA. VEGF controls lung Th2 inflammation via the miR-1-Mpl (myeloproliferative leukemia virus oncogene)-P-selectin axis. J Exp Med 2013;210:1993-2010.
45. Li H, Edin ML, Bradbury JA, Graves JP, DeGraff LM, Gruzdev A, Cheng J, Dackor RT, Wang PM, Bortner CD, et al. Cyclooxygenase-2 inhibits T helper cell type 9 differentiation during allergic lung inflammation via down-regulation of IL-17RB. Am J Respir Crit Care Med 2013;187:812-822.
46. Park GY, Lee YG, Berdyshev E, Nyenhuis S, Du J, Fu P, Gorshkova IA, Li Y, Chung S, Karpurapu M, et al. Autotaxin production of lysophosphatidic acid mediates allergic asthmatic inflammation. Am J Respir Crit Care Med 2013;188:928-940.
47. Georas SN. Allergic to autotaxin: a new role for lysophospholipase D and lysophosphatidic acid in asthma? Am J Respir Crit Care Med 2013;188:889-891.
48. Ray A, Khare A, Krishnamoorthy N, Qi Z, Ray P. Regulatory T cells in many flavors control asthma. Mucosal Immunol 2010;3:216-229.
49. Jin HS, Park Y, Elly C, Liu YC. Itch expression by Treg cells controls Th2 inflammatory responses. J Clin Invest 2013;123:4923-4934.
50. Mays LE, Ammon-Treiber S, Mothes B, Alkhaled M, Rottenberger J, Müller-Hermelink ES, Grimm M, Mezger M, Beer-Hammer S, von Stebut E, et al. Modified Foxp3 mRNA protects against asthma through an IL-10-dependent mechanism. J Clin Invest 2013;123:1216-1228.
51. Hox V, Vanoirbeek JA, Alpizar YA, Voedisch S, Callebaut I, Bobic S, Sharify A, De Vooght V, Van Gerven L, Devos F, et al. Crucial role of transient receptor potential ankyrin 1 and mast cells in induction of nonallergic airway hyperreactivity in mice. Am J Respir Crit Care Med 2013;187:486-493.
52. Caceres AI, Brackmann M, Elia MD, Bessac BF, del Camino D, D'Amours M, Witek JS, Fanger CM, Chong JA, Hayward NJ, et al. A sensory neuronal ion channel essential for airway inflammation and hyperreactivity in asthma. Proc Natl Acad Sci USA 2009;106:9099-9104.
53. 2 groups IIA and X in the airways and asthma severity. Clin Exp Allergy 2011;41:801-810.
54. 2 group X in asthma. Am J Respir Crit Care Med 2013;188:42-50.
55. Yick CY, Zwinderman AH, Kunst PW, Grünberg K, Mauad T, Fluiter K, Bel EH, Lutter R, Baas F, Sterk PJ. Glucocorticoid-induced changes in gene expression of airway smooth muscle in patients with asthma. Am J Respir Crit Care Med 2013;187:1076-1084.
56. Drake MG, Scott GD, Proskocil BJ, Fryer AD, Jacoby DB, Kaufman EH. Toll-like receptor 7 rapidly relaxes human airways. Am J Respir Crit Care Med 2013;188:664-672.
57. - channel in airway smooth muscle contributes to airway hyperresponsiveness. Am J Respir Crit Care Med 2013;187:374-381.
58. Weng CM, Chen BC, Wang CH, Feng PH, Lee MJ, Huang CD, Kuo HP, Lin CH. The endothelin A receptor mediates fibrocyte differentiation in chronic obstructive asthma: the involvement of connective tissue growth factor. Am J Respir Crit Care Med 2013;188:298-308.
59. Perret JL, Dharmage SC, Matheson MC, Johns DP, Gurrin LC, Burgess JA, Marrone J, Markos J, Morrison S, Feather I, et al. The interplay between the effects of lifetime asthma, smoking, and atopy on fixed airflow obstruction in middle age. Am J Respir Crit Care Med 2013;187:42-48.
60. Johansson MW, Kruger SJ, Schiebler ML, Evans MD, Sorkness RL, Denlinger LC, Busse WW, Jarjour NN, Montgomery RR, Mosher DF, et al. Markers of vascular perturbation correlate with airway structural change in asthma. Am J Respir Crit Care Med 2013;188:167-178.
61. Takabayashi T, Kato A, Peters AT, Hulse KE, Suh LA, Carter R, Norton J, Grammer LC, Cho SH, Tan BK, et al. Excessive fibrin deposition in nasal polyps caused by fibrinolytic impairment through reduction of tissue plasminogen activator expression. Am J Respir Crit Care Med 2013;187:49-57.
62. Short PM, Williamson PA, Anderson WJ, Lipworth BJ. Randomized placebo-controlled trial to evaluate chronic dosing effects of propranolol in asthma. Am J Respir Crit Care Med 2013;187:1308-1314.
63. Tse SM, Li L, Butler MG, Fung V, Kharbanda EO, Larkin EK, Vollmer WM, Miroshnik I, Rusinak D, Weiss ST, et al. Statin exposure is associated with decreased asthma-related emergency department visits and oral corticosteroid use. Am J Respir Crit Care Med 2013;188:1076-1082.
64. Busse WW, Holgate S, Kerwin E, Chon Y, Feng J, Lin J, Lin SL. Randomized, double-blind, placebo-controlled study of brodalumab, a human anti-IL-17 receptor monoclonal antibody, in moderate to severe asthma. Am J Respir Crit Care Med 2013;188:1294-1302.
65. Parulekar AD, Boomer JS, Patterson BM, Yin-Declue H, Deppong CM, Wilson BS, Jarjour NN, Castro M, Green JM. A randomized controlled trial to evaluate inhibition of T-cell costimulation in allergen-induced airway inflammation. Am J Respir Crit Care Med 2013;187:494-501.
66. Teijaro JR, Njau MN, Verhoeven D, Chandran S, Nadler SG, Hasday J, Farber DL. Costimulation modulation uncouples protection from immunopathology in memory T cell responses to influenza virus. J Immunol 2009;182:6834-6843.
67. Wenzel SE, Wang L, Pirozzi G. Dupilumab in persistent asthma. N Engl J Med 2013;369:1276.
68. Hanania NA, Wenzel S, Rosén K, Hsieh HJ, Mosesova S, Choy DF, Lal P, Arron JR, Harris JM, Busse W. Exploring the effects of omalizumab in allergic asthma: an analysis of biomarkers in the EXTRA study. Am J Respir Crit Care Med 2013;187:804-811.