Attenuated P2X 7 pore function as a risk factor for virus-induced loss of asthma control

American Journal of Respiratory and Critical Care Medicine

Volumn 179, Issue 4, 2009, Pages 265-270

  Denlinger, Loren C ^a   Shi, Lei ^a   Guadarrama, Arturo ^a   Schell, Kathy ^b   Green, Dawn ^a   Morrin, Alison ^a   Hogan, Kirk ^a   Sorkness, Ronald L ^a   Busse, William W ^a   Gern, James E ^a  

^a UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^b UNIVERSITY OF WISCONSIN   (United States)

Author keywords

Asthma; Neutrophils; P2X 7; Virus

Indexed keywords

CORTICOSTEROID DERIVATIVE; PURINERGIC P2X7 RECEPTOR; BIOLOGICAL MARKER; BRONCHODILATING AGENT; CORTICOSTEROID; PURINERGIC P2 RECEPTOR; SALBUTAMOL;

ADULT; ALLERGIC ASTHMA; ARTICLE; BLOOD SAMPLING; CLINICAL ARTICLE; CLINICAL FEATURE; COLD; CONTROLLED STUDY; CONVALESCENCE; DISEASE CONTROL; FEMALE; FLOW CYTOMETRY; HUMAN; LUNG FUNCTION; MALE; NEUTROPHIL COUNT; PATIENT MONITORING; PEAK EXPIRATORY FLOW; PRIORITY JOURNAL; PROTEIN FUNCTION; RESPIRATORY TRACT INFLAMMATION; RHINOVIRUS; RISK FACTOR; ASTHMA; BLOOD; BRONCHITIS; CHANNEL GATING; COMMON COLD; IMMUNOLOGY; METHODOLOGY; NEUTROPHIL; NOSE MUCUS; NUCLEAR PORE; RISK; VIROLOGY; VIRUS INFECTION;

ADRENAL CORTEX HORMONES; ALBUTEROL; ASTHMA; BIOLOGICAL MARKERS; BRONCHITIS; BRONCHODILATOR AGENTS; COMMON COLD; FLOW CYTOMETRY; HUMANS; ION CHANNEL GATING; NASAL LAVAGE FLUID; NEUTROPHILS; NUCLEAR PORE; ODDS RATIO; PEAK EXPIRATORY FLOW RATE; RECEPTORS, PURINERGIC P2; RISK FACTORS; VIRUS DISEASES;

EID: 60749087353     PISSN: 1073449X     EISSN: 15354970     Source Type: Journal    
DOI: 10.1164/rccm.200802-293OC     Document Type: Article

References (46)

1. Johnston SL, Pattemore PK, Sanderson G, Smith S, Campbell MJ, Josephs LK, Cunningham A, Robinson BS, Myint SH, Ward ME, et al. The relationship between upper respiratory infections and hospital admissions for asthma: a time-trend analysis. Am J Respir Crit Care Med 1996;154:654-660.
2. Atmar RL, Guy E, Guntupalli KK, Zimmerman JL, Bandi VD, Baxter BD, Greenberg SB. Respiratory tract viral infections in inner-city asthmatic adults. Arch Intern Med 1998;158:2453-2459.
3. Jacoby DB. Virus-induced asthma attacks. JAMA 2002;287:755-761.
4. Singh AM, Moore PE, Gern JE, Lemanske RF Jr, Hartert TV. Bronchiolitis to asthma: a review and call for studies of gene-virus interactions in asthma causation. Am J Respir Crit Care Med 2007;175:108-119.
5. Fraenkel DJ, Bardin PG, Sanderson G, Lampe F, Johnston SL, Holgate ST. Lower airways inflammation during rhinovirus colds in normal and in asthmatic subjects. Am J Respir Crit Care Med 1995;151:879-886.
6. Gern JE, Calhoun W, Swenson C, Shen G, Busse WW. Rhinovirus infection preferentially increases lower airway responsiveness in allergic subjects. Am J Respir Crit Care Med 1997;155:1872-1876.
7. Fleming HE, Little FF, Schnurr D, Avila PC, Wong H, Liu J, Yagi S, Boushey HA. Rhinovirus-16 colds in healthy and in asthmatic subjects: similar changes in upper and lower airways. Am J Respir Crit Care Med 1999;160:100-108.
8. Jarjour NN, Gern JE, Kelly EA, Swenson CA, Dick CR, Busse WW. The effect of an experimental rhinovirus 16 infection on bronchial lavage neutrophils. J Allergy Clin Immunol 2000;105:1169-1177.
9. Bardin PG, Fraenkel DJ, Sanderson G, van Schalkwyk EM, Holgate ST, Johnston SL. Peak expiratory flow changes during experimental rhinovirus infection. Eur Respir J 2000;16:980-985.
10. Pizzichini MM, Pizzichini E, Efthimiadis A, Chauhan AJ, Johnston SL, Hussack P, Mahony J, Dolovich J, Hargreave FE. Asthma and natural colds. Inflammatory indices in induced sputum: a feasibility study. Am J Respir Crit Care Med 1998;158:1178-1184.
11. Hoebee B, Bont L, Rietveld E, van Oosten M, Hodemaekers HM, Nagelkerke NJ, Neijens HJ, Kimpen JL, Kimman TG. Influence of promoter variants of interleukin-10, interleukin-9, and tumor necrosis factor-a genes on respiratory syncytial virus bronchiolitis. J Infect Dis 2004;189:239-247.
12. Hull J, Rowlands K, Lockhart E, Moore C, Sharland M, Kwiatkowski D. Variants of the chemokine receptor CCR5 are associated with severe bronchiolitis caused by respiratory syncytial virus. J Infect Dis 2003;188:904-907.
13. Hull J, Thomson A, Kwiatkowski D. Association of respiratory syncytial virus bronchiolitis with the interleukin 8 gene region in UK families. Thorax 2000;55:1023-1027.
14. Lahti M, Lofgren J, Marttila R, Renko M, Klaavuniemi T, Haataja R, Ramet M, Hallman M. Surfactant protein D gene polymorphism associated with severe respiratory syncytial virus infection. Pediatr Res 2002;51:696-699.
15. Buell GN, Talabot F, Gos A, Lorenz J, Lai E, Morris MA, Antonarakis SE. Gene structure and chromosomal localization of the human P2X7 receptor. Receptors Channels 1998;5:347-354.
16. Xu J, Postma DS, Howard TD, Koppelman GH, Zheng SL, Stine OC, Bleecker ER, Meyers DA. Major genes regulating total serum immunoglobulin E levels in families with asthma. Am J Hum Genet 2000;67:1163-1173.
17. Malerba G, Lauciello MC, Scherpbier T, Trabetti E, Galavotti R, Cusin V, Pescollderungg L, Zanoni G, Martinati LC, Boner AL, et al. Linkage analysis of chromosome 12 markers in Italian families with atopic asthmatic children. Am J Respir Crit Care Med 2000;162:1587-1590.
18. 18.Raby BA, Silverman EK, Lazarus R, Lange C, Kwiatkowski DJ, Weiss ST. Chromosome 12q harbors multiple genetic loci related to asthma and asthma-related phenotypes. Hum Mol Genet 2003;12:1973-1979.
19. Khakh BS, North RA. P2X receptors as cell-surface ATP sensors in health and disease. Nature 2006;442:527-532.
20. Marino A, Rodrig Y, Metioui M, Lagneaux L, Alzola E, Fernandez M, Fogarty DJ, Matute C, Moran A, Dehaye JP. Regulation by P2 agonists of the intracellular calcium concentration in epithelial cells freshly isolated from rat trachea. Biochim Biophys Acta 1999;1439:395-405.
21. Ma W, Korngreen A, Weil S, Cohen EB, Priel A, Kuzin L, Silberberg SD. Pore properties and pharmacological features of the P2X receptor channel in airway ciliated cells. J Physiol 2006;571:503-517.
22. Idzko M, Hammad H, van Nimwegen M, Kool M, Willart MAM, Muskens F, Hoogsteden HC, Luttmann W, Ferrari D, Di Virgilio F, et al. Extracellular ATP triggers and maintains asthmatic airway inflammation by activating dendritic cells. Nat Med 2007;13:913-919.
23. Wark PA, Johnston SL, Moric I, Simpson JL, Hensley MJ, Gibson PG. Neutrophil degranulation and cell lysis is associated with clinical severity in virus-induced asthma. Eur Respir J 2002;19:68-75.
24. Esther CR, Alexis NE, Clas ML, Lazarowski ER, Donaldson SH, Ribeiro CM, Moore CG, Davis SD, Boucher RC. Extracellular purines are biomorkers of neutrophilic airway inflammation. Eur Respir J 2008;31:949-956.
25. Labasi JM, Petrushova N, Donovan C, McCurdy S, Lira P, Payette MM, Brissette W, Wicks JR, Audoly L, Gabel CA. Absence of the P2X7 receptor alters leukocyte function and attenuates an inflammatory response. J Immunol 2002;168:6436-6445.
26. Li CM, Campbell SJ, Kumararatne DS, Bellamy R, Ruwende C, McAdam KP, Hill AV, Lammas DA. Association of a polymorphism in the P2X7 gene with tuberculosis in a Gambian population. J Infect Dis 2002;186:1458-1462.
27. 7 receptor abolishes ATP- mediated killing of mycobacteria. J Immunol 2003;171:5442-5446.
28. 7 gene increases susceptibility to extrapulmonary tuberculosis. Am J Respir Crit Care Med 2007;175:360-366.
29. 7R-dependent phospholipase D activation. Immunity 2003; 19:403-412.
30. 7 nucleotide receptor function in human monocytes by extracellular ions and receptor density. Am J Physiol Cell Physiol 2001;280:C943-C953.
31. 7 receptors. Am J Physiol Cell Physiol 2002;283:C77-C84.
32. 7 nucleotide receptor polymorphisms by a novel monocyte poreassay predictive of alterations in lipopolysaccharide-induced cytokine production. J Immunol 2005;174:4424-4431.
33. 7 pore function predicts allele linkage disequilibrium. Clin Chem 2006;52:995-1004.
34. Denlinger L, Guadarrama A, Green D, Hogan K, Vrtis R, Lee W, Crisafi G, Morin A, Sorkness R, Busse W, et al. Regulation of asthmatic airway neutrophilia by P2X7 function during a cold [abstract]. Am J Respir Crit Care Med 2007;174:A474.
35. 7 flow cytometric assay for a multi-center clinical trial. Cytometry B Clin Cytom 2008;74B:319-329.
36. jackson GG, Dowling HF, Spiesman IG, Bonand AV. Transmission of the common cold to volunteers under controlled conditions: the common cold as a clinical entity. Arch Intern Med 1958;101:267-278.
37. Gern JE, Vrtis R, Grindle KA, Swenson C, Busse WW. Relationship of upper and lower airway cytokines to outcome of experimental rhinovirus infection. Am J Respir Crit Care Med 2000;162:2226-2231.
38. Lee WM, Grindle K, Pappas T, Marshall DJ, Moser MJ, Beaty EL, Shult PA, Prudent JR, Gern JE. High-throughput, sensitive, and accurate multiplex PCR-microsphere flow cytometry system for large-scale comprehensive detection of respiratory viruses. J Clin Microbiol 2007;45:2626-2634.
39. Zhu Z, Gwaltney JM, Wu Y, Elias JA. Rhinovirus stimulation of interleukin-8 in vivo and in vitro: role of NF-κB. Am J Physiol 1997;273:L814-L824.
40. Levandowski RA, Ou DW, Jackson GG. Acute-phase decrease of T lymphocyte subsets in rhinovirus infection. J Infect Dis 1986;153:743-748.
41. 7 receptors. Am J Physiol Cell Physiol 2000;279:C1189-C1197.
42. 7 purinergic receptor: characterization and possible participation in antigen presentation. J Immunol 1999;163:1958-1965.
43. 7 receptor in the formation of multinucleated giant cells. J Immunol 2006;177:7257-7265.
44. Wang H, Perters N, Schwarze J. Plasmacytoid dendritic cells limit viral replication, pulmonary inflammation, and airway hyperresponsive-ness in respiratory syncytial virus infection. JImmunol 2006;177:6263-6270.
45. 7 receptor stimulates plasma membrane trafficking in the FRTL rat thyrocyte cell line. Am J Physiol Cell Physiol 2004;287:C992-C1002.
46. Bont L, Heijnen CJ, Kavelaars A, van Aalderen WM, Brus F, Draaisma JT, Geelen SM, Kimpen JL. Monocyte IL-10 production during respiratory syncytial virus bronchiolitis is associated with recurrent wheezing in a one-year follow-up study. Am J Respir Crit Care Med 2000;161:1518-1523.