Estrogen receptor β protects against in vivo injury in RPE cells

Experimental Eye Research

Volumn 90, Issue 1, 2010, Pages 10-16

  Elliot, Sharon J ^a   Catanuto, Paola ^a   Espinosa Heidmann, Diego G ^b   Fernandez, Pedro ^a   Hernandez, Eleut ^a   Saloupis, Peter ^b   Korach, Kenneth ^c   Karl, Michael ^d   Cousins, Scott W ^b  

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^b DUKE UNIVERSITY EYE CENTER   (United States)

^c NATIONAL INSTITUTES OF HEALTH   (United States)

^d FLORIDA INTERNATIONAL UNIVERSITY   (United States)

Author keywords

ERKO mice; estrogen receptors; extracellular matrix; mouse retinal pigmented ephitelial cells

Indexed keywords

COLLAGEN; ESTROGEN RECEPTOR BETA; GELATINASE A; MATRIX METALLOPROTEINASE 14; MITOGEN ACTIVATED PROTEIN KINASE; TISSUE INHIBITOR OF METALLOPROTEINASE 2;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRUCH MEMBRANE; CHOROID CAPILLARY LAYER; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; FEMALE; ILLUMINATION; IN VIVO STUDY; LIPID DIET; MOUSE; NONHUMAN; PIGMENT EPITHELIUM; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RETINA INJURY; TRANSMISSION ELECTRON MICROSCOPY;

ANIMALS; BLOTTING, WESTERN; BRUCH MEMBRANE; CELL CULTURE TECHNIQUES; COLLAGEN; DIETARY FATS; ESTROGEN RECEPTOR BETA; EXTRACELLULAR MATRIX; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FEMALE; IN SITU HYBRIDIZATION; LIGHT; MACULAR DEGENERATION; MATRIX METALLOPROTEINASE 14; MATRIX METALLOPROTEINASE 2; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICROSCOPY, ELECTRON, TRANSMISSION; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; OXIDATIVE STRESS; RETINAL PIGMENT EPITHELIUM; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TISSUE INHIBITOR OF METALLOPROTEINASE-2;

EID: 70749131890     PISSN: 00144835     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.exer.2009.09.001     Document Type: Article

References (35)

1. Age-Related Macular Degeneration. National Eye Institute. 2009.
2. Adminstration on Aging. Older women (2005). www.aoa.gov
3. Bjornstrom L., and Sjoberg M. Mechanisms of estrogen receptor signaling: convergence of genomic and nongenomic actions on target genes. Mol. Endocrinol. 19 (2005) 833-842
4. Catanuto P., Espinosa-Heidmann D., Pereira-Simon S., Sanchez P., Salas P., Hernandez E.P., Cousins S.W., and Elliot S.J. Mouse retinal pigmented epithelial cell lines retain their phenotypic characteristics after transfection with Human Papilloma Virus: a new tool to further the study of RPE biology. Exp. Eye Res. 88 (2009) 99-105
5. Couse J.F., Lindzey J., Grandien K., Gustafsson J.A., and Korach K.S. Tissue distribution and quantitative analysis of estrogen receptor-α (ERα) and estrogen receptor-β (ERβ) messenger ribonucleic acid in the wild-type and ERα-knockout mouse. Endocrinology 138 (1997) 4613-4621
6. Cousins S.W., Espinosa-Heidmann D.G., Alexandridou A., Sall J., Dubovy S., and Csaky K. The role of aging, high fat diet and blue light exposure in an experimental mouse model for basal laminar deposit formation. Exp. Eye Res. 75 (2002) 543-553
7. Cousins S.W., Marin-Castano M.E., Espinosa-Heidmann D.G., Alexandridou A., Striker L., and Elliot S. Female gender, estrogen loss, and Sub-RPE deposit formation in aged mice. Invest. Ophthalmol. Vis. Sci. 44 (2003) 1221-1229
8. Cumming R.G., and Mitchell P. Hormone replacement therapy, reproductive factors, and Cataract the blue Mountains eye study. Am. J. Epidemiol 145 (1997) 242-249
9. Cvoro A., Tatomer D., Tee M.K., Zogovic T., Harris H.A., and Leitman D.C. Selective estrogen receptor- agonists repress transcription of proinflammatory genes. J. Immunol. 180 (2008) 630-636
10. Draghici S., Khatri P., Martins R.P., Ostermeier G.C., and Krawetz S.A. Global functional profiling of gene expression. Genomics 81 (2003) 98-104
11. Elliot S., Catanuto P., Fernandez P., Espinosa-Heidmann D., Karl M., Korach K., and Cousins S.W. Subtype specific estrogen receptor action protects against changes in MMP-2 activation in mouse retinal pigmented epithelial cells. Exp. Eye Res. 86 (2008) 653-660
12. Elliot S., Catanuto P., Stetler-Stevenson W., and Cousins S.W. Retinal pigment epithelium protection from oxidant-mediated loss of MMP-2 activation requires both MMP-14 and TIMP-2. Invest. Ophthalmol. Vis. Sci. 47 (2006) 1696-1702
13. Elliot S.J., Karl M., Berho M., Potier M., Zheng F., Leclercq B., Striker G.E., and Striker L.J. Estrogen deficiency accelerates progression of glomerulosclerosis in susceptible mice. Am. J. Pathol. 162 (2003) 1441-1448
14. Espinosa-Heidmann D.G., Marin-Castano M.E., Pereira-Simon S., Hernandez E.P., Elliot S., and Cousins S.W. Gender and estrogen supplementation increases severity of experimental choroidal neovascularization. Exp. Eye Res. 80 (2005) 413-423
15. Freeman E.E., Munoz B., Bressler S.B., and West S.K. Hormone replacement therapy, reproductive factors, and age-related macular degeneration: the Salisbury Eye Evaluation Project. Ophthalmic Epidemiol. 12 (2005) 37-45
16. Haan M.N., Klein R., Klein B.E., Deng Y., Blythe L.K., Seddon J.M., Musch D.C., Kuller L.H., Hyman L.G., and Wallace R.B. Hormone therapy and age-related macular degeneration: The Women's Health Initiative Sight Exam Study. Arch. Ophthalmol. 124 (2006) 988-992
17. Karl M., Berho M., Pignac-Kobinger J., Striker G.E., and Elliot S.J. Differential effects of continuous and intermittent 17beta-estradiol replacement and tamoxifen therapy on the prevention of glomerulosclerosis: modulation of the mesangial cell phenotype in vivo. Am. J. Pathol. 169 (2006) 351-361
18. Karl M., Potier M., Schulman I.H., Rivera A., Werner H., Fornoni A., and Elliot S.J. Autocrine activation of the local insulin-like growth factor I system is up-regulated by estrogen receptor (ER)-independent estrogen actions and accounts for decreased ER expression in type 2 diabetic mesangial cells. Endocrinology 146 (2005) 889-900
19. Kharas M.G., and Fruman D.A. ABL oncogenes and phosphoinositide 3-kinase: mechanism of activation and downstream effectors. Cancer Res. 65 (2005) 2047-2053
20. Khatri P., Draghici S., Ostermeier G.C., and Krawetz S.A. Profiling gene expression using onto-express. Genomics 79 (2002) 266-270
21. Kobayashi K., Kobayashi H., Ueda M., and Honda Y. Estrogen receptor expression in bovine and rat retinas. Invest. Ophthalmol. Vis. Sci. 39 (1998) 2105-2110
22. Levin E.R. Bidirectional signaling between the estrogen receptor and the epidermal growth factor receptor. Mol. Endocrinol. 17 (2003) 309-317
23. Marin-Castano M.E., Csaky K.G., and Cousins S.W. Nonlethal oxidant injury to human retinal pigment epithelium cells causes cell membrane blebbing but decreased MMP-2 activity. Invest. Ophthalmol. Vis. Sci. 46 (2005) 3331-3340
24. Marin-Castano M.E., Elliot S.J., Potier M., Karl M., Striker L.J., Striker G.E., Csaky K.G., and Cousins S.W. Regulation of estrogen receptors and MMP-2 expression by estrogens in human retinal pigment epithelium. Invest. Ophthalmol. Vis. Sci. 44 (2003) 50-59
25. Marin-Castano M.E., Striker G.E., Alcazar O., Catanuto P., Espinosa-Heidmann D.G., and Cousins S.W. Repetitive nonlethal oxidant injury to retinal pigment epithelium decreased extracellular matrix turnover in vitro and induced sub-RPE deposits in vivo. Invest. Ophthalmol. Vis. Sci. 47 (2006) 4098-4112
26. McDonnell D.P. The molecular determinants of estrogen receptor pharmacology. Maturitas 48 Suppl. 1 (2004) S7-S12
27. Monroe D.G., Secreto F.J., Subramaniam M., Getz B.J., Khosla S., and Spelsberg T.C. Estrogen receptor alpha and beta heterodimers exert unique effects on estrogen- and tamoxifen-dependent gene expression in human U2OS osteosarcoma cells. Mol. Endocrinol. 19 (2005) 1555-1568
28. Munaut C., Lambert V., Noel A., Frankenne F., Deprez M., Foidart J.M., and Rakic J.M. Presence of oestrogen receptor type {beta} in human retina. Br. J. Ophthalmol. 85 (2001) 877-882
29. Nagai N., Klimava A., Lee W.H., Izumi-Nagai K., and Handa J.T. CTGF is increased in basal deposits and regulates matrix production through the ERK (p42/p44mapk) MAPK and the p38 mapk signaling pathways. Invest. Ophthalmol. Vis. Sci 50 (2008) 1903-1910
30. Ogueta S.B., Schwartz S.D., Yamashita C.K., and Farber D.B. Estrogen receptor in the human eye: influence of gender and age on gene expression. Invest. Ophthalmol. Vis. Sci. 40 (1999) 1906-1911
31. Prins G.S., and Korach K.S. The role of estrogens and estrogen receptors in normal prostate growth and disease. Steroids 73 (2008) 233-244
32. Saville B., Wormke M., Wang F., Nguyen T., Enmark E., Kuiper G., Gustafsson J.A., and Safe S. Ligand-, cell-, and estrogen receptor subtype (alpha/beta)-dependent activation at GC-rich (Sp1) promoter elements. J. Biol. Chem. 275 (2000) 5379-5387
33. Tusher V.G., Tibshirani R., and Chu G. Significance analysis of microarrays applied to the ionizing radiation response. Proc. Natl. Acad. Sci. U.S.A 98 (2001) 5116-5121
34. Wingrove C.S., Garr E., Godsland I.F., and Stevenson J.C. 17beta-oestradiol enhances release of matrix metalloproteinase-2 from human vascular smooth muscle cells. Biochim. Biophys. Acta 1406 (1998) 169-174
35. Zhang D., and Brodt P. Type 1 insulin-like growth factor regulates MT1-MMP synthesis and tumor invasion via PI 3-kinase/Akt signaling. Oncogene 22 (2003) 974-982