Finasteride-induced depression: New insights into possible pathomechanisms

Journal of Cosmetic Dermatology

Volumn 9, Issue 4, 2010, Pages 331-332

  Römer, Benedikt ^a   Gass, Peter ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Adverse drug reaction; Depression; Male pattern baldness; Neurogenesis

Indexed keywords

20ALPHA DIHYDROPROGESTERONE; 3ALPHA HYDROXY 5ALPHA PREGNAN 20 ONE; ANDROGEN; ANDROSTANOLONE; DEOXYCORTICOSTERONE; DIHYDRODEOXYCORTICOSTERONE; FINASTERIDE; PROGESTERONE; STEROID 5ALPHA REDUCTASE; TESTOSTERONE; TETRAHYDRODEOXYCORTICOSTERONE; UNCLASSIFIED DRUG;

ANXIETY; ARTICLE; BRAIN DEVELOPMENT; DEPRESSION; EMOTION; ENZYME ACTIVITY; ENZYME INHIBITION; HAIR GROWTH; HIPPOCAMPUS; HUMAN; MALE TYPE ALOPECIA; MEMORY; NERVE CELL PLASTICITY; NEURAL STEM CELL; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; SIDE EFFECT; STEROID METABOLISM;

5-ALPHA REDUCTASE INHIBITORS; ANIMALS; DEPRESSION; FINASTERIDE; HUMANS; LIMBIC SYSTEM; MICE;

EID: 78649787861     PISSN: 14732130     EISSN: 14732165     Source Type: Journal    
DOI: 10.1111/j.1473-2165.2010.00533.x     Document Type: Article

References (13)

1. Kaufman KD, Olsen EA, Whiting D et al. Finasteride in the treatment of men with androgenetic alopecia. Finasteride male pattern hair loss study group. J Am Acad Dermatol 1998; 39: 578-89.
2. Sudduth SL, Koronkowski MJ. Finasteride: the first 5 alpha-reductase inhibitor. Pharmacotherapy 1993; 13: 309-25; discussion 325-309.
3. Van Neste D, Fuh V, Sanchez-Pedreno P et al. Finasteride increases anagen hair in men with androgenetic alopecia. Br J Dermatol 2000; 143: 804-10.
4. Duskova M, Hill M, Hanus M et al. Finasteride treatment and neuroactive steroid formation. Prague Med Rep 2009; 110: 222-30.
5. Dubrovsky BO. Steroids, neuroactive steroids and neurosteroids in psychopathology. Prog Neuropsychopharmacol Biol Psychiatry 2005; 29: 169-92.
6. Belelli D, Lambert JJ. Neurosteroids: endogenous regulators of the gaba(a) receptor. Nat Rev Neurosci 2005; 6: 565-75.
7. Lambert JJ, Cooper MA, Simmons RD et al. Neurosteroids: endogenous allosteric modulators of gaba(a) receptors. Psychoneuroendocrinology 2009; 34 (Suppl 1):S48-58. Epub.
8. Uzunova V, Sheline Y, Davis JM et al. Increase in the cerebrospinal fluid content of neurosteroids in patients with unipolar major depression who are receiving fluoxetine or fluvoxamine. Proc Natl Acad Sci USA 1998; 95: 3239-44.
9. Pinna G, Costa E, Guidotti A. SSRIs act as selective brain steroidogenic stimulants (SBSSs) at low doses that are inactive on 5-HT reuptake. Curr Opin Pharmacol 2009; 9: 24-30.
10. Locchi F, Dall'olio R, Gandolfi O, Rimondini R. Olanzapine counteracts stress-induced anxiety-like behavior in rats. Neurosci Lett 2008; 438: 146-9.
11. Finn DA, Beadles-Bohling AS, Beckley EH et al. A new look at the 5alpha-reductase inhibitor finasteride. CNS Drug Rev 2006; 12: 53-76.
12. Rahimi-Ardabili B, Pourandarjani R, Habibollahi P, Mualeki A. Finasteride induced depression: a prospective study. BMC Clin Pharmacol 2006; 6: 7.
13. Römer B, Pfeiffer N, Lewicka S et al. Finasteride treatment inhibits adult hippocampal neurogenesis in male mice. Pharmacopsychiatry 2010; 43: 174-8.