Adenine nucleotide translocase is acetylated in vivo in human muscle: Modeling predicts a decreased ADP affinity and altered control of oxidative phosphorylation

Biochemistry

Volumn 53, Issue 23, 2014, Pages 3817-3829

  Mielke, Clinton ^a   Lefort, Natalie ^a   McLean, Carrie G ^a   Cordova, Jeanine M ^a   Langlais, Paul R ^b   Bordner, Andrew J ^b   Te, Jerez A ^b   Ozkan, S Banu ^a   Willis, Wayne T ^a   Mandarino, Lawrence J ^a,b  

^a ARIZONA STATE UNIVERSITY   (United States)

^b MAYO CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLATION; AMINO ACIDS; BINDING ENERGY; BIOPSY; CELL MEMBRANES; INSULIN; MITOCHONDRIA; MOLECULAR BIOLOGY; MOLECULAR DYNAMICS; MUSCLE; NUCLEOTIDES; PHYSIOLOGY;

ADENINE NUCLEOTIDE TRANSLOCASE; INNER MITOCHONDRIAL MEMBRANES; MATHEMATICAL DESCRIPTIONS; MITOCHONDRIAL FUNCTION; MOLECULAR DYNAMICS MODELING; MOLECULAR MODELING TECHNIQUES; OXIDATIVE PHOSPHORYLATION; SUBSTANTIAL REDUCTION;

PROTEINS;

ADENINE NUCLEOTIDE; ADENINE NUCLEOTIDE TRANSLOCASE; ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; ASPARTATE AMINOTRANSFERASE; BETA TUBULIN; CHOLESTEROL; CYTOCHROME B; GLUCOSE; HEMOGLOBIN A1C; HISTONE H3; INSULIN; ISOCITRATE DEHYDROGENASE 2; LACTATE DEHYDROGENASE; MALATE DEHYDROGENASE; MANGANESE SUPEROXIDE DISMUTASE; MITOCHONDRIAL PROTEIN; MYOGLOBIN; MYOMESIN; MYOSIN; MYOSIN LIGHT CHAIN; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE; TRIACYLGLYCEROL; VALOSIN CONTAINING PROTEIN; VOLTAGE DEPENDENT ANION CHANNEL 1;

ACETYLATION; ADULT; AEROBIC CAPACITY; AEROBIC METABOLISM; ARTICLE; BINDING AFFINITY; BINDING SITE; CHOLESTEROL BLOOD LEVEL; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DISSOCIATION CONSTANT; EXERCISE; FEMALE; GLUCOSE BLOOD LEVEL; GLUCOSE METABOLISM; HEART RATE; HUMAN; HUMAN TISSUE; HYDROGEN BOND; IN VIVO STUDY; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; INSULIN SENSITIVITY; MALE; MEMBRANE POTENTIAL; MITOCHONDRIAL MEMBRANE; MITOCHONDRION; MOLECULAR DYNAMICS; MOLECULAR MODEL; MUSCLE BIOPSY; OXIDATIVE PHOSPHORYLATION; PERCUTANEOUS BIOPSY; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEOMICS; SKELETAL MUSCLE; STEADY STATE; TRIACYLGLYCEROL BLOOD LEVEL; VASTUS LATERALIS MUSCLE;

ACETYLATION; ADENINE NUCLEOTIDE TRANSLOCATOR 1; ADENOSINE DIPHOSPHATE; ADULT; BINDING SITES; BODY MASS INDEX; DOWN-REGULATION; FEMALE; HUMANS; INSULIN RESISTANCE; LYSINE; MALE; MIDDLE AGED; MITOCHONDRIA, MUSCLE; MOLECULAR DOCKING SIMULATION; MOLECULAR DYNAMICS SIMULATION; MOTOR ACTIVITY; MUSCLE PROTEINS; MUSCLE, SKELETAL; OBESITY; OXIDATIVE PHOSPHORYLATION; PROTEIN PROCESSING, POST-TRANSLATIONAL;

EID: 84902578793     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi401651e     Document Type: Article

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