Glycogen synthase: Key effect of exercise on insulin action

Exercise and Sport Sciences Reviews

Volumn 32, Issue 3, 2004, Pages 90-94

  Christ Roberts, Christine Y ^a   Mandarino, Lawrence J ^a  

^a Mays Cancer Center at UT Health San Antonio   (United States)

Author keywords

Diabetes; Glucose uptake; Physical activity; Skeletal muscle

Indexed keywords

GLUCOSE TRANSPORTER 4; GLYCOGEN SYNTHASE;

AEROBIC CAPACITY; DIABETES MELLITUS; ENZYME ACTIVITY; EXERCISE; GLUCOSE OXIDATION; GLUCOSE TRANSPORT; HORMONE ACTION; HUMAN; INSULIN METABOLISM; INSULIN RESISTANCE; INSULIN SENSITIVITY; PHYSICAL ACTIVITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVIEW; SKELETAL MUSCLE;

BLOOD GLUCOSE; EXERCISE; GLYCOGEN SYNTHASE; HUMANS; INSULIN; INSULIN RESISTANCE; MODELS, BIOLOGICAL;

EID: 3142564626     PISSN: 00916331     EISSN: None     Source Type: Journal    
DOI: 10.1097/00003677-200407000-00003     Document Type: Review

References (15)

1. Aschenbach, W.G., Y. Suzuki, K. Breeden, C. Prats, M.F. Hirshman, S.D. Dufresne, K. Sakamoto, P. Giuseppe Vilardo, M. Steele, J.-H. Kim, S.-L. Jing, L.J. Goodyear, and A.A. DePaoli-Roach. The muscle-specific protein phosphatase PP1G/RGL (GM) is essential for activation of glycogen synthase by exercise. J. Biol. Chem. 276:39959-39967, 2001.
2. Christ, C.Y., D. Hunt, J. Hancock, R. Garcia-Macedo, L.J. Mandarino, and J.L. Ivy. Exercise training improves muscle insulin resistance but not insulin receptor signaling in obese Zucker rats. J. Appl. Physiol. 92:736-744, 2002.
3. Christ-Roberts, C.Y., T. Pratipanawatr, W. Pratipanawatr, R. Berria, R. Belfort, S. Kashyap, and L.J. Mandarino. Exercise training increases glycogen synthase activity and GLUT4 expression but not insulin receptor signaling in obese and type 2 diabetic subjects. Metabolism In press.
4. Christ-Roberts, C.Y., T. Pratipanawatr, W. Pratipanawatr, R. Berria, R. Belfort, and L.J. Mandarino. Increased insulin receptor signaling and glycogen synthase activity contribute to the synergistic effect of exercise on insulin action. J. Appl. Physiol. 95:2519-2529, 2003.
5. Cusi, K., K. Maezono, A. Osman, M. Pendergrass, M.E. Patti, T. Pratipanawatr, R.A. DeFronzo, C.R. Kahn, and L.J. Mandarino. Insulin resistance differentially affects the PI 3-kinase and MAP kinase-mediated signaling in human muscle. J. Clin. Invest. 105:311-320, 2000.
6. Cusi, K., T. Pratipanawatr, J. Koval, P. Ngo, A. Barrentine, J. Finlayson, R.A. DeFronzo, and L. Mandarino. Post-transcriptional defect in exercise-induced hexokinase II (HKII) expression in type 2 diabetes. Diabetes 48:A13, 1999.
7. DeFronzo, R., E. Ferrannini, Y. Sato, P. Felig, and J. Wahren. Synergistic interaction between exercise and insulin on peripheral glucose uptake. J. Clin. Invest. 68:1468-1474, 1981.
8. Dela, F., J.J. Larsen, K. Mikines, T. Ploug, L.N. Petersen, and H. Galbo. Insulin-stimulated muscle glucose clearance in patients with NIDDM: Effects of one-legged physical training. Diabetes 44:1010-1020, 1995.
9. Goodyear, L., F. Giorgino, T. Balon, G. Condorelli, and R. Smith. Effects of contractile activity on tyrosine phosphoproteins and P13-kinase activity in rat skeletal muscle. Am. J. Physiol. 268:E987-E995, 1995.
10. Goodyear, L., M. Hirshman, and E. Horton. Exercise-induced translocation of skeletal muscle glucose transporters. Am. J. Physiol. 261:E795-E799, 1991.
11. Houmard, J., C. Shaw, M. Hickey, and C. Tanner. Effect of short-term exercise training on insulin-stimulated P13-kinase activity in human skeletal muscle. Am. J. Physiol. 277:E1055-1060, 1999.
12. Koval, J., K. Maezono, M.E. Patti, M. Pendergrass, R.A. DeFronzo, and L.J. Mandarino. Differential effects of moderate exercise and physiological hyperinsulinemia on phosphorylation and activity of insulin signaling proteins in vivo in human skeletal muscle. Med. Sci. Sports Exerc. 31:998-104, 1999.
13. Koval, J.A., R.A. DeFronzo, R.M. O'Doherty, R. Printz, H. Ardehali, D.K. Granner, and L.J. Mandarino. Regulation of hexokinase II activity and expression in human muscle by moderate exercise. Am. J. Physiol. 274:E304-E308, 1998.
14. Kurth-Kraczek, E.J., M.F. Hirshman, L.J. Goodyear, and W.W. Winder. 5′ AMP-activated protein kinase activation causes GLUT4 translocation in skeletal muscle. Diabetes 48:1667-1671, 1999.
15. Youngren, J.F., S. Keen, J.L. Kulp, C.J. Tanner, J.A. Houmard, and I.D. Goldfine. Enhanced muscle insulin receptor autophosphorylation with short-term aerobic exercise training. Am. J. Physiol. Endocrinol. Metab. 280:E528-533, 2001.