Top down metabolic control analysis

Journal of Theoretical Biology

Volumn 182, Issue 3, 1996, Pages 351-360

  Brand, Martin D ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

METABOLIC REGULATION; PRIORITY JOURNAL; REVIEW;

EID: 0030574107     PISSN: 00225193     EISSN: None     Source Type: Journal    
DOI: 10.1006/jtbi.1996.0174     Document Type: Article

References (88)

1. AINSCOW, E. K. & BRAND, M. D. (1995). Top-down control analysis of systems with more than one common intermediate. Eur. Biochem. 231, 579-586.
2. BARRETT, J. & PRECIOUS, W. Y. (1995). Application of metabolic control analysis to the pathways of carbohydrate breakdown in Hymenolepsis diminuta. Int. J. Parasitol. 25, 431-436.
3. BOHNENSACK, R. (1985). Theory of steady-state control in complex metabolic networks. Biomed. Biochim. Acta 44, 1567-1578.
4. BRAND, M. D. (1990). The proton leak across the mitochondrial inner membrane. Biochim. Biophys. Acta 1018, 128-133.
5. BRAND, M. D. (1993). Control of oxidative phosphorylation in liver mitochondria and cells: top down control analysis and top-down elasticity analysis. In: Surviving Hypoxia: mechanisms of control and adaptation (Hochachka, P. W., Lutz, P. L., Sick, T., Rosenthal, M. & van den Thillart, G., eds) pp. 295-309. Boca Raton: CRC Press.
6. BRAND, M. D. & BROWN, G. C. (1994). The experimental application of control analysis to metabolic systems. In: Biothermokinetics (Westerhoff, H. V. ed.) pp. 27-35. Andover, U.K: Intercept.
7. BRAND, M. D. & KESSELER, A. (1995). Control analysis of energy metabolism in mitochondria. Biochem. Soc. Trans. 23, 371-376.
8. BRAND, M. D. & MURPHY, M. P. (1987). Control analysis of electron flux through the respiratory chain in mitochondria and cells. Biol. Rev. 62, 141-193.
9. BRAND, M. D., HAFNER, R. P. & BROWN, G. C. (1988a). The quantitative importance of proton leak in the control of non-phosphorylating respiration in isolated mitochondria. EBEC Short Reports 5, 128.
10. BRAND, M. D., HAFNER, R. P. & BROWN, G. C. (1988b). Control of respiration in non-phosphorylating mitochondria is shared between the proton leak and the respiratory chain. Biochem. J. 255, 535-539.
11. BRAND, M. D., D'ALLESSANDRI, L., REIS, H. M. G. P. V. & HAFNER, R. P. (1990). Stimulation of the electron transport chain in mitochondria isolated from rats treated with mannoheptulose or glucagon. Arch. Biochem. Biophys. 283, 278-284.
12. BRAND, M. D., COUTURE, P., ELSE, P. L., WITHERS, K. W. & HULBERT, A. J. (1991). Evolution of energy metabolism: proton permeability of the inner membrane of liver mitochondria is greater in a mammal than a reptile. Biochem. J. 275, 81-86.
13. BRAND, M. D., CHIEN, L.-F. & ROLFE, D. F. S. (1993a). Control of oxidative phosphorylation in liver mitochondria and hepatocytes. Biochem. Soc. Trans. 21, 757-762.
14. BRAND, M. D., HARPER, M.-E. & TAYLOR, H. C. (1993b). Control of the effective P/O ratio of oxidative phosphorylation in liver mitochondria and hepatocytes. Biochem. J. 291, 739-748.
15. BRAND, M. D., VALLIS, B. P. S. & KESSELER, A. (1994). The sum of flux control coefficients in the electron-transport chain of mitochondria. Eur. J. Biochem. 226, 819-829.
16. BROWN, G. C. (1994) Control analysis applied to the whole body: control by organs over plasma concentrations and organ fluxes of substances in the blood. Biochem. J. 297, 115-122.
17. BROWN, G. C., HAFNER, R. P. & BRAND, M. D. (1990a). A 'top-down' approach to the determination of control coefficients in metabolic control theory. Eur. J. Biochem. 188, 321-325.
18. BROWN, G. C., LAKIN-THOMAS, P. L. & BRAND, M. D. (1990b). Control of respiration and oxidative phosphorylation in isolated rat liver cells. Eur. J. Biochem. 192, 355-362.
19. BUTTGEREIT, F. & BRAND, M. D. (1995). A hierarchy of ATP-consuming processes in mammalian cells. Biochem. J. 312, 163-167.
20. BUTTGEREIT, F., GRANT, A., MÜLLER, M. & BRAND, M. D. (1994). The effects of methylprednisolone on oxidative phosphorylation in Concanavalin-A-stimulated thymocytes. Top down elasticity analysis and control analysis. Eur. J. Biochem. 223, 513-519.
21. CORNISH-BOWDEN, A. & HOFMEYR, J.-H. S. (1994). Determination of control coefficients in intact metabolic systems. Biochem. J. 298, 367-375.
22. FELL, D. A. (1992). Metabolic control analysis: a survey of its theoretical and experimental development. Biochem. J. 286, 313-330.
23. FELL, D. A. & SAURO, H. M. (1985). Metabolic control and its analysis. Additional relationships between elasticities and control coefficients. Eur. J. Biochem. 148, 555-561.
24. FELL, D. A. & SAURO, H. M. (1990). Metabolic control and its analysis. The effects of high enzyme concentrations. Eur. J. Biochem. 192, 183-187.
25. FUSI, F., SGARAGLI, G. & MURPHY, M. P. (1992). Interaction of butylated hydroxyanisole with mitochondrial oxidative phosphorylation. Biochem. Pharmacol. 43, 1203-1208.
26. HAFNER, R. P., NOBES, C. D., MCGOWN, A. D. & BRAND, M. D. (1988). Altered relationship between protonmotive force and respiration rate in non-phosphorlyating liver mitochondria isolated from rats of different thyroid hormone status. Eur. J. Biochem. 178, 511-518.
27. HAFNER, R. P., BROWN, G. C. & BRAND, M. D. (1990a). Analysis of the control of respiration rate, phosphorylation rate, proton leak rate and protonmotive force in isolated mitochondria using the 'top-down' approach of metabolic control theory. Eur. J. Biochem. 188, 313-319.
28. HAFNER, R. P., BROWN, G. C. & BRAND, M. D. (1990b). Thyroid-hormone control of state-3 respiration in isolated rat liver mitochondria. Biochem. J. 265, 731-734.
29. HARPER, M.-E. & BRAND, M. D. (1993). The quantitative contributions of mitochondrial proton leak and ATP turnover reactions to the changed respiration rates of hepatocytes from rats of different thyroid status. J. Biol. Chem. 268, 14850-14860.
30. HARPER, M.-E. & BRAND, M. D. (1994). Hyperthyroidism stimulates mitochondrial proton leak and ATP turnover in rat hepatocytes but does not change the overall kinetics of substrate oxidation reactions. Can J. Physiol. Pharmacol. 72, 899-908.
31. HARPER, M.-E. & BRAND, M. D. (1995). Use of top-down elasticity analysis to identify sites of thyroid hormone-induced thermogenesis. Proc. Soc. Exp. Biol. Med. 208, 228-237.
32. HARPER, M.-E., BALLANTYNE, J. S., LEACH, M. & BRAND, M. D. (1993). Effects of thyroid hormones on oxidative phosphorylation, Biochem. Soc. Trans. 21, 785-792.
33. HEINRICH, R. & RAPOPORT, T. A. (1974a). A linear steady-state treatment of enzymic chains. General properties, control and effector strength. Eur. J. Biochem. 42, 89-95.
34. HEINRICH, R. & RAPOPORT, T. A. (1974b). A linear steady-state treatment of enzymic chains. Critique of the crossover theorem and a general procedure to identify interaction sites with an effector. Eur. J. Biochem. 42, 97-105.
35. HEINRICH, R., RAPOPORT, S. M. & RAPOPORT, T. A. (1977). Metabolic regulation and mathematical models. Prog. Biophys. Mol. Biol. 32, 1-82.
36. HOFMEYR, J.-H. & CORNISH-BOWDEN, A. (1991). Quantitative assessment of regulation in metabolic systems. Eur. J. Biochem. 200, 223-236.
37. HOFMEYR, J.-H., KACSER, H. & VAN DER MERWE, K. J. (1986). Metabolic control analysis of moiety-conserved cycles. Eur. J. Biochem. 155, 631-641.
38. HOFMEYR, J.-H., CORNISH-BOWDEN, A. & ROHWER, J. M. (1993). Taking enzyme kinetics out of control; putting control into regulation. Eur. J. Biochem. 212, 833-837.
39. KACSER, H. (1983). The control of enzyme systems in vivo: elasticity analysis of the steady state. Biochem. Soc. Trans. 11, 35-40.
40. KACSER, H. & BURNS, J. A. (1973). The control of flux. Symp. Soc. Exp. Biol. 27, 65-104.
41. KACSER, H. & BURNS, J. A. (1979). Molecular democracy: who shares the controls? Biochem. Soc. Trans. 7, 1149-1160.
42. KACSER, H., SAURO, H. M. & ACERENZA, L. (1990). Enzyme-enzyme interactions and control analysis. 1. The case of non-additivity: monomer-oligomer associations. Eur. J. Biochem. 187, 481-491.
43. KACSER, H., BURNS, J. A. & FELL, D. A. (1995). The control of flux. Biochem. Soc. Trans. 23, 341-366.
44. KAHN, D. & WESTERHOFF, H. V. (1991). Control theory of regulatory cascades. J. theor. Biol. 153, 255-285.
45. KAHN, D. & WESTERHOFF, H. V. (1993). The regulatory strength: How to be precise about regulation and homeostasis. Acta Biotheoretica. 41, 85-96.
46. KASHIWAYA, Y., SATO, K., TSUCHIYA, N., THOMAS, S., FELL, D. A., VEECH, R. L. & PASSONEAU, J. V. (1994). Control of glucose utilisation in working perfused rat heart. J. Biol. Chem. 269, 25502-25514.
47. KESSELER, A. & BRAND, M. D. (1994a). Localisation of the sites of action of cadmium on oxidative phosphorylation in potato tuber mitochondria using top-down elasticity analysis. Eur. J. Biochem. 225, 897-906.
48. KESSELER, A. & BRAND, M. D. (1994b). Effects of cadmium on the control and internal regulation of oxidative phosphorylation in potato tuber mitochondria. Eur. J. Biochem. 225, 907-922.
49. KESSELER, A. & BRAND, M. D. (1994c). Quantitative determination of the regulation of oxidative phosphorylation by cadmium in potato tuber mitochondria. Eur. J. Biochem. 225, 923-935.
50. KESSELER, A. & BRAND, M. D. (1995). The mechanism of the stimulation of state 4 respiration by cadmium in potato tuber (Solanum tuberosum) mitochondria. Plant Physiol. Biochem. 33, 519-528.
51. KESSELER, A., DIOLEZ, P., BRINKMANN, K. & BRAND, M. D. (1992). Characterisation of the control of respiration in potato tuber mitochondria using the top-down approach of metabolic control analysis. Eur. J. Biochem. 210, 775-784.
52. KHOLODENKO, B. N. (1988). How do external parameters control fluxes and concentrations of metabolites? An additional relationship in the theory of metabolic control. FEBS Lett. 232, 383-386.
53. KHOLODENKO, B. N. & WESTERHOFF, H. V. (1993). Metabolic channeling and control of flux. FEBS Lett. 320, 71-74.
54. KHOLODENKO, B. N., LYUBAREV, A. E. & KURGANOV, B. I. (1992). Control of the metabolic flux in a system with high enzyme concentrations and moiety-conserved cycles. The sum of the flux control coefficients can drop significantly below unity. Eur. J. Biochem. 210, 147-153.
55. KHOLODENKO, B. N., CASCANTE, M. & WESTERHOFF, H. V. (1993). Dramatic changes in control properties that accompany channelling and metabolite sequestration. FEBS Lett. 336, 381-384.
56. KHOLODENKO, B. N., SAURO, H. M. & WESTERHOFF, H. V. (1994). Control by enzymes, coenzymes and conserved moieties. A generalisation of the connectivity theorem of metabolic control analysis. Eur. J. Biochem. 225, 179-186.
57. KHOLODENKO, B. N., SCHUSTER, S., ROHWER, J. M., CASCANTE, M. & WESTERHOFF, H. V. (1995). Composite control of cell function: metabolic pathways behaving as single control units. FEBS Lett. 368, 1-4.
58. KORZENIEWSKI, B. & FRONCISZ, W. (1992). Theoretical studies on the control of the oxidative phosphorylation system. Biochem. Biophys. Acta 1102, 67-75.
59. KORZENIEWSKI, B., HARPER, M.-E. & BRAND, M. D. (1995). Proportional activation coefficients during stimulation of oxidative phosphorylation by lactate and pyruvate or by vasopressin. Biochim. Biophys. Acta 1229, 315-322.
60. KUNZ, W. S. (1991). Application of the theory of steady-state flux control to mitochondrial β-oxidation. Biomed. Biochim. Acta 50, 1143-1157.
61. LETELLIER, T., REDER, C. & MAZAT, J-P. (1991). CONTROL: software for the analysis of the control of metabolic networks. CABIOS 7, 383-390.
62. MAKINS, R. A., DRYNAN, L. F., ZAMMIT, V. A. & QUANT, P. A. (1995). Top-down regulation analyses of palmitoyl-CoA oxidation and ketogenesis in isolated rat liver mitochondria. Biochem. Soc. Trans. 23, 288S.
63. MOORE, A. L., LEACH, G., WHITEHOUSE, D. G., VAN DEN BERGEN, C. W. M., WAGNER, A. M. & KRAB, K. (1994). Control of oxidative phosphorylation in plant mitochondria: the role of non-phosphorylating pathways. Biochim. Biophys. Acta 1187, 145-151.
64. MURPHY, M. P. & BRAND, M. D. (1986). The control of electron flux through cytochrome oxidase. Biochem. Soc. Trans. 14, 887-888.
65. MURPHY, M. P. & BRAND, M. D. (1987). The control of electron flux through cytochrome oxidase. Biochem. J. 243, 499-505.
66. NOBES, C. D., HAY, W. W. & BRAND, M. D. (1990). The mechanism of stimulation of respiration by fatty acids in isolated hepatocytes. J. Biol. Chem. 265, 12910-12915.
67. + leak in mitochondria and its relevance to metabolic rate. Nature 362, 628-630.
68. PRECIOUS, W. Y. & BARRETT, J. (1993). Quantification of the control of carbohydrate catabolism in the tapeworm Hymenoleptis diminuta. Biochem. Cell Biol. 71, 315-323.
69. QUANT, P. A. (1993). Experimental application of top-down control analysis to metabolic systems. Trends Biochem. Sci. 18, 26-30.
70. QUANT, P. A. & MAKINS, R. A. (1994). Metabolic control analysis of hepatic β-oxidation - the top-down approach. Biochem. Soc. Trans. 22, 441-446.
71. QUANT, P. A., ROBIN, D., ROBIN, P., GIRARD, J. & BRAND, M. D. (1989). Control of acetoacetate production from exogenous palmitoyl-CoA in isolated rat liver mitochondria. Biochem. Soc. Trans. 17, 1089-1090.
72. QUANT, P. A., ROBIN, D., ROBIN, P., BROWN, G. C., GIRARD, J. & BRAND, M. D. (1993). A top-down control analysis in isolated rat liver mitochondria: can the 3-hydroxy-3-methylglutaryl-CoA pathway be rate-controlling for ketogenesis? Biochim. Biophys. Acta 1156, 135-143.
73. REDER, C. (1988). Metabolic control theory: a structural approach. J. theor. Biol. 135, 175-201.
74. ROLFE, D. F. S. & BRAND, M. D. (1996). Proton leak and control of oxidative phosphorylation in perfused, resting rat skeletal muscle. Biochim. Biophys. Acta 1276, 45-50.
75. ROLFE, D. F. S., HULBERT, A. J. & BRAND, M. D. (1994). Characteristics of mitochondrial proton leak and control of oxidative phosphorylation in the major oxygen consuming tissues of the rat. Biochim. Biophys. Acta 1188, 405-416.
76. SAURO, H. M. (1990). Regulatory responses and control analysis: assessment of the relative importance of internal effectors. In: Control of metabolic processes (Cornish-Bowden, A. & Cardenas, M. L., eds) pp. 225-230. New York: Plenum.
77. SAURO, H. M. & KACSER, H. (1990). Enzyme-enzyme interactions and control analysis. 2. The case of non-independence: heterologous associations. Eur. J. Biochem. 187, 493-500.
78. SCHUSTER, S., KAHN, D. & WESTERHOFF, H. V. (1993). Modular analysis of the control of complex metabolic pathways. Biophys. Chem. 48, 1-17.
79. SMALL, J. R. & FELL, D. A. (1990). Covalent modification and metabolic control analysis. Modification to the theorems and their applications to metabolic systems containing covalently modifiable enzymes. Eur. J. Biochem. 191, 405-411.
80. TENREIRO, A. M. VAZ PINTO, V., ARRABACA, J. D., DIOLEZ, P. & MOREAU, F. (1994). Top down analysis of control applied to plant mitochondria during substrate competition. EBEC Short Rep. 8, 103.
81. THOMAS, S. & FELL, D. A. (1993). A computer program for the algebraic determination of control coefficients in Metabolic Control Analysis. Biochem. J. 292, 351-360.
82. THOMAS, S. & FELL, D. A. (1994). Metabolic control analysis: sensitivity of control coefficients to experimentally determined variables. J. Theor. Biol. 167, 175-200.
83. VAZ PINTO, V., TENREIRO, A. M., ARRABAÇA, J. D. & MOREAU, F. (1994). The control of oxidative phosphorylation in plant mitochondria respiring malate. EBEC Short Rep. 8, 104.
84. WESTERHOFF, H. V. (1989). Control, regulation and thermodynamics of free-energy transduction. Biochimie 71, 877-886.
85. WESTERHOFF, H. V. & KAHN, K. (1993). Control involving metabolism and gene expression: the square-matrix method for modular decomposition. Acta Biotheoretica 41, 75-83.
86. WESTERHOFF, H. V. & VAN DAM, K. (1987). Thermodynamics and Control of Biological Free Energy Transduction. Amsterdam: Elsevier.
87. WESTERHOFF, H. V., GROEN, A. K. & WANDERS, R. J. A. (1984). Modern theories of metabolic control and their applications. Biosci. Rep. 4, 1-22.
88. WESTERHOFF, H. V., PLOMP, P. J. A. M., GROEN, A. K., WANDERS, R. J. A., BODE, J. A. & VAN DAM, K. (1987). On the origin of the limited control of mitochondrial respiration by the adenine nucleotide translocator. Arch. Biochem. Biophys. 257, 154-169.