Junín virus infection of human hematopoietic progenitors impairs in vitro proplatelet formation and platelet release via a bystander effect involving type I IFN signaling

PLoS Pathogens

Volumn 6, Issue 4, 2010, Pages 1-14

  Pozner, Roberto G ^a   Ure, Agustín E ^b   de Giusti, Carolina Jaquenod ^b   D'Atri, Lina P ^a   Italiano, Joseph E ^c,d   Torres, Oscar ^a   Romanowski, Victor ^b   Schattner, Mirta ^a   Gómez, Ricardo M ^b  

^a Facultad de Ciencias Naturales e Instituto M Lillo   (Argentina)

^b Inst de Biotecnología Y Biología Molecular IBBM   (Argentina)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

^d BOSTON CHILDREN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; BETA INTERFERON; CD71 ANTIGEN; PADGEM PROTEIN; THROMBOPOIETIN; TRANSCRIPTION FACTOR NF E2; CD34 ANTIGEN; INTERFERON; LEUKOCYTE ANTIGEN; NFE2 PROTEIN, HUMAN; TRANSCRIPTION FACTOR NF E2 P45 SUBUNIT; TRANSFERRIN RECEPTOR;

ANTIGEN EXPRESSION; ARGENTINE HEMORRHAGIC FEVER; ARTICLE; BYSTANDER EFFECT; CD34 SELECTION; CELL CULTURE; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; GENE EXPRESSION REGULATION; GENE LOCATION; HEMATOPOIESIS; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; JUNIN VIRUS; LYMPHOCYTE ACTIVATION; MEGAKARYOCYTE; MEGAKARYOPOIESIS; NONHUMAN; PARACRINE SIGNALING; PHENOTYPE; SIGNAL TRANSDUCTION; THROMBOCYTE RELEASE REACTION; THROMBOCYTOPENIA; ULTRASTRUCTURE; VIRUS CULTURE; ARENAVIRUS INFECTION; CELL SEPARATION; CYTOLOGY; FETUS BLOOD; FLOW CYTOMETRY; METABOLISM; PHYSIOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; THROMBOCYTE; THROMBOCYTOPOIESIS; TRANSMISSION ELECTRON MICROSCOPY; VIROLOGY;

ARENAVIRIDAE; JUNIN VIRUS;

ANTIGENS, CD; ANTIGENS, CD34; ARENAVIRIDAE INFECTIONS; BLOOD PLATELETS; BYSTANDER EFFECT; CELL SEPARATION; FETAL BLOOD; FLOW CYTOMETRY; HEMATOPOIETIC STEM CELLS; HUMANS; INTERFERON TYPE I; JUNIN VIRUS; MICROSCOPY, ELECTRON, TRANSMISSION; NF-E2 TRANSCRIPTION FACTOR, P45 SUBUNIT; RECEPTORS, TRANSFERRIN; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; THROMBOPOIESIS;

EID: 77954052983     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1000847     Document Type: Article

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