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Volumn 134, Issue 1, 2014, Pages 105-110

Impact of point-of-care testing for CYP2C19 on platelet inhibition in patients with acute coronary syndrome and early dual antiplatelet therapy in the emergency setting

Author keywords

Acute coronary syndrome; Clopidogrel; CYP2C19; Pharmacogenetics; Prasugrel; Ticagrelor

Indexed keywords

ACETYLSALICYLIC ACID; ADENOSINE; ANTITHROMBOCYTIC AGENT; CYP2C19 PROTEIN, HUMAN; CYTOCHROME P450 2C19; PIPERAZINE DERIVATIVE; PRASUGREL; THIOPHENE DERIVATIVE; TICAGRELOR;

EID: 84902553307     PISSN: 00493848     EISSN: 18792472     Source Type: Journal    
DOI: 10.1016/j.thromres.2014.05.006     Document Type: Article
Times cited : (22)

References (34)
  • 1
    • 70149101223 scopus 로고    scopus 로고
    • Ticagrelor versus clopidogrel in patients with acute coronary syndromes
    • L. Wallentin, R.C. Becker, A. Budaj, C.P. Cannon, H. Emanuelsson, and C. Held et al. Ticagrelor versus clopidogrel in patients with acute coronary syndromes N Engl J Med 361 11 2009 1045 1057
    • (2009) N Engl J Med , vol.361 , Issue.11 , pp. 1045-1057
    • Wallentin, L.1    Becker, R.C.2    Budaj, A.3    Cannon, C.P.4    Emanuelsson, H.5    Held, C.6
  • 2
    • 84886391924 scopus 로고    scopus 로고
    • Genetic variation of platelet function and pharmacology:An update of current knowledge
    • T. Geisler, E. Elke Schaeffeler, M. Gawaz, and M. Schwab Genetic variation of platelet function and pharmacology:An update of current knowledge Thromb Haemost 110 2 2013
    • (2013) Thromb Haemost , vol.110 , Issue.2
    • Geisler, T.1    Elke Schaeffeler, E.2    Gawaz, M.3    Schwab, M.4
  • 3
    • 0028457506 scopus 로고
    • The potential social impact of predictive genetic testing for susceptibility to common chronic diseases: A review and proposed research agenda
    • C. Davison, S. Macintyre, and G.D. Smith The potential social impact of predictive genetic testing for susceptibility to common chronic diseases: a review and proposed research agenda Sociol Health Illn 16 3 1994 340 371
    • (1994) Sociol Health Illn , vol.16 , Issue.3 , pp. 340-371
    • Davison, C.1    Macintyre, S.2    Smith, G.D.3
  • 4
    • 71849117072 scopus 로고    scopus 로고
    • Predictive genetic testing for coronary artery disease
    • C.T. Johansen, and R.A. Hegele Predictive genetic testing for coronary artery disease Crit Rev Clin Lab Sci 46 5-6 2009 343 360
    • (2009) Crit Rev Clin Lab Sci , vol.46 , Issue.56 , pp. 343-360
    • Johansen, C.T.1    Hegele, R.A.2
  • 6
    • 84860538806 scopus 로고    scopus 로고
    • Point-of-care genetic testing for personalisation of antiplatelet treatment (RAPID GENE): A prospective, randomised, proof-of-concept trial
    • J.D. Roberts, G.A. Wells, M.R. Le May, M. Labinaz, C. Glover, and M. Froeschl et al. Point-of-care genetic testing for personalisation of antiplatelet treatment (RAPID GENE): a prospective, randomised, proof-of-concept trial Lancet 379 9827 2012 1705 1711
    • (2012) Lancet , vol.379 , Issue.9827 , pp. 1705-1711
    • Roberts, J.D.1    Wells, G.A.2    Le May, M.R.3    Labinaz, M.4    Glover, C.5    Froeschl, M.6
  • 7
    • 84856158305 scopus 로고    scopus 로고
    • ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation: The Task Force for the management of acute coronary syndromes (ACS) in patients presenting without persistent ST-segment elevation of the European Society of Cardiology (ESC)
    • C.W. Hamm, J.P. Bassand, S. Agewall, J. Bax, E. Boersma, and H. Bueno et al. ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation: The Task Force for the management of acute coronary syndromes (ACS) in patients presenting without persistent ST-segment elevation of the European Society of Cardiology (ESC) Eur Heart J 32 23 2011 2999 3054
    • (2011) Eur Heart J , vol.32 , Issue.23 , pp. 2999-3054
    • Hamm, C.W.1    Bassand, J.P.2    Agewall, S.3    Bax, J.4    Boersma, E.5    Bueno, H.6
  • 8
    • 84866732231 scopus 로고    scopus 로고
    • ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation
    • Task Force on the management of STseamiotESoC, P.G. Steg, S.K. James, D. Atar, L.P. Badano, and C. Blomstrom-Lundqvist et al. ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation Eur Heart J 33 20 2012 2569 2619
    • (2012) Eur Heart J , vol.33 , Issue.20 , pp. 2569-2619
    • Steg, P.G.1    James, S.K.2    Atar, D.3    Badano, L.P.4    Blomstrom-Lundqvist, C.5
  • 10
    • 55449137355 scopus 로고    scopus 로고
    • CYP2C19 and nongenetic factors predict poor responsiveness to clopidogrel loading dose after coronary stent implantation
    • T. Geisler, E. Schaeffeler, J. Dippon, S. Winter, V. Buse, and C. Bischofs et al. CYP2C19 and nongenetic factors predict poor responsiveness to clopidogrel loading dose after coronary stent implantation Pharmacogenomics 9 9 2008 1251 1259
    • (2008) Pharmacogenomics , vol.9 , Issue.9 , pp. 1251-1259
    • Geisler, T.1    Schaeffeler, E.2    Dippon, J.3    Winter, S.4    Buse, V.5    Bischofs, C.6
  • 11
    • 77958466789 scopus 로고    scopus 로고
    • Impact of inflammatory markers on platelet inhibition and cardiovascular outcome including stent thrombosis in patients with symptomatic coronary artery disease
    • K. Muller, S. Aichele, M. Herkommer, B. Bigalke, K. Stellos, and P. Htun et al. Impact of inflammatory markers on platelet inhibition and cardiovascular outcome including stent thrombosis in patients with symptomatic coronary artery disease Atherosclerosis 213 1 2010 256 262
    • (2010) Atherosclerosis , vol.213 , Issue.1 , pp. 256-262
    • Muller, K.1    Aichele, S.2    Herkommer, M.3    Bigalke, B.4    Stellos, K.5    Htun, P.6
  • 12
    • 38349090725 scopus 로고    scopus 로고
    • Assessment of ADP-induced platelet aggregation with light transmission aggregometry and multiple electrode platelet aggregometry before and after clopidogrel treatment
    • D. Sibbing, S. Braun, S. Jawansky, W. Vogt, J. Mehilli, and A. Schomig et al. Assessment of ADP-induced platelet aggregation with light transmission aggregometry and multiple electrode platelet aggregometry before and after clopidogrel treatment Thromb Haemost 99 1 2008 121 126
    • (2008) Thromb Haemost , vol.99 , Issue.1 , pp. 121-126
    • Sibbing, D.1    Braun, S.2    Jawansky, S.3    Vogt, W.4    Mehilli, J.5    Schomig, A.6
  • 13
    • 60949083948 scopus 로고    scopus 로고
    • Platelet reactivity after clopidogrel treatment assessed with point-of-care analysis and early drug-eluting stent thrombosis
    • D. Sibbing, S. Braun, T. Morath, J. Mehilli, W. Vogt, and A. Schomig et al. Platelet reactivity after clopidogrel treatment assessed with point-of-care analysis and early drug-eluting stent thrombosis J Am Coll Cardiol 53 10 2009 849 856
    • (2009) J Am Coll Cardiol , vol.53 , Issue.10 , pp. 849-856
    • Sibbing, D.1    Braun, S.2    Morath, T.3    Mehilli, J.4    Vogt, W.5    Schomig, A.6
  • 14
    • 33845358942 scopus 로고    scopus 로고
    • Multiple electrode aggregometry: A new device to measure platelet aggregation in whole blood
    • O. Tóth, A. Calatzis, S. Penz, H. Losonczy, and W. Siess Multiple electrode aggregometry: a new device to measure platelet aggregation in whole blood Thromb Haemost 96 6 2006 781 788
    • (2006) Thromb Haemost , vol.96 , Issue.6 , pp. 781-788
    • Tóth, O.1    Calatzis, A.2    Penz, S.3    Losonczy, H.4    Siess, W.5
  • 15
    • 0034007388 scopus 로고    scopus 로고
    • Phenotyping of drug-metabolizing enzymes in adults: A review of in-vivo cytochrome P450 phenotyping probes
    • D.S. Streetman, J.S. Bertino Jr., and A.N. Nafziger Phenotyping of drug-metabolizing enzymes in adults: a review of in-vivo cytochrome P450 phenotyping probes Pharmacogenetics 10 3 2000 187 216
    • (2000) Pharmacogenetics , vol.10 , Issue.3 , pp. 187-216
    • Streetman, D.S.1    Bertino, Jr.J.S.2    Nafziger, A.N.3
  • 17
    • 77958105401 scopus 로고    scopus 로고
    • Genetic variants in ABCB1 and CYP2C19 and cardiovascular outcomes after treatment with clopidogrel and prasugrel in the TRITON-TIMI 38 trial: A pharmacogenetic analysis
    • J.L. Mega, S.L. Close, S.D. Wiviott, L. Shen, J.R. Walker, and T. Simon et al. Genetic variants in ABCB1 and CYP2C19 and cardiovascular outcomes after treatment with clopidogrel and prasugrel in the TRITON-TIMI 38 trial: a pharmacogenetic analysis Lancet 376 9749 2010 1312 1319
    • (2010) Lancet , vol.376 , Issue.9749 , pp. 1312-1319
    • Mega, J.L.1    Close, S.L.2    Wiviott, S.D.3    Shen, L.4    Walker, J.R.5    Simon, T.6
  • 18
    • 84879663285 scopus 로고    scopus 로고
    • Clopidogrel pretreatment in primary percutaneous coronary intervention: Prevalence of high on-treatment platelet reactivity and impact on preprocedural patency of the infarct-related artery
    • J.L. Ferreiro, S. Homs, J. Berdejo, G. Roura, J. Gomez-Lara, and R. Romaguera et al. Clopidogrel pretreatment in primary percutaneous coronary intervention: prevalence of high on-treatment platelet reactivity and impact on preprocedural patency of the infarct-related artery Thromb Haemost 110 1 2013 110 117
    • (2013) Thromb Haemost , vol.110 , Issue.1 , pp. 110-117
    • Ferreiro, J.L.1    Homs, S.2    Berdejo, J.3    Roura, G.4    Gomez-Lara, J.5    Romaguera, R.6
  • 19
    • 4544304784 scopus 로고    scopus 로고
    • Platelet function predicts myocardial damage in patients with acute myocardial infarction
    • M. Frossard, I. Fuchs, J.M. Leitner, K. Hsieh, M. Vlcek, and H. Losert et al. Platelet function predicts myocardial damage in patients with acute myocardial infarction Circulation 110 11 2004 1392 1397
    • (2004) Circulation , vol.110 , Issue.11 , pp. 1392-1397
    • Frossard, M.1    Fuchs, I.2    Leitner, J.M.3    Hsieh, K.4    Vlcek, M.5    Losert, H.6
  • 20
    • 33750967096 scopus 로고    scopus 로고
    • Platelet function in patients with acute coronary syndrome (ACS) predicts recurrent ACS
    • I. Fuchs, M. Frossard, A. Spiel, E. Riedmuller, A.N. Laggner, and B. Jilma Platelet function in patients with acute coronary syndrome (ACS) predicts recurrent ACS J Thromb Haemost 4 12 2006 2547 2552
    • (2006) J Thromb Haemost , vol.4 , Issue.12 , pp. 2547-2552
    • Fuchs, I.1    Frossard, M.2    Spiel, A.3    Riedmuller, E.4    Laggner, A.N.5    Jilma, B.6
  • 21
    • 84868637235 scopus 로고    scopus 로고
    • Pharmacodynamic effect of switching therapy in patients with high on-treatment platelet reactivity and genotype variation with high clopidogrel Dose versus prasugrel: The RESET GENE trial
    • G. Sardella, S. Calcagno, M. Mancone, R. Palmirotta, L. Lucisano, and E. Canali et al. Pharmacodynamic effect of switching therapy in patients with high on-treatment platelet reactivity and genotype variation with high clopidogrel Dose versus prasugrel: the RESET GENE trial Circ Cardiovasc Interv 5 5 2012 698 704
    • (2012) Circ Cardiovasc Interv , vol.5 , Issue.5 , pp. 698-704
    • Sardella, G.1    Calcagno, S.2    Mancone, M.3    Palmirotta, R.4    Lucisano, L.5    Canali, E.6
  • 22
    • 79951785678 scopus 로고    scopus 로고
    • First analysis of the relation between CYP2C19 genotype and pharmacodynamics in patients treated with ticagrelor versus clopidogrel: The ONSET/OFFSET and RESPOND genotype studies
    • U.S. Tantry, K.P. Bliden, C. Wei, R.F. Storey, M. Armstrong, and K. Butler et al. First analysis of the relation between CYP2C19 genotype and pharmacodynamics in patients treated with ticagrelor versus clopidogrel: the ONSET/OFFSET and RESPOND genotype studies Circ Cardiovasc Genet 3 6 2010 556 566
    • (2010) Circ Cardiovasc Genet , vol.3 , Issue.6 , pp. 556-566
    • Tantry, U.S.1    Bliden, K.P.2    Wei, C.3    Storey, R.F.4    Armstrong, M.5    Butler, K.6
  • 23
    • 77958100874 scopus 로고    scopus 로고
    • Effect of CYP2C19 and ABCB1 single nucleotide polymorphisms on outcomes of treatment with ticagrelor versus clopidogrel for acute coronary syndromes: A genetic substudy of the PLATO trial
    • L. Wallentin, S. James, R.F. Storey, M. Armstrong, B.J. Barratt, and J. Horrow et al. Effect of CYP2C19 and ABCB1 single nucleotide polymorphisms on outcomes of treatment with ticagrelor versus clopidogrel for acute coronary syndromes: a genetic substudy of the PLATO trial Lancet 376 9749 2010 1320 1328
    • (2010) Lancet , vol.376 , Issue.9749 , pp. 1320-1328
    • Wallentin, L.1    James, S.2    Storey, R.F.3    Armstrong, M.4    Barratt, B.J.5    Horrow, J.6
  • 24
    • 84863680949 scopus 로고    scopus 로고
    • Ticagrelor versus prasugrel in acute coronary syndrome patients with high on-clopidogrel platelet reactivity following percutaneous coronary intervention: A pharmacodynamic study
    • D. Alexopoulos, A. Galati, I. Xanthopoulou, E. Mavronasiou, G. Kassimis, and K.C. Theodoropoulos et al. Ticagrelor versus prasugrel in acute coronary syndrome patients with high on-clopidogrel platelet reactivity following percutaneous coronary intervention: a pharmacodynamic study J Am Coll Cardiol 60 3 2012 193 199
    • (2012) J Am Coll Cardiol , vol.60 , Issue.3 , pp. 193-199
    • Alexopoulos, D.1    Galati, A.2    Xanthopoulou, I.3    Mavronasiou, E.4    Kassimis, G.5    Theodoropoulos, K.C.6
  • 25
    • 84875997213 scopus 로고    scopus 로고
    • Comparison of prasugrel and ticagrelor loading doses in ST-segment elevation myocardial infarction patients: RAPID (Rapid Activity of Platelet Inhibitor Drugs) primary PCI study
    • G. Parodi, R. Valenti, B. Bellandi, A. Migliorini, R. Marcucci, and V. Comito et al. Comparison of prasugrel and ticagrelor loading doses in ST-segment elevation myocardial infarction patients: RAPID (Rapid Activity of Platelet Inhibitor Drugs) primary PCI study J Am Coll Cardiol 61 15 2013 1601 1606
    • (2013) J Am Coll Cardiol , vol.61 , Issue.15 , pp. 1601-1606
    • Parodi, G.1    Valenti, R.2    Bellandi, B.3    Migliorini, A.4    Marcucci, R.5    Comito, V.6
  • 26
    • 84873530056 scopus 로고    scopus 로고
    • Randomized assessment of ticagrelor versus prasugrel antiplatelet effects in patients with ST-segment-elevation myocardial infarction
    • D. Alexopoulos, I. Xanthopoulou, V. Gkizas, G. Kassimis, K.C. Theodoropoulos, and G. Makris et al. Randomized assessment of ticagrelor versus prasugrel antiplatelet effects in patients with ST-segment-elevation myocardial infarction Circ Cardiovasc Interv 5 6 2012 797 804
    • (2012) Circ Cardiovasc Interv , vol.5 , Issue.6 , pp. 797-804
    • Alexopoulos, D.1    Xanthopoulou, I.2    Gkizas, V.3    Kassimis, G.4    Theodoropoulos, K.C.5    Makris, G.6
  • 27
    • 45849149636 scopus 로고    scopus 로고
    • Platelet collagen receptor glycoprotein VI as a possible novel indicator for the acute coronary syndrome
    • B. Bigalke, T. Geisler, K. Stellos, H. Langer, K. Daub, and E. Kremmer et al. Platelet collagen receptor glycoprotein VI as a possible novel indicator for the acute coronary syndrome Am Heart J 156 1 2008 193 200
    • (2008) Am Heart J , vol.156 , Issue.1 , pp. 193-200
    • Bigalke, B.1    Geisler, T.2    Stellos, K.3    Langer, H.4    Daub, K.5    Kremmer, E.6
  • 28
    • 0038649988 scopus 로고    scopus 로고
    • Clopidogrel for coronary stenting: Response variability, drug resistance, and the effect of pretreatment platelet reactivity
    • P.A. Gurbel, K.P. Bliden, B.L. Hiatt, and C.M. O'Connor Clopidogrel for coronary stenting: response variability, drug resistance, and the effect of pretreatment platelet reactivity Circulation 107 23 2003 2908 2913
    • (2003) Circulation , vol.107 , Issue.23 , pp. 2908-2913
    • Gurbel, P.A.1    Bliden, K.P.2    Hiatt, B.L.3    O'Connor, C.M.4
  • 29
    • 84873559846 scopus 로고    scopus 로고
    • Pretreatment platelet reactivity contribution to residual, post-treatment platelet reactivity in prasugrel-treated and ticagrelor-treated patients
    • D. Alexopoulos, I. Xanthopoulou, P. Davlouros, G. Tsigkas, A. Damelou, and K.C. Theodoropoulos et al. Pretreatment platelet reactivity contribution to residual, post-treatment platelet reactivity in prasugrel-treated and ticagrelor-treated patients J Thromb Haemost 11 2 2013 381 384
    • (2013) J Thromb Haemost , vol.11 , Issue.2 , pp. 381-384
    • Alexopoulos, D.1    Xanthopoulou, I.2    Davlouros, P.3    Tsigkas, G.4    Damelou, A.5    Theodoropoulos, K.C.6
  • 30
    • 79961114506 scopus 로고    scopus 로고
    • Intrinsic platelet reactivity before P2Y12 blockade contributes to residual platelet reactivity despite high-level P2Y12 blockade by prasugrel or high-dose clopidogrel. Results from PRINCIPLE-TIMI 44
    • A.L. Frelinger III, A.D. Michelson, S.D. Wiviott, D. Trenk, F.J. Neumann, and D.L. Miller et al. Intrinsic platelet reactivity before P2Y12 blockade contributes to residual platelet reactivity despite high-level P2Y12 blockade by prasugrel or high-dose clopidogrel. Results from PRINCIPLE-TIMI 44 Thromb Haemost 106 2 2011 219 226
    • (2011) Thromb Haemost , vol.106 , Issue.2 , pp. 219-226
    • Frelinger III, A.L.1    Michelson, A.D.2    Wiviott, S.D.3    Trenk, D.4    Neumann, F.J.5    Miller, D.L.6
  • 31
    • 84871262634 scopus 로고    scopus 로고
    • CYP2C19*2 and*17 alleles have a significant impact on platelet response and bleeding risk in patients treated with prasugrel after acute coronary syndrome
    • T. Cuisset, M. Loosveld, P.E. Morange, J. Quilici, P.J. Moro, and N. Saut et al. CYP2C19*2 and*17 alleles have a significant impact on platelet response and bleeding risk in patients treated with prasugrel after acute coronary syndrome JACC Cardiovasc Interv 5 12 2012 1280 1287
    • (2012) JACC Cardiovasc Interv , vol.5 , Issue.12 , pp. 1280-1287
    • Cuisset, T.1    Loosveld, M.2    Morange, P.E.3    Quilici, J.4    Moro, P.J.5    Saut, N.6
  • 32
    • 84875225074 scopus 로고    scopus 로고
    • Effect of CYP2C19*2 and*17 genetic variants on platelet response to clopidogrel and prasugrel maintenance dose and relation to bleeding complications
    • C. Grosdidier, J. Quilici, M. Loosveld, L. Camoin, P.J. Moro, and N. Saut et al. Effect of CYP2C19*2 and*17 genetic variants on platelet response to clopidogrel and prasugrel maintenance dose and relation to bleeding complications Am J Cardiol 111 7 2013 985 990
    • (2013) Am J Cardiol , vol.111 , Issue.7 , pp. 985-990
    • Grosdidier, C.1    Quilici, J.2    Loosveld, M.3    Camoin, L.4    Moro, P.J.5    Saut, N.6
  • 33
    • 84879624900 scopus 로고    scopus 로고
    • Cytochrome P450 2B6 and 2C9 genotype polymorphism-a possible cause of prasugrel low responsiveness
    • C.C. Franken, A.F. Kaiser, J.C. Kruger, K. Overbeck, A. Mugge, and H. Neubauer Cytochrome P450 2B6 and 2C9 genotype polymorphism-a possible cause of prasugrel low responsiveness Thromb Haemost 110 1 2013 131 140
    • (2013) Thromb Haemost , vol.110 , Issue.1 , pp. 131-140
    • Franken, C.C.1    Kaiser, A.F.2    Kruger, J.C.3    Overbeck, K.4    Mugge, A.5    Neubauer, H.6
  • 34
    • 69249219296 scopus 로고    scopus 로고
    • Association of cytochrome P450 2C19 genotype with the antiplatelet effect and clinical efficacy of clopidogrel therapy
    • A.R. Shuldiner, J.R. O'Connell, K.P. Bliden, A. Gandhi, K. Ryan, and R.B. Horenstein et al. Association of cytochrome P450 2C19 genotype with the antiplatelet effect and clinical efficacy of clopidogrel therapy JAMA 302 8 2009 849 857
    • (2009) JAMA , vol.302 , Issue.8 , pp. 849-857
    • Shuldiner, A.R.1    O'Connell, J.R.2    Bliden, K.P.3    Gandhi, A.4    Ryan, K.5    Horenstein, R.B.6


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